CA2238518A1 - Glucose monitoring apparatus and method using laser-induced emission spectroscopy - Google Patents
Glucose monitoring apparatus and method using laser-induced emission spectroscopyInfo
- Publication number
- CA2238518A1 CA2238518A1 CA002238518A CA2238518A CA2238518A1 CA 2238518 A1 CA2238518 A1 CA 2238518A1 CA 002238518 A CA002238518 A CA 002238518A CA 2238518 A CA2238518 A CA 2238518A CA 2238518 A1 CA2238518 A1 CA 2238518A1
- Authority
- CA
- Canada
- Prior art keywords
- glucose
- sample
- light
- return light
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract 8
- 239000008103 glucose Substances 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 2
- 238000004993 emission spectroscopy Methods 0.000 title 1
- 238000012544 monitoring process Methods 0.000 title 1
- 230000005284 excitation Effects 0.000 abstract 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 238000001069 Raman spectroscopy Methods 0.000 abstract 1
- 238000002839 fiber optic waveguide Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Optics & Photonics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
A glucose monitor, and related method, determines the concentration of glucose in a sample with water, using a predictive regression model. The glucose monitor illuminates the sample with ultraviolet excitation light that induces the water and any glucose present in the sample to emit return light that includes raman scattered light and glucose emission or fluorescence light.
The return light is monitored and processed using a predictive regression model to determine the concentration of glucose in the sample. The predictive regression model accounts for nonlinearities between the glucose concentration and intensity of return light within different wavelength bands at a predetermined excitation light energgy or the intensity of return light within a predetermined wavelength band at different excitation energy levels. A fiber-optic waveguide is used to guide the excitation light from a laser excitation source to the sample and the return light from the sample to a sensor.
The return light is monitored and processed using a predictive regression model to determine the concentration of glucose in the sample. The predictive regression model accounts for nonlinearities between the glucose concentration and intensity of return light within different wavelength bands at a predetermined excitation light energgy or the intensity of return light within a predetermined wavelength band at different excitation energy levels. A fiber-optic waveguide is used to guide the excitation light from a laser excitation source to the sample and the return light from the sample to a sensor.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/566,313 US6232609B1 (en) | 1995-12-01 | 1995-12-01 | Glucose monitoring apparatus and method using laser-induced emission spectroscopy |
| US08/566,313 | 1995-12-01 | ||
| PCT/US1996/018532 WO1997020495A1 (en) | 1995-12-01 | 1996-11-19 | Glucose monitoring apparatus and method using laser-induced emission spectroscopy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2238518A1 true CA2238518A1 (en) | 1997-06-12 |
| CA2238518C CA2238518C (en) | 2007-05-22 |
Family
ID=38156715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002238518A Expired - Fee Related CA2238518C (en) | 1995-12-01 | 1996-11-19 | Glucose monitoring apparatus and method using laser-induced emission spectroscopy |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2238518C (en) |
-
1996
- 1996-11-19 CA CA002238518A patent/CA2238518C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2238518C (en) | 2007-05-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT863718E (en) | Apparatus and method for monitoring glucose using laser-induced emission spectroscopy | |
| IL109231A0 (en) | Method and apparatus for determining the concentration of glucose in a sample | |
| US5174297A (en) | Diagnostic apparatus for living tissues and medical treatment apparatus with diagnostic apparatus | |
| EP0822395A3 (en) | Method and apparatus for Raman correlation spectroscopy | |
| WO2001040771A3 (en) | Apparatus and method for analyzing fluids | |
| MY131304A (en) | Simultaneous monitoring of multiple water treatment performance indicators | |
| EP1562038A3 (en) | Method for laser induced fluorescence attenuation spectroscopy | |
| IL141344A (en) | On-site analyzer | |
| FI951673A (en) | Method and apparatus for glucose analysis in a biological matrix | |
| CA2575118C (en) | Multi-wavelength fluorometric system for on-line monitoring of bioprocesses | |
| NO20010910D0 (en) | Method and apparatus for measuring film thickness | |
| DE69219767D1 (en) | METHOD AND DEVICE FOR MONITORING THE GLUCOSE CONCENTRATION | |
| EP1496351A3 (en) | Solid-state fluorometer and methods of use therefor | |
| CA2322198A1 (en) | Method and system for detecting fecal and ingesta contamination on the carcasses of meat animals | |
| PT1034422E (en) | APPARATUS AND PROCESS FOR THE MEDICATION OF OPTICAL PROPERTIES BY INTERMEDIATE FOR RETROACTIVE CONTROL | |
| CA2081347A1 (en) | Method and apparatus for examining an object | |
| JPS641949A (en) | Regeneration of electrophoretic gel | |
| DE50012845D1 (en) | Sample carrier for the IR spectroscopy of sample liquids | |
| NZ509205A (en) | Method for determining the quality of fleshy fruit such as berries measuring chlorophyll fluorescence | |
| CA2238518A1 (en) | Glucose monitoring apparatus and method using laser-induced emission spectroscopy | |
| JPS649345A (en) | Method of analyzing porphyrins | |
| CA2220913A1 (en) | Determination of anionic species concentration by near infrared spectroscopy | |
| WO2005067110A3 (en) | A semiconductor laser-pumped, small-cavity fiber laser and an optical spectroscopy apparatus and method for measurement of analyte concentrations or other such species in a specimen employing such a laser | |
| GB2310717A (en) | Quantitative detection of chemical species | |
| SE9404274D0 (en) | Device at a gel electrophoresis apparatus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |