ES2138971T3 - Regulador de la apoptosis. - Google Patents

Regulador de la apoptosis.

Info

Publication number
ES2138971T3
ES2138971T3 ES92914177T ES92914177T ES2138971T3 ES 2138971 T3 ES2138971 T3 ES 2138971T3 ES 92914177 T ES92914177 T ES 92914177T ES 92914177 T ES92914177 T ES 92914177T ES 2138971 T3 ES2138971 T3 ES 2138971T3
Authority
ES
Spain
Prior art keywords
apoptosis regulator
link
carboestiril
carbonocarbon
benzoil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92914177T
Other languages
English (en)
Spanish (es)
Inventor
Satoru Nakai
Koutoku Aihara
Hitomi Mori
Michiaki Tominaga
Masakazu Adachi
Hiroyuki Ichikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2138971T3 publication Critical patent/ES2138971T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES92914177T 1991-07-03 1992-07-02 Regulador de la apoptosis. Expired - Lifetime ES2138971T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP16258791 1991-07-03
JP3346992 1992-02-20
JP4571892 1992-03-03
JP10058592 1992-03-25

Publications (1)

Publication Number Publication Date
ES2138971T3 true ES2138971T3 (es) 2000-02-01

Family

ID=27459795

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92914177T Expired - Lifetime ES2138971T3 (es) 1991-07-03 1992-07-02 Regulador de la apoptosis.

Country Status (11)

Country Link
US (5) US5672603A (OSRAM)
EP (1) EP0552373B1 (OSRAM)
KR (1) KR100196368B1 (OSRAM)
AU (1) AU648690B2 (OSRAM)
CA (1) CA2090876A1 (OSRAM)
DE (1) DE69230131T2 (OSRAM)
DK (1) DK0552373T3 (OSRAM)
ES (1) ES2138971T3 (OSRAM)
MX (1) MX9203950A (OSRAM)
TW (1) TW229157B (OSRAM)
WO (1) WO1993000902A1 (OSRAM)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464833A (en) * 1992-08-19 1995-11-07 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulating composition
JP3054743B2 (ja) * 1993-03-02 2000-06-19 大塚製薬株式会社 移植組織の拒絶反応抑制剤
GB9311132D0 (en) 1993-05-28 1993-07-14 Eisai London Res Lab Ltd Control of cell death
EP0674515B1 (en) * 1993-10-21 1999-09-22 Otsuka Pharmaceutical Co., Ltd. The use of carbostyril derivatives for the preparation of a medicament for the inhibition of Interleukin-8
US5504093A (en) * 1994-08-01 1996-04-02 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
MX9603868A (es) * 1995-01-11 1997-03-29 Otsuka Pharma Co Ltd Composicion farmaceutica de derivados de indeno para la regulacion de la apoptosis.
WO1998046229A1 (en) * 1995-06-21 1998-10-22 Otsuka Pharmaceutical Co., Ltd. Il-8 and mcaf production inhibitors
JPH0971532A (ja) * 1995-09-06 1997-03-18 Otsuka Pharmaceut Co Ltd 発癌抑制剤
US5700803A (en) * 1995-12-12 1997-12-23 Otsuka Pharmaceutical Co., Ltd. Method for reducing infarct size in subjects afflicted with ischemic heart disease
WO1998048807A1 (en) * 1997-04-25 1998-11-05 Otsuka Pharmaceutical Co., Ltd. Hyaluronate synthesis inhibitors
US6008209A (en) * 1997-04-28 1999-12-28 Hoffmann-La Roche Inc. Method of using vitamin D3 analogs with bis C-20 side chains
WO1999015179A1 (en) * 1997-09-25 1999-04-01 Regents Of The University Of Minnesota Methods of limiting apoptosis of cells
US6281191B1 (en) 1997-12-29 2001-08-28 Vladimir I. Slesarev Compositions and methods for treating hepatitis-C
FR2774289B1 (fr) * 1998-02-03 2002-05-24 Goemar Lab Sa Medicament pour le traitement des dereglements de l'apoptose
PT1520588E (pt) 1998-07-13 2015-03-31 Univ Texas Usos de anticorpos para amino fosfolípidos para o tratamento do cancro
SI1107795T1 (en) 1998-09-04 2003-06-30 The Regents Of The University Of Michigan Thiomolybdate associated with at least one carbohydrate, and its use for preventing or treating diseases characterized by aberrant vascularization, such as cancer, wet type macular degeneration, rheumatoid arthritis
US6277974B1 (en) 1999-12-14 2001-08-21 Cogent Neuroscience, Inc. Compositions and methods for diagnosing and treating conditions, disorders, or diseases involving cell death
US20030044413A1 (en) * 2000-08-15 2003-03-06 Regents Of The University Of Minnesota Methods of limiting apoptosis of cells
EP1467767A2 (en) * 2001-12-20 2004-10-20 Cogent Neuroscience, Inc. Methods for treating conditions,disorders,or diseases involving cell death
CN101653603B (zh) 2002-07-15 2014-07-09 得克萨斯大学体系董事会 磷脂酰乙醇胺结合肽缀合物及其治疗病毒感染的用途
ATE451108T1 (de) * 2002-11-07 2009-12-15 Univ Minnesota Verfahren zur behandlung von verletzungen des nervensystems in verbindung mit einer blutung
US20060204481A1 (en) * 2003-04-02 2006-09-14 Steer Clifford J Methods of promoting cell viability
CN102018693B (zh) 2004-01-22 2013-03-13 迈阿密大学 局部辅酶q10制剂及其使用方法
EP1871385A1 (en) * 2005-02-10 2008-01-02 Regents Of The University Of Minnesota Methods for treating visual disorders
EP2136831B1 (en) 2007-03-02 2012-09-12 The Cleveland Clinic Foundation Anti-angiogenic peptides
MX2010005104A (es) 2007-11-09 2010-08-04 Peregrine Pharmaceuticals Inc Composiciones de anticuerpo anti-factor de crecimiento endotelial vascular y metodos.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5430184A (en) * 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative
JPS6038384B2 (ja) * 1978-03-24 1985-08-31 大塚製薬株式会社 チオセミカルバゾン誘導体
JPS5777676A (en) * 1980-10-31 1982-05-15 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5793962A (en) * 1980-12-01 1982-06-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS62135423A (ja) * 1985-12-09 1987-06-18 Otsuka Pharmaceut Co Ltd 低酸素症改善剤

Also Published As

Publication number Publication date
DE69230131D1 (de) 1999-11-18
CA2090876A1 (en) 1993-01-04
EP0552373B1 (en) 1999-10-13
AU648690B2 (en) 1994-04-28
WO1993000902A1 (fr) 1993-01-21
US5798358A (en) 1998-08-25
DE69230131T2 (de) 2000-03-02
US5872120A (en) 1999-02-16
EP0552373A4 (en) 1993-09-22
KR930702002A (ko) 1993-09-08
US5925640A (en) 1999-07-20
AU2231792A (en) 1993-02-11
KR100196368B1 (ko) 1999-06-15
US5672603A (en) 1997-09-30
HK1004469A1 (en) 1998-11-27
MX9203950A (es) 1993-05-01
EP0552373A1 (en) 1993-07-28
US5916890A (en) 1999-06-29
DK0552373T3 (da) 1999-12-27
TW229157B (OSRAM) 1994-09-01

Similar Documents

Publication Publication Date Title
ES2138971T3 (es) Regulador de la apoptosis.
ES2142000T3 (es) Derivados del acido metoxiiminoacetico y fungicidas agricolas y horticolas que los contienen como ingrediente activo.
ES2063108T3 (es) Derivados de 3-aril-pirrolidin-2,4-diona.
ES2155134T3 (es) Derivados de imidazolidina y su utilizacion.
ES2094719T3 (es) Derivados de pirazol y herbicidas que los contienen.
ES2097872T3 (es) Fenilpirazolidinonas como agentes broncodilatadores y antiinflamatorios.
ES2141559T3 (es) Derivados de 2-ciano-1-sulfonamidofenil-1,3-diona y su uso como herbicidas.
ES2181928T3 (es) Derivados de diester de acido fosfonico.
ES2030777T3 (es) Un metodo para preparar un derivado de n-indanil-carboxamida, y fungicida agricola/horticola que contiene el derivado como ingrediente activo.
ES2062691T3 (es) Derivados hidrogenados de la rapamicina.
ES2172069T3 (es) Derivado tetrapeptidico.
ES2171416T3 (es) Remedio contra la trombocitopenia.
ES2087107T3 (es) Sulfonilaminocarboniltriazolinonas.
ES2053778T3 (es) Procedimiento para la obtencion de derivados del tiazol.
ES2031865T3 (es) Un procedimiento para preparar derivados de imidas.
ATE2295T1 (de) Desinfektionsmittel auf basis von alkoholen und seine verwendung zur hautdesinfektion.
ES2109993T3 (es) Derivados de 4-desoxi-4-epipodofilotoxina o sus sales farmaceuticamente aceptables.
MX9100607A (es) Compuesto triciclico novedoso o sales del mismo,metodo para producir el mismo y agente antimicrobiano que lo contiene
ES2069281T3 (es) Derivado de fenantreno.
ES2039200T3 (es) Derivados isotiazolonicos.
ES8700232A1 (es) Un procedimiento para producir 1a,25-dihidroxi-26,27-dime- tilcolecalciferol
ES2196000T3 (es) Compuesto de pirroloazepina.
TR23462A (tr) Karbamat ve tiyokarbamat olabilen aromatik bilesiklerle hasaratin bueyuemesini ayarlayin bilesikleri ihtiva eden zararlilari kontrol altina almaya mahsus bilesimler
ES2032752T3 (es) Procedimiento de preparacion de derivados de la 1-bencenosulfonil-2-oxo-5-alcoxi-pirrolidina.
ES2190471T3 (es) Procedimiento para producir derivados de guanidina, intermedios de dichos compuestos y su produccion.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 552373

Country of ref document: ES