ES2111567T3 - Inhibidores de la trombina basados en la secuencia de aminoacidos de la hirudina. - Google Patents

Inhibidores de la trombina basados en la secuencia de aminoacidos de la hirudina.

Info

Publication number
ES2111567T3
ES2111567T3 ES91910717T ES91910717T ES2111567T3 ES 2111567 T3 ES2111567 T3 ES 2111567T3 ES 91910717 T ES91910717 T ES 91910717T ES 91910717 T ES91910717 T ES 91910717T ES 2111567 T3 ES2111567 T3 ES 2111567T3
Authority
ES
Spain
Prior art keywords
amino acid
hirudine
acid sequence
thrombin inhibitors
inhibitors based
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91910717T
Other languages
English (en)
Inventor
John Dimaio
Feng Ni
Yasuo Konishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
National Research Council of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Application granted granted Critical
Publication of ES2111567T3 publication Critical patent/ES2111567T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE PRESENTA UN INHIBIDOR DE LA TROMBINA QUE COMPRENDE UNA PRIMERA PARTE GRANULAR HIDROFOBICA QUE INTERACTUA CON LA ZONA CATALITICA DE LA TROMBINA SENSIBLE A LA PROTEOLISIS Y UNA SEGUNDA PARTE QUE AL MENOS MANTIENE EL CARACTER HIDROFOBICO Y ACIDICO DE LOS AMINOACIDOS 55 A 60 DE LA HIRUDINA NATIVA EN LA REGION NO CATALITICA DEL TERMINAL C DE LA M-ACETIL-HIRUDINA 45-65. ENTRE LA PRIMERA Y LA SEGUNDA PARTE SE ENCUENTRA UNA MOLECULA DIVALENTE ENLAZADORA QUE TIENE UNA LONGITUD DE CADENA DE AL MENOS 10 ATOMOS DE CARBONO. PREFERIBLEMENTE, LA PARTE HIDROFOBICA COMPRENDE AL MENOS UN ACIDO AMINO DE CONFIGURACION D. LOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES TROMBOTICAS.
ES91910717T 1990-06-15 1991-06-14 Inhibidores de la trombina basados en la secuencia de aminoacidos de la hirudina. Expired - Lifetime ES2111567T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53832290A 1990-06-15 1990-06-15

Publications (1)

Publication Number Publication Date
ES2111567T3 true ES2111567T3 (es) 1998-03-16

Family

ID=24146434

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91910717T Expired - Lifetime ES2111567T3 (es) 1990-06-15 1991-06-14 Inhibidores de la trombina basados en la secuencia de aminoacidos de la hirudina.

Country Status (14)

Country Link
EP (1) EP0536177B1 (es)
JP (1) JP2669510B2 (es)
KR (1) KR100212162B1 (es)
AT (1) ATE160356T1 (es)
AU (1) AU654820B2 (es)
CA (1) CA2085465C (es)
DE (1) DE69128247T2 (es)
DK (1) DK0536177T3 (es)
ES (1) ES2111567T3 (es)
FI (1) FI925696A (es)
GR (1) GR3026150T3 (es)
HU (1) HUT63440A (es)
NO (1) NO309040B1 (es)
WO (1) WO1991019734A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
AU648096B2 (en) * 1990-07-24 1994-04-14 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
IT1265023B1 (it) * 1993-04-16 1996-10-28 Dev Biotechnological Processes Inibitori della trombina, loro preparazione ed uso per applicazioni terapeutiche, profilattiche e diagnostiche
KR100330465B1 (ko) * 1993-06-11 2002-11-23 메렐 파마슈티칼스 인크. 삼관능성항트롬빈및항혈소판펩티드
ATE198603T1 (de) * 1993-10-25 2001-01-15 Ca Nat Research Council Bivalente thrombininhibitore
GB9506212D0 (en) * 1995-03-27 1995-05-17 Iaf Biochem Int Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component
SI1278549T1 (sl) 2000-05-02 2009-04-30 Theravance Inc Sestavek, ki vsebuje ciklodekstrin in glikopeptidni antibiotik

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
JPS606647A (ja) * 1983-06-17 1985-01-14 Microbial Chem Res Found アルフアメニン及びその関連化合物と合成法
US5196404B1 (en) 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin

Also Published As

Publication number Publication date
ATE160356T1 (de) 1997-12-15
GR3026150T3 (en) 1998-05-29
HU9203968D0 (en) 1993-03-29
EP0536177B1 (en) 1997-11-19
CA2085465C (en) 2001-07-24
FI925696A0 (fi) 1992-12-15
EP0536177A1 (en) 1993-04-14
AU654820B2 (en) 1994-11-24
DE69128247D1 (de) 1998-01-02
JPH06500073A (ja) 1994-01-06
AU8085591A (en) 1992-01-07
JP2669510B2 (ja) 1997-10-29
WO1991019734A3 (en) 1992-02-20
KR100212162B1 (ko) 1999-08-02
NO924834L (no) 1992-12-15
NO309040B1 (no) 2000-12-04
WO1991019734A2 (en) 1991-12-26
DK0536177T3 (da) 1998-07-27
CA2085465A1 (en) 1991-12-16
NO924834D0 (no) 1992-12-14
DE69128247T2 (de) 1998-03-19
HUT63440A (en) 1993-08-30
FI925696A (fi) 1992-12-15

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