ES2116572T3 - Parche para la administracion percutanea de sustancias de contenido quimicamente basico, farmaceuticamente eficaces y volatiles, y un metodo para su fabricacion. - Google Patents
Parche para la administracion percutanea de sustancias de contenido quimicamente basico, farmaceuticamente eficaces y volatiles, y un metodo para su fabricacion.Info
- Publication number
- ES2116572T3 ES2116572T3 ES94900072T ES94900072T ES2116572T3 ES 2116572 T3 ES2116572 T3 ES 2116572T3 ES 94900072 T ES94900072 T ES 94900072T ES 94900072 T ES94900072 T ES 94900072T ES 2116572 T3 ES2116572 T3 ES 2116572T3
- Authority
- ES
- Spain
- Prior art keywords
- matrix
- substances
- volatile
- content
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000126 substance Substances 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000011159 matrix material Substances 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 239000003292 glue Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A UN EMPLASTO PARA ADMINISTRACION TRANSDERMAL DE SUSTANCIAS DE CONTENIDO BASICAMENTE QUIMICO, VOLATILES, CON ACTIVIDAD FARMACEUTICA, QUE CONTIENE UN SISTEMA DE MULTIPLES ELEMENTOS, ABARCANDO: (A) UNA MATRIZ, EN LA QUE ESTA DISTRIBUIDA COMO SUSTANCIA ACTIVA LA SUSTANCIA VOLATIL ANTES INDICADA O UNA DE SUS SALES ACEPTABLES FISIOLOGICAMENTE, DONDE LA MATRIZ CONTIENE UN PEGAMENTO DE ADHERENCIA, (B) UN ELEMENTO DE UNA COMPOSICION DE PEGAMENTO DE ADHERENCIA, QUE CONTIENE GRUPOS BASICOS -EN EL CASO DE QUE (A) CONTIENE UNA SAL-, QUE LIBERA LA BASE LIBRE A PARTIR DE SU SAL, (C) UNA CAPA DE REVERSO IMPERMEABLE PARA LAS SUSTANCIAS DE CONTENIDO DIFUNDIBLE DE (A) Y (B) Y (D) UNA SUSTANCIA DE CONTENIDO DIFUNDIBLE DE LA LAMINA DE ADHERENCIA IMPERMEABLE DE (A) Y (B), DONDE LA MATRIZ (A) O AL MENOS UNA PARTE DE (B), RESPECTIVAMENTE, EN EL CASO DE QUE LA MATRIZ O UNA PARTE DEL (B) TENGA CONTACTO CON LA LAMINA (D) DE RETIRADA, CON UNA CAPACIDAD DE ADHERENCIA (TACK) DE TAL MODO, QUE ESSUFICIENTE PARA LA FIJACION DEL EMPLASTO SOBRE LA PIEL. CADA PARTE APLICADA ENTRE LA MATRIZ (A) Y LA LAMINA (D) DE RETIRADA ES SUSTANCIA ACTIVA, CON PREFERENCIA DEPRENIL O UNA DE SUS SALES O AMBAS COSAS DE FORMA PERMEABLE. LA INVENCION SE REFIERE ADEMAS A UN PROCEDIMIENTO PARA LA ELABORACION DE UN EMPLASTO DE ESTE TIPO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP92118036A EP0593807A1 (en) | 1992-10-22 | 1992-10-22 | Patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature and a process for preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2116572T3 true ES2116572T3 (es) | 1998-07-16 |
Family
ID=8210159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94900072T Expired - Lifetime ES2116572T3 (es) | 1992-10-22 | 1993-10-20 | Parche para la administracion percutanea de sustancias de contenido quimicamente basico, farmaceuticamente eficaces y volatiles, y un metodo para su fabricacion. |
Country Status (24)
| Country | Link |
|---|---|
| EP (2) | EP0593807A1 (es) |
| JP (1) | JP3731016B2 (es) |
| KR (1) | KR100261913B1 (es) |
| AT (1) | ATE165001T1 (es) |
| AU (1) | AU674902B2 (es) |
| CA (1) | CA2146645C (es) |
| CZ (1) | CZ290122B6 (es) |
| DE (1) | DE59308413D1 (es) |
| DK (1) | DK0665745T3 (es) |
| ES (1) | ES2116572T3 (es) |
| FI (1) | FI112325B (es) |
| HR (1) | HRP931308A2 (es) |
| HU (1) | HU221594B (es) |
| IL (1) | IL107360A (es) |
| MY (1) | MY109783A (es) |
| NO (1) | NO311404B1 (es) |
| NZ (1) | NZ257829A (es) |
| PH (1) | PH30790A (es) |
| PL (1) | PL173552B1 (es) |
| SI (1) | SI9300559A (es) |
| SK (1) | SK51595A3 (es) |
| WO (1) | WO1994008571A2 (es) |
| YU (1) | YU48350B (es) |
| ZA (1) | ZA937807B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4433191A1 (de) * | 1994-09-17 | 1996-03-21 | Lohmann Therapie Syst Lts | Selbstklebendes Pflaster zur Abgabe von Wirkstoff an die Umgebung eines Trägers |
| US6299901B1 (en) | 1995-01-13 | 2001-10-09 | Somerset Pharmaceuticals, Inc. | Methods and pharmaceutical compositions employing desmethylselegiline |
| US6319954B1 (en) | 1995-01-13 | 2001-11-20 | Somerset Pharmaceuticals, Inc. | S-(+)-desmethylselegiline and its use in the therapeutic methods and pharmaceutical compositions |
| US6033682A (en) | 1995-01-13 | 2000-03-07 | Somerset Pharmaceuticals, Inc. | S(+) desmethylselegiline and its use in therapeutic methods and pharmaceutical compositions |
| US6348208B1 (en) | 1995-01-13 | 2002-02-19 | Somerset Pharmaceuticals, Inc. | Methods and pharmaceutical compositions employing desmethylselegiline |
| US6316022B1 (en) | 1995-06-07 | 2001-11-13 | Noven Pharmaceuticals, Inc. | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures |
| JPH11506744A (ja) | 1995-06-07 | 1999-06-15 | ノウブン ファーマシューティカルズ インク． | 室温で液体である低分子量薬を含む経皮組成物 |
| WO1997006788A1 (en) * | 1995-08-14 | 1997-02-27 | Janssen Pharmaceutica N.V. | Transdermal administration of vorozole |
| DE19533772C1 (de) * | 1995-09-12 | 1998-01-02 | Hexal Ag | Tacrin/Selegilin-Pflaster |
| US7150881B2 (en) | 1997-06-26 | 2006-12-19 | Mylan Technologies, Inc. | Adhesive mixture for transdermal delivery of highly plasticizing drugs |
| DE19733981A1 (de) * | 1997-08-06 | 1999-02-11 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System (TTS) zur Abgabe von Wirkstoff durch die Haut an einen Organismus und Verfahren zur Applikation auf der Haut |
| AU9553398A (en) * | 1997-11-04 | 1999-05-24 | Clear Sport Ltd | Improvements relating to adhesive devices such as strips, tapes, patches and thelike, for application to the human body |
| ES2178405T3 (es) | 1998-03-16 | 2002-12-16 | Somerset Pharmaceuticals Inc | Uso de selegilina o de desmetilselegilina para tratar heridas, quemaduras y lesiones cutaneas. |
| DE19814083C2 (de) | 1998-03-30 | 2002-02-07 | Lohmann Therapie Syst Lts | Verfahren zur Herstellung von transdermalen therapeutischen Systemen unter Verwendung von basischen Alkalimetallsalzen zur Umwandlung von Wirkstoffsalzen in die freien Basen |
| DE19814257A1 (de) * | 1998-03-31 | 1999-10-07 | Asta Medica Ag | Brauseformulierungen |
| DE19826592A1 (de) * | 1998-06-15 | 1999-12-16 | Lohmann Therapie Syst Lts | Verfahren zur Herstellung eines aus einzelnen Schichten bestehenden Laminats |
| DE19950066A1 (de) * | 1999-10-16 | 2001-04-26 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit einem Gehalt an Tulobuterol-hydrochlorid zur Verabreichung des Bronchodilatators Tulobuterol über die Haut |
| EP1441708B1 (en) | 2001-11-05 | 2009-04-08 | Krele Pharmaceuticals LLC | Compositions and methods for increasing compliance with therapies using aldehyde dehydrogenase inhibitors and treating alcoholism |
| US8246978B2 (en) | 2007-07-10 | 2012-08-21 | Agile Therapeutics, Inc. | Dermal delivery device with reduced loss of its volatile components |
| US20100087768A1 (en) | 2008-10-02 | 2010-04-08 | Forlano Paula | Transdermal drug delivery system for liquid active ingredient |
| CN108186611A (zh) | 2010-04-30 | 2018-06-22 | 帝国制药美国公司 | 丙炔基氨基茚满透皮组合物 |
| WO2012129429A2 (en) | 2011-03-24 | 2012-09-27 | Teikoku Pharma Usa, Inc. | Transdermal compositions comprising an active agent layer and an active agent conversion layer |
| US9205061B2 (en) | 2012-11-02 | 2015-12-08 | Teikoku Pharma Usa, Inc. | Propynylaminoindan transdermal compositions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| GB8807504D0 (en) * | 1988-03-29 | 1988-05-05 | Sandoz Ltd | Improvements in/relating to organic compounds |
-
1992
- 1992-10-22 EP EP92118036A patent/EP0593807A1/en not_active Withdrawn
-
1993
- 1993-09-20 PH PH46901A patent/PH30790A/en unknown
- 1993-09-23 MY MYPI93001931A patent/MY109783A/en unknown
- 1993-10-19 HR HR931308A patent/HRP931308A2/hr not_active Application Discontinuation
- 1993-10-20 JP JP50965794A patent/JP3731016B2/ja not_active Expired - Fee Related
- 1993-10-20 DK DK94900072T patent/DK0665745T3/da active
- 1993-10-20 CZ CZ19951022A patent/CZ290122B6/cs not_active IP Right Cessation
- 1993-10-20 NZ NZ257829A patent/NZ257829A/en not_active IP Right Cessation
- 1993-10-20 ES ES94900072T patent/ES2116572T3/es not_active Expired - Lifetime
- 1993-10-20 EP EP94900072A patent/EP0665745B1/de not_active Expired - Lifetime
- 1993-10-20 CA CA002146645A patent/CA2146645C/en not_active Expired - Fee Related
- 1993-10-20 HU HU9501125A patent/HU221594B/hu not_active IP Right Cessation
- 1993-10-20 DE DE59308413T patent/DE59308413D1/de not_active Expired - Lifetime
- 1993-10-20 KR KR1019950701535A patent/KR100261913B1/ko not_active Expired - Fee Related
- 1993-10-20 AT AT94900072T patent/ATE165001T1/de active
- 1993-10-20 AU AU54627/94A patent/AU674902B2/en not_active Ceased
- 1993-10-20 SK SK515-95A patent/SK51595A3/sk unknown
- 1993-10-20 PL PL93308292A patent/PL173552B1/pl not_active IP Right Cessation
- 1993-10-20 WO PCT/EP1993/002899 patent/WO1994008571A2/de not_active Ceased
- 1993-10-21 YU YU67293A patent/YU48350B/sh unknown
- 1993-10-21 ZA ZA937807A patent/ZA937807B/xx unknown
- 1993-10-21 IL IL107360A patent/IL107360A/en not_active IP Right Cessation
- 1993-10-22 SI SI9300559A patent/SI9300559A/sl unknown
-
1995
- 1995-04-20 FI FI951887A patent/FI112325B/fi not_active IP Right Cessation
- 1995-04-21 NO NO19951523A patent/NO311404B1/no not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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