ES2113098T3 - Comprobador de glucosa por fluorescencia y procedimiento. - Google Patents

Comprobador de glucosa por fluorescencia y procedimiento.

Info

Publication number
ES2113098T3
ES2113098T3 ES94913344T ES94913344T ES2113098T3 ES 2113098 T3 ES2113098 T3 ES 2113098T3 ES 94913344 T ES94913344 T ES 94913344T ES 94913344 T ES94913344 T ES 94913344T ES 2113098 T3 ES2113098 T3 ES 2113098T3
Authority
ES
Spain
Prior art keywords
glucose
sample
light
concentration
monitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94913344T
Other languages
English (en)
Inventor
Marigo Stavridi
Warren S Grundfest
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cedars Sinai Medical Center
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Application granted granted Critical
Publication of ES2113098T3 publication Critical patent/ES2113098T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6402—Atomic fluorescence; Laser induced fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Emergency Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

SE PRESENTA UN MONITOR DE GLUCOSA Y UN METODO RELACIONADO QUE DETERMINA LA CONCENTRACION DE GLUCOSA EN UNA MUESTRA MONITORIZANDO LA LUZ FLUORESCENTE PRODUCIDA DIRECTAMENTE POR CUALQUIER GLUCOSA PRESENTE EN LA MUESTRA. EL MONITOR DE GLUCOSA ILUMINA LA MUESTRA CON LUZ DE EXCITACION ULTRAVIOLETA (16) QUE INDUCE A CUALQUIER GLUCOSA PRESENTE EN LA MUESTRA A EMITIR FLUORESCENCIA, SIENDO LA LUZ FLUORESCENTE MONITORIZADA Y PROCESADA PARA DETERMINAR LA CONCENTRACION DE GLUCOSA EN LA MUESTRA. UN SENSOR (18) MONITORIZA LA LUZ DE RETORNO, QUE INCLUYE LA LUZ FLUORESCENTE (20) PRODUCIDA POR CUALQUIERA GLUCOSA EN LA MUESTRA, Y GENERA UNA PRIMERA Y UNA SEGUNDA SEÑAL ELECTRICA INDICATIVA DE LA INTENSIDAD DE LA LUZ EN DOS BANDAS DE LONGITUDES DE ONDA. UNA BANDA DE LONGITUDES DE ONDA INCLUYE UN PICO ESPECTRAL CARACTERISTICO DE LA FLUORESCENCIA DE LA GLUCOSA, Y LA OTRA BANDA DE LONGITUDES DE ONDA ES UNA BANDA DE REFERENCIA QUE TIENE UNAS CARACTERISTICAS ESPECTRALES CONOCIDAS. UN PROCESADOR (22) PROCESA ENTONCES LA PRIMERA Y LA SEGUNDA SEÑAL ELECTRICA PARA DETERMINAR LA CONCENTRACION DE GLUCOSA EN LA MUESTRA. UNA GUIA DE ONDAS DE FIBRA OPTICA SE EMPLEA PARA GUIAR LA LUZ DE EXCITACION DESDE UNA FUENTE DE LUZ LASER HASTA LA MUESTRA Y LA LUZ DE RETORNO DESDE LA MUESTRA HASTA EL SENSOR. LA GUIA DE ONDAS DE FIBRA OPTICA ESTA ALOJADA EN UN CATETER O SONDA QUE ESTA ADAPTADO PARA MONITORIZAR LA CONCENTRACION DE GLUCOSA DE FORMA PERCUTANEA EN LOS TEJIDOS DE LA CAVIDAD ORAL DE LA BOCA DE UNA PERSONA.
ES94913344T 1993-04-06 1994-04-01 Comprobador de glucosa por fluorescencia y procedimiento. Expired - Lifetime ES2113098T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/043,580 US5341805A (en) 1993-04-06 1993-04-06 Glucose fluorescence monitor and method

Publications (1)

Publication Number Publication Date
ES2113098T3 true ES2113098T3 (es) 1998-04-16

Family

ID=21927895

Family Applications (2)

Application Number Title Priority Date Filing Date
ES94913344T Expired - Lifetime ES2113098T3 (es) 1993-04-06 1994-04-01 Comprobador de glucosa por fluorescencia y procedimiento.
ES97100429T Expired - Lifetime ES2202501T3 (es) 1993-04-06 1994-04-01 Monitor de fluorescencia de glucosa y metodo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES97100429T Expired - Lifetime ES2202501T3 (es) 1993-04-06 1994-04-01 Monitor de fluorescencia de glucosa y metodo.

Country Status (11)

Country Link
US (1) US5341805A (es)
EP (2) EP0694165B1 (es)
JP (2) JP3643842B2 (es)
AT (2) ATE243846T1 (es)
DE (2) DE69408976T2 (es)
DK (2) DK0779508T3 (es)
ES (2) ES2113098T3 (es)
GR (1) GR3026579T3 (es)
IL (1) IL109231A (es)
PT (1) PT779508E (es)
WO (1) WO1994023284A1 (es)

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