ES2176202T3 - Promotores eucarioticos sinteticos que contienen dos elementos inducibles. - Google Patents
Promotores eucarioticos sinteticos que contienen dos elementos inducibles.Info
- Publication number
- ES2176202T3 ES2176202T3 ES93907705T ES93907705T ES2176202T3 ES 2176202 T3 ES2176202 T3 ES 2176202T3 ES 93907705 T ES93907705 T ES 93907705T ES 93907705 T ES93907705 T ES 93907705T ES 2176202 T3 ES2176202 T3 ES 2176202T3
- Authority
- ES
- Spain
- Prior art keywords
- elements
- pct
- promoters
- inducible
- inducible elements
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Electrophonic Musical Instruments (AREA)
- Soil Working Implements (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Multicomponent Fibers (AREA)
- Developing Agents For Electrophotography (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Electrotherapy Devices (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
SE PRESENTAN PROMOTORES EUCARIOTICOS, INDUCIBLES, SINTETICOS PARA LA REGULACION DE LA TRANSCRIPCION DE UN GEN QUE CONSIGUEN NIVELES MEJORADOS DE EXPRESION DE PROTEINA Y NIVELES BASALES INFERIORES DE LA EXPRESION DEL GEN. DICHOS PROMOTORES CONTIENEN AL MENOS DOS CLASES DIFERENTES DE ELEMENTOS INDUCIBLES, USUALMENTE MEDIANTE LA MODIFICACION DE UN PROMOTOR NATIVO QUE CONTENGA UNO O MAS ELEMENTOS INDUCIBLES INSERTANDO EL OTRO DE LOS ELEMENTOS INDUCIBLES. EN CIERTAS CONFORMACIONES, SE SUMINISTRAN ELEMENTOS ADICIONALES SENSIBLES AL METAL (MRES) Y/O ELEMENTOS SENSIBLES A LOS GLUCOCORTICOIDES (GRES) A LOS PROMOTORES NATIVOS, PARTICULARMENTE LOS PROMOTORES HMT-IIA Y MMTV-LTR. UNO O MAS ELEMENTOS CONSTITUTIVOS PUEDEN SER FUNCIONALMENTE DESACTIVADOS PARA SUMINISTRAR LOS NIVELES BASALES INFERIORES DE LA EXPRESION DEL GEN.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929206874A GB9206874D0 (en) | 1992-03-30 | 1992-03-30 | Generation of improved inducible mammalian expression vectors |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2176202T3 true ES2176202T3 (es) | 2002-12-01 |
Family
ID=10713085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93907705T Expired - Lifetime ES2176202T3 (es) | 1992-03-30 | 1993-03-30 | Promotores eucarioticos sinteticos que contienen dos elementos inducibles. |
Country Status (17)
Country | Link |
---|---|
US (1) | US5559027A (es) |
EP (1) | EP0633941B1 (es) |
JP (1) | JP2701983B2 (es) |
KR (1) | KR100208311B1 (es) |
AT (1) | ATE217649T1 (es) |
AU (1) | AU667532B2 (es) |
BR (1) | BR9306167A (es) |
CA (1) | CA2128602C (es) |
DE (1) | DE69331931T2 (es) |
DK (1) | DK0633941T3 (es) |
ES (1) | ES2176202T3 (es) |
FI (1) | FI113548B (es) |
GB (1) | GB9206874D0 (es) |
NO (1) | NO316451B1 (es) |
PT (1) | PT633941E (es) |
RU (1) | RU2128225C1 (es) |
WO (1) | WO1993020218A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6071695A (en) * | 1992-02-21 | 2000-06-06 | Creative Biomolecules, Inc. | Methods and products for identification of modulators of osteogenic protein-1 gene expression |
US5512483A (en) * | 1993-05-21 | 1996-04-30 | Mcgill University | Expression vectors responsive to steroid hormones |
JPH07163368A (ja) * | 1993-12-15 | 1995-06-27 | Hayashibara Biochem Lab Inc | 組換えdnaとその組換えdnaを含む形質転換体 |
AU703445B2 (en) * | 1994-06-07 | 1999-03-25 | Stryker Corporation | Methods and compositions for modulating morphogenic protein expression |
EP1003911A1 (en) | 1997-07-14 | 2000-05-31 | Valentis Inc. | Method for the identification of synthetic cell- or tissue-specific transcriptional regulatory regions |
AU748334B2 (en) | 1997-10-16 | 2002-05-30 | Board Of Regents, The University Of Texas System | Models and treatments for cardiac hypertrophy in relation with NF-AT3 function |
FR2772786A1 (fr) * | 1997-12-18 | 1999-06-25 | Inst Nat Sante Rech Med | Sequences nucleotidiques chevauchantes, et leur utilisation dans le cadre de la detection de xenohormones ainsi que dans des compositions pharmaceutiques |
JP2002537311A (ja) * | 1999-02-19 | 2002-11-05 | オクタジーン・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ホルモン−ホルモン受容体の複合体および核酸構築物、並びに遺伝子治療におけるそれらの使用 |
US8008459B2 (en) * | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
US7341847B2 (en) * | 2003-04-02 | 2008-03-11 | Agency For Science, Technology And Research | Promoter construct for gene expression in neuronal cells |
US7951532B2 (en) | 2003-11-12 | 2011-05-31 | Children's Hospital Medical Center | Method of screening a midkine modulating agent |
KR100647490B1 (ko) * | 2004-10-04 | 2006-11-23 | 사회복지법인 삼성생명공익재단 | 저산소 조건 및 다른 스트레스에 특이적으로 반응할 수있는 키메라 인핸서 요소를 포함하는 벡터, 상기 벡터를포함하는 약제학적 조성물 및 상기 조성물을 이용하는 방법 |
JP2009508596A (ja) | 2005-09-19 | 2009-03-05 | ヒストジェニックス コーポレイション | 細胞支持基材及びその調製方法 |
KR101369237B1 (ko) * | 2006-09-04 | 2014-03-04 | 바이오-에너지가부시키가이샤 | 폴리에스테르 폴리올 |
RU2370280C2 (ru) * | 2007-10-08 | 2009-10-20 | Институт физико-химической биологии им. А.Н.Белозерского | СПОСОБ СУПЕРПРОДУКЦИИ В РАСТЕНИИ АНТИТЕЛ ПРОТИВ ОНКОГЕНА HER2/neu |
ES2533952T3 (es) | 2009-02-09 | 2015-04-16 | Morphosys Ag | Producción de mezclas oligoclonales de inmunoglobulinas en células individuales |
EP2571991A1 (en) | 2010-05-20 | 2013-03-27 | Evolva SA | Method of producing isoprenoid compounds in yeast |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
CA3083682A1 (en) | 2017-11-30 | 2019-06-06 | Friedrich Miescher Institute For Biomedical Research | Synpiii, a promoter for the specific expression of genes in retinal pigment epithelium |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3280392D1 (de) * | 1981-11-23 | 1992-03-26 | University Patents Inc | Steuerung der dna-sequenzen-transkription. |
EP0511285A4 (en) * | 1990-01-18 | 1993-05-26 | Us Commerce | Vector with multiple target response elements affecting gene expression |
EP0514488B1 (en) * | 1990-02-09 | 2000-09-13 | The Salk Institute For Biological Studies | Retinoid receptor compositions and methods |
-
1992
- 1992-03-30 GB GB929206874A patent/GB9206874D0/en active Pending
-
1993
- 1993-03-30 US US08/256,720 patent/US5559027A/en not_active Expired - Lifetime
- 1993-03-30 DE DE69331931T patent/DE69331931T2/de not_active Expired - Lifetime
- 1993-03-30 WO PCT/CA1993/000130 patent/WO1993020218A1/en active IP Right Grant
- 1993-03-30 JP JP5516926A patent/JP2701983B2/ja not_active Expired - Lifetime
- 1993-03-30 AT AT93907705T patent/ATE217649T1/de active
- 1993-03-30 KR KR1019940702959A patent/KR100208311B1/ko not_active IP Right Cessation
- 1993-03-30 RU RU94042389A patent/RU2128225C1/ru active
- 1993-03-30 ES ES93907705T patent/ES2176202T3/es not_active Expired - Lifetime
- 1993-03-30 PT PT93907705T patent/PT633941E/pt unknown
- 1993-03-30 DK DK93907705T patent/DK0633941T3/da active
- 1993-03-30 CA CA002128602A patent/CA2128602C/en not_active Expired - Lifetime
- 1993-03-30 AU AU38833/93A patent/AU667532B2/en not_active Expired
- 1993-03-30 BR BR9306167A patent/BR9306167A/pt not_active Application Discontinuation
- 1993-03-30 EP EP93907705A patent/EP0633941B1/en not_active Expired - Lifetime
-
1994
- 1994-09-26 FI FI944451A patent/FI113548B/fi not_active IP Right Cessation
- 1994-09-29 NO NO19943610A patent/NO316451B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO316451B1 (no) | 2004-01-26 |
DE69331931D1 (de) | 2002-06-20 |
PT633941E (pt) | 2002-10-31 |
CA2128602A1 (en) | 1993-10-14 |
CA2128602C (en) | 2008-01-22 |
EP0633941A1 (en) | 1995-01-18 |
ATE217649T1 (de) | 2002-06-15 |
KR100208311B1 (ko) | 1999-07-15 |
KR950700420A (ko) | 1995-01-16 |
GB9206874D0 (en) | 1992-05-13 |
RU2128225C1 (ru) | 1999-03-27 |
JP2701983B2 (ja) | 1998-01-21 |
JPH07501456A (ja) | 1995-02-16 |
FI113548B (fi) | 2004-05-14 |
BR9306167A (pt) | 1998-01-13 |
FI944451A (fi) | 1994-09-26 |
NO943610D0 (no) | 1994-09-29 |
US5559027A (en) | 1996-09-24 |
DK0633941T3 (da) | 2002-06-17 |
FI944451A0 (fi) | 1994-09-26 |
AU3883393A (en) | 1993-11-08 |
RU94042389A (ru) | 1997-03-10 |
AU667532B2 (en) | 1996-03-28 |
NO943610L (no) | 1994-11-30 |
WO1993020218A1 (en) | 1993-10-14 |
DE69331931T2 (de) | 2002-09-12 |
EP0633941B1 (en) | 2002-05-15 |
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