ES2229335T3 - Nuevos imidazoles sustituidos con cicloalquilo. - Google Patents
Nuevos imidazoles sustituidos con cicloalquilo.Info
- Publication number
- ES2229335T3 ES2229335T3 ES97905576T ES97905576T ES2229335T3 ES 2229335 T3 ES2229335 T3 ES 2229335T3 ES 97905576 T ES97905576 T ES 97905576T ES 97905576 T ES97905576 T ES 97905576T ES 2229335 T3 ES2229335 T3 ES 2229335T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- imidazole
- fluorophenyl
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
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- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1001096P | 1996-01-11 | 1996-01-11 | |
| US10010P | 1996-01-11 |
Publications (1)
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|---|---|
| ES2229335T3 true ES2229335T3 (es) | 2005-04-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97905576T Expired - Lifetime ES2229335T3 (es) | 1996-01-11 | 1997-01-10 | Nuevos imidazoles sustituidos con cicloalquilo. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6329526B1 (enExample) |
| EP (1) | EP0889726B1 (enExample) |
| JP (1) | JP2000503304A (enExample) |
| CN (1) | CN1213305A (enExample) |
| AP (1) | AP9700912A0 (enExample) |
| AR (1) | AR005434A1 (enExample) |
| AT (1) | ATE276248T1 (enExample) |
| AU (1) | AU715315B2 (enExample) |
| BR (1) | BR9708149A (enExample) |
| CZ (1) | CZ218198A3 (enExample) |
| DE (1) | DE69730704T2 (enExample) |
| ES (1) | ES2229335T3 (enExample) |
| HU (1) | HUP9901233A2 (enExample) |
| ID (1) | ID18759A (enExample) |
| IL (1) | IL125224A0 (enExample) |
| MA (1) | MA24055A1 (enExample) |
| MX (1) | MX9805628A (enExample) |
| NO (1) | NO983182L (enExample) |
| NZ (1) | NZ330889A (enExample) |
| PL (1) | PL327939A1 (enExample) |
| TR (1) | TR199801350T2 (enExample) |
| UY (1) | UY24434A1 (enExample) |
| WO (1) | WO1997025048A1 (enExample) |
| ZA (1) | ZA97173B (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5916891A (en) | 1992-01-13 | 1999-06-29 | Smithkline Beecham Corporation | Pyrimidinyl imidazoles |
| ZA9610687B (en) * | 1995-12-22 | 1997-09-29 | Smithkline Beecham Corp | Novel synthesis. |
| AP9700912A0 (en) | 1996-01-11 | 1997-01-31 | Smithkline Beecham Corp | Novel cycloalkyl substituted imidazoles |
| US6046208A (en) * | 1996-01-11 | 2000-04-04 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US5756499A (en) * | 1996-01-11 | 1998-05-26 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| WO1997035856A1 (en) * | 1996-03-25 | 1997-10-02 | Smithkline Beecham Corporation | Novel treatment for cns injuries |
| WO1997035855A1 (en) * | 1996-03-25 | 1997-10-02 | Smithkline Beecham Corporation | Novel treatment for cns injuries |
| WO1998007425A1 (en) | 1996-08-21 | 1998-02-26 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
| US5929076A (en) * | 1997-01-10 | 1999-07-27 | Smithkline Beecham Corporation | Cycloalkyl substituted imidazoles |
| US6087381A (en) | 1997-05-22 | 2000-07-11 | G. D. Searle & Company | Pyrazole derivatives as p38 kinase inhibitors |
| US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| US20020156104A1 (en) | 1997-06-13 | 2002-10-24 | Jerry L. Adams | Novel pyrazole and pyrazoline substituted compounds |
| JP2002505690A (ja) | 1997-06-19 | 2002-02-19 | スミスクライン・ビーチャム・コーポレイション | 新規なアリールオキシピリミジン置換イミダゾール化合物 |
| US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6251914B1 (en) | 1997-07-02 | 2001-06-26 | Smithkline Beecham Corporation | Cycloalkyl substituted imidazoles |
| TW517055B (en) | 1997-07-02 | 2003-01-11 | Smithkline Beecham Corp | Novel substituted imidazole compounds |
| US6562832B1 (en) | 1997-07-02 | 2003-05-13 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6489325B1 (en) | 1998-07-01 | 2002-12-03 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6362193B1 (en) | 1997-10-08 | 2002-03-26 | Smithkline Beecham Corporation | Cycloalkenyl substituted compounds |
| JP2001526230A (ja) | 1997-12-19 | 2001-12-18 | スミスクライン・ビーチャム・コーポレイション | ヘテロアリール置換イミダゾール化合物、その医薬組成物および使用 |
| US6096899A (en) * | 1998-04-14 | 2000-08-01 | The Regents Of The University Of Michigan | Cylic imidazole compounds having relatively low hydrogen content and relatively high nitrogen content and polymers formed therefrom |
| GB9809869D0 (en) * | 1998-05-09 | 1998-07-08 | Medical Res Council | Inhibition of protein kinases |
| BR9910621A (pt) | 1998-05-22 | 2001-01-30 | Smithkline Beecham Corp | Novos compostos de imidazol 2-alquil substituìdos |
| US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| ES2221426T3 (es) | 1998-08-20 | 2004-12-16 | Smithkline Beecham Corporation | Nuevos compuestos de triazol sustituidos. |
| US6548503B1 (en) | 1998-11-04 | 2003-04-15 | Smithkline Beecham Corporation | Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines |
| US6239279B1 (en) | 1998-12-16 | 2001-05-29 | Smithkline Beecham Corporation | Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives |
| US6930101B1 (en) | 1999-05-17 | 2005-08-16 | The Regents Of The University Of California | Thiazolopyrimidines useful as TNFα inhibitors |
| KR20020032591A (ko) * | 1999-09-17 | 2002-05-03 | 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 | 라이노바이러스 감염에서의 ｃｓａｉｄ의 용도 |
| JP2003514900A (ja) | 1999-11-23 | 2003-04-22 | スミスクライン・ビーチャム・コーポレイション | ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４−ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物 |
| US6759410B1 (en) | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
| DE60023025T2 (de) | 1999-11-23 | 2006-07-13 | Smithkline Beecham Corp. | 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren |
| CO5261556A1 (es) | 1999-12-08 | 2003-03-31 | Pharmacia Corp | Composiciones inhibidoras de ciclooxigenasa-2 que tiene rapido acceso de efecto terapeutico |
| US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| US6673818B2 (en) | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
| US7473695B2 (en) * | 2001-10-22 | 2009-01-06 | Mitsubishi Tanabe Pharma Corporation | 4-imidazolin-2-one compounds |
| AU2003245989A1 (en) | 2002-07-09 | 2004-01-23 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
| US20050009931A1 (en) * | 2003-03-20 | 2005-01-13 | Britten Nancy Jean | Dispersible pharmaceutical composition for treatment of mastitis and otic disorders |
| US20050004098A1 (en) * | 2003-03-20 | 2005-01-06 | Britten Nancy Jean | Dispersible formulation of an anti-inflammatory agent |
| ES2270361T3 (es) * | 2003-03-20 | 2007-04-01 | Pharmacia Corporation | Formulacion dispersable de un agente antiinflamatorio. |
| US20040214753A1 (en) * | 2003-03-20 | 2004-10-28 | Britten Nancy Jean | Dispersible pharmaceutical composition for treatment of mastitis and otic disorders |
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-
1997
- 1997-01-02 AP AP9700912A patent/AP9700912A0/xx unknown
- 1997-01-08 MA MA24456A patent/MA24055A1/fr unknown
- 1997-01-08 UY UY24434A patent/UY24434A1/es unknown
- 1997-01-09 ZA ZA97173A patent/ZA97173B/xx unknown
- 1997-01-10 DE DE69730704T patent/DE69730704T2/de not_active Expired - Fee Related
- 1997-01-10 JP JP9525466A patent/JP2000503304A/ja not_active Ceased
- 1997-01-10 AT AT97905576T patent/ATE276248T1/de not_active IP Right Cessation
- 1997-01-10 CN CN97192881A patent/CN1213305A/zh active Pending
- 1997-01-10 ES ES97905576T patent/ES2229335T3/es not_active Expired - Lifetime
- 1997-01-10 BR BR9708149A patent/BR9708149A/pt unknown
- 1997-01-10 WO PCT/US1997/000619 patent/WO1997025048A1/en not_active Ceased
- 1997-01-10 HU HU9901233A patent/HUP9901233A2/hu unknown
- 1997-01-10 TR TR1998/01350T patent/TR199801350T2/xx unknown
- 1997-01-10 ID IDP970056A patent/ID18759A/id unknown
- 1997-01-10 PL PL97327939A patent/PL327939A1/xx unknown
- 1997-01-10 EP EP97905576A patent/EP0889726B1/en not_active Expired - Lifetime
- 1997-01-10 IL IL12522497A patent/IL125224A0/xx unknown
- 1997-01-10 AR ARP970100105A patent/AR005434A1/es unknown
- 1997-01-10 AU AU22425/97A patent/AU715315B2/en not_active Ceased
- 1997-01-10 NZ NZ330889A patent/NZ330889A/xx unknown
- 1997-01-10 CZ CZ982181A patent/CZ218198A3/cs unknown
- 1997-01-10 US US09/101,416 patent/US6329526B1/en not_active Expired - Fee Related
-
1998
- 1998-07-10 NO NO983182A patent/NO983182L/no not_active Application Discontinuation
- 1998-07-10 MX MX9805628A patent/MX9805628A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE276248T1 (de) | 2004-10-15 |
| MA24055A1 (fr) | 1997-10-01 |
| PL327939A1 (en) | 1999-01-04 |
| NZ330889A (en) | 2000-03-27 |
| ZA97173B (en) | 1997-07-18 |
| AU715315B2 (en) | 2000-01-20 |
| WO1997025048A1 (en) | 1997-07-17 |
| ID18759A (id) | 1998-05-07 |
| DE69730704T2 (de) | 2005-09-22 |
| TR199801350T2 (xx) | 1998-10-21 |
| EP0889726B1 (en) | 2004-09-15 |
| AR005434A1 (es) | 1999-06-23 |
| UY24434A1 (es) | 1997-06-06 |
| HUP9901233A2 (hu) | 2000-04-28 |
| AU2242597A (en) | 1997-08-01 |
| DE69730704D1 (de) | 2004-10-21 |
| NO983182L (no) | 1998-09-09 |
| JP2000503304A (ja) | 2000-03-21 |
| MX9805628A (es) | 1998-11-29 |
| US6329526B1 (en) | 2001-12-11 |
| IL125224A0 (en) | 1999-03-12 |
| EP0889726A4 (en) | 1999-07-21 |
| CN1213305A (zh) | 1999-04-07 |
| BR9708149A (pt) | 1999-07-27 |
| CZ218198A3 (cs) | 1999-09-15 |
| EP0889726A1 (en) | 1999-01-13 |
| AP9700912A0 (en) | 1997-01-31 |
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