ES2118778T3 - Formacion de microparticulas proteinicas por precipitacion en un antidisolvente. - Google Patents

Formacion de microparticulas proteinicas por precipitacion en un antidisolvente.

Info

Publication number
ES2118778T3
ES2118778T3 ES92119498T ES92119498T ES2118778T3 ES 2118778 T3 ES2118778 T3 ES 2118778T3 ES 92119498 T ES92119498 T ES 92119498T ES 92119498 T ES92119498 T ES 92119498T ES 2118778 T3 ES2118778 T3 ES 2118778T3
Authority
ES
Spain
Prior art keywords
solvent
precipitation
formation
protein microparticles
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92119498T
Other languages
English (en)
Other versions
ES2118778T5 (es
Inventor
Pablo G Debenedetti
Gio-Bin Lim
Homme Robert K Prud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25156397&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2118778(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Princeton University filed Critical Princeton University
Publication of ES2118778T3 publication Critical patent/ES2118778T3/es
Application granted granted Critical
Publication of ES2118778T5 publication Critical patent/ES2118778T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/98—Preparation of granular or free-flowing enzyme compositions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/141—Feedstock
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

UN METODO PARA FORMAR MICROPARTICULAS DE MATERIAL QUE CONSISTE EN PONER UN GAS ANTIDISOLVENTE SUPERCRITICO EN CONTACTO CON UNA SOLUCION DE DICHO MATERIAL EN UN DISOLVENTE A UNA RELACION CONTROLADA PARA EXPANDIR LA SOLUCION Y PRECIPITAR EL MATERIAL.
ES92119498T 1991-11-14 1992-11-13 Formacion de microparticulas proteinicas por precipitacion en un antidisolvente. Expired - Lifetime ES2118778T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/792,292 US6063910A (en) 1991-11-14 1991-11-14 Preparation of protein microparticles by supercritical fluid precipitation
US792292 1991-11-14

Publications (2)

Publication Number Publication Date
ES2118778T3 true ES2118778T3 (es) 1998-10-01
ES2118778T5 ES2118778T5 (es) 2005-07-16

Family

ID=25156397

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92119498T Expired - Lifetime ES2118778T5 (es) 1991-11-14 1992-11-13 Formacion de microparticulas proteinicas por precipitacion en un antidisolvente.

Country Status (9)

Country Link
US (1) US6063910A (es)
EP (1) EP0542314B9 (es)
JP (1) JP3342899B2 (es)
AT (1) ATE167870T1 (es)
AU (1) AU668367B2 (es)
CA (1) CA2083027C (es)
DE (1) DE69226064T3 (es)
DK (1) DK0542314T4 (es)
ES (1) ES2118778T5 (es)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
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AU668367B2 (en) 1996-05-02
DE69226064T3 (de) 2005-07-07
EP0542314B2 (en) 2005-01-05
JP3342899B2 (ja) 2002-11-11
DE69226064T2 (de) 1998-10-29
US6063910A (en) 2000-05-16
DK0542314T3 (da) 1999-04-12
CA2083027C (en) 2004-01-20
AU2831092A (en) 1993-05-20
EP0542314A1 (en) 1993-05-19
DE69226064D1 (de) 1998-08-06
EP0542314B1 (en) 1998-07-01
CA2083027A1 (en) 1993-05-15
ES2118778T5 (es) 2005-07-16
ATE167870T1 (de) 1998-07-15
EP0542314B9 (en) 2005-05-04
DK0542314T4 (da) 2005-05-17

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