ES2194835T3 - Agentes antitromboticos a base de tripeptidos. - Google Patents
Agentes antitromboticos a base de tripeptidos.Info
- Publication number
- ES2194835T3 ES2194835T3 ES91308785T ES91308785T ES2194835T3 ES 2194835 T3 ES2194835 T3 ES 2194835T3 ES 91308785 T ES91308785 T ES 91308785T ES 91308785 T ES91308785 T ES 91308785T ES 2194835 T3 ES2194835 T3 ES 2194835T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- amino
- substituted
- antitrombotic
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- External Artificial Organs (AREA)
- Inert Electrodes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE PRESENTAN INHIBIDORES DE LA TROMBINA REPRESENTADOS POR LA FORMULA: EN LA QUE A(C = O)CICLOHEXILGLICIL, CICLOHEXENILGLICIL, TIENIGLICIL O NAFTILGLICIL, EN DONDE EL GRUPO (ALFA)-AMINO ESTA PREFERIBLEMENTE SUBSTITUIDO POR ALQUIL POR EJ. METIL O UN GRUPO ALCOXICARBONIL, CICLOXICARBONIL O ARILCOXICARBONIL, POR EJ. T-BUTILOXICARBONIL. A (C = O)TAL COMO UN (ALFA)-METOXIFENILACETIL; O UN GRUPO BICICLICO TAL COMO UN GRUPO TETRAHIDROISOQUINOLIN-1-OIL; O UN GRUPO CICLOALQUILCARBONIL (AMINO SUBSTITUIDO) TAL COMO 1-AMINOCICLO EXIL CARBONIL. TAMBIEN SE SUMINISTRA UN METODO PARA INHIBIR LA FORMACION DE COAGULOS DE SANGRE EN EL HOMBRE Y LOS ANIMALES MEDIANTE LA ADMINISTRACION DE UN INHIBIDOR DE LA TROMBINA DE LA FORMULA ARRIBA REPRESENTADA, ASI MISMO SE PRESENTAN FORMULACIONES FARMACEUTICAS UTILES EN EL PRESENTE METODO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58955390A | 1990-09-28 | 1990-09-28 | |
US75609191A | 1991-09-06 | 1991-09-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2194835T3 true ES2194835T3 (es) | 2003-12-01 |
Family
ID=27080589
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95201960T Expired - Lifetime ES2169105T3 (es) | 1990-09-28 | 1991-09-26 | Agentes antitromboticos tripeptidicos. |
ES91308785T Expired - Lifetime ES2194835T3 (es) | 1990-09-28 | 1991-09-26 | Agentes antitromboticos a base de tripeptidos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95201960T Expired - Lifetime ES2169105T3 (es) | 1990-09-28 | 1991-09-26 | Agentes antitromboticos tripeptidicos. |
Country Status (22)
Country | Link |
---|---|
EP (4) | EP0684258A2 (es) |
JP (1) | JP3023019B2 (es) |
KR (1) | KR100219993B1 (es) |
CN (1) | CN1036399C (es) |
AT (2) | ATE211147T1 (es) |
AU (1) | AU645347B2 (es) |
BR (1) | BR9104181A (es) |
CA (1) | CA2052013C (es) |
CZ (1) | CZ285980B6 (es) |
DE (2) | DE69132884T2 (es) |
DK (1) | DK0685489T3 (es) |
ES (2) | ES2169105T3 (es) |
FI (1) | FI107733B (es) |
HU (2) | HU217441B (es) |
IE (1) | IE913423A1 (es) |
IL (1) | IL99527A (es) |
MX (1) | MX9101280A (es) |
NO (1) | NO309984B1 (es) |
NZ (1) | NZ239907A (es) |
PT (1) | PT99068B (es) |
RU (1) | RU2077538C1 (es) |
SK (1) | SK281731B6 (es) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US6008217A (en) * | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
US5430023A (en) * | 1990-09-28 | 1995-07-04 | Eli Lilly And Company | Tripeptide antithrombotic agents |
CA2071621C (en) * | 1991-06-19 | 1996-08-06 | Ahihiko Hosoda | Aldehyde derivatives |
CA2075154A1 (en) * | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
SE9102462D0 (sv) * | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
US5416093A (en) * | 1991-11-12 | 1995-05-16 | Eli Lilly And Company | Antithrombotic agents |
DE69314478T2 (de) * | 1992-03-04 | 1999-02-11 | Gyogyszerkutato Intezet | Neuartige antikoagulierende peptidderivate und arzneimittel die solche enthalten so wie entsprechendes herstellungsverfahren |
US5583146A (en) * | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
US5455229A (en) * | 1992-12-23 | 1995-10-03 | Eli Lilly And Company | Method for minimizing and containing ischemic and reperfusion injury |
US5672582A (en) * | 1993-04-30 | 1997-09-30 | Merck & Co., Inc. | Thrombin inhibitors |
JPH06340619A (ja) * | 1993-05-03 | 1994-12-13 | Bristol Myers Squibb Co | グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤 |
US5780631A (en) * | 1993-06-03 | 1998-07-14 | Astra Aktiebolag | Starting materials in the synthesis of thrombin and kininogenase inhibitors |
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US6984627B1 (en) | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
US5462964A (en) * | 1993-10-20 | 1995-10-31 | The Du Pont Merck Pharmaceutical Company | Dipeptide boronic acid inhibitors of trypsin-like enzymes |
US5439888A (en) * | 1994-03-04 | 1995-08-08 | Eli Lilly And Company | Antithrombotic agents |
US5488037A (en) * | 1994-03-04 | 1996-01-30 | Eli Lilly And Company | Antithrombotic agents |
US5484772A (en) * | 1994-03-04 | 1996-01-16 | Eli Lilly And Company | Antithrombotic agents |
ZA951617B (en) * | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
AU1884395A (en) * | 1994-03-04 | 1995-09-18 | Eli Lilly And Company | Antithrombotic agents |
US5602101A (en) * | 1994-03-04 | 1997-02-11 | Eli Lilly And Company | Antithrombotic agents |
US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
GB2287027A (en) * | 1994-03-04 | 1995-09-06 | Lilly Co Eli | Tripeptide antithrombotic agents |
US5885967A (en) * | 1994-03-04 | 1999-03-23 | Eli Lilly And Company | Antithrombotic agents |
ZA951618B (en) * | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
CA2143533A1 (en) * | 1994-03-04 | 1995-09-05 | Kenneth D. Kurz | Antithrombotic agents |
US5436229A (en) * | 1994-03-04 | 1995-07-25 | Eli Lilly And Company | Bisulfite adducts of arginine aldehydes |
US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
DE4421052A1 (de) | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5756466A (en) * | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US5510369A (en) * | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
SE9404196D0 (sv) * | 1994-12-02 | 1994-12-02 | Astra Ab | New antithrombotic formulation |
US5710130A (en) * | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
US5629324A (en) * | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
US6046169A (en) * | 1995-06-07 | 2000-04-04 | Cor Therapeutics, Inc. | Inhibitors of factor XA |
US6069130A (en) | 1995-06-07 | 2000-05-30 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
US5721214A (en) * | 1995-06-07 | 1998-02-24 | Cor Therapeutics, Inc. | Inhibitors of factor Xa |
US6022861A (en) * | 1995-06-07 | 2000-02-08 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
US5919765A (en) * | 1995-06-07 | 1999-07-06 | Cor Therapeutics, Inc. | Inhibitors of factor XA |
US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
AR005245A1 (es) | 1995-12-21 | 1999-04-28 | Astrazeneca Ab | Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion |
HU224315B1 (hu) * | 1996-06-05 | 2005-07-28 | Gyógyszerkutató Intézet Kft. | Véralvadásgátló hatású peptidil-arginin-aldehid-származékok és a vegyületeket tartalmazó gyógyszerkészítmények |
HU222199B1 (hu) * | 1996-06-05 | 2003-05-28 | Gyógyszerkutató Intézet Kft. | Véralvadásgátló hatású peptid-aldehid-származékok és a vegyületeket tartalmazó gyógyszerkészítmények |
US6245743B1 (en) | 1996-06-05 | 2001-06-12 | Cor Therapeutics, Inc. | Inhibitors of factor Xa |
US5798377A (en) * | 1996-10-21 | 1998-08-25 | Merck & Co., Inc. | Thrombin inhibitors |
CA2289625A1 (en) | 1997-05-15 | 1998-11-19 | Charles Van Jackson | Antithrombotic compound |
EP1051431A1 (de) | 1998-01-26 | 2000-11-15 | Basf Aktiengesellschaft | Thrombininhibitoren |
KR100377557B1 (ko) * | 1999-02-12 | 2003-03-26 | 주식회사 엘지생명과학 | 아실 구아니딘 작용기를 갖는 선택적 트롬빈 억제제 |
US6528503B2 (en) | 2000-12-18 | 2003-03-04 | Merck & Co., Inc. | Thrombin inhibitors |
CA2431588A1 (en) | 2000-12-18 | 2002-06-27 | Merck & Co., Inc. | Benzylamine derivatives and their use as thrombin inhibitors |
CA2436176A1 (en) | 2001-02-09 | 2002-08-22 | Merck & Co., Inc. | Thrombin inhibitors |
IL160488A0 (en) * | 2001-08-21 | 2004-07-25 | Ivax Inst For Drug Res Ltd | Peptide arginals and methods for treating disseminated intravascular coagulation |
US7084134B2 (en) | 2002-05-02 | 2006-08-01 | Merk & Co., Inc. | Thrombin inhibitors |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU178398B (en) * | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
HU192646B (en) * | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
IL89770A (en) * | 1988-03-28 | 1994-12-29 | British Tech Group | Analgesic peptides and pharmaceutical compositions containing them and the process for the preparation of some such compounds |
DE3827415A1 (de) * | 1988-08-12 | 1990-02-15 | Behringwerke Ag | Peptidderivate, verfahren zu ihrer herstellung und ihre verwendung |
GB8823480D0 (en) * | 1988-10-06 | 1988-11-16 | Ciba Geigy Ag | Antidote |
-
1991
- 1991-09-19 IL IL9952791A patent/IL99527A/xx active IP Right Grant
- 1991-09-23 CA CA002052013A patent/CA2052013C/en not_active Expired - Fee Related
- 1991-09-23 HU HU037/91A patent/HU217441B/hu not_active IP Right Cessation
- 1991-09-23 NZ NZ239907A patent/NZ239907A/en unknown
- 1991-09-23 SK SK2913-91A patent/SK281731B6/sk unknown
- 1991-09-23 CZ CS912913A patent/CZ285980B6/cs not_active IP Right Cessation
- 1991-09-26 MX MX9101280A patent/MX9101280A/es not_active IP Right Cessation
- 1991-09-26 EP EP95201959A patent/EP0684258A2/en not_active Ceased
- 1991-09-26 EP EP95201960A patent/EP0685489B1/en not_active Expired - Lifetime
- 1991-09-26 EP EP91308785A patent/EP0479489B1/en not_active Expired - Lifetime
- 1991-09-26 KR KR1019910016772A patent/KR100219993B1/ko not_active IP Right Cessation
- 1991-09-26 NO NO913773A patent/NO309984B1/no unknown
- 1991-09-26 AT AT95201960T patent/ATE211147T1/de not_active IP Right Cessation
- 1991-09-26 ES ES95201960T patent/ES2169105T3/es not_active Expired - Lifetime
- 1991-09-26 DK DK95201960T patent/DK0685489T3/da active
- 1991-09-26 ES ES91308785T patent/ES2194835T3/es not_active Expired - Lifetime
- 1991-09-26 AT AT91308785T patent/ATE234857T1/de not_active IP Right Cessation
- 1991-09-26 DE DE69132884T patent/DE69132884T2/de not_active Expired - Fee Related
- 1991-09-26 DE DE69133217T patent/DE69133217T2/de not_active Expired - Fee Related
- 1991-09-26 EP EP97203616A patent/EP0837071A1/en not_active Withdrawn
- 1991-09-26 AU AU84780/91A patent/AU645347B2/en not_active Ceased
- 1991-09-26 PT PT99068A patent/PT99068B/pt not_active IP Right Cessation
- 1991-09-26 RU SU5001658/04A patent/RU2077538C1/ru not_active IP Right Cessation
- 1991-09-27 CN CN91109042A patent/CN1036399C/zh not_active Expired - Fee Related
- 1991-09-27 FI FI914566A patent/FI107733B/fi active
- 1991-09-27 JP JP3249093A patent/JP3023019B2/ja not_active Expired - Fee Related
- 1991-09-27 BR BR919104181A patent/BR9104181A/pt not_active Application Discontinuation
- 1991-09-27 IE IE342391A patent/IE913423A1/en not_active Application Discontinuation
-
1995
- 1995-06-22 HU HU95P/P00399P patent/HU211634A9/hu unknown
Also Published As
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