ES2212340T3 - Secuencias de peptidos como regiones bisagra en fragmentos de inmunoglobulina similares a proteinas y su uso en medicina. - Google Patents
Secuencias de peptidos como regiones bisagra en fragmentos de inmunoglobulina similares a proteinas y su uso en medicina.Info
- Publication number
- ES2212340T3 ES2212340T3 ES98944070T ES98944070T ES2212340T3 ES 2212340 T3 ES2212340 T3 ES 2212340T3 ES 98944070 T ES98944070 T ES 98944070T ES 98944070 T ES98944070 T ES 98944070T ES 2212340 T3 ES2212340 T3 ES 2212340T3
- Authority
- ES
- Spain
- Prior art keywords
- hinge
- fab
- protein
- proteins
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/867—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
- Jellies, Jams, And Syrups (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9720054.7A GB9720054D0 (en) | 1997-09-19 | 1997-09-19 | Biological products |
| GB9720054 | 1997-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2212340T3 true ES2212340T3 (es) | 2004-07-16 |
Family
ID=10819407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98944070T Expired - Lifetime ES2212340T3 (es) | 1997-09-19 | 1998-09-21 | Secuencias de peptidos como regiones bisagra en fragmentos de inmunoglobulina similares a proteinas y su uso en medicina. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6642356B1 (https=) |
| EP (1) | EP1015495B1 (https=) |
| JP (1) | JP4257030B2 (https=) |
| AT (1) | ATE257160T1 (https=) |
| AU (1) | AU9174398A (https=) |
| DE (1) | DE69820885T2 (https=) |
| ES (1) | ES2212340T3 (https=) |
| GB (1) | GB9720054D0 (https=) |
| WO (1) | WO1999015549A2 (https=) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0013810D0 (en) | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
| AU2002337920A1 (en) * | 2001-10-19 | 2003-04-28 | Zymogenetics, Inc. | Dimerized growth factor and materials and methods for producing it |
| GB0303337D0 (en) * | 2003-02-13 | 2003-03-19 | Celltech R&D Ltd | Biological products |
| NZ544924A (en) * | 2003-06-27 | 2009-03-31 | Biogen Idec Inc | Modified binding molecules comprising connecting peptides |
| GB0315457D0 (en) * | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| HUE026260T2 (en) | 2003-11-21 | 2016-06-28 | Ucb Biopharma Sprl | A method for treating multiple sclerosis by inhibiting IL-17 activity |
| ATE517914T1 (de) * | 2004-03-08 | 2011-08-15 | Zymogenetics Inc | Dimere fusionsproteine und materialien und verfahren zu deren herstellung |
| WO2006074399A2 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
| EP1838736B1 (en) | 2005-01-05 | 2013-03-06 | Biogen Idec MA Inc. | Cripto binding molecules |
| US8008443B2 (en) | 2005-04-26 | 2011-08-30 | Medimmune, Llc | Modulation of antibody effector function by hinge domain engineering |
| ES2382879T3 (es) | 2005-09-14 | 2012-06-14 | Ucb Pharma, S.A. | Conjugado de anticuerpo - polímero de peine. |
| GB0614780D0 (en) | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
| ME00832B (me) | 2007-03-22 | 2012-03-20 | Ucb Biopharma Sprl | Vezivni proteini uključujući antitjela, derivate antitjela i fragmente antitjela, koji specifično vezuju cd154 i njihova upotreba |
| GB0717337D0 (en) | 2007-09-06 | 2007-10-17 | Ucb Pharma Sa | Method of treatment |
| EP2535349A1 (en) | 2007-09-26 | 2012-12-19 | UCB Pharma S.A. | Dual specificity antibody fusions |
| WO2011030107A1 (en) | 2009-09-10 | 2011-03-17 | Ucb Pharma S.A. | Multivalent antibodies |
| GB0916630D0 (en) | 2009-09-22 | 2009-11-04 | Secr Defence | Antibody |
| GB201005063D0 (en) | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
| GB0920127D0 (en) | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
| GB0920324D0 (en) | 2009-11-19 | 2010-01-06 | Ucb Pharma Sa | Antibodies |
| GB201000467D0 (en) | 2010-01-12 | 2010-02-24 | Ucb Pharma Sa | Antibodies |
| GB201005064D0 (en) | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
| ES2717883T3 (es) | 2010-03-25 | 2019-06-26 | Ucb Biopharma Sprl | Moléculas de DVD-LG estabilizadas con disulfuro |
| US10208349B2 (en) | 2011-01-07 | 2019-02-19 | Ucb Biopharma Sprl | Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy |
| GB201100282D0 (en) | 2011-01-07 | 2011-02-23 | Ucb Pharma Sa | Biological methods |
| EP2565667A1 (en) | 2011-08-31 | 2013-03-06 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Direction of arrival estimation using watermarked audio signals and microphone arrays |
| US20140234903A1 (en) | 2011-09-05 | 2014-08-21 | Eth Zurich | Biosynthetic gene cluster for the production of peptide/protein analogues |
| WO2013068571A1 (en) | 2011-11-11 | 2013-05-16 | Ucb Pharma S.A. | Albumin binding antibodies and binding fragments thereof |
| JP2015524821A (ja) * | 2012-08-02 | 2015-08-27 | ジェイエヌ バイオサイエンシーズ エルエルシー | システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質 |
| MX2016010951A (es) | 2014-03-05 | 2016-11-29 | Ucb Biopharma Sprl | Proteinas de fc multimericas. |
| JP6851322B2 (ja) | 2015-05-27 | 2021-03-31 | ユーシービー バイオファルマ エスアールエル | 神経疾患を治療する方法 |
| US11254744B2 (en) * | 2015-08-07 | 2022-02-22 | Imaginab, Inc. | Antigen binding constructs to target molecules |
| US20180271998A1 (en) | 2015-12-04 | 2018-09-27 | Merrimack Pharmaceuticals, Inc. | Disulfide-stabilized fabs |
| US11266745B2 (en) | 2017-02-08 | 2022-03-08 | Imaginab, Inc. | Extension sequences for diabodies |
| US20210095006A1 (en) | 2017-12-14 | 2021-04-01 | CSL Behring Lengnau AG | RECOMBINANT IgG Fc MULTIMERS FOR THE TREATMENT OF NEUROMYELITIS OPTICA |
| GB201804243D0 (en) * | 2018-03-16 | 2018-05-02 | Liverpool School Tropical Medicine | Hinge sequences |
| KR102870868B1 (ko) | 2018-06-01 | 2025-10-15 | 노파르티스 아게 | Bcma에 대한 결합 분자 및 이의 용도 |
| JP7489407B2 (ja) | 2019-05-21 | 2024-05-23 | ノバルティス アーゲー | Ｃｄ１９結合分子及びその使用 |
| CN118994397A (zh) | 2019-05-21 | 2024-11-22 | 诺华股份有限公司 | 针对bcma的三特异性结合分子及其用途 |
| US12037378B2 (en) | 2019-05-21 | 2024-07-16 | Novartis Ag | Variant CD58 domains and uses thereof |
| BR112022002067A2 (pt) | 2019-08-08 | 2022-06-14 | Regeneron Pharma | Formatos de molécula de ligação ao antígeno |
| AU2020344164A1 (en) | 2019-09-13 | 2022-04-14 | CSL Behring Lengnau AG | Recombinant IgG Fc multimers for the treatment of immune complex-mediated kidney disorders |
| MX2022005330A (es) | 2019-11-05 | 2022-05-26 | Regeneron Pharma | Moleculas de union multiespecificas con scfv en el extremo nterminal. |
| WO2021127487A2 (en) | 2019-12-20 | 2021-06-24 | Regeneron Pharmaceuticals, Inc. | Novel il2 agonists and methods of use thereof |
| US20230128499A1 (en) | 2020-03-27 | 2023-04-27 | Novartis Ag | Bispecific combination therapy for treating proliferative diseases and autoimmune diseases |
| WO2021231447A1 (en) | 2020-05-12 | 2021-11-18 | Regeneron Pharmaceuticals, Inc. | Novel il10 agonists and methods of use thereof |
| TW202231292A (zh) | 2020-10-13 | 2022-08-16 | 美商健生生物科技公司 | 用於調節分化簇ｉｖ及／或ｖｉｉｉ的經生物工程改造之ｔ細胞介導之免疫力、材料、及其他方法 |
| IL302412A (en) | 2020-11-06 | 2023-06-01 | Novartis Ag | Anti-CD19 and B-cell targeting agent combination therapy for the treatment of B-cell malignancies |
| CA3199095A1 (en) | 2020-11-06 | 2022-05-12 | Novartis Ag | Cd19 binding molecules and uses thereof |
| CA3219609A1 (en) | 2021-05-04 | 2022-11-10 | Regeneron Pharmaceuticals, Inc. | Multispecific fgf21 receptor agonists and their uses |
| AU2022314734A1 (en) | 2021-07-19 | 2024-02-08 | Regeneron Pharmaceuticals, Inc. | Il12 receptor agonists and methods of use thereof |
| KR20240046251A (ko) | 2021-08-16 | 2024-04-08 | 리제너론 파아마슈티컬스, 인크. | 신규 il27 수용체 효능제 및 그의 사용 방법 |
| KR20240099460A (ko) | 2021-11-11 | 2024-06-28 | 리제너론 파아마슈티컬스, 인크. | Cd20-pd1 결합 분자 및 이의 사용 방법 |
| KR20250024872A (ko) | 2022-05-11 | 2025-02-19 | 리제너론 파마슈티칼스 인코포레이티드 | 다중특이적 결합 분자 전구단백질 및 이의 용도 |
| CA3257348A1 (en) | 2022-05-27 | 2023-11-30 | Regeneron Pharmaceuticals, Inc. | INTERLEUKIN-2 PROPROTEINS AND THEIR USES |
| CA3258187A1 (en) | 2022-06-04 | 2023-12-07 | Regeneron Pharmaceuticals, Inc. | INTERLEUKIN-2 PROPROTEINS AND THEIR USES |
| CN120051483A (zh) | 2022-08-18 | 2025-05-27 | 再生元制药公司 | 干扰素前蛋白及其用途 |
| US20240067691A1 (en) | 2022-08-18 | 2024-02-29 | Regeneron Pharmaceuticals, Inc. | Interferon receptor agonists and uses thereof |
| EP4634220A2 (en) | 2022-12-16 | 2025-10-22 | Regeneron Pharmaceuticals, Inc. | Antigen-binding molecules that bind to aav particles and uses |
| US20240252601A1 (en) | 2022-12-23 | 2024-08-01 | Regeneron Pharmaceuticals, Inc. | Ace2 fusion proteins and uses thereof |
| IL322055A (en) | 2023-01-13 | 2025-09-01 | Regeneron Pharma | IL12 receptor agonists and methods of using them |
| KR20250148746A (ko) | 2023-01-13 | 2025-10-14 | 리제너론 파아마슈티컬스, 인크. | Fgfr3 결합 분자 및 그의 사용 방법 |
| JP2026507123A (ja) | 2023-02-28 | 2026-02-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｔ細胞活性化剤およびその使用方法 |
| EP4673462A2 (en) | 2023-02-28 | 2026-01-07 | Regeneron Pharmaceuticals, Inc. | Multivalent anti-spike protein binding molecules and uses thereof |
| CN121057744A (zh) | 2023-02-28 | 2025-12-02 | 再生元制药公司 | 多价抗刺突蛋白结合分子及其用途 |
| EP4709756A1 (en) | 2023-05-10 | 2026-03-18 | Regeneron Pharmaceuticals, Inc. | Cd20-pd1 binding molecules and methods of use thereof |
| CN121752592A (zh) | 2023-05-12 | 2026-03-27 | 再生元制药公司 | 干扰素受体拮抗剂及其用途 |
| EP4630457A1 (en) | 2023-08-18 | 2025-10-15 | Regeneron Pharmaceuticals, Inc. | Bispecific antigen-binding molecules and uses thereof |
| WO2025106469A1 (en) | 2023-11-14 | 2025-05-22 | Regeneron Pharmaceuticals, Inc. | Engineered heavy chain variable domains and uses thereof |
| WO2025122614A1 (en) | 2023-12-05 | 2025-06-12 | Regeneron Pharmaceuticals, Inc. | Il18 receptor agonists and methods of use thereof |
| WO2025133290A1 (en) | 2023-12-21 | 2025-06-26 | Temper Bio | Protein for immune regulation |
| WO2025199243A1 (en) | 2024-03-20 | 2025-09-25 | Regeneron Pharmaceuticals, Inc. | Trivalent multispecific binding molecules and methods of use thereof |
| WO2025240335A1 (en) | 2024-05-13 | 2025-11-20 | Regeneron Pharmaceuticals, Inc. | Fgfr3 binding molecules and methods of use thereof |
| US20250361309A1 (en) | 2024-05-24 | 2025-11-27 | Regeneron Pharmaceuticals, Inc. | Tumor-targeted split il12 receptor agonists |
| WO2025255452A2 (en) | 2024-06-07 | 2025-12-11 | Regeneron Pharmaceuticals, Inc. | Antigen-binding molecules that bind to aav particles and uses thereof |
| WO2025255480A1 (en) | 2024-06-07 | 2025-12-11 | Regeneron Pharmaceuticals, Inc. | Tetravalent multispecific binding molecules and methods of use thereof |
| US20260055171A1 (en) | 2024-06-11 | 2026-02-26 | Regeneron Pharmaceuticals, Inc. | Vegf antagonists and methods of use thereof |
| WO2026025058A1 (en) | 2024-07-25 | 2026-01-29 | Regeneron Pharmaceuticals, Inc. | Aav viral particles retargeted to egfr-expressing cancer cells |
| WO2026039791A1 (en) | 2024-08-16 | 2026-02-19 | Regeneron Pharmaceuticals, Inc. | Tumor-targeted split il2 receptor agonists |
| WO2026076013A1 (en) | 2024-10-01 | 2026-04-09 | Regeneron Pharmaceuticals, Inc. | Tumor-targeted il2 receptor agonists and multispecific t-cell engagers |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0284898A3 (de) | 1987-04-02 | 1990-06-27 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Hinge-Peptid, Verfahren zu seiner Herstellung und seine Verwendung zur Herstellung synthetischer Immunogene |
| JPH07509128A (ja) * | 1992-07-13 | 1995-10-12 | バイオネブラスカ・インコーポレーテッド | 組換型ポリペプチドの修飾方法 |
-
1997
- 1997-09-19 GB GBGB9720054.7A patent/GB9720054D0/en not_active Ceased
-
1998
- 1998-09-21 EP EP98944070A patent/EP1015495B1/en not_active Expired - Lifetime
- 1998-09-21 AU AU91743/98A patent/AU9174398A/en not_active Abandoned
- 1998-09-21 DE DE69820885T patent/DE69820885T2/de not_active Expired - Fee Related
- 1998-09-21 JP JP2000512854A patent/JP4257030B2/ja not_active Expired - Fee Related
- 1998-09-21 WO PCT/GB1998/002851 patent/WO1999015549A2/en not_active Ceased
- 1998-09-21 US US09/508,930 patent/US6642356B1/en not_active Expired - Fee Related
- 1998-09-21 AT AT98944070T patent/ATE257160T1/de not_active IP Right Cessation
- 1998-09-21 ES ES98944070T patent/ES2212340T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4257030B2 (ja) | 2009-04-22 |
| WO1999015549A2 (en) | 1999-04-01 |
| DE69820885D1 (de) | 2004-02-05 |
| AU9174398A (en) | 1999-04-12 |
| US6642356B1 (en) | 2003-11-04 |
| DE69820885T2 (de) | 2004-12-16 |
| WO1999015549A3 (en) | 1999-06-17 |
| GB9720054D0 (en) | 1997-11-19 |
| EP1015495B1 (en) | 2004-01-02 |
| JP2001517423A (ja) | 2001-10-09 |
| EP1015495A2 (en) | 2000-07-05 |
| ATE257160T1 (de) | 2004-01-15 |
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