ES2199734T3 - Vacuna con adyuvante de aceite. - Google Patents
Vacuna con adyuvante de aceite.Info
- Publication number
- ES2199734T3 ES2199734T3 ES00123909T ES00123909T ES2199734T3 ES 2199734 T3 ES2199734 T3 ES 2199734T3 ES 00123909 T ES00123909 T ES 00123909T ES 00123909 T ES00123909 T ES 00123909T ES 2199734 T3 ES2199734 T3 ES 2199734T3
- Authority
- ES
- Spain
- Prior art keywords
- vaccine
- oil
- adjuvant
- oil adjuvant
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000010779 crude oil Substances 0.000 description 1
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Polymers OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- YKZPPPNXRZHVGX-PXYKVGKMSA-L dipotassium;(2s)-2-aminobutanedioate;hydron;hydrate Chemical compound [H+].[H+].O.[K+].[K+].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O YKZPPPNXRZHVGX-PXYKVGKMSA-L 0.000 description 1
- WDRWZVWLVBXVOI-QTNFYWBSSA-L dipotassium;(2s)-2-aminopentanedioate Chemical compound [K+].[K+].[O-]C(=O)[C@@H](N)CCC([O-])=O WDRWZVWLVBXVOI-QTNFYWBSSA-L 0.000 description 1
- BIQSIHSUENWJGR-LHWPGRLPSA-L disodium;(2s)-2-aminopentanedioate;hydrate Chemical compound O.[Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O BIQSIHSUENWJGR-LHWPGRLPSA-L 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- FCZCIXQGZOUIDN-UHFFFAOYSA-N ethyl 2-diethoxyphosphinothioyloxyacetate Chemical compound CCOC(=O)COP(=S)(OCC)OCC FCZCIXQGZOUIDN-UHFFFAOYSA-N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000005021 gait Effects 0.000 description 1
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- OOYGSFOGFJDDHP-KMCOLRRFSA-N kanamycin A sulfate Chemical compound OS(O)(=O)=O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N OOYGSFOGFJDDHP-KMCOLRRFSA-N 0.000 description 1
- 229960002064 kanamycin sulfate Drugs 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012092 media component Substances 0.000 description 1
- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000013919 monopotassium glutamate Nutrition 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 239000003129 oil well Substances 0.000 description 1
- 229960002969 oleic acid Drugs 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229960000625 oxytetracycline Drugs 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 229920001083 polybutene Polymers 0.000 description 1
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229940068988 potassium aspartate Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- WTWSHHITWMVLBX-DKWTVANSSA-M sodium;(2s)-2-aminobutanedioate;hydron Chemical compound [Na+].[O-]C(=O)[C@@H](N)CC(O)=O WTWSHHITWMVLBX-DKWTVANSSA-M 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940031626 subunit vaccine Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229940074410 trehalose Drugs 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 229940124973 vaccine residual Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31612199 | 1999-11-05 | ||
| JP31612199A JP2001131087A (ja) | 1999-11-05 | 1999-11-05 | オイルアジュバントワクチン |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2199734T3 true ES2199734T3 (es) | 2004-03-01 |
Family
ID=18073491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00123909T Expired - Lifetime ES2199734T3 (es) | 1999-11-05 | 2000-11-03 | Vacuna con adyuvante de aceite. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20050158330A1 (enExample) |
| EP (1) | EP1097721B1 (enExample) |
| JP (1) | JP2001131087A (enExample) |
| KR (1) | KR100726818B1 (enExample) |
| CN (1) | CN100384473C (enExample) |
| AU (1) | AU780054B2 (enExample) |
| DE (1) | DE60002650T2 (enExample) |
| DK (1) | DK1097721T3 (enExample) |
| ES (1) | ES2199734T3 (enExample) |
| TW (1) | TW581682B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6620976B2 (en) | 2001-03-27 | 2003-09-16 | Nof Corporation | Polyethylene glycol and process for producing the same |
| FR2824279B1 (fr) * | 2001-05-04 | 2004-05-28 | Seppic Sa | Emulsion e/h concentree |
| US6676958B2 (en) | 2001-06-19 | 2004-01-13 | Advanced Bioadjuvants, Llc | Adjuvant composition for mucosal and injection delivered vaccines |
| WO2003000291A1 (fr) * | 2001-06-22 | 2003-01-03 | Techno Network Shikoku Co., Ltd. | Vesicules lipidiques, processus de production de vesicules lipidiques et procede d'immobilisation de gene sur ces vesicules lipidiques |
| FR2824269B1 (fr) * | 2001-09-03 | 2012-03-02 | Seppic Sa | Composition adjuvante constituee de 1% a 15% de tensioactifs a hlb global compris entre 5 et 8 et de 85% a 99% de corps gras |
| TWI350174B (en) * | 2003-03-12 | 2011-10-11 | Wyeth Corp | Adjuvanted bovine vaccines |
| GB2421908A (en) * | 2004-12-23 | 2006-07-12 | Univ College London Hospitals | Medicament for treatment of inflammatory diseases |
| CN101111258B (zh) * | 2005-01-19 | 2011-07-06 | 大日本住友制药株式会社 | 稀释用乳化组合物及癌疫苗组合物 |
| ES2388684T3 (es) | 2005-04-25 | 2012-10-17 | Cadila Pharmaceuticals Limited | Adyuvantes de vacunas |
| EP2172263A4 (en) * | 2007-07-02 | 2015-08-05 | Nisshin Oillio Group Ltd | E / H / E EMULSION COMPOSITION |
| US8010465B2 (en) * | 2008-02-26 | 2011-08-30 | Microsoft Corporation | Predicting candidates using input scopes |
| CN101721694B (zh) * | 2009-11-07 | 2013-01-30 | 中国农业科学院兰州兽医研究所 | 山羊支原体肺炎二联灭活疫苗及其制备方法 |
| IN2014DN05879A (enExample) * | 2012-01-31 | 2015-05-22 | Benemilk Ltd | |
| CN102580082B (zh) * | 2012-02-28 | 2014-12-10 | 肇庆大华农生物药品有限公司 | 一种禽用灭活疫苗及其制备方法 |
| CN103223164B (zh) * | 2013-04-15 | 2014-08-20 | 华南农业大学 | 一种水包油包水型佐剂疫苗及其制备方法 |
| US20150359880A1 (en) * | 2014-06-16 | 2015-12-17 | Biomune Company | Dual adjuvant vaccine compositions, preparation and uses |
| CN104398478B (zh) * | 2014-11-03 | 2017-05-10 | 江苏省农业科学院 | 兽用药物的复乳型载体及其应用 |
| US20200129429A1 (en) * | 2017-03-15 | 2020-04-30 | Vivavax Inc. | Biocompatible and biodegradable emulsions and compositions, and methods of use thereof |
| JP2019001770A (ja) * | 2017-06-15 | 2019-01-10 | エス・ピー・ジーテクノ株式会社 | 乳化型ワクチン製剤とその生成用デバイス |
| CN107596364B (zh) * | 2017-09-19 | 2021-03-12 | 洛阳赛威生物科技有限公司 | 一种w/o/w佐剂组合物、制备的疫苗组合物及其制备方法 |
| CN107595774B (zh) * | 2017-10-24 | 2020-01-31 | 湖北医药学院 | 一种自乳化纳米复乳及其制备方法和应用 |
| CN108578688B (zh) * | 2018-04-03 | 2022-02-11 | 武汉轻工大学 | 多重纳米乳疫苗佐剂的制备方法 |
| CN110585439B (zh) * | 2019-09-30 | 2023-06-09 | 长春生物制品研究所有限责任公司 | 一种改良型的冻干甲型肝炎减毒活疫苗稳定剂、疫苗半成品、疫苗成品及其制备方法 |
| CN113546162B (zh) * | 2021-05-31 | 2023-07-18 | 江苏省农业科学院 | 一种支原体疫苗及其制备方法 |
| CN113940994B (zh) * | 2021-11-09 | 2023-09-15 | 南华大学 | 壳聚糖-Pickering乳液白细胞介素12佐剂体系的制备方法及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2649012B1 (fr) * | 1989-07-03 | 1991-10-25 | Seppic Sa | Emulsions multiphasiques injectables |
| FR2649013B1 (fr) * | 1989-07-03 | 1991-10-25 | Seppic Sa | Vaccins et vecteurs de principes actifs fluides contenant une huile metabolisable |
| US5622649A (en) * | 1991-06-27 | 1997-04-22 | Emory University | Multiple emulsions and methods of preparation |
| ATE353225T1 (de) * | 1995-11-30 | 2007-02-15 | Chemo Sero Therapeut Res Inst | Öladjuvierter impfstoff und verfahren zu seiner herstellung |
| JPH11106351A (ja) * | 1997-10-02 | 1999-04-20 | Chemo Sero Therapeut Res Inst | オイルアジュバントワクチンおよびその製造方法 |
| US20060003012A9 (en) * | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
-
1999
- 1999-11-05 JP JP31612199A patent/JP2001131087A/ja active Pending
-
2000
- 2000-11-03 DE DE60002650T patent/DE60002650T2/de not_active Expired - Fee Related
- 2000-11-03 EP EP00123909A patent/EP1097721B1/en not_active Expired - Lifetime
- 2000-11-03 AU AU69713/00A patent/AU780054B2/en not_active Ceased
- 2000-11-03 ES ES00123909T patent/ES2199734T3/es not_active Expired - Lifetime
- 2000-11-03 TW TW089123170A patent/TW581682B/zh not_active IP Right Cessation
- 2000-11-03 DK DK00123909T patent/DK1097721T3/da active
- 2000-11-05 CN CNB001374818A patent/CN100384473C/zh not_active Expired - Fee Related
- 2000-11-06 KR KR1020000065477A patent/KR100726818B1/ko not_active Expired - Fee Related
-
2004
- 2004-12-17 US US11/016,389 patent/US20050158330A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60002650D1 (de) | 2003-06-18 |
| AU780054B2 (en) | 2005-02-24 |
| JP2001131087A (ja) | 2001-05-15 |
| DK1097721T3 (da) | 2003-09-01 |
| CN1307903A (zh) | 2001-08-15 |
| EP1097721A3 (en) | 2001-05-23 |
| DE60002650T2 (de) | 2004-03-11 |
| TW581682B (en) | 2004-04-01 |
| EP1097721B1 (en) | 2003-05-14 |
| KR20010051463A (ko) | 2001-06-25 |
| KR100726818B1 (ko) | 2007-06-12 |
| AU6971300A (en) | 2001-05-10 |
| EP1097721A2 (en) | 2001-05-09 |
| CN100384473C (zh) | 2008-04-30 |
| US20050158330A1 (en) | 2005-07-21 |
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