ES2117664T3 - Carboximetilmanoglucanos y derivados de los mismos. - Google Patents

Carboximetilmanoglucanos y derivados de los mismos.

Info

Publication number
ES2117664T3
ES2117664T3 ES92905093T ES92905093T ES2117664T3 ES 2117664 T3 ES2117664 T3 ES 2117664T3 ES 92905093 T ES92905093 T ES 92905093T ES 92905093 T ES92905093 T ES 92905093T ES 2117664 T3 ES2117664 T3 ES 2117664T3
Authority
ES
Spain
Prior art keywords
rings
carboxymethylmannoglucan
mannopyranose
salt
opened
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92905093T
Other languages
English (en)
Inventor
Kazuhiro Inoue
Teruomi Ito
Takayuchi Kawaguchi
Katsutoshi Aono
Satoshi Okuno
Toshiro Yano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Drug Delivery System Institute Ltd
Original Assignee
Drug Delivery System Institute Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drug Delivery System Institute Ltd filed Critical Drug Delivery System Institute Ltd
Application granted granted Critical
Publication of ES2117664T3 publication Critical patent/ES2117664T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UN CARBOXIMETILMANOGLUCANO FORMADO POR UNIDADES DE TETRASACARIDOS REPRESENTADO POR LA FORMULA GENERAL (I) Y SUS SALES; Y OTRO CARBOXIMETILMANOGLUCANO EN DONDE SE ABREN PARTE O TODOS LOS ANILLOS DE MANOPIRANOSA DE LAS UNIDADES DE TETRASACARIDOS Y SE ABREN PARTE O TODOS LOS ANILLOS DE GLUCOPIRANOSA, ENTRE LOS ANILLOS DE GLUCOPIRANOSA DE LA CADENA PRINCIPAL, DE LOS QUE NO SE RAMIFICA NINGUNO DE LOS ANILLOS DE MANOPIRANOSA, Y SUS SAL; EN DONDE DE R1 A R12 REPRESENTAN CADA UNO HIDROGENO O CARBOXIMETILO. ESTOS COMPUESTOS ACTUAN COMO PORTADOR FARMACEUTICO UTIL PARA RETRASAR LA DESAPARICION DE UN PRODUCTO FARMACEUTICO EN SANGRE E INCREMENTAR SU DIRECTIVIDAD HACIA TEJIDOS CANCERIGENOS.
ES92905093T 1991-02-21 1992-02-21 Carboximetilmanoglucanos y derivados de los mismos. Expired - Lifetime ES2117664T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2754491 1991-02-21
JP36039591 1991-12-27

Publications (1)

Publication Number Publication Date
ES2117664T3 true ES2117664T3 (es) 1998-08-16

Family

ID=26365480

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92905093T Expired - Lifetime ES2117664T3 (es) 1991-02-21 1992-02-21 Carboximetilmanoglucanos y derivados de los mismos.

Country Status (9)

Country Link
US (3) US5567690A (es)
EP (1) EP0526649B1 (es)
JP (1) JPH0784481B1 (es)
AT (1) ATE166361T1 (es)
CA (1) CA2081025A1 (es)
DE (1) DE69225542T2 (es)
DK (1) DK0526649T3 (es)
ES (1) ES2117664T3 (es)
WO (1) WO1992014759A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465188B1 (en) 1990-06-11 2002-10-15 Gilead Sciences, Inc. Nucleic acid ligand complexes
DK0526649T3 (da) * 1991-02-21 1998-10-07 Drug Delivery System Inst Ltd Carboxymethylmannoglucan og derivater deraf.
JP2610792B2 (ja) * 1993-02-26 1997-05-14 株式会社ディ・ディ・エス研究所 多糖誘導体および薬物担体
US8071737B2 (en) * 1995-05-04 2011-12-06 Glead Sciences, Inc. Nucleic acid ligand complexes
DE19524515A1 (de) * 1995-07-05 1997-01-09 Deutsches Krebsforsch Saccharid-Konjugate
TW409058B (en) 1996-06-06 2000-10-21 Daiichi Seiyaku Co Method for preparation of a drug complex
TW527183B (en) 1996-06-06 2003-04-11 Daiichi Seiyaku Co Drug complex
US6387853B1 (en) 1998-03-27 2002-05-14 Bj Services Company Derivatization of polymers and well treatments using the same
AU3733399A (en) 1998-05-22 1999-12-13 Daiichi Pharmaceutical Co., Ltd. Drug composites
CN1661044A (zh) 1998-10-30 2005-08-31 第一制药株式会社 Dds化合物及其测定方法
CN1133654C (zh) * 1999-08-05 2004-01-07 武汉大学 灵芝α-(1→3)-D-葡聚糖羧甲基化衍生物及其用途和制备方法
CN100457766C (zh) * 2006-09-26 2009-02-04 重庆邮电大学 非天然活性葡聚四糖烷基苷类化合物及其制备方法和应用
CN115746153A (zh) * 2022-11-09 2023-03-07 华东理工大学 环甘露聚糖及其制备方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1053718B (it) * 1973-04-04 1981-10-10 Zambeletti Spa L Metodo per prolungare l azione di farmaci attraverso la formazione di composti mcromolecolari
JPS5366442A (en) * 1976-11-18 1978-06-13 Takuma Sasaki Antitumors
JPS5385000A (en) * 1976-12-31 1978-07-26 Akira Misaki Glucan and its preparation
JPS6045163B2 (ja) * 1977-07-01 1985-10-08 協和醗酵工業株式会社 新規組成物
JPS5461112A (en) * 1977-10-24 1979-05-17 Ono Pharmaceut Co Ltd Oncostatic polysaccharide* its preparation* and oncostatic drugs containing it as an effective component
DE3071815D1 (en) * 1980-08-05 1986-12-11 Debat Lab Use of glycosylglucanes in the treatment of infections of the large intestines
US4454289A (en) * 1981-03-06 1984-06-12 Takara Shuzo Co., Ltd. Polysaccharides having anticarcinogenic activity and method for producing same
JPS59124901A (ja) * 1982-12-29 1984-07-19 Dai Ichi Seiyaku Co Ltd 多糖誘導体
JPS61152634A (ja) * 1984-12-27 1986-07-11 Sugiyama Sangyo Kagaku Kenkyusho 固定化生理活性物質の製造法
IL73972A0 (en) * 1984-12-31 1985-03-31 Yeda Res & Dev Agents based on platinum compounds
US4872885A (en) * 1986-02-27 1989-10-10 Kawasaki Jukogyo Kagushiki Kaisha Dispersant for aqueous slurry of carbonaceous solid and aqueous carbonaceous solid slurry composition incorporating said dispersant therein
DE3624307C1 (de) * 1986-07-18 1987-11-12 Agfa Gevaert Ag Vorrichtung zum Aufnehmen und Absetzen von Spulen
GB8713662D0 (en) * 1987-06-11 1987-07-15 Skandigen Ab Hyaluronic acid derivatives
JPS63310827A (ja) * 1987-06-15 1988-12-19 Sanwa Kagaku Kenkyusho Co Ltd ニコチン酸誘導体を主剤とする徐放性製剤
JPH0659409B2 (ja) * 1987-10-06 1994-08-10 義明 本里 架橋グルコマンナンイオン交換体
IT1224421B (it) * 1987-12-29 1990-10-04 Lamberti Flli Spa Galattomannani modificati e realtivo procedimento di preparazione
JPH01190636A (ja) * 1988-01-22 1989-07-31 Green Cross Corp:The 制癌作用物質複合体
US5026735A (en) * 1988-06-08 1991-06-25 Minnesota Mining And Manufacturing Company Treatment of hazardous materials with aqueous air foam of polyhydroxy polymer
US5124363A (en) * 1988-06-08 1992-06-23 Minnesota Mining And Manufacturing Company Aqueous air foams of polyhydroxy polymer
NZ232619A (en) * 1989-02-22 1992-06-25 Sanwa Kagaku Kenkyusho Co Pharmaceutical formulations comprising 2',5'-dioxo-spiro-(4h-1-benzopyran-4,4'-imidazolidine) derivatives
JP2726520B2 (ja) * 1989-10-20 1998-03-11 名糖産業株式会社 有機磁性複合体
DK0526649T3 (da) * 1991-02-21 1998-10-07 Drug Delivery System Inst Ltd Carboxymethylmannoglucan og derivater deraf.
JPH0539521A (ja) * 1991-08-02 1993-02-19 Nippon Steel Corp 含クロム溶鋼の脱炭精錬法

Also Published As

Publication number Publication date
CA2081025A1 (en) 1992-08-22
DE69225542T2 (de) 1998-09-10
DE69225542D1 (de) 1998-06-25
ATE166361T1 (de) 1998-06-15
DK0526649T3 (da) 1998-10-07
JPH0784481B1 (es) 1995-09-13
US5863908A (en) 1999-01-26
US5567690A (en) 1996-10-22
WO1992014759A1 (en) 1992-09-03
EP0526649A1 (en) 1993-02-10
EP0526649B1 (en) 1998-05-20
US5863907A (en) 1999-01-26
EP0526649A4 (en) 1993-09-08

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