ES2150980T3 - Un procedimiento para producir inmunosupresores y una nueva especie microbiana a emplear en el mismo. - Google Patents
Un procedimiento para producir inmunosupresores y una nueva especie microbiana a emplear en el mismo.Info
- Publication number
- ES2150980T3 ES2150980T3 ES94902795T ES94902795T ES2150980T3 ES 2150980 T3 ES2150980 T3 ES 2150980T3 ES 94902795 T ES94902795 T ES 94902795T ES 94902795 T ES94902795 T ES 94902795T ES 2150980 T3 ES2150980 T3 ES 2150980T3
- Authority
- ES
- Spain
- Prior art keywords
- producing
- immunosuppressants
- procedure
- microbial species
- new microbial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Abstract
LA INVENCION SE REFIERE AL PROCESO PARA PRODUCIR CICLOSPORINA, ESPECIALMENTE CICLOSPORINA A, CULTIVANDO UNA CLASE DE LAS NUEVAS ESPECIES DE TOLYPOCLADIUM EN UN MEDIO NUTRIENTE QUE CONTENGA FUENTES DE CARBON, FUENTES DE NITROGENO Y SALES MINERALES, Y, SI SE DESEA, AISLANDO Y PURIFICANDO LA CICLOSPORINA RESULTANTE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI925940A FI92334C (fi) | 1992-12-30 | 1992-12-30 | Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta |
PCT/FI1993/000568 WO1994016091A1 (en) | 1992-12-30 | 1993-12-29 | A process for producing immunosuppressives and a novel microbial species to be employed therein |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2150980T3 true ES2150980T3 (es) | 2000-12-16 |
Family
ID=8536483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94902795T Expired - Lifetime ES2150980T3 (es) | 1992-12-30 | 1993-12-29 | Un procedimiento para producir inmunosupresores y una nueva especie microbiana a emplear en el mismo. |
Country Status (20)
Country | Link |
---|---|
US (1) | US5409816A (es) |
EP (1) | EP0677116B1 (es) |
JP (1) | JP3530531B2 (es) |
KR (1) | KR100283503B1 (es) |
AT (1) | ATE196655T1 (es) |
AU (1) | AU674723B2 (es) |
CA (1) | CA2152963C (es) |
DE (1) | DE69329500T2 (es) |
DK (1) | DK0677116T3 (es) |
EE (1) | EE03114B1 (es) |
ES (1) | ES2150980T3 (es) |
FI (1) | FI92334C (es) |
GR (1) | GR3035139T3 (es) |
HK (1) | HK1014035A1 (es) |
HU (1) | HU217683B (es) |
PL (1) | PL177023B1 (es) |
PT (1) | PT677116E (es) |
RU (1) | RU2112807C1 (es) |
SG (1) | SG49072A1 (es) |
WO (1) | WO1994016091A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0725076B1 (en) * | 1995-02-01 | 2001-06-06 | National Research Development Corporation of India | A process for the preparation of cyclosporin A from tolypocladium species |
KR100360675B1 (ko) * | 1995-02-28 | 2003-01-14 | 내셔널 리서어치 디벨럽먼트 코포레이션 | 사이클로스포린a제조방법 |
US5709797A (en) * | 1996-06-05 | 1998-01-20 | Poli Industria Chimica S.P.A. | Method of isolating cyclosporins |
US5747330A (en) * | 1996-06-05 | 1998-05-05 | Poli Industria Chimica | Antibiotic producing microbe |
HU223054B1 (hu) * | 1997-03-25 | 2004-03-01 | BIOGAL Gyógyszergyár Rt. | Tisztítási eljárás nagytisztaságú ciklosporin A előállítására |
US6423233B1 (en) * | 2000-08-15 | 2002-07-23 | Biogal Gyogyszergyar Rt. | Purification process |
KR100496929B1 (ko) * | 1997-03-25 | 2005-09-30 | 테바 기오기스제르갸르 레스즈베니타르사사그 | 시클로스포린의정제방법 |
US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
NZ502362A (en) | 1997-10-08 | 2001-05-25 | Isotechnika Inc | Deuterated cyclosporine A derivatives and their use as immunomodulating agents |
AU769429C (en) | 1998-12-30 | 2004-10-28 | Dexcel Limited | Dispersible concentrate for the delivery of cyclosporin |
US7732404B2 (en) * | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
CA2396381A1 (en) * | 2000-01-20 | 2001-07-26 | Akira Yanagawa | Nasally administrable cyclic peptide compositions |
ATE306558T1 (de) * | 2000-02-29 | 2005-10-15 | Biocon Ltd | Herstellung und reinigung von cyclosporin-a |
WO2003033526A2 (en) * | 2001-10-19 | 2003-04-24 | Isotechnika Inc. | Synthesis of cyclosporin analogs |
US7862552B2 (en) * | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
EP2151450A1 (de) | 2008-07-29 | 2010-02-10 | Sandoz AG | Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden |
US10945443B2 (en) | 2017-09-29 | 2021-03-16 | Valent Biosciences Llc | Tolypocladium album strain |
RU2679051C1 (ru) * | 2018-02-16 | 2019-02-05 | Федеральное государственное учреждение Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук | Штамм streptomyces hygroscopicus bkm ac-2737d - продуцент антибиотика рапамицина и способ увеличения его продуктивности |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE295870C (es) * | ||||
US3878047A (en) * | 1973-02-02 | 1975-04-15 | Upjohn Co | Process for production of AT-125 |
US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
US4215199A (en) * | 1978-06-05 | 1980-07-29 | Sandoz Ltd. | Antibiotic production |
DD298276A5 (de) * | 1988-10-11 | 1992-02-13 | Institut Fuer Mikrobiologie Und Experimentelle Therapie,De | Verfahren zur herstellung von cyclosporin a |
DD295870A5 (de) * | 1988-10-11 | 1991-11-14 | Arzneimittelwerk Dresden Gmbh,De | Verfahren zur mikrobiellen gewinnung von cyclosporinen |
HU201577B (en) * | 1988-12-20 | 1990-11-28 | Gyogyszerkutato Intezet | Process for producing cyclosporin antibiotics |
WO1992013094A1 (fr) * | 1991-01-25 | 1992-08-06 | Fujisawa Pharmaceutical Co., Ltd. | Procede pour produire de la cyclosporine a et/ou c |
ES2078374T3 (es) * | 1991-04-06 | 1995-12-16 | Dresden Arzneimittel | Procedimiento para la produccion por fermentacion y aislamiento de ciclosporina a, y nuevas cepas formadoras de ciclosporina. |
-
1992
- 1992-12-30 FI FI925940A patent/FI92334C/fi not_active IP Right Cessation
-
1993
- 1993-02-22 US US08/020,545 patent/US5409816A/en not_active Expired - Fee Related
- 1993-12-29 KR KR1019950702677A patent/KR100283503B1/ko not_active IP Right Cessation
- 1993-12-29 HU HU9501951A patent/HU217683B/hu not_active IP Right Cessation
- 1993-12-29 DK DK94902795T patent/DK0677116T3/da active
- 1993-12-29 ES ES94902795T patent/ES2150980T3/es not_active Expired - Lifetime
- 1993-12-29 RU RU95114383A patent/RU2112807C1/ru not_active IP Right Cessation
- 1993-12-29 EP EP94902795A patent/EP0677116B1/en not_active Expired - Lifetime
- 1993-12-29 SG SG1996005777A patent/SG49072A1/en unknown
- 1993-12-29 PT PT94902795T patent/PT677116E/pt unknown
- 1993-12-29 WO PCT/FI1993/000568 patent/WO1994016091A1/en active IP Right Grant
- 1993-12-29 AT AT94902795T patent/ATE196655T1/de not_active IP Right Cessation
- 1993-12-29 PL PL93309613A patent/PL177023B1/pl not_active IP Right Cessation
- 1993-12-29 DE DE69329500T patent/DE69329500T2/de not_active Expired - Fee Related
- 1993-12-29 JP JP51571394A patent/JP3530531B2/ja not_active Expired - Fee Related
- 1993-12-29 AU AU57014/94A patent/AU674723B2/en not_active Ceased
- 1993-12-29 CA CA002152963A patent/CA2152963C/en not_active Expired - Fee Related
-
1994
- 1994-11-16 EE EE9400184A patent/EE03114B1/xx not_active IP Right Cessation
-
1998
- 1998-12-23 HK HK98115143A patent/HK1014035A1/xx not_active IP Right Cessation
-
2000
- 2000-12-22 GR GR20000402825T patent/GR3035139T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2152963A1 (en) | 1994-07-21 |
DE69329500D1 (de) | 2000-11-02 |
HU9501951D0 (en) | 1995-08-28 |
PT677116E (pt) | 2001-01-31 |
FI925940A0 (fi) | 1992-12-30 |
HU217683B (hu) | 2000-03-28 |
ATE196655T1 (de) | 2000-10-15 |
WO1994016091A1 (en) | 1994-07-21 |
AU674723B2 (en) | 1997-01-09 |
US5409816A (en) | 1995-04-25 |
EE03114B1 (et) | 1998-08-17 |
RU2112807C1 (ru) | 1998-06-10 |
PL177023B1 (pl) | 1999-09-30 |
SG49072A1 (en) | 1998-05-18 |
CA2152963C (en) | 2003-05-27 |
EP0677116B1 (en) | 2000-09-27 |
HK1014035A1 (en) | 1999-09-17 |
PL309613A1 (en) | 1995-10-30 |
KR100283503B1 (ko) | 2001-03-02 |
JP3530531B2 (ja) | 2004-05-24 |
AU5701494A (en) | 1994-08-15 |
FI92334B (fi) | 1994-07-15 |
KR960700346A (ko) | 1996-01-19 |
JPH08505059A (ja) | 1996-06-04 |
HUT72702A (en) | 1996-05-28 |
DK0677116T3 (da) | 2000-12-27 |
FI92334C (fi) | 1994-10-25 |
EP0677116A1 (en) | 1995-10-18 |
GR3035139T3 (en) | 2001-04-30 |
DE69329500T2 (de) | 2001-06-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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