CA2749312A1 - Sugar-modified gapped oligonucleotides - Google Patents
Sugar-modified gapped oligonucleotides Download PDFInfo
- Publication number
- CA2749312A1 CA2749312A1 CA2749312A CA2749312A CA2749312A1 CA 2749312 A1 CA2749312 A1 CA 2749312A1 CA 2749312 A CA2749312 A CA 2749312A CA 2749312 A CA2749312 A CA 2749312A CA 2749312 A1 CA2749312 A1 CA 2749312A1
- Authority
- CA
- Canada
- Prior art keywords
- oligonucleotide
- oligonucleotides
- nucleoside
- subsequence
- deoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C—CHEMISTRY; METALLURGY
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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| US6346614B1 (en) * | 1992-07-23 | 2002-02-12 | Hybridon, Inc. | Hybrid oligonucleotide phosphorothioates |
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| US7569551B2 (en) | 2000-02-25 | 2009-08-04 | The University Of British Columbia | Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides |
| DK2796553T3 (da) | 2000-03-30 | 2019-09-30 | Whitehead Inst Biomedical Res | Rna-sekvensspecifikke formidlere af rna-interferens |
| EP1191097A1 (en) | 2000-09-21 | 2002-03-27 | Leids Universitair Medisch Centrum | Induction of exon skipping in eukaryotic cells |
| CZ302719B6 (cs) | 2000-12-01 | 2011-09-21 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití |
| CA2469685C (en) | 2002-01-17 | 2013-03-12 | The University Of British Columbia | Bispecific antisense oligonucleotides that inhibit igfbp-2 and igfbp-5 and methods of using same |
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| WO2005030260A1 (en) * | 2003-10-01 | 2005-04-07 | The University Of British Columbia | Bispecific oligonucleotide for the treatment of cns malignancies |
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| US8710020B2 (en) * | 2004-04-02 | 2014-04-29 | The University Of British Columbia | Clusterin antisense therapy for treatment of cancer |
| USRE47769E1 (en) | 2004-06-28 | 2019-12-17 | The University Of Western Australia | Antisense oligonucleotides for inducing exon skipping and methods of use thereof |
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| DK1814595T3 (da) * | 2004-11-23 | 2014-03-31 | Univ British Columbia | Behandling af cancer med en kombination af et middel, som forstyrrer EGF-signalvejen og et oligonucleotid, som reducerer clusterinniveauerne |
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| WO2007123391A1 (en) | 2006-04-20 | 2007-11-01 | Academisch Ziekenhuis Leiden | Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene. |
| EP1857548A1 (en) | 2006-05-19 | 2007-11-21 | Academisch Ziekenhuis Leiden | Means and method for inducing exon-skipping |
| US20070275029A1 (en) * | 2006-05-26 | 2007-11-29 | Ico Therapeutics Inc. | Therapeutic drug combinations and delivery systems comprising c-raf kinase antisense polynucleotides for treating ocular diseases and disorders |
| ES2373246T3 (es) | 2006-08-11 | 2012-02-01 | Prosensa Technologies B.V. | Oligonucleótidos monocatenarios complementarios de elementos repetitivos para el tratamiento de trastornos genéticos asociados a la inestabilidad de repeticiones de adn. |
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-
1997
- 1997-02-07 CA CA2749312A patent/CA2749312A1/en not_active Abandoned
- 1997-02-07 DE DE69729179T patent/DE69729179T2/de not_active Expired - Lifetime
- 1997-02-07 KR KR1019980706209A patent/KR19990082476A/ko not_active Withdrawn
- 1997-02-07 TR TR1998/01581T patent/TR199801581T2/xx unknown
- 1997-02-07 PL PL97328563A patent/PL328563A1/xx unknown
- 1997-02-07 AU AU19552/97A patent/AU725262B2/en not_active Ceased
- 1997-02-07 NZ NZ331217A patent/NZ331217A/en not_active IP Right Cessation
- 1997-02-07 CN CN97193129A patent/CN1214688A/zh active Pending
- 1997-02-07 SK SK1091-98A patent/SK109198A3/sk unknown
- 1997-02-07 DK DK97907581T patent/DK0882061T3/da active
- 1997-02-07 CA CA2246229A patent/CA2246229C/en not_active Expired - Lifetime
- 1997-02-07 HU HU9901118A patent/HUP9901118A3/hu unknown
- 1997-02-07 IL IL12575997A patent/IL125759A0/xx unknown
- 1997-02-07 BR BR9707529-9A patent/BR9707529A/pt not_active Application Discontinuation
- 1997-02-07 JP JP52941297A patent/JP4293636B2/ja not_active Expired - Lifetime
- 1997-02-07 ES ES97907581T patent/ES2221039T3/es not_active Expired - Lifetime
- 1997-02-07 WO PCT/US1997/002043 patent/WO1997030067A1/en not_active Ceased
- 1997-02-07 AT AT97907581T patent/ATE267207T1/de active
- 1997-02-07 EP EP97907581A patent/EP0882061B1/en not_active Expired - Lifetime
- 1997-02-07 CZ CZ982434A patent/CZ243498A3/cs unknown
- 1997-02-11 US US08/802,331 patent/US6451991B1/en not_active Expired - Lifetime
- 1997-02-13 ZA ZA9701208A patent/ZA971208B/xx unknown
-
1998
- 1998-08-13 NO NO983718A patent/NO983718L/no unknown
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|---|---|
| WO1997030067A1 (en) | 1997-08-21 |
| AU1955297A (en) | 1997-09-02 |
| ZA971208B (en) | 1997-10-23 |
| ATE267207T1 (de) | 2004-06-15 |
| NZ331217A (en) | 2000-02-28 |
| CZ243498A3 (cs) | 1999-09-15 |
| DK0882061T3 (da) | 2004-09-27 |
| TR199801581T2 (xx) | 1998-10-21 |
| EP0882061A1 (en) | 1998-12-09 |
| EP0882061A4 (en) | 2000-12-13 |
| DE69729179T2 (de) | 2004-12-30 |
| EP0882061B1 (en) | 2004-05-19 |
| IL125759A0 (en) | 1999-04-11 |
| CA2246229A1 (en) | 1997-08-21 |
| US6451991B1 (en) | 2002-09-17 |
| CA2246229C (en) | 2011-08-23 |
| HUP9901118A2 (hu) | 1999-07-28 |
| NO983718D0 (no) | 1998-08-13 |
| JP4293636B2 (ja) | 2009-07-08 |
| HUP9901118A3 (en) | 2000-06-28 |
| AU725262B2 (en) | 2000-10-12 |
| PL328563A1 (en) | 1999-02-01 |
| JP2000504725A (ja) | 2000-04-18 |
| ES2221039T3 (es) | 2004-12-16 |
| CN1214688A (zh) | 1999-04-21 |
| SK109198A3 (en) | 1999-06-11 |
| KR19990082476A (ko) | 1999-11-25 |
| DE69729179D1 (de) | 2004-06-24 |
| NO983718L (no) | 1998-10-13 |
| BR9707529A (pt) | 2000-01-04 |
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