ES2221039T3 - Oligonucleotidos abiertos modificados con azucar. - Google Patents
Oligonucleotidos abiertos modificados con azucar.Info
- Publication number
- ES2221039T3 ES2221039T3 ES97907581T ES97907581T ES2221039T3 ES 2221039 T3 ES2221039 T3 ES 2221039T3 ES 97907581 T ES97907581 T ES 97907581T ES 97907581 T ES97907581 T ES 97907581T ES 2221039 T3 ES2221039 T3 ES 2221039T3
- Authority
- ES
- Spain
- Prior art keywords
- baselineskip
- oligonucleotide
- oligonucleotides
- sequence
- nucleoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 239000002777 nucleoside Substances 0.000 claims description 79
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- 150000004713 phosphodiesters Chemical class 0.000 claims description 27
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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| AU767133B2 (en) | 1999-02-26 | 2003-10-30 | University Of British Columbia, The | TRPM-2 antisense therapy |
| US7569551B2 (en) | 2000-02-25 | 2009-08-04 | The University Of British Columbia | Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides |
| KR101215789B1 (ko) | 2000-03-30 | 2012-12-26 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체 |
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| SI1407044T2 (en) | 2000-12-01 | 2018-03-30 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Rna interference mediating small rna molecules |
| CA2469685C (en) | 2002-01-17 | 2013-03-12 | The University Of British Columbia | Bispecific antisense oligonucleotides that inhibit igfbp-2 and igfbp-5 and methods of using same |
| CA2524255C (en) | 2003-03-21 | 2014-02-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
| EP1667731B1 (en) * | 2003-10-01 | 2013-05-22 | The University Of British Columbia | Bispecific oligonucleotide for the treatment of cns malignancies |
| KR101147147B1 (ko) | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
| US8710020B2 (en) | 2004-04-02 | 2014-04-29 | The University Of British Columbia | Clusterin antisense therapy for treatment of cancer |
| USRE48960E1 (en) | 2004-06-28 | 2022-03-08 | The University Of Western Australia | Antisense oligonucleotides for inducing exon skipping and methods of use thereof |
| ATE498685T1 (de) | 2004-06-28 | 2011-03-15 | Univ Western Australia | Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon |
| US7923206B2 (en) | 2004-11-22 | 2011-04-12 | Dharmacon, Inc. | Method of determining a cellular response to a biological agent |
| US7935811B2 (en) | 2004-11-22 | 2011-05-03 | Dharmacon, Inc. | Apparatus and system having dry gene silencing compositions |
| US7923207B2 (en) | 2004-11-22 | 2011-04-12 | Dharmacon, Inc. | Apparatus and system having dry gene silencing pools |
| CA2584646C (en) * | 2004-11-23 | 2015-11-03 | The University Of British Columbia | Treatment of cancer with a combination of an agent that perturbs the egf signaling pathway and an oligonucleotide that reduces clusterin levels |
| US8288354B2 (en) | 2005-12-28 | 2012-10-16 | The Scripps Research Institute | Natural antisense and non-coding RNA transcripts as drug targets |
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| WO2007139943A2 (en) * | 2006-05-26 | 2007-12-06 | Ico Therapeutics Inc. | Therapeutic drug combinations and delivery systems comprising c-raf kinase antisense polynucleotides for treating ocular diseases and disorders |
| DK2049664T3 (da) | 2006-08-11 | 2012-01-02 | Prosensa Technologies Bv | Enkeltstrengede oligonukleotider, som er komplementære til repetitive elementer, til behandling af med DNA-repetitiv-ustabilitet associerede lidelser |
| EP2081949B1 (en) | 2006-09-22 | 2014-12-10 | GE Healthcare Dharmacon, Inc. | Tripartite oligonucleotide complexes and methods for gene silencing by rna interference |
| CA2693048C (en) | 2007-07-12 | 2016-10-18 | Prosensa Technologies B.V. | Molecules for targeting compounds to various selected organs or tissues |
| EP2614827B1 (en) | 2007-10-26 | 2017-06-28 | Academisch Ziekenhuis Leiden | Means and methods for counteracting muscle disorders |
| USRE48468E1 (en) | 2007-10-26 | 2021-03-16 | Biomarin Technologies B.V. | Means and methods for counteracting muscle disorders |
| CA2714120A1 (en) | 2008-02-08 | 2009-08-13 | Prosensa Holding Bv | Methods and means for treating dna repeat instability associated genetic disorders |
| US8188060B2 (en) | 2008-02-11 | 2012-05-29 | Dharmacon, Inc. | Duplex oligonucleotides with enhanced functionality in gene regulation |
| EP2119783A1 (en) | 2008-05-14 | 2009-11-18 | Prosensa Technologies B.V. | Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means |
| WO2010040112A2 (en) | 2008-10-03 | 2010-04-08 | Curna, Inc. | Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1 |
| JP5763539B2 (ja) * | 2008-10-24 | 2015-08-12 | アイシス ファーマシューティカルズ， インコーポレーテッド | ５’及び２’ビス置換ヌクレオシド及びそれから製造されるオリゴマー化合物 |
| EP4174178A1 (en) | 2008-10-24 | 2023-05-03 | Sarepta Therapeutics, Inc. | Multiple exon skipping compositions for dmd |
| EP2370582B1 (en) | 2008-12-04 | 2017-05-10 | CuRNA, Inc. | Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene |
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| AU725262B2 (en) | 2000-10-12 |
| TR199801581T2 (xx) | 1998-10-21 |
| ZA971208B (en) | 1997-10-23 |
| US6451991B1 (en) | 2002-09-17 |
| CA2749312A1 (en) | 1997-08-21 |
| CN1214688A (zh) | 1999-04-21 |
| WO1997030067A1 (en) | 1997-08-21 |
| PL328563A1 (en) | 1999-02-01 |
| CZ243498A3 (cs) | 1999-09-15 |
| DE69729179D1 (de) | 2004-06-24 |
| CA2246229A1 (en) | 1997-08-21 |
| EP0882061A1 (en) | 1998-12-09 |
| DK0882061T3 (da) | 2004-09-27 |
| AU1955297A (en) | 1997-09-02 |
| EP0882061B1 (en) | 2004-05-19 |
| SK109198A3 (en) | 1999-06-11 |
| ATE267207T1 (de) | 2004-06-15 |
| NO983718L (no) | 1998-10-13 |
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