ES2187033T3 - Procedimiento para la preparacion de l-carnitina. - Google Patents

Procedimiento para la preparacion de l-carnitina.

Info

Publication number
ES2187033T3
ES2187033T3 ES98929879T ES98929879T ES2187033T3 ES 2187033 T3 ES2187033 T3 ES 2187033T3 ES 98929879 T ES98929879 T ES 98929879T ES 98929879 T ES98929879 T ES 98929879T ES 2187033 T3 ES2187033 T3 ES 2187033T3
Authority
ES
Spain
Prior art keywords
reaction
preparation
carnitine
procedure
hydroxybutyrolactone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98929879T
Other languages
English (en)
Inventor
Il-Suk Byun
Kyung-Il Kim
Chan-Ah Bong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lotte Fine Chemical Co Ltd
Original Assignee
Samsung Fine Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samsung Fine Chemicals Co Ltd filed Critical Samsung Fine Chemicals Co Ltd
Application granted granted Critical
Publication of ES2187033T3 publication Critical patent/ES2187033T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere al procedimiento para la preparación de L-carnitina expresada por la fórmula (1), que es útil en producción industrial debido al hecho de que cada reacción en fase de solución acuosa se realiza continuamente en el reactor sin proceso de purificación separado. Más particularmente esta reacción se refiere a éstos procedimientos, en los que se utiliza hidroxibutirolactona- (S)-3- activada como materia prima para realizar las siguientes reacciones químicas bajo condiciones específicas: una reacción de apertura de anillo, epoxidación en el centro quiral que es inversamente convertido, y una sustitución nucleofílica de dimetilamina.
ES98929879T 1997-07-28 1998-06-17 Procedimiento para la preparacion de l-carnitina. Expired - Lifetime ES2187033T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19970035473 1997-07-28
KR1019970057813A KR100255039B1 (ko) 1997-07-28 1997-11-03 L-카르니틴의제조방법

Publications (1)

Publication Number Publication Date
ES2187033T3 true ES2187033T3 (es) 2003-05-16

Family

ID=26632965

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98929879T Expired - Lifetime ES2187033T3 (es) 1997-07-28 1998-06-17 Procedimiento para la preparacion de l-carnitina.

Country Status (9)

Country Link
US (1) US6342034B1 (es)
EP (1) EP1000014B1 (es)
JP (1) JP3259230B2 (es)
KR (1) KR100255039B1 (es)
CN (1) CN1265092A (es)
CA (1) CA2298664A1 (es)
DE (1) DE69811083T2 (es)
ES (1) ES2187033T3 (es)
WO (1) WO1999005092A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713290B2 (en) 1998-07-24 2004-03-30 Samsung Fine Chemicals Co., Ltd. Process for preparing optically pure (S)-3-hydroxy-γ-butyrolactone
EP1100952B1 (en) 1998-07-24 2002-10-09 Samsung Fine Chemicals Co., Ltd. Process for preparing optically pure (s)-3,4-dihydroxybutyric acid derivatives
KR100461572B1 (ko) * 1999-03-27 2004-12-14 삼성정밀화학 주식회사 Ｌ-카르니틴 칼슘 염과 이의 제조방법
CN1158244C (zh) 1999-05-18 2004-07-21 希格马托制药工业公司 由s－(一)－氯代琥珀酸或其衍生物制备r－(一)－肉毒碱的方法
US6713639B1 (en) 2002-10-28 2004-03-30 Council Of Scientific And Industrial Research Process for preparing enantiomerically pure (S)-3-hydroxy-gamma-butyrolactone
GB0306394D0 (en) * 2003-03-20 2003-04-23 Univ Nottingham Carnitine retention
JP4967659B2 (ja) * 2004-09-08 2012-07-04 和光純薬工業株式会社 Ｌ−カルニチンの精製方法
CN1312118C (zh) * 2004-11-10 2007-04-25 浙江大学 肉碱的合成工艺
KR100846673B1 (ko) * 2006-03-22 2008-07-16 엔자이텍 주식회사 엘-카르니틴의 제조방법
WO2007139238A1 (en) * 2006-05-26 2007-12-06 Enzytech, Ltd. Process for l-carnitine and acetyl l-carnitine hydrochloride
CN101838212B (zh) * 2010-05-20 2013-03-13 北京科技大学 一种以（r）-（-）-3-氯-1，2-丙二醇为手性起始原料合成l-肉碱的方法
CN102952028A (zh) * 2011-08-16 2013-03-06 凯瑞斯德生化(苏州)有限公司 一种l-肉碱及其中间体的制备方法
JP7113784B2 (ja) * 2019-05-07 2022-08-05 旭化成株式会社 ヒドロキシ酸の製造方法。

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1156852B (it) 1978-07-10 1987-02-04 Sigma Tau Ind Farmaceuti Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni
IT1142201B (it) 1980-06-24 1986-10-08 Sigma Tau Ind Farmaceuti Procedimento per la produzione enzimatica di l-carnitina
IT1136945B (it) 1981-03-18 1986-09-03 Anic Spa Processo per la preparazione di l-carnitina
JPS59192095A (ja) 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
JPS59231048A (ja) 1983-06-11 1984-12-25 Hamari Yakuhin Kogyo Kk ｌ（−）―カルニチンの製造法
AU549565B2 (en) 1983-11-02 1986-01-30 Pirrel S.p.A L (-) carnotine hydrochloride and l (-) carnotine inner salt
FI86889C (fi) 1984-03-29 1992-10-26 Lonza Ag Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett
CH658857A5 (de) 1984-04-04 1986-12-15 Lonza Ag Optisch aktives di-(3-chlor-2-oxy-propyltrimethylammonium)-tartrat.
JPS6191160A (ja) 1984-10-09 1986-05-09 Nisshin Flour Milling Co Ltd Ｌ−カルニチンの製造法
IT1189069B (it) 1986-03-14 1988-01-28 Donegani Guido Ist Processo per la preparazione biotecnologica della l(-)-carnitina cloruro
US5248601A (en) 1986-03-14 1993-09-28 Franco Francalanci Process for preparing L(-)-carnitine chloride
JPH01131143A (ja) 1987-11-16 1989-05-24 Earth Chem Corp Ltd ｄ，ｌ−カルニチンニトリルクロライドの光学分割法
IT1240833B (it) 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento
CA2049536C (en) 1991-05-13 1999-07-06 Rawle I. Hollingsworth Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof
IT1261230B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
US5473104A (en) 1994-09-13 1995-12-05 Neurocrine Biosciences, Inc. Process for the preparation of L-carnitine
KR100247563B1 (ko) * 1997-07-16 2000-04-01 박영구 키랄3,4-에폭시부티르산및이의염의제조방법
US6114566A (en) * 1999-05-24 2000-09-05 Board Of Trustees Operating Michigan State University 4-cyano-3-hydroxybutanoyl hydrazines, derivatives and process for the preparation thereof

Also Published As

Publication number Publication date
KR100255039B1 (ko) 2000-05-01
JP2000516967A (ja) 2000-12-19
CN1265092A (zh) 2000-08-30
DE69811083T2 (de) 2003-10-09
WO1999005092A1 (en) 1999-02-04
KR19990013237A (ko) 1999-02-25
JP3259230B2 (ja) 2002-02-25
DE69811083D1 (de) 2003-03-06
CA2298664A1 (en) 1999-02-04
US6342034B1 (en) 2002-01-29
EP1000014A1 (en) 2000-05-17
EP1000014B1 (en) 2003-01-29

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