DE69128247T2 - Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz - Google Patents

Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz

Info

Publication number
DE69128247T2
DE69128247T2 DE69128247T DE69128247T DE69128247T2 DE 69128247 T2 DE69128247 T2 DE 69128247T2 DE 69128247 T DE69128247 T DE 69128247T DE 69128247 T DE69128247 T DE 69128247T DE 69128247 T2 DE69128247 T2 DE 69128247T2
Authority
DE
Germany
Prior art keywords
hirudin
sequence
thrombin
thrombin inhibitors
bulky hydrophobic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69128247T
Other languages
English (en)
Other versions
DE69128247D1 (de
Inventor
John Dimaio
Feng Ni
Yasuo Konishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
National Research Council of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Publication of DE69128247D1 publication Critical patent/DE69128247D1/de
Application granted granted Critical
Publication of DE69128247T2 publication Critical patent/DE69128247T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69128247T 1990-06-15 1991-06-14 Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz Expired - Fee Related DE69128247T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53832290A 1990-06-15 1990-06-15
PCT/CA1991/000213 WO1991019734A2 (en) 1990-06-15 1991-06-14 Thrombin inhibitors based on the amino acid sequence of hirudin

Publications (2)

Publication Number Publication Date
DE69128247D1 DE69128247D1 (de) 1998-01-02
DE69128247T2 true DE69128247T2 (de) 1998-03-19

Family

ID=24146434

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69128247T Expired - Fee Related DE69128247T2 (de) 1990-06-15 1991-06-14 Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz

Country Status (14)

Country Link
EP (1) EP0536177B1 (de)
JP (1) JP2669510B2 (de)
KR (1) KR100212162B1 (de)
AT (1) ATE160356T1 (de)
AU (1) AU654820B2 (de)
CA (1) CA2085465C (de)
DE (1) DE69128247T2 (de)
DK (1) DK0536177T3 (de)
ES (1) ES2111567T3 (de)
FI (1) FI925696A (de)
GR (1) GR3026150T3 (de)
HU (1) HUT63440A (de)
NO (1) NO309040B1 (de)
WO (1) WO1991019734A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
EP0540574B1 (de) * 1990-07-24 1996-09-11 Merrell Pharmaceuticals Inc. Antigerinnungspeptide
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
IT1265023B1 (it) * 1993-04-16 1996-10-28 Dev Biotechnological Processes Inibitori della trombina, loro preparazione ed uso per applicazioni terapeutiche, profilattiche e diagnostiche
EP0702696B1 (de) * 1993-06-11 2003-07-30 Merrell Pharmaceuticals Inc. Trifunktionelle antithrombin-und antiplättchenpeptide
ES2153433T3 (es) * 1993-10-25 2001-03-01 Ca Nat Research Council Inhibidores de trombina bivalentes.
GB9506212D0 (en) * 1995-03-27 1995-05-17 Iaf Biochem Int Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component
BR0110530A (pt) 2000-05-02 2003-04-08 Theravance Inc Composições farmacêuticas contendo um antibiótico glicopeptìdico e uma ciclodextrina

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
JPS606647A (ja) * 1983-06-17 1985-01-14 Microbial Chem Res Found アルフアメニン及びその関連化合物と合成法
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin

Also Published As

Publication number Publication date
JP2669510B2 (ja) 1997-10-29
WO1991019734A2 (en) 1991-12-26
FI925696A0 (fi) 1992-12-15
FI925696A (fi) 1992-12-15
DE69128247D1 (de) 1998-01-02
NO924834D0 (no) 1992-12-14
WO1991019734A3 (en) 1992-02-20
KR100212162B1 (ko) 1999-08-02
NO924834L (no) 1992-12-15
EP0536177B1 (de) 1997-11-19
ATE160356T1 (de) 1997-12-15
AU654820B2 (en) 1994-11-24
HUT63440A (en) 1993-08-30
EP0536177A1 (de) 1993-04-14
CA2085465A1 (en) 1991-12-16
NO309040B1 (no) 2000-12-04
GR3026150T3 (en) 1998-05-29
AU8085591A (en) 1992-01-07
DK0536177T3 (da) 1998-07-27
JPH06500073A (ja) 1994-01-06
CA2085465C (en) 2001-07-24
ES2111567T3 (es) 1998-03-16
HU9203968D0 (en) 1993-03-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee