ATE306558T1 - Herstellung und reinigung von cyclosporin-a - Google Patents
Herstellung und reinigung von cyclosporin-aInfo
- Publication number
- ATE306558T1 ATE306558T1 AT00914350T AT00914350T ATE306558T1 AT E306558 T1 ATE306558 T1 AT E306558T1 AT 00914350 T AT00914350 T AT 00914350T AT 00914350 T AT00914350 T AT 00914350T AT E306558 T1 ATE306558 T1 AT E306558T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclosporin
- purification
- production
- alum
- extracted
- Prior art date
Links
- 229930105110 Cyclosporin A Natural products 0.000 title abstract 3
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
- 108010036949 Cyclosporine Proteins 0.000 title abstract 3
- 229960001265 ciclosporin Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 241000427940 Fusarium solani Species 0.000 abstract 1
- 229940037003 alum Drugs 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000010563 solid-state fermentation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2000/000018 WO2001064935A1 (en) | 2000-02-29 | 2000-02-29 | Manufacture and purification of cyclosporin a |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE306558T1 true ATE306558T1 (de) | 2005-10-15 |
Family
ID=11076228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00914350T ATE306558T1 (de) | 2000-02-29 | 2000-02-29 | Herstellung und reinigung von cyclosporin-a |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7176001B1 (de) |
| EP (1) | EP1261732B1 (de) |
| AT (1) | ATE306558T1 (de) |
| AU (1) | AU2000235743A1 (de) |
| CA (1) | CA2401700A1 (de) |
| DE (1) | DE60023189D1 (de) |
| WO (1) | WO2001064935A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1763084B (zh) * | 2005-10-11 | 2010-04-21 | 山东新时代药业有限公司 | 高纯度环孢菌素a的制备方法 |
| CN116445298B (zh) * | 2023-05-19 | 2025-10-21 | 福建省微生物研究所 | 一种发酵产环孢菌素a的茄病镰刀菌株及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3904476A (en) * | 1973-05-29 | 1975-09-09 | Mobil Oil Corp | Treatment of cells of a hydrocarbon-consuming microorganism |
| US4117118A (en) | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
| SE448386B (sv) * | 1978-10-18 | 1987-02-16 | Sandoz Ag | Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem |
| US4466885A (en) * | 1982-07-13 | 1984-08-21 | Husky Oil Operations Ltd. | Method for removing solids and water from petroleum crudes |
| US4569793A (en) * | 1984-09-26 | 1986-02-11 | Shell Oil Company | Cyanohydrination catalyst |
| US4762923A (en) * | 1986-11-21 | 1988-08-09 | Merck & Co. Inc. | Fermentation analogs of virginiamycin M1 |
| US4843054A (en) * | 1987-02-26 | 1989-06-27 | Arco Chemical Technology, Inc. | Preparation of filterable double metal cyanide complex catalyst for propylene oxide polymerization |
| HU201577B (en) | 1988-12-20 | 1990-11-28 | Gyogyszerkutato Intezet | Process for producing cyclosporin antibiotics |
| EP0507968B1 (de) * | 1991-04-06 | 1995-09-06 | Arzneimittelwerk Dresden Gmbh | Verfahren zur fermentativen Herstellung und Isolierung von Cyclosporin A sowie neue Cyclosporin- bildende Stämme |
| FI92334C (fi) * | 1992-12-30 | 1994-10-25 | Leiras Oy | Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta |
| CA2108655A1 (en) | 1993-10-18 | 1995-04-19 | Argyrios Margaritis | Supercritical co2 extraction of cyclosporin a |
| KR0126610B1 (ko) | 1994-10-18 | 1997-12-29 | 김충환 | 고생산 세포융합변이균주에 의한 사이클로스포린 a의 제조방법 |
| EP0725076B1 (de) * | 1995-02-01 | 2001-06-06 | National Research Development Corporation of India | Verfahren zur Gewinnung von Cyclosporin A aus einer Tolypocladiumspecies |
| US5747330A (en) | 1996-06-05 | 1998-05-05 | Poli Industria Chimica | Antibiotic producing microbe |
| DE69732238T2 (de) * | 1997-10-31 | 2005-12-08 | Société des Produits Nestlé S.A. | Herstellung eines Hydrolysates |
| US6197573B1 (en) | 1998-11-17 | 2001-03-06 | Biocon India Limited | Solid state fermentation |
-
2000
- 2000-02-29 AT AT00914350T patent/ATE306558T1/de not_active IP Right Cessation
- 2000-02-29 DE DE60023189T patent/DE60023189D1/de not_active Expired - Lifetime
- 2000-02-29 WO PCT/IN2000/000018 patent/WO2001064935A1/en not_active Ceased
- 2000-02-29 CA CA002401700A patent/CA2401700A1/en not_active Abandoned
- 2000-02-29 EP EP00914350A patent/EP1261732B1/de not_active Expired - Lifetime
- 2000-02-29 US US10/220,226 patent/US7176001B1/en not_active Expired - Fee Related
- 2000-02-29 AU AU2000235743A patent/AU2000235743A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001064935A1 (en) | 2001-09-07 |
| CA2401700A1 (en) | 2001-09-07 |
| US7176001B1 (en) | 2007-02-13 |
| EP1261732A1 (de) | 2002-12-04 |
| AU2000235743A1 (en) | 2001-09-12 |
| EP1261732B1 (de) | 2005-10-12 |
| DE60023189D1 (de) | 2006-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |