ES2192781T3 - Composicion farmaceutica para combinacion de piperidinoalcanol y un descongestivo. - Google Patents
Composicion farmaceutica para combinacion de piperidinoalcanol y un descongestivo.Info
- Publication number
- ES2192781T3 ES2192781T3 ES98937010T ES98937010T ES2192781T3 ES 2192781 T3 ES2192781 T3 ES 2192781T3 ES 98937010 T ES98937010 T ES 98937010T ES 98937010 T ES98937010 T ES 98937010T ES 2192781 T3 ES2192781 T3 ES 2192781T3
- Authority
- ES
- Spain
- Prior art keywords
- amount
- formulation
- weight
- approximately
- base material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invención se refiere a una composición farmacéutica que se presenta en forma de un comprimido constituido por dos capas, que comprende: a) una primera zona discontinua constituida por la fórmula (A), que contiene una cantidad, suficiente para tener una actividad descongestionante, de un medicamento simpaticomimético, o una sal farmacéuticamente aceptable de éste, en una cantidad comprendida entre 18 y 39% en peso aproximado de la formulación (A), y un primer material base de soporte que contiene una mezcla (i) de cera de carnauba, en una cantidad comprendida entre 59 y 81% en peso aproximadamente de la formulación (A); y (ii) de un antiadherente apropiado, en una cantidad comprendida entre 0,25 y 2,00 en peso aproximadamente de la formulación (A); garantizando dicho primer material base de soporte la liberación prolongada del simpaticomimético; y (b) una segunda zona discontinua constituida por la formulación (B), que contiene una cantidad, suficiente para tener una actividad antihistamínica, de un piperidino-alcanol, o una sal farmacéuticamente aceptable de éste, en una cantidad comprendida entre 15 y 30% en peso aproximadamente de la formulación (B), y un segundo material base de soporte, que contiene una mezcla (i) de un diluyente a base de celulosa, en una cantidad comprendida entre 27 y 73% en peso aproximadamente de la formulación (B); (ii) de un almidón pregelatinizado, en una cantidad comprendida entre 15 y 30% en peso aproximadamente de la formulación (B); (iii) de un agente de desintegración apropiado, en una cantidad comprendida entre 0,25 y 6.00% en peso de la formulación (B); y (iV) un lubricante apropiado en una cantidad de aproximadamente 0,25 a 2.00 en peso de Formulación (B); donde dicho segundo material base de soporte proporciona una liberación inmediata del piperidino-alcanol o una sal farmacéuticamente aceptable de éste.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92015897A | 1997-08-26 | 1997-08-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2192781T3 true ES2192781T3 (es) | 2003-10-16 |
Family
ID=25443270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98937010T Expired - Lifetime ES2192781T3 (es) | 1997-08-26 | 1998-07-21 | Composicion farmaceutica para combinacion de piperidinoalcanol y un descongestivo. |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6039974A (es) |
| EP (1) | EP0998272B1 (es) |
| JP (1) | JP4344405B2 (es) |
| KR (1) | KR100514264B1 (es) |
| CN (1) | CN1159012C (es) |
| AR (1) | AR013947A1 (es) |
| AT (1) | ATE238773T1 (es) |
| AU (1) | AU725811B2 (es) |
| BR (1) | BR9812001A (es) |
| CZ (1) | CZ295461B6 (es) |
| DE (1) | DE69814086T2 (es) |
| DK (1) | DK0998272T3 (es) |
| EE (1) | EE04294B1 (es) |
| ES (1) | ES2192781T3 (es) |
| HK (1) | HK1025904A1 (es) |
| HU (1) | HU224921B1 (es) |
| ID (1) | ID22891A (es) |
| IL (1) | IL133420A (es) |
| NO (1) | NO318246B1 (es) |
| NZ (1) | NZ501248A (es) |
| OA (1) | OA11285A (es) |
| PL (1) | PL192079B1 (es) |
| PT (1) | PT998272E (es) |
| RU (1) | RU2207879C2 (es) |
| SI (1) | SI0998272T1 (es) |
| SK (1) | SK283803B6 (es) |
| TR (1) | TR200000517T2 (es) |
| TW (1) | TW570812B (es) |
| UA (1) | UA60335C2 (es) |
| WO (1) | WO1999009957A1 (es) |
| ZA (1) | ZA987552B (es) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU693892B2 (en) * | 1994-05-18 | 1998-07-09 | Aventisub Ii Inc. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudormophs thereof |
| US20030045722A1 (en) * | 1994-05-18 | 2003-03-06 | Henton Daniel R. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
| DE69624559T2 (de) | 1995-02-28 | 2003-07-10 | Aventis Pharma Inc | Arzneizubereitungen für piperidinalkanolderivate |
| US8022095B2 (en) | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
| AU2276801A (en) * | 1999-12-20 | 2001-07-03 | Schering Corporation | Extended release oral dosage composition |
| US20020094345A1 (en) | 2000-10-06 | 2002-07-18 | Sara Abelaira | Pharmaceutical compositions containing epinastine and pseudoephedrine |
| AU2002220248A1 (en) * | 2000-11-06 | 2002-05-15 | Andrx Pharmaceuticals, Inc. | Once a day antihistamine and decongestant formulation |
| FR2818552B1 (fr) * | 2000-12-26 | 2003-02-07 | Servier Lab | Compositions pharmaceutique solide thermoformable pour la liberation controlee d'ivabradine |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| CA2444456A1 (en) * | 2001-04-09 | 2002-10-17 | Teva Pharmaceutical Industries Ltd. | Polymorphs of fexofenadine hydrochloride |
| US20030021849A1 (en) * | 2001-04-09 | 2003-01-30 | Ben-Zion Dolitzky | Polymorphs of fexofenadine hydrochloride |
| US7052706B2 (en) * | 2001-06-08 | 2006-05-30 | Nostrum Pharmaceuticals, Inc. | Control release formulation containing a hydrophobic material as the sustained release agent |
| US6863901B2 (en) | 2001-11-30 | 2005-03-08 | Collegium Pharmaceutical, Inc. | Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration |
| US6827946B2 (en) * | 2001-12-05 | 2004-12-07 | Collegium Pharmaceutical, Inc. | Compositions containing both sedative and non-sedative antihistamines |
| US8263124B2 (en) | 2002-04-04 | 2012-09-11 | Dr. Reddy's Laboratories Limited | Anthistamine-decongestant pharmaceutical compositions |
| WO2003104197A1 (en) * | 2002-06-10 | 2003-12-18 | Teva Pharmaceutical Industries Ltd. | Polymorphic form xvi of fexofenadine hydrochloride |
| US6663892B1 (en) | 2002-08-19 | 2003-12-16 | L. Perrigo Company | Multiple portion tablet |
| US20050152967A1 (en) * | 2003-03-28 | 2005-07-14 | Pfab, Lp | Dynamic variable release |
| EP1715856B1 (en) * | 2003-12-31 | 2012-07-11 | Actavis Group PTC ehf. | Atomoxetine formulations |
| US20050220877A1 (en) * | 2004-03-31 | 2005-10-06 | Patel Ashish A | Bilayer tablet comprising an antihistamine and a decongestant |
| MXPA06012281A (es) * | 2004-04-26 | 2007-07-18 | Teva Pharma | Formas cristalinas de clorhidrato de fexofenadina y procesos para su preparacion. |
| PL1773816T3 (pl) | 2004-06-24 | 2015-06-30 | Vertex Pharma | Modulatory transporterów posiadających kasetę wiążącą ATP |
| EP1685106A2 (en) * | 2004-09-28 | 2006-08-02 | Teva Pharmaceutical Industries, Inc. | Fexofendadine crystal form and processes for its preparation thereof |
| WO2006048699A1 (en) * | 2004-11-04 | 2006-05-11 | Wockhardt Limited | Pharmaceutical compositions of antihistamine and decongestant |
| CA2600736A1 (en) * | 2005-03-16 | 2006-09-21 | Dr. Reddy's Laboratories Ltd. | Delivery system for multiple drugs |
| HUE049976T2 (hu) | 2005-12-28 | 2020-11-30 | Vertex Pharma | N-[2,4-bisz(1,1-dimetil-etil)-5-hidroxi-fenil]-1,4-dihidro-4-oxo-kinolin-3-karboxamid amorf alakjának gyógyászati kompozíciói |
| BRPI0712960A2 (pt) * | 2006-06-30 | 2012-04-17 | Teva Pharma | compostos farmacêuticos que incluem uma combinação de piperidinoalcanol e descongestionante |
| US20080095843A1 (en) * | 2006-07-11 | 2008-04-24 | Nutalapati Siva R K | Controlled-release formulations |
| US20080085311A1 (en) * | 2006-10-05 | 2008-04-10 | Tripathi Sanjay S | Antihistamine-decongestant combinations |
| TW200836774A (en) * | 2007-02-01 | 2008-09-16 | Takeda Pharmaceutical | Solid preparation |
| WO2008105920A1 (en) * | 2007-02-28 | 2008-09-04 | Collegium Pharmaceutical, Inc. | Antihistamine combination |
| US20100143471A1 (en) * | 2007-03-21 | 2010-06-10 | Lupin Limited | Novel reduced dose pharmaceutical compositions of fexofenadine and pseudoephedrine |
| US20090076080A1 (en) * | 2007-09-19 | 2009-03-19 | Protia, Llc | Deuterium-enriched fexofenadine |
| EP2366380A1 (en) | 2008-03-21 | 2011-09-21 | Mylan Pharmaceuticals, Inc. | Extended release formulation containing a wax |
| US20100256184A1 (en) * | 2008-08-13 | 2010-10-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| MX2011005184A (es) * | 2008-11-19 | 2011-07-28 | Merial Ltd | Composiciones que comprenden un aril pirazol y/o una formamidina, metodos y usos de las mismas. |
| KR101852173B1 (ko) | 2009-03-20 | 2018-04-27 | 버텍스 파마슈티칼스 인코포레이티드 | 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법 |
| US20120100221A1 (en) | 2009-06-02 | 2012-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions containing a combination of an antihistamine and a decongestant |
| BR112014021090B1 (pt) | 2012-02-27 | 2023-01-24 | Vertex Pharmaceuticals Incorporated | Composição farmacêutica e uso de n-[2,4-bis(1,1-dimetiletil)-5-hidróxifenil]-1,4-di-hidro-4-oxoquinolina3-carboxamida na preparação da mesma |
| ES2821528T3 (es) | 2012-11-14 | 2021-04-26 | Grace W R & Co | Composiciones que contienen un material biológicamente activo y un óxido inorgánico no ordenado |
| US10058542B1 (en) | 2014-09-12 | 2018-08-28 | Thioredoxin Systems Ab | Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith |
| KR20170063954A (ko) | 2014-10-07 | 2017-06-08 | 버텍스 파마슈티칼스 인코포레이티드 | 낭성 섬유증 막횡단 전도도 조절자의 조정제의 공-결정 |
| JP2019218313A (ja) | 2018-06-21 | 2019-12-26 | 沢井製薬株式会社 | プソイドエフェドリン又はその薬学的に許容される塩を含有する徐放製剤 |
| EP4351526A1 (en) * | 2021-06-07 | 2024-04-17 | R.P. Scherer Technologies, LLC | Protective coating for moisture sensitive pharmaceutical compositions |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3806526A (en) * | 1972-01-28 | 1974-04-23 | Richardson Merrell Inc | 1-aroylalkyl-4-diphenylmethyl piperidines |
| US3878217A (en) * | 1972-01-28 | 1975-04-15 | Richardson Merrell Inc | Alpha-aryl-4-substituted piperidinoalkanol derivatives |
| US4060634A (en) * | 1973-09-26 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Rapidly resorbable glibenclamide |
| DE2348334C2 (de) * | 1973-09-26 | 1982-11-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue Zubereitungsform des N-4-[2-(5-Chlor-2-methoxybenzamido)äthyl]- phenyl-sulfonyl-N'-cyclohexylharnstoffs |
| US3966949A (en) * | 1973-10-12 | 1976-06-29 | Richardson-Merrell Inc. | Pharmaceutical compositions and preparing same |
| FR2408345A1 (fr) * | 1976-11-30 | 1979-06-08 | Besins Jean Louis | Nouvelle composition a action anti-conceptionnelle |
| US4285957A (en) * | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof |
| US4254129A (en) * | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| US4285958A (en) * | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof |
| US4254130A (en) * | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| EP0111114A3 (de) * | 1982-11-06 | 1985-10-09 | Telefonbau und Normalzeit GmbH | Schaltungsanordnung für eine Fernsprechvermittlungsanlage, insbesondere Fernsprechnebenstellenanlage mit zusätzlichem Datenverkehr |
| GB8613811D0 (en) * | 1986-06-06 | 1986-07-09 | Phares Pharm Res Nv | Composition & method |
| US4609675A (en) * | 1984-08-17 | 1986-09-02 | The Upjohn Company | Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing |
| DK164642C (da) * | 1984-08-30 | 1992-12-14 | Merrell Dow Pharma | Farmaceutisk middel indeholdende terfenadin i form af en varmsmelte paafyldt paa kapsler |
| US4639458A (en) * | 1985-01-22 | 1987-01-27 | Merck & Co., Inc. | Tablet and formulation |
| US4916163A (en) * | 1985-06-04 | 1990-04-10 | The Upjohn Company | Spray-dried lactose formulation of micronized glyburide |
| SE457326B (sv) * | 1986-02-14 | 1988-12-19 | Lejus Medical Ab | Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa |
| US4963540A (en) * | 1986-04-16 | 1990-10-16 | Maxson Wayne S | Method for treatment of premenstrual syndrome |
| SE8603812D0 (sv) * | 1986-09-12 | 1986-09-12 | Draco Ab | Administration of liposomes to mammals |
| DE3720493A1 (de) * | 1987-06-20 | 1989-01-26 | Nattermann A & Cie | Arzneizubereitungen mit mikronisierten ebselen-kristallen |
| CN1053570C (zh) * | 1987-10-07 | 2000-06-21 | 默尔多药物公司 | 哌啶子基链烷醇的药用组合物-减充血剂复方的制备方法 |
| AR240018A1 (es) * | 1987-10-07 | 1990-01-31 | Merrell Pharma Inc | Procedimiento para preparar una composicion que comprende derivados de piperidinoalcanol. |
| US4996061A (en) * | 1987-10-07 | 1991-02-26 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical composition for piperidinoalkanol-decongestant combination |
| US4929605A (en) * | 1987-10-07 | 1990-05-29 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical composition for piperidinoalkanol derivatives |
| JPH0196920A (ja) * | 1987-10-09 | 1989-04-14 | Fujitsu Ltd | ウエーハの識別方法 |
| US4999226A (en) * | 1988-06-01 | 1991-03-12 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical compositions for piperidinoalkanol-ibuprofen combination |
| ZA90341B (en) * | 1989-01-23 | 1990-10-31 | Merrell Dow Pharma | Liquid pharmaceutical composition for piperidinoalkanol derivatives |
| US4990535A (en) * | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
| US5376386A (en) * | 1990-01-24 | 1994-12-27 | British Technology Group Limited | Aerosol carriers |
| IT1246188B (it) * | 1990-07-27 | 1994-11-16 | Resa Farma | Procedimento per la preparazione di composizioni farmaceutiche aventi aumentata velocita' di dissoluzione della sostanza attiva e composizioni ottenute. |
| US5271944A (en) * | 1991-04-05 | 1993-12-21 | Biofor, Ltd. | Pharmacologically enhanced formulations |
| SE9101090D0 (sv) * | 1991-04-11 | 1991-04-11 | Astra Ab | Process for conditioning of water-soluble substances |
| IT1250421B (it) * | 1991-05-30 | 1995-04-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive. |
| US5169638A (en) * | 1991-10-23 | 1992-12-08 | E. R. Squibb & Sons, Inc. | Buoyant controlled release powder formulation |
| US5516803A (en) * | 1991-10-30 | 1996-05-14 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
| JP3026841B2 (ja) * | 1991-12-12 | 2000-03-27 | グラクソ、グループ、リミテッド | 医 薬 |
| US5301664A (en) * | 1992-03-06 | 1994-04-12 | Sievers Robert E | Methods and apparatus for drug delivery using supercritical solutions |
| DE69320952T2 (de) * | 1992-05-11 | 1999-05-27 | Merrell Pharma Inc | Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten |
| US5429825A (en) * | 1992-06-26 | 1995-07-04 | Mcneil-Ppc, Inc. | Rotomelt granulation |
| RO116043B1 (ro) * | 1992-08-03 | 2000-10-30 | Sepracor Inc | Compozitie farmaceutica |
| US5474757A (en) * | 1992-10-16 | 1995-12-12 | Rutgers University | Prevention of acetaminophen overdose toxicity with organosulfur compounds |
| US5314697A (en) * | 1992-10-23 | 1994-05-24 | Schering Corporation | Stable extended release oral dosage composition comprising loratadine and pseudoephedrine |
| SE9203743D0 (sv) * | 1992-12-11 | 1992-12-11 | Astra Ab | Efficient use |
| IT1264517B1 (it) * | 1993-05-31 | 1996-09-24 | Ekita Investments Nv | Compressa farmaceutica atta al rilascio in tempi successivi dei principi attivi in essa veicolati |
| WO1995000482A1 (en) * | 1993-06-24 | 1995-01-05 | Albany Molecular Research, Inc. | Piperidine derivatives and process for their production |
| IT1264696B1 (it) * | 1993-07-09 | 1996-10-04 | Applied Pharma Res | Forme farmaceutiche destinate alla somministrazione orale in grado di rilasciare sostanze attive a velocita' controllata e differenziata |
| CA2128821A1 (en) * | 1993-07-27 | 1995-01-28 | Dilip J. Gole | Freeze-dried pharmaceutical dosage form and process for separation thereof |
| CA2128820A1 (en) * | 1993-07-27 | 1995-01-28 | Walter G. Gowan, Jr. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
| US5895664A (en) * | 1993-09-10 | 1999-04-20 | Fuisz Technologies Ltd. | Process for forming quickly dispersing comestible unit and product therefrom |
| WO1995010278A1 (en) * | 1993-10-15 | 1995-04-20 | Hoechst Marion Roussel, Inc. | Treatment of allergic disorders with terfenadine carboxylate |
| US5451409A (en) * | 1993-11-22 | 1995-09-19 | Rencher; William F. | Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends |
| US5478858A (en) * | 1993-12-17 | 1995-12-26 | The Procter & Gamble Company | 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists |
| US5458879A (en) * | 1994-03-03 | 1995-10-17 | The Procter & Gamble Company | Oral vehicle compositions |
| AU693892B2 (en) * | 1994-05-18 | 1998-07-09 | Aventisub Ii Inc. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudormophs thereof |
| US5567439A (en) * | 1994-06-14 | 1996-10-22 | Fuisz Technologies Ltd. | Delivery of controlled-release systems(s) |
| DE69624559T2 (de) * | 1995-02-28 | 2003-07-10 | Aventis Pharma Inc | Arzneizubereitungen für piperidinalkanolderivate |
| US5574045A (en) * | 1995-06-06 | 1996-11-12 | Hoechst Marion Roussel, Inc. | Oral pharmaceutical composition of piperidinoalkanol compounds in solution form |
| EP0920315B1 (en) * | 1996-08-16 | 2005-12-28 | Schering Corporation | Treatment of upper airway allergic responses with a combination of histamine receptor antagonists |
| JPH10114655A (ja) * | 1996-10-09 | 1998-05-06 | Kyowa Hakko Kogyo Co Ltd | 固形製剤 |
| US5837379A (en) * | 1997-01-31 | 1998-11-17 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
| GB9707934D0 (en) * | 1997-04-18 | 1997-06-04 | Danbiosyst Uk | Improved delivery of drugs to mucosal surfaces |
| CN1253508A (zh) * | 1997-04-30 | 2000-05-17 | 沃尼尔－朗伯公司 | 局部鼻用抗炎组合物 |
| DE19720312A1 (de) * | 1997-05-15 | 1998-11-19 | Hoechst Ag | Zubereitung mit erhöhter in vivo Verträglichkeit |
| US6120803A (en) * | 1997-08-11 | 2000-09-19 | Alza Corporation | Prolonged release active agent dosage form adapted for gastric retention |
| EP1003528B1 (en) * | 1997-08-14 | 2002-09-25 | Aventis Pharmaceuticals Inc. | Method of enhancing bioavailability of fexofenadine and its derivatives |
| US5869479A (en) * | 1997-08-14 | 1999-02-09 | Schering Corporation | Treatment of upper airway allergic responses |
-
1998
- 1998-07-21 KR KR10-1999-7011550A patent/KR100514264B1/ko not_active IP Right Cessation
- 1998-07-21 WO PCT/US1998/015237 patent/WO1999009957A1/en active IP Right Grant
- 1998-07-21 JP JP51430099A patent/JP4344405B2/ja not_active Expired - Lifetime
- 1998-07-21 CN CNB988085275A patent/CN1159012C/zh not_active Expired - Lifetime
- 1998-07-21 NZ NZ501248A patent/NZ501248A/en not_active IP Right Cessation
- 1998-07-21 ID IDW991512A patent/ID22891A/id unknown
- 1998-07-21 EE EEP200000098A patent/EE04294B1/xx unknown
- 1998-07-21 IL IL13342098A patent/IL133420A/en not_active IP Right Cessation
- 1998-07-21 PT PT98937010T patent/PT998272E/pt unknown
- 1998-07-21 SI SI9830454T patent/SI0998272T1/xx unknown
- 1998-07-21 PL PL337348A patent/PL192079B1/pl unknown
- 1998-07-21 RU RU99125326/14A patent/RU2207879C2/ru active
- 1998-07-21 ES ES98937010T patent/ES2192781T3/es not_active Expired - Lifetime
- 1998-07-21 HU HU0002183A patent/HU224921B1/hu unknown
- 1998-07-21 BR BR9812001-8A patent/BR9812001A/pt not_active IP Right Cessation
- 1998-07-21 EP EP98937010A patent/EP0998272B1/en not_active Expired - Lifetime
- 1998-07-21 UA UA99126576A patent/UA60335C2/uk unknown
- 1998-07-21 AU AU85820/98A patent/AU725811B2/en not_active Expired
- 1998-07-21 SK SK1777-99A patent/SK283803B6/sk not_active IP Right Cessation
- 1998-07-21 DK DK98937010T patent/DK0998272T3/da active
- 1998-07-21 CZ CZ19994581A patent/CZ295461B6/cs not_active IP Right Cessation
- 1998-07-21 TR TR2000/00517T patent/TR200000517T2/xx unknown
- 1998-07-21 DE DE69814086T patent/DE69814086T2/de not_active Expired - Lifetime
- 1998-07-21 AT AT98937010T patent/ATE238773T1/de active
- 1998-07-31 US US09/127,478 patent/US6039974A/en not_active Expired - Lifetime
- 1998-08-20 ZA ZA987552A patent/ZA987552B/xx unknown
- 1998-08-21 TW TW087113848A patent/TW570812B/zh not_active IP Right Cessation
- 1998-08-25 AR ARP980104196A patent/AR013947A1/es not_active Application Discontinuation
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2000
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- 2000-02-25 NO NO20000932A patent/NO318246B1/no not_active IP Right Cessation
- 2000-08-15 HK HK00105074A patent/HK1025904A1/xx not_active IP Right Cessation
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