ES2206438T3 - Derivados de isoindolo-indolona, su procedimiento de preparaacion y las composiciones farmaceuticas que los contienen. - Google Patents
Derivados de isoindolo-indolona, su procedimiento de preparaacion y las composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2206438T3 ES2206438T3 ES02290598T ES02290598T ES2206438T3 ES 2206438 T3 ES2206438 T3 ES 2206438T3 ES 02290598 T ES02290598 T ES 02290598T ES 02290598 T ES02290598 T ES 02290598T ES 2206438 T3 ES2206438 T3 ES 2206438T3
- Authority
- ES
- Spain
- Prior art keywords
- branched
- linear
- formula
- compound
- oxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 9
- 238000002360 preparation method Methods 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 43
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 10
- 125000004423 acyloxy group Chemical group 0.000 claims abstract description 9
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 8
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 6
- 230000003287 optical effect Effects 0.000 claims abstract description 5
- 150000003839 salts Chemical class 0.000 claims abstract description 5
- 239000002253 acid Substances 0.000 claims abstract description 4
- APRMMGIMYPZNPC-UHFFFAOYSA-N 1,3-dimethoxyisoindolo[2,3-a]indol-6-one Chemical compound C12=CC=CC=C2C(=O)N2C1=CC1=C(OC)C=C(OC)C=C12 APRMMGIMYPZNPC-UHFFFAOYSA-N 0.000 claims abstract description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 3
- PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 claims description 6
- 230000001193 melatoninergic effect Effects 0.000 claims description 6
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 claims description 6
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims description 4
- IRPIYZBBHNVOHO-UHFFFAOYSA-N 2-hydroxy-8,9-dimethoxyisoindolo[2,3-a]indol-6-one Chemical compound OC1=CC=C2N3C(=O)C(C=C(C(=C4)OC)OC)=C4C3=CC2=C1 IRPIYZBBHNVOHO-UHFFFAOYSA-N 0.000 claims description 3
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- 239000003638 chemical reducing agent Substances 0.000 claims description 2
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- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract description 4
- 125000006526 (C1-C2) alkyl group Chemical group 0.000 abstract 1
- 125000005199 aryl carbonyloxy group Chemical group 0.000 abstract 1
- 239000000047 product Substances 0.000 description 24
- 238000002844 melting Methods 0.000 description 14
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- XLYPHUGUKGMURE-UHFFFAOYSA-N 5-hydroxy-2-nitrobenzaldehyde Chemical compound OC1=CC=C([N+]([O-])=O)C(C=O)=C1 XLYPHUGUKGMURE-UHFFFAOYSA-N 0.000 description 11
- 238000011282 treatment Methods 0.000 description 11
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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- OWXQQVBJEAJOBD-UHFFFAOYSA-N 2,7,10-trihydroxyisoindolo[2,3-a]indol-6-one Chemical compound OC1=CC=C(O)C2=C1C1=CC3=CC(O)=CC=C3N1C2=O OWXQQVBJEAJOBD-UHFFFAOYSA-N 0.000 description 1
- UFMFGBMKHDMOTF-UHFFFAOYSA-N 2,7-dihydroxy-10-methoxyisoindolo[2,3-a]indol-6-one Chemical compound OC1=CC=C2N3C(=O)C(C(O)=CC=C4OC)=C4C3=CC2=C1 UFMFGBMKHDMOTF-UHFFFAOYSA-N 0.000 description 1
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- PPJDXDBDZMZCJL-UHFFFAOYSA-N 3-benzyl-2-hydroxy-8,10-dimethoxyisoindolo[2,3-a]indol-6-one Chemical compound C1=2C(OC)=CC(OC)=CC=2C(=O)N(C2=C3)C1=CC2=CC(O)=C3CC1=CC=CC=C1 PPJDXDBDZMZCJL-UHFFFAOYSA-N 0.000 description 1
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- HFWBBGYPGAWRIT-UHFFFAOYSA-N 4,7-dihydroxy-3h-2-benzofuran-1-one Chemical compound OC1=CC=C(O)C2=C1COC2=O HFWBBGYPGAWRIT-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- Public Health (AREA)
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- General Chemical & Material Sciences (AREA)
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0103293A FR2821843B1 (fr) | 2001-03-12 | 2001-03-12 | Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR0103293 | 2001-03-12 |
Publications (1)
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|---|---|
| ES2206438T3 true ES2206438T3 (es) | 2004-05-16 |
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| ES02290598T Expired - Lifetime ES2206438T3 (es) | 2001-03-12 | 2002-03-11 | Derivados de isoindolo-indolona, su procedimiento de preparaacion y las composiciones farmaceuticas que los contienen. |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2826009B1 (fr) * | 2001-06-13 | 2003-08-15 | Servier Lab | Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE60309324T2 (de) * | 2002-06-21 | 2007-05-10 | Suven Life Sciences Ltd. | Tetracyclische arylcarbonyl indole mit serotoninrezeptoraffinität als arzneimittel, verfahren zu ihrer herstellung und pharmazeutische zubereitungen |
| CN1662538A (zh) * | 2002-06-21 | 2005-08-31 | 苏文生命科学有限公司 | 可作为治疗剂的对血清素受体具有亲和力的芳烷基吲哚、其制备工艺及其含有该物质的药物组合物 |
| KR100776118B1 (ko) * | 2002-11-28 | 2007-11-15 | 수벤 라이프 사이언시스 리미티드 | 엔-아릴술포닐-3-아미노알콕시인돌 |
| EA009367B1 (ru) * | 2002-12-18 | 2007-12-28 | Сувен Лайф Сайенсиз Лимитед | ПРОИЗВОДНЫЕ 5-ТИА-5-ДИОКСО-4b-АЗАИНДЕНО[2,1-a]ИНДЕНА, ОБЛАДАЮЩИЕ АФФИННОСТЬЮ К РЕЦЕПТОРУ СЕРОТОНИНА |
| RU2387655C2 (ru) * | 2004-08-09 | 2010-04-27 | Бристол-Маерс Сквибб Компани | Ингибиторы репликации вируса гепатита с |
| ES2580702B1 (es) | 2015-02-25 | 2017-06-08 | Palobiofarma, S.L. | Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina |
| US20240090802A1 (en) | 2022-09-02 | 2024-03-21 | Dexcom, Inc. | Continuous analyte sensor devices and methods |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5377098A (en) * | 1976-12-16 | 1978-07-08 | Sumitomo Chem Co Ltd | Preparation of indoloisoquinoline derivative |
| US4452808A (en) * | 1982-12-07 | 1984-06-05 | Smithkline Beckman Corporation | 4-Aminoalkyl-2(3H)-indolones |
| US5441955A (en) * | 1993-11-19 | 1995-08-15 | Pathogenesis Corporation | Indolo[2,1-biquinazoline-6,12-dione antibacterial compounds and methods of use thereof |
| FR2743365A1 (fr) * | 1996-01-10 | 1997-07-11 | Rhone Poulenc Rorer Sa | Derives de 5h,10h-imidazo(1,2-a)indolo(3,2-e)pyrazine-4-one, leur preparation et les medicaments les contenant |
| AU2001268677A1 (en) * | 2000-06-23 | 2002-01-08 | Cognetix, Inc. | Subtype selective melatonergics |
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2001
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2002
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- 2002-03-09 KR KR10-2002-0012699A patent/KR100450313B1/ko not_active Expired - Fee Related
- 2002-03-11 CA CA002376876A patent/CA2376876C/fr not_active Expired - Fee Related
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- 2002-03-11 NO NO20021198A patent/NO20021198L/no not_active Application Discontinuation
- 2002-03-11 EP EP02290598A patent/EP1241169B1/fr not_active Expired - Lifetime
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- 2002-03-11 AT AT02290598T patent/ATE248171T1/de not_active IP Right Cessation
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- 2002-03-11 AR ARP020100863A patent/AR034583A1/es active IP Right Grant
- 2002-03-11 HU HU0200913A patent/HUP0200913A3/hu unknown
- 2002-03-11 ES ES02290598T patent/ES2206438T3/es not_active Expired - Lifetime
- 2002-03-11 PT PT02290598T patent/PT1241169E/pt unknown
- 2002-03-11 DE DE60200023T patent/DE60200023T2/de not_active Expired - Fee Related
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2003
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