ZA97173B - Novel cycloalkyl substituted imidazoles - Google Patents

Novel cycloalkyl substituted imidazoles

Info

Publication number
ZA97173B
ZA97173B ZA97173A ZA97173A ZA97173B ZA 97173 B ZA97173 B ZA 97173B ZA 97173 A ZA97173 A ZA 97173A ZA 97173 A ZA97173 A ZA 97173A ZA 97173 B ZA97173 B ZA 97173B
Authority
ZA
South Africa
Prior art keywords
cycloalkyl substituted
substituted imidazoles
novel cycloalkyl
novel
imidazoles
Prior art date
Application number
ZA97173A
Other languages
English (en)
Inventor
Jerry L Adams
Ravi S Garigipati
Margaret E Sorenson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of ZA97173B publication Critical patent/ZA97173B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Detergent Compositions (AREA)
ZA97173A 1996-01-11 1997-01-09 Novel cycloalkyl substituted imidazoles ZA97173B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1001096P 1996-01-11 1996-01-11

Publications (1)

Publication Number Publication Date
ZA97173B true ZA97173B (en) 1997-07-18

Family

ID=21743297

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA97173A ZA97173B (en) 1996-01-11 1997-01-09 Novel cycloalkyl substituted imidazoles

Country Status (24)

Country Link
US (1) US6329526B1 (xx)
EP (1) EP0889726B1 (xx)
JP (1) JP2000503304A (xx)
CN (1) CN1213305A (xx)
AP (1) AP9700912A0 (xx)
AR (1) AR005434A1 (xx)
AT (1) ATE276248T1 (xx)
AU (1) AU715315B2 (xx)
BR (1) BR9708149A (xx)
CZ (1) CZ218198A3 (xx)
DE (1) DE69730704T2 (xx)
ES (1) ES2229335T3 (xx)
HU (1) HUP9901233A2 (xx)
ID (1) ID18759A (xx)
IL (1) IL125224A0 (xx)
MA (1) MA24055A1 (xx)
MX (1) MX9805628A (xx)
NO (1) NO983182L (xx)
NZ (1) NZ330889A (xx)
PL (1) PL327939A1 (xx)
TR (1) TR199801350T2 (xx)
UY (1) UY24434A1 (xx)
WO (1) WO1997025048A1 (xx)
ZA (1) ZA97173B (xx)

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US6239279B1 (en) 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
US6930101B1 (en) 1999-05-17 2005-08-16 The Regents Of The University Of California Thiazolopyrimidines useful as TNFα inhibitors
BR0014041A (pt) * 1999-09-17 2003-07-15 Smithkline Beecham Corp Utilização de csaids em infecção por rinovìrus
ATE296809T1 (de) 1999-11-23 2005-06-15 Smithkline Beecham Corp 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren
WO2001038313A1 (en) 1999-11-23 2001-05-31 Smithkline Beecham Corporation 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/p39 kINASE INHIBITORS
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US6673818B2 (en) 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
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US20050009931A1 (en) * 2003-03-20 2005-01-13 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
US7105467B2 (en) * 2003-07-08 2006-09-12 Pharmacore, Inc. Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives
US7105707B2 (en) * 2003-12-17 2006-09-12 Pharmacore, Inc. Process for preparing alkynyl-substituted aromatic and heterocyclic compounds
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WO2006062069A1 (ja) * 2004-12-06 2006-06-15 Santen Pharmaceutical Co., Ltd. ｐ３８ＭＡＰキナーゼ阻害剤を有効成分とする掻痒治療剤
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
JP2007145819A (ja) * 2005-10-28 2007-06-14 Tanabe Seiyaku Co Ltd 医薬組成物
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EP2111861A1 (en) 2008-04-21 2009-10-28 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type IV inhibitors
US20150044178A1 (en) 2011-12-28 2015-02-12 Kyoto Prefectural Public University Corporation Normalization of culture of corneal endothelial cells
US10813920B2 (en) 2013-11-14 2020-10-27 The Doshisha Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage
WO2019071147A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
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AP9700912A0 (en) 1996-01-11 1997-01-31 Smithkline Beecham Corp Novel cycloalkyl substituted imidazoles
KR19990077164A (ko) 1996-01-11 1999-10-25 스티븐 베네티아너 신규 치환된 이미다졸 화합물
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Also Published As

Publication number Publication date
JP2000503304A (ja) 2000-03-21
CZ218198A3 (cs) 1999-09-15
IL125224A0 (en) 1999-03-12
TR199801350T2 (xx) 1998-10-21
UY24434A1 (es) 1997-06-06
EP0889726B1 (en) 2004-09-15
AU715315B2 (en) 2000-01-20
BR9708149A (pt) 1999-07-27
DE69730704D1 (de) 2004-10-21
EP0889726A1 (en) 1999-01-13
WO1997025048A1 (en) 1997-07-17
ATE276248T1 (de) 2004-10-15
CN1213305A (zh) 1999-04-07
ES2229335T3 (es) 2005-04-16
NO983182L (no) 1998-09-09
DE69730704T2 (de) 2005-09-22
EP0889726A4 (en) 1999-07-21
ID18759A (id) 1998-05-07
PL327939A1 (en) 1999-01-04
HUP9901233A2 (hu) 2000-04-28
AP9700912A0 (en) 1997-01-31
AR005434A1 (es) 1999-06-23
US6329526B1 (en) 2001-12-11
MX9805628A (es) 1998-11-29
MA24055A1 (fr) 1997-10-01
AU2242597A (en) 1997-08-01
NZ330889A (en) 2000-03-27

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