ES2132618T3 - Procedimiento para la preparacion de diesteres asimetricos de acido fosforico y de sus sales. - Google Patents
Procedimiento para la preparacion de diesteres asimetricos de acido fosforico y de sus sales.Info
- Publication number
- ES2132618T3 ES2132618T3 ES95905641T ES95905641T ES2132618T3 ES 2132618 T3 ES2132618 T3 ES 2132618T3 ES 95905641 T ES95905641 T ES 95905641T ES 95905641 T ES95905641 T ES 95905641T ES 2132618 T3 ES2132618 T3 ES 2132618T3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- procedure
- isolated
- phosphoric acid
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 title abstract 2
- 150000005690 diesters Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 239000003960 organic solvent Substances 0.000 abstract 3
- -1 HYDROXYL GROUPS Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 150000003014 phosphoric acid esters Chemical class 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fuel Cell (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
EL OBJETO DE LA PRESENTE INVENCION ES UN PROCEDIMIENTO PARA OBTENER DIESTERES ASIMETRICOS DE ACIDO FOSFORICO. EL PROCEDIMIENTO SE CARACTERIZA PORQUE UN ESTER DE ACIDO FOSFORICO SE CONDENSA CON UN COMPUESTO QUE CONTIENE GRUPOS HIDROXILO EN PRESENCIA DE UN CLORURO DE ACIDO ARIL-SULFONICO Y DE UNA BASE ORGANICA; DESPUES DE LA HIDROLISIS SE PRECIPITA EL RESIDUO DE LA EVAPORACION CON UN DISOLVENTE ORGANICO, LA SAL FORMADA DE ACIDO ARIL-SULFONICO/PIRIDINA SE CRISTALIZA CASI TOTALMENTE, Y SE RECICLA, EL DERIVADO LIPIDICO RESULTANTE SE PRECIPITA COMO SAL POCO SOLUBLE AL AÑADIR UNA SOLUCION QUE CONTENGA IONES ALCALINOTERREOS, Y SE AISLA; LA SAL DIFICILMENTE SOLUBLE SE AISLA POR SUSPENSION EN UN DISOLVENTE ORGANICO NO MISCIBLE CON AGUA Y EN UN ACIDO INORGANICO DILUIDO EN AGUA, Y SE AISLA COMO ACIDO LIBRE EN EL DISOLVENTE ORGANICO, OPCIONALMENTE EL PRODUCTO EN BRUTO SE PUEDE PURIFICAR POR CROMATOGRAFIA PREPARATIVA UTILIZANDO UNA COLUMNA DE FASE INVERSA, Y A CONTINUACION SE PUEDE CONVERTIR EL ACIDO LIBRE EN LA SAL QUE SE DESEE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4402492A DE4402492A1 (de) | 1994-01-28 | 1994-01-28 | Verfahren zur Herstellung von unsymmetrischen Phosphorsäurediestern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2132618T3 true ES2132618T3 (es) | 1999-08-16 |
Family
ID=6508875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95905641T Expired - Lifetime ES2132618T3 (es) | 1994-01-28 | 1995-01-21 | Procedimiento para la preparacion de diesteres asimetricos de acido fosforico y de sus sales. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5734042A (es) |
| EP (1) | EP0741740B1 (es) |
| JP (1) | JP3609411B2 (es) |
| KR (1) | KR100242357B1 (es) |
| AT (1) | ATE178610T1 (es) |
| AU (1) | AU1417195A (es) |
| BR (1) | BR9506654A (es) |
| CA (1) | CA2181474C (es) |
| DE (2) | DE4402492A1 (es) |
| DK (1) | DK0741740T3 (es) |
| ES (1) | ES2132618T3 (es) |
| FI (1) | FI115836B (es) |
| HU (1) | HU222438B1 (es) |
| PL (1) | PL179560B1 (es) |
| SI (1) | SI9520031A (es) |
| TW (1) | TW399059B (es) |
| WO (1) | WO1995020596A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0791056T3 (da) * | 1994-11-12 | 2005-07-04 | Heidelberg Pharma Gmbh | Lipidopspaltende enzymkompleks |
| US7026469B2 (en) | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
| GB0608876D0 (en) | 2006-05-05 | 2006-06-14 | Medivir Ab | Combination therapy |
| DE112020006626A5 (de) | 2020-03-30 | 2022-12-08 | Chiracon Gmbh | Fosalvudin und Fozivudintidoxil zur Anwendung bei der Behandlung der Krankheit Covid-19 und die Verwendung von deren strukturvereinfachten Derivaten |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5289681A (en) * | 1976-01-22 | 1977-07-27 | Yamasa Shoyu Co Ltd | Preparation of aracytidine -5# phosphoric acid ester derivatives |
| JPS552601A (en) * | 1978-06-20 | 1980-01-10 | Yamasa Shoyu Co Ltd | Anti-tumor agent for non-injection use |
| JPS552602A (en) * | 1978-06-20 | 1980-01-10 | Yamasa Shoyu Co Ltd | 1-beta-d-arabinofranosylcytosine-5'-phosphoric acid oleyl ester |
| DD138213A1 (de) * | 1978-08-03 | 1979-10-17 | Hans Brachwitz | Verfahren zur herstellung von 1-0-alkyl(acyl)-3-chlor-3-desoxy-glycero-2-phosphorsaeure-omega-halogenalkylestern |
| DE3263939D1 (en) * | 1981-12-09 | 1985-07-04 | Teijin Ltd | 5-fluoro-2'-deoxyuridine derivatives and a process for the preparation thereof |
| IT1238683B (it) * | 1990-02-09 | 1993-09-01 | Istituto Chemioterapico | Procedimento di preparazione di l-a-glicerilfosforil-d-myoinositolo e suoi sali da fosfatidi grezzi o parzialmente purificati |
| IT1240614B (it) * | 1990-03-30 | 1993-12-17 | Istituto Chemioterapico Italiano Fine Chimicals | Procedimento per la separazione dei principali componenti di una miscela di fosfolipidi grezzi deacilati |
| IT1254991B (it) * | 1992-06-24 | 1995-10-11 | Chemi Spa | Procedimento per la preparazione di glicerofosfolipidi |
| DE4226279A1 (de) * | 1992-08-08 | 1994-02-10 | Boehringer Mannheim Gmbh | Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel |
| DE4321978A1 (de) * | 1993-07-01 | 1995-01-12 | Boehringer Mannheim Gmbh | Liponucleotide von Desoxynucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel |
-
1994
- 1994-01-28 DE DE4402492A patent/DE4402492A1/de not_active Withdrawn
-
1995
- 1995-01-21 AU AU14171/95A patent/AU1417195A/en not_active Abandoned
- 1995-01-21 CA CA002181474A patent/CA2181474C/en not_active Expired - Fee Related
- 1995-01-21 SI SI9520031A patent/SI9520031A/sl not_active IP Right Cessation
- 1995-01-21 US US08/682,571 patent/US5734042A/en not_active Expired - Lifetime
- 1995-01-21 JP JP51987395A patent/JP3609411B2/ja not_active Expired - Fee Related
- 1995-01-21 ES ES95905641T patent/ES2132618T3/es not_active Expired - Lifetime
- 1995-01-21 BR BR9506654A patent/BR9506654A/pt not_active IP Right Cessation
- 1995-01-21 KR KR1019960704058A patent/KR100242357B1/ko not_active IP Right Cessation
- 1995-01-21 EP EP95905641A patent/EP0741740B1/de not_active Expired - Lifetime
- 1995-01-21 WO PCT/EP1995/000219 patent/WO1995020596A1/de active IP Right Grant
- 1995-01-21 AT AT95905641T patent/ATE178610T1/de not_active IP Right Cessation
- 1995-01-21 DE DE59505592T patent/DE59505592D1/de not_active Expired - Lifetime
- 1995-01-21 PL PL95315671A patent/PL179560B1/pl not_active IP Right Cessation
- 1995-01-21 HU HU9602062A patent/HU222438B1/hu not_active IP Right Cessation
- 1995-01-21 DK DK95905641T patent/DK0741740T3/da active
- 1995-01-24 TW TW084100605A patent/TW399059B/zh not_active IP Right Cessation
-
1996
- 1996-07-29 FI FI963005A patent/FI115836B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE4402492A1 (de) | 1995-08-03 |
| TW399059B (en) | 2000-07-21 |
| DE59505592D1 (de) | 1999-05-12 |
| WO1995020596A1 (de) | 1995-08-03 |
| US5734042A (en) | 1998-03-31 |
| JPH09508135A (ja) | 1997-08-19 |
| HUT74709A (en) | 1997-02-28 |
| PL179560B1 (pl) | 2000-09-29 |
| PL315671A1 (en) | 1996-11-25 |
| CA2181474C (en) | 2008-04-29 |
| ATE178610T1 (de) | 1999-04-15 |
| EP0741740B1 (de) | 1999-04-07 |
| AU1417195A (en) | 1995-08-15 |
| FI963005A0 (fi) | 1996-07-29 |
| JP3609411B2 (ja) | 2005-01-12 |
| DK0741740T3 (da) | 1999-10-18 |
| CA2181474A1 (en) | 1995-08-03 |
| FI963005A (fi) | 1996-07-29 |
| SI9520031A (en) | 1997-04-30 |
| EP0741740A1 (de) | 1996-11-13 |
| BR9506654A (pt) | 1997-09-16 |
| KR100242357B1 (ko) | 2000-02-01 |
| HU222438B1 (hu) | 2003-07-28 |
| HU9602062D0 (en) | 1996-09-30 |
| FI115836B (fi) | 2005-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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