ES2219926T3 - Composiciones y metodos para el tratamiento del trastorno deficitario de la atencion y del trastorno de la hiperactividad con deficit de la atencion por medio de metilfenidato. - Google Patents
Composiciones y metodos para el tratamiento del trastorno deficitario de la atencion y del trastorno de la hiperactividad con deficit de la atencion por medio de metilfenidato.Info
- Publication number
- ES2219926T3 ES2219926T3 ES98963170T ES98963170T ES2219926T3 ES 2219926 T3 ES2219926 T3 ES 2219926T3 ES 98963170 T ES98963170 T ES 98963170T ES 98963170 T ES98963170 T ES 98963170T ES 2219926 T3 ES2219926 T3 ES 2219926T3
- Authority
- ES
- Spain
- Prior art keywords
- methylphenidate
- polymer
- composition according
- weight
- natural
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6951097P | 1997-12-15 | 1997-12-15 | |
| US69510P | 1997-12-15 | ||
| US163351 | 1998-09-30 | ||
| US09/163,351 US6210705B1 (en) | 1997-12-15 | 1998-09-30 | Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2219926T3 true ES2219926T3 (es) | 2004-12-01 |
Family
ID=26750154
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10011358.8T Expired - Lifetime ES2452517T3 (es) | 1997-12-15 | 1998-12-14 | Composiciones y métodos para el tratamiento del trastorno de déficit de atención y del trastorno de déficit de atención e hiperactividad con metilfenidato |
| ES98963170T Expired - Lifetime ES2219926T3 (es) | 1997-12-15 | 1998-12-14 | Composiciones y metodos para el tratamiento del trastorno deficitario de la atencion y del trastorno de la hiperactividad con deficit de la atencion por medio de metilfenidato. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10011358.8T Expired - Lifetime ES2452517T3 (es) | 1997-12-15 | 1998-12-14 | Composiciones y métodos para el tratamiento del trastorno de déficit de atención y del trastorno de déficit de atención e hiperactividad con metilfenidato |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6210705B1 (enExample) |
| EP (2) | EP2314288B1 (enExample) |
| JP (3) | JP4316800B2 (enExample) |
| KR (1) | KR100633348B1 (enExample) |
| CN (1) | CN1368876A (enExample) |
| AR (1) | AR014062A1 (enExample) |
| AT (1) | ATE260652T1 (enExample) |
| AU (1) | AU752027B2 (enExample) |
| BR (1) | BR9814282A (enExample) |
| CA (1) | CA2315237C (enExample) |
| CZ (2) | CZ300535B6 (enExample) |
| DE (1) | DE69822199T2 (enExample) |
| DK (1) | DK1037615T3 (enExample) |
| ES (2) | ES2452517T3 (enExample) |
| HK (1) | HK1049447A1 (enExample) |
| HU (1) | HU226615B1 (enExample) |
| IL (1) | IL136760A0 (enExample) |
| LV (1) | LV12558B (enExample) |
| NO (1) | NO329974B1 (enExample) |
| NZ (1) | NZ505689A (enExample) |
| PE (1) | PE20000120A1 (enExample) |
| PL (1) | PL195315B1 (enExample) |
| PT (1) | PT1037615E (enExample) |
| RU (1) | RU2233156C2 (enExample) |
| SI (1) | SI20360B (enExample) |
| TR (1) | TR200001736T2 (enExample) |
| TW (2) | TWI244396B (enExample) |
| WO (1) | WO1999030694A2 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| US20020102291A1 (en) * | 1997-12-15 | 2002-08-01 | Noven Pharmaceuticals, Inc. | Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate |
| GB9913458D0 (en) * | 1999-06-09 | 1999-08-11 | Medeva Europ Ltd | The therapeutic use of d-threo-methylphenidate |
| GB9918735D0 (en) * | 1999-08-09 | 1999-10-13 | Straken Limited | Transdermal patches |
| CO5261532A1 (es) * | 1999-11-15 | 2003-03-31 | Novartis Ag | Compuestos heterociclicos sililados, procedimiento para la preparacion de estos y composicion farmaceutica que los contiene |
| ATE252903T1 (de) * | 1999-12-17 | 2003-11-15 | Celltech Pharma Europ Ltd | Arzneimittel zur behandlung konvulsivischer zustände |
| US6455066B1 (en) | 2000-03-10 | 2002-09-24 | Epicept Corporation | Intradermal-penetration agents for topical local anesthetic administration |
| US6905016B2 (en) * | 2000-03-14 | 2005-06-14 | Noven Pharmaceuticals, Inc. | Packaging system for transdermal drug delivery systems |
| US7674480B2 (en) * | 2000-06-23 | 2010-03-09 | Teva Pharmaceutical Industries Ltd. | Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition |
| US20020119187A1 (en) * | 2000-09-29 | 2002-08-29 | Cantor Adam S. | Composition for the transdermal delivery of fentanyl |
| DE10060550C1 (de) * | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten |
| BR0207955A (pt) * | 2001-03-07 | 2004-02-25 | Hisamitsu Pharmaceutical Co | Agente de emplastro |
| FR2822049B1 (fr) * | 2001-03-13 | 2003-08-01 | Dbv Medica 1 | Patch destine notamment a depister l'etat de sensibilisation d'un sujet a un allergene, procede de fabrication et utilisation |
| ATE364380T1 (de) * | 2001-03-16 | 2007-07-15 | Alza Corp | Transdermales pflaster zur verabreichung von fentanyl |
| US20050208117A1 (en) * | 2001-03-16 | 2005-09-22 | Venkatraman Subramanian S | Transdermal administration of fentanyl and analogs thereof |
| DE10141652B4 (de) * | 2001-08-24 | 2011-04-07 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System auf der Basis von Polyacrylat-Haftklebern ohne funktionelle Gruppen und seine Verwendung |
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| US20030049272A1 (en) * | 2001-08-30 | 2003-03-13 | Yatindra Joshi | Pharmaceutical composition which produces irritation |
| JP4354678B2 (ja) * | 2002-08-28 | 2009-10-28 | 久光製薬株式会社 | 貼付剤 |
| US6913768B2 (en) | 2002-09-24 | 2005-07-05 | Shire Laboratories, Inc. | Sustained release delivery of amphetamine salts |
| HUE026034T2 (en) | 2002-12-13 | 2016-05-30 | Durect Corp | Oral delivery system containing an oral high-viscosity carrier |
| AU2004285505B2 (en) * | 2003-10-28 | 2010-12-23 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery device |
| WO2006078984A2 (en) * | 2005-01-20 | 2006-07-27 | Institute For Molecular Medicine, Inc. | Uses of methylphenidate derivatives |
| KR101318806B1 (ko) | 2005-01-20 | 2013-10-16 | 인스티튜트 포 몰리큘러 메디신, 인코포레이티드 | 메틸페니데이트 유도체 및 그 용도 |
| US9393218B2 (en) * | 2005-12-23 | 2016-07-19 | Epinamics Gmbh | Use of film-forming hair care polymers from the group of polyurethanes and pharmaceutical preparations and patches that contain these polymers |
| MX2008008211A (es) * | 2005-12-23 | 2008-09-03 | Epinamics Gmbh | Uso de polimeros para el cuidado del cabello formando peliculas del grupo de los poliuretanos y preparaciones farmaceuticas y parches conteniendo estos polimeros. |
| CA2643037C (en) * | 2006-02-27 | 2014-08-05 | Noven Pharmaceuticals, Inc. | Compositions and methods for delivery of amino-functional drugs |
| MX2008013613A (es) * | 2006-05-01 | 2008-10-30 | Colgate Palmolive Co | Composicion para el cuidado oral con compuesto de silicona. |
| US20100104621A1 (en) * | 2007-02-21 | 2010-04-29 | Connected Health Systems, Llc | Treating adhd and other diseases involving inflammation |
| KR101583680B1 (ko) * | 2007-10-15 | 2016-01-08 | 알자 코퍼레이션 | 펜타닐의 1일-1회 교체 경피 투여 |
| FR2924349B1 (fr) | 2007-12-03 | 2010-01-01 | Dbv Tech | Methode de desensibilitation aux allergenes |
| FR2924350B1 (fr) * | 2007-12-03 | 2010-08-13 | Dbv Tech | Procede et compositions pour la vaccination par voie cutanee |
| JP2011506318A (ja) | 2007-12-06 | 2011-03-03 | デュレクト コーポレーション | 経口医薬製剤 |
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| FR2926466B1 (fr) * | 2008-01-23 | 2010-11-12 | Dbv Tech | Procede de fabrication de patchs par electrospray |
| WO2009146320A1 (en) | 2008-05-27 | 2009-12-03 | Dmi Life Sciences, Inc. | Therapeutic methods and compounds |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| JP5155128B2 (ja) * | 2008-12-11 | 2013-02-27 | 日東電工株式会社 | メチルフェニデート貼付製剤 |
| EP2942196B8 (en) * | 2009-06-05 | 2018-01-10 | Babcock & Wilcox MEGTEC, LLC | Improved infrared float bar |
| EP2364695A1 (en) | 2010-02-10 | 2011-09-14 | Nitto Denko Corporation | Methylphenidate patch preparation |
| US20110200663A1 (en) * | 2010-02-12 | 2011-08-18 | Nitto Denko Corporation | Methylphenidate patch preparation |
| US8927010B2 (en) | 2011-03-23 | 2015-01-06 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US10905652B2 (en) | 2011-03-23 | 2021-02-02 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US9498447B2 (en) | 2011-03-23 | 2016-11-22 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US8916588B2 (en) | 2011-03-23 | 2014-12-23 | Ironshore Pharmaceuticals & Development, Inc. | Methods for treatment of attention deficit hyperactivity disorder |
| US9119809B2 (en) | 2011-03-23 | 2015-09-01 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US11241391B2 (en) | 2011-03-23 | 2022-02-08 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US9283214B2 (en) | 2011-03-23 | 2016-03-15 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US10292937B2 (en) | 2011-03-23 | 2019-05-21 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
| US9603809B2 (en) | 2011-03-23 | 2017-03-28 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
| EP4316488A3 (en) | 2011-03-23 | 2024-02-28 | Ironshore Pharmaceuticals & Development, Inc. | Methods and compositions for treatment of attention deficit disorder |
| PH12014500049A1 (en) | 2011-07-28 | 2016-07-29 | Kempharm Inc | Methylphenidate-prodrugs, processes of making and using the same |
| CA2891467A1 (en) | 2012-10-15 | 2014-04-24 | Noven Pharmaceuticals, Inc. | Compositions and methods for the transdermal delivery of methylphenidate |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
| AR094289A1 (es) | 2012-12-28 | 2015-07-22 | Noven Pharma | Sistemas de administracion transdermica de farmacos para levonorgestrel y etinil estradiol |
| JP6359032B2 (ja) | 2012-12-28 | 2018-07-18 | ノーヴェン ファーマシューティカルズ インコーポレイテッド | 経皮薬物送達用のマルチポリマー組成物 |
| US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
| WO2014159582A1 (en) | 2013-03-14 | 2014-10-02 | Noven Pharmaceuticals, Inc | Amphetamine transdermal compositions with acrylic block copolymer |
| TW201521769A (zh) | 2013-03-15 | 2015-06-16 | Durect Corp | 具有流變改質劑以減少溶解變異性之組成物 |
| AR095259A1 (es) | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria |
| AR095260A1 (es) | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones de anfetaminas transdérmicas estables y métodos de fabricación |
| US9782383B2 (en) | 2013-12-25 | 2017-10-10 | Fujimoto Co., Ltd. | Prophylactic and therapeutic agent for attention-deficit/hyperactivity disorder |
| US9980921B2 (en) * | 2016-06-30 | 2018-05-29 | Taho Pharmaceuticals Ltd. | Transdermal delivery system containing methylphenidate or its salts and methods thereof |
| US12274794B2 (en) | 2016-07-06 | 2025-04-15 | Orient Pharma Co., Ltd. | Oral dosage form with drug composition, barrier layer and drug layer |
| CN106511264A (zh) * | 2016-11-15 | 2017-03-22 | 北京万全德众医药生物技术有限公司 | 一种盐酸哌甲酯口服溶液剂及其制备方法 |
| BR112019011640B1 (pt) | 2016-12-11 | 2021-08-17 | Kempharm, Inc | Compostos conjugados de d-metilfenidato, composições que compreendem os mesmos e kit farmacêutico que compreende as ditas composições |
| EP3598982A1 (en) | 2018-07-23 | 2020-01-29 | Centre National De La Recherche Scientifique | Bioconjugates of neuropeptides derivatives |
| JP7600661B2 (ja) * | 2020-12-11 | 2024-12-17 | artience株式会社 | 貼付剤 |
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| US2957880A (en) | 1953-12-23 | 1960-10-25 | Ciba Pharm Prod Inc | Process for the conversion of stereoisomers |
| US4310509A (en) | 1979-07-31 | 1982-01-12 | Minnesota Mining And Manufacturing Company | Pressure-sensitive adhesive having a broad spectrum antimicrobial therein |
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| US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5474783A (en) | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
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-
1998
- 1998-09-30 US US09/163,351 patent/US6210705B1/en not_active Expired - Lifetime
- 1998-12-14 KR KR1020007006477A patent/KR100633348B1/ko not_active Expired - Fee Related
- 1998-12-14 PL PL98341596A patent/PL195315B1/pl unknown
- 1998-12-14 AU AU18249/99A patent/AU752027B2/en not_active Ceased
- 1998-12-14 HK HK03101632.9A patent/HK1049447A1/zh unknown
- 1998-12-14 SI SI9820083A patent/SI20360B/sl not_active IP Right Cessation
- 1998-12-14 DK DK98963170T patent/DK1037615T3/da active
- 1998-12-14 ES ES10011358.8T patent/ES2452517T3/es not_active Expired - Lifetime
- 1998-12-14 EP EP10011358.8A patent/EP2314288B1/en not_active Expired - Lifetime
- 1998-12-14 PT PT98963170T patent/PT1037615E/pt unknown
- 1998-12-14 HU HU0004539A patent/HU226615B1/hu not_active IP Right Cessation
- 1998-12-14 AT AT98963170T patent/ATE260652T1/de active
- 1998-12-14 TW TW092128573A patent/TWI244396B/zh not_active IP Right Cessation
- 1998-12-14 ES ES98963170T patent/ES2219926T3/es not_active Expired - Lifetime
- 1998-12-14 BR BR9814282-8A patent/BR9814282A/pt not_active Application Discontinuation
- 1998-12-14 NZ NZ505689A patent/NZ505689A/xx not_active IP Right Cessation
- 1998-12-14 CZ CZ20002209A patent/CZ300535B6/cs not_active IP Right Cessation
- 1998-12-14 WO PCT/US1998/026560 patent/WO1999030694A2/en not_active Ceased
- 1998-12-14 IL IL13676098A patent/IL136760A0/xx not_active IP Right Cessation
- 1998-12-14 EP EP98963170A patent/EP1037615B1/en not_active Expired - Lifetime
- 1998-12-14 CN CN98813634A patent/CN1368876A/zh active Pending
- 1998-12-14 CA CA002315237A patent/CA2315237C/en not_active Expired - Lifetime
- 1998-12-14 TW TW087120741A patent/TWI242452B/zh not_active IP Right Cessation
- 1998-12-14 TR TR2000/01736T patent/TR200001736T2/xx unknown
- 1998-12-14 DE DE69822199T patent/DE69822199T2/de not_active Expired - Lifetime
- 1998-12-14 RU RU2000119097/15A patent/RU2233156C2/ru not_active IP Right Cessation
- 1998-12-14 JP JP2000538677A patent/JP4316800B2/ja not_active Expired - Lifetime
- 1998-12-14 CZ CZ2009-132A patent/CZ305817B6/cs not_active IP Right Cessation
- 1998-12-15 AR ARP980106392A patent/AR014062A1/es not_active Application Discontinuation
- 1998-12-15 PE PE1998001219A patent/PE20000120A1/es not_active Application Discontinuation
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2000
- 2000-06-15 NO NO20003096A patent/NO329974B1/no not_active IP Right Cessation
- 2000-07-17 LV LVP-00-92A patent/LV12558B/en unknown
- 2000-07-18 US US09/618,626 patent/US6348211B1/en not_active Expired - Lifetime
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2008
- 2008-11-13 JP JP2008291364A patent/JP2009073856A/ja active Pending
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2012
- 2012-12-26 JP JP2012282405A patent/JP2013056944A/ja active Pending
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