AU2000235743A1 - Manufacture and purification of cyclosporin a - Google Patents
Manufacture and purification of cyclosporin aInfo
- Publication number
- AU2000235743A1 AU2000235743A1 AU2000235743A AU3574300A AU2000235743A1 AU 2000235743 A1 AU2000235743 A1 AU 2000235743A1 AU 2000235743 A AU2000235743 A AU 2000235743A AU 3574300 A AU3574300 A AU 3574300A AU 2000235743 A1 AU2000235743 A1 AU 2000235743A1
- Authority
- AU
- Australia
- Prior art keywords
- cyclosporin
- manufacture
- purification
- alum
- extracted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Abstract
The present invention provides an improved method for the manufacture of Cyclosporin A is disclosed. Cyclosporin A is produced by solid state fermentation of Fusarium solani in a bioreactor under optimal fermentation parameters. The product is extracted and further purified by treating with alum and subsequent chromatographic procedures to get pharmaceutical acceptable purity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IN2000/000018 WO2001064935A1 (en) | 2000-02-29 | 2000-02-29 | Manufacture and purification of cyclosporin a |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2000235743A1 true AU2000235743A1 (en) | 2001-09-12 |
Family
ID=11076228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2000235743A Abandoned AU2000235743A1 (en) | 2000-02-29 | 2000-02-29 | Manufacture and purification of cyclosporin a |
Country Status (7)
Country | Link |
---|---|
US (1) | US7176001B1 (en) |
EP (1) | EP1261732B1 (en) |
AT (1) | ATE306558T1 (en) |
AU (1) | AU2000235743A1 (en) |
CA (1) | CA2401700A1 (en) |
DE (1) | DE60023189D1 (en) |
WO (1) | WO2001064935A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1763084B (en) * | 2005-10-11 | 2010-04-21 | 山东新时代药业有限公司 | High purity cyclosporin A preparation method |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3904476A (en) * | 1973-05-29 | 1975-09-09 | Mobil Oil Corp | Treatment of cells of a hydrocarbon-consuming microorganism |
US4117118A (en) | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
SE448386B (en) * | 1978-10-18 | 1987-02-16 | Sandoz Ag | NEW CYCLOSPORIN DERIVATIVES, PROCEDURE FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
US4466885A (en) * | 1982-07-13 | 1984-08-21 | Husky Oil Operations Ltd. | Method for removing solids and water from petroleum crudes |
US4569793A (en) * | 1984-09-26 | 1986-02-11 | Shell Oil Company | Cyanohydrination catalyst |
US4762923A (en) * | 1986-11-21 | 1988-08-09 | Merck & Co. Inc. | Fermentation analogs of virginiamycin M1 |
US4843054A (en) * | 1987-02-26 | 1989-06-27 | Arco Chemical Technology, Inc. | Preparation of filterable double metal cyanide complex catalyst for propylene oxide polymerization |
HU201577B (en) | 1988-12-20 | 1990-11-28 | Gyogyszerkutato Intezet | Process for producing cyclosporin antibiotics |
EP0507968B1 (en) * | 1991-04-06 | 1995-09-06 | Arzneimittelwerk Dresden Gmbh | Method for the fermentative production and isolation of cyclosporin A and new cyclosporin forming strains |
FI92334C (en) * | 1992-12-30 | 1994-10-25 | Leiras Oy | Process for producing cyclosporins and new Tolypocladium strain useful in the process |
CA2108655A1 (en) | 1993-10-18 | 1995-04-19 | Argyrios Margaritis | Supercritical co2 extraction of cyclosporin a |
KR0126610B1 (en) | 1994-10-18 | 1997-12-29 | 김충환 | Producing method of cyclosporina by cell fusioned microorganism |
EP0725076B1 (en) * | 1995-02-01 | 2001-06-06 | National Research Development Corporation of India | A process for the preparation of cyclosporin A from tolypocladium species |
US5747330A (en) | 1996-06-05 | 1998-05-05 | Poli Industria Chimica | Antibiotic producing microbe |
EP0913097B1 (en) * | 1997-10-31 | 2005-01-12 | Societe Des Produits Nestle S.A. | Production of a hydrolysate |
US6197573B1 (en) * | 1998-11-17 | 2001-03-06 | Biocon India Limited | Solid state fermentation |
-
2000
- 2000-02-29 DE DE60023189T patent/DE60023189D1/en not_active Expired - Lifetime
- 2000-02-29 AT AT00914350T patent/ATE306558T1/en not_active IP Right Cessation
- 2000-02-29 EP EP00914350A patent/EP1261732B1/en not_active Expired - Lifetime
- 2000-02-29 WO PCT/IN2000/000018 patent/WO2001064935A1/en active IP Right Grant
- 2000-02-29 AU AU2000235743A patent/AU2000235743A1/en not_active Abandoned
- 2000-02-29 CA CA002401700A patent/CA2401700A1/en not_active Abandoned
- 2000-02-29 US US10/220,226 patent/US7176001B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2001064935A1 (en) | 2001-09-07 |
CA2401700A1 (en) | 2001-09-07 |
DE60023189D1 (en) | 2006-02-23 |
ATE306558T1 (en) | 2005-10-15 |
US7176001B1 (en) | 2007-02-13 |
EP1261732A1 (en) | 2002-12-04 |
EP1261732B1 (en) | 2005-10-12 |
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