DK0677116T3 - Fremgangsmåde til fremstilling af immunosuppressive midler og en ny mikroorganismeart til anvendelse deri - Google Patents

Fremgangsmåde til fremstilling af immunosuppressive midler og en ny mikroorganismeart til anvendelse deri

Info

Publication number
DK0677116T3
DK0677116T3 DK94902795T DK94902795T DK0677116T3 DK 0677116 T3 DK0677116 T3 DK 0677116T3 DK 94902795 T DK94902795 T DK 94902795T DK 94902795 T DK94902795 T DK 94902795T DK 0677116 T3 DK0677116 T3 DK 0677116T3
Authority
DK
Denmark
Prior art keywords
preparation
immunosuppressive agents
microorganism species
novel microorganism
cyclosporin
Prior art date
Application number
DK94902795T
Other languages
Danish (da)
English (en)
Inventor
Juhani Lundell
Anja Kopio
Timo Korpela
Matti Ankelo
Original Assignee
Santen Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Oy filed Critical Santen Oy
Application granted granted Critical
Publication of DK0677116T3 publication Critical patent/DK0677116T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
DK94902795T 1992-12-30 1993-12-29 Fremgangsmåde til fremstilling af immunosuppressive midler og en ny mikroorganismeart til anvendelse deri DK0677116T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI925940A FI92334C (fi) 1992-12-30 1992-12-30 Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta
PCT/FI1993/000568 WO1994016091A1 (en) 1992-12-30 1993-12-29 A process for producing immunosuppressives and a novel microbial species to be employed therein

Publications (1)

Publication Number Publication Date
DK0677116T3 true DK0677116T3 (da) 2000-12-27

Family

ID=8536483

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94902795T DK0677116T3 (da) 1992-12-30 1993-12-29 Fremgangsmåde til fremstilling af immunosuppressive midler og en ny mikroorganismeart til anvendelse deri

Country Status (20)

Country Link
US (1) US5409816A (es)
EP (1) EP0677116B1 (es)
JP (1) JP3530531B2 (es)
KR (1) KR100283503B1 (es)
AT (1) ATE196655T1 (es)
AU (1) AU674723B2 (es)
CA (1) CA2152963C (es)
DE (1) DE69329500T2 (es)
DK (1) DK0677116T3 (es)
EE (1) EE03114B1 (es)
ES (1) ES2150980T3 (es)
FI (1) FI92334C (es)
GR (1) GR3035139T3 (es)
HK (1) HK1014035A1 (es)
HU (1) HU217683B (es)
PL (1) PL177023B1 (es)
PT (1) PT677116E (es)
RU (1) RU2112807C1 (es)
SG (1) SG49072A1 (es)
WO (1) WO1994016091A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0725076B1 (en) * 1995-02-01 2001-06-06 National Research Development Corporation of India A process for the preparation of cyclosporin A from tolypocladium species
KR100360675B1 (ko) * 1995-02-28 2003-01-14 내셔널 리서어치 디벨럽먼트 코포레이션 사이클로스포린a제조방법
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
US6423233B1 (en) * 2000-08-15 2002-07-23 Biogal Gyogyszergyar Rt. Purification process
HU223054B1 (hu) * 1997-03-25 2004-03-01 BIOGAL Gyógyszergyár Rt. Tisztítási eljárás nagytisztaságú ciklosporin A előállítására
KR100496929B1 (ko) * 1997-03-25 2005-09-30 테바 기오기스제르갸르 레스즈베니타르사사그 시클로스포린의정제방법
DE69832984T2 (de) 1997-10-08 2006-09-21 Isotechnika, Inc., Edmonton DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
US7026290B1 (en) 1998-12-30 2006-04-11 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosprin
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
CN1406124A (zh) * 2000-01-20 2003-03-26 巴斯利尔药物股份公司 鼻给药的环肽组合物
CA2401700A1 (en) * 2000-02-29 2001-09-07 Biocon India Limited Manufacture and purification of cyclosporin a
DK1714977T3 (da) 2001-10-19 2009-07-06 Isotechnika Inc Syntese af cyclosporinanaloger
US7862552B2 (en) * 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
EP2151450A1 (de) * 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
US10945443B2 (en) 2017-09-29 2021-03-16 Valent Biosciences Llc Tolypocladium album strain
RU2679051C1 (ru) * 2018-02-16 2019-02-05 Федеральное государственное учреждение Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук Штамм streptomyces hygroscopicus bkm ac-2737d - продуцент антибиотика рапамицина и способ увеличения его продуктивности

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE295870C (es) *
US3878047A (en) * 1973-02-02 1975-04-15 Upjohn Co Process for production of AT-125
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
DD298276A5 (de) * 1988-10-11 1992-02-13 Institut Fuer Mikrobiologie Und Experimentelle Therapie,De Verfahren zur herstellung von cyclosporin a
DD295870A5 (de) * 1988-10-11 1991-11-14 Arzneimittelwerk Dresden Gmbh,De Verfahren zur mikrobiellen gewinnung von cyclosporinen
HU201577B (en) * 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
ATE158022T1 (de) * 1991-01-25 1997-09-15 Fujisawa Pharmaceutical Co Prozess zur produktion von cyclosporin-a und/oder c
ATE127528T1 (de) * 1991-04-06 1995-09-15 Dresden Arzneimittel Verfahren zur fermentativen herstellung und isolierung von cyclosporin a sowie neue cyclosporin- bildende stämme.

Also Published As

Publication number Publication date
ATE196655T1 (de) 2000-10-15
WO1994016091A1 (en) 1994-07-21
PL309613A1 (en) 1995-10-30
HU217683B (hu) 2000-03-28
HK1014035A1 (en) 1999-09-17
JP3530531B2 (ja) 2004-05-24
FI92334C (fi) 1994-10-25
PL177023B1 (pl) 1999-09-30
CA2152963C (en) 2003-05-27
US5409816A (en) 1995-04-25
KR960700346A (ko) 1996-01-19
JPH08505059A (ja) 1996-06-04
GR3035139T3 (en) 2001-04-30
SG49072A1 (en) 1998-05-18
RU2112807C1 (ru) 1998-06-10
PT677116E (pt) 2001-01-31
EP0677116B1 (en) 2000-09-27
FI92334B (fi) 1994-07-15
CA2152963A1 (en) 1994-07-21
HU9501951D0 (en) 1995-08-28
HUT72702A (en) 1996-05-28
AU674723B2 (en) 1997-01-09
FI925940A0 (fi) 1992-12-30
DE69329500T2 (de) 2001-06-07
EE03114B1 (et) 1998-08-17
EP0677116A1 (en) 1995-10-18
ES2150980T3 (es) 2000-12-16
DE69329500D1 (de) 2000-11-02
KR100283503B1 (ko) 2001-03-02
AU5701494A (en) 1994-08-15

Similar Documents

Publication Publication Date Title
DK0677116T3 (da) Fremgangsmåde til fremstilling af immunosuppressive midler og en ny mikroorganismeart til anvendelse deri
YU47100B (sh) Mikrobiološki postupak za proizvodnju ciklosporinskog kompleksa ili njegovih komponenti
EP0508985A4 (en) Method and kit for purifying nucleic acids
ATE117019T1 (de) Neue hyperthermostabile alpha - amylase.
BG60053B2 (bg) Метод за повишаване способността за получаване на антибиотик
ES2193144T3 (es) Compuestos de dna que comprenden secuencias que codifican manuronano c-5-epimerasa.
HUP0200296A2 (en) Microbial transformation method for the preparation of an epothilone
BG50282A3 (en) Method for the preparation of l- carnitine in a microbiological way
NO302072B1 (no) Azabicyklo-arylacetylen- og -arylenyn-oksimer som cholinerge midler og preparater inneholdende slike
DK0698667T3 (da) Xylanase, mikroorganismer til produktion deraf, DNA-molekyler, fremgangsmåder til fremstilling af denne xylanase og anvendelser deraf
KR950700988A (ko) 미생물, 이들의 제조방법 및 이들의 사용(Micro-organisms, preparation method therefor and uses thereof)
HUP0105180A2 (hu) Eljárás 2-amino-4-klór-1,3,5-triazin-származékok előállítására
BG33589A3 (en) Method for glucoseisomeric enzime obtaining
DK0712831T3 (da) Fremgangsmåde til selektiv dehalogenering
MX9407877A (es) Sustrato de cultivo solido que incluye cebada.
ATE108483T1 (de) Cytochrom-p-450-enzyme.
DK392087D0 (da) Antibiotikum a 42867 og syreadditionssalte deraf
ES8403096A1 (es) Procedimiento para preparar derivados fluorados de alcano diamina, inhibidores de decarboxilasa.
EP0316907A3 (en) Enzyme inhibitor and method of producing the same
FR2657882B1 (fr) Fragments d'adn comprenant le gene de la 1-deshydrogenase, micro-organismes transformes par lesdits fragments et applications desdits fragments et micro-organismes.
KR920018214A (ko) 6-히드록시피콜린산의 미생물학적 제조방법
UA18613A (uk) Живильhе середовище для вирощуваhhя мікобактерій туберкульозу бичачого виду
KR920018213A (ko) 6-히드록시니코틴산의 미생물학적 제조방법
SU751099A1 (ru) Способ культивирования шигелл зонне
MX9706609A (es) Procedimiento para la obtencion de aminas opticamente activas.