BR0110530A - Composições farmacêuticas contendo um antibiótico glicopeptìdico e uma ciclodextrina - Google Patents

Composições farmacêuticas contendo um antibiótico glicopeptìdico e uma ciclodextrina

Info

Publication number
BR0110530A
BR0110530A BR0110530-2A BR0110530A BR0110530A BR 0110530 A BR0110530 A BR 0110530A BR 0110530 A BR0110530 A BR 0110530A BR 0110530 A BR0110530 A BR 0110530A
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
cyclodextrin
compositions containing
glycopeptide antibiotic
disclosed
Prior art date
Application number
BR0110530-2A
Other languages
English (en)
Inventor
Kevin Judice
Yongqi Mu
Jeng-Pyng Shaw
Michael W Conner
John Pace
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of BR0110530A publication Critical patent/BR0110530A/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"COMPOSIçõES FARMACêUTICAS CONTENDO UM ANTIBIóTICO GLICOPEPTìDICO E UMA CICLODEXTRINA". São reveladas composições farmacêuticas contendo uma ciclodextrina e uma quantidade terapeuticamente eficaz de um antibiótico glicopeptídico ou um sal desse. Também são revelados métodos de tratamento de doenças bacterianas em um mamífero pela administração de tais composições farmacêuticas.
BR0110530-2A 2000-05-02 2001-05-01 Composições farmacêuticas contendo um antibiótico glicopeptìdico e uma ciclodextrina BR0110530A (pt)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US20117800P 2000-05-02 2000-05-02
US21341000P 2000-06-22 2000-06-22
US21342800P 2000-06-22 2000-06-22
US21341700P 2000-06-22 2000-06-22
US21314600P 2000-06-22 2000-06-22
US21341500P 2000-06-22 2000-06-22
US22672700P 2000-08-18 2000-08-18
PCT/US2001/014000 WO2001082971A2 (en) 2000-05-02 2001-05-01 Cyclodextrin containing glycopeptide antibiotic compositions

Publications (1)

Publication Number Publication Date
BR0110530A true BR0110530A (pt) 2003-04-08

Family

ID=27569291

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0110530-2A BR0110530A (pt) 2000-05-02 2001-05-01 Composições farmacêuticas contendo um antibiótico glicopeptìdico e uma ciclodextrina

Country Status (12)

Country Link
US (5) US6858584B2 (pt)
EP (1) EP1278549B1 (pt)
JP (2) JP4870314B2 (pt)
CN (1) CN1223378C (pt)
AT (1) ATE416791T1 (pt)
AU (1) AU2001259306A1 (pt)
BR (1) BR0110530A (pt)
CA (2) CA2408008C (pt)
DE (1) DE60136926D1 (pt)
ES (1) ES2316445T3 (pt)
SI (1) SI1278549T1 (pt)
WO (1) WO2001082971A2 (pt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1278549T1 (sl) 2000-05-02 2009-04-30 Theravance Inc Sestavek, ki vsebuje ciklodekstrin in glikopeptidni antibiotik
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
TWI312785B (en) * 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
US7499410B2 (en) 2001-12-26 2009-03-03 Cisco Technology, Inc. Fibre channel switch that enables end devices in different fabrics to communicate with one another while retaining their unique fibre channel domain—IDs
US7599360B2 (en) * 2001-12-26 2009-10-06 Cisco Technology, Inc. Methods and apparatus for encapsulating a frame for transmission in a storage area network
GB0206930D0 (en) * 2002-03-23 2002-05-08 Univ Durham Method and apparatus for the formation of hydrophobic surfaces
US7406034B1 (en) 2002-04-01 2008-07-29 Cisco Technology, Inc. Methods and apparatus for fibre channel frame delivery
US7616637B1 (en) 2002-04-01 2009-11-10 Cisco Technology, Inc. Label switching in fibre channel networks
US7206288B2 (en) * 2002-06-12 2007-04-17 Cisco Technology, Inc. Methods and apparatus for characterizing a route in fibre channel fabric
US7433326B2 (en) 2002-11-27 2008-10-07 Cisco Technology, Inc. Methods and devices for exchanging peer parameters between network devices
EP1641480A1 (en) * 2003-05-27 2006-04-05 Theravance, Inc. Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
TWI342312B (en) * 2003-10-22 2011-05-21 Theravance Inc Hydrochloride salts of a glycopeptide phosphonate derivative
CA2579096C (en) * 2004-09-08 2012-11-13 Chelsea Therapeutics, Inc. Quinazoline derivatives as metabolically inert antifolate compounds
US7593324B2 (en) * 2004-10-25 2009-09-22 Cisco Technology, Inc. Graceful port shutdown protocol for fibre channel interfaces
US7916628B2 (en) 2004-11-01 2011-03-29 Cisco Technology, Inc. Trunking for fabric ports in fibre channel switches and attached devices
BRPI0516657A (pt) 2004-11-29 2008-09-16 Univ Nagoya Nat Univ Corp derivados de monÈmero antibiótico de glicopeptìdeo
US7649844B2 (en) * 2004-12-29 2010-01-19 Cisco Technology, Inc. In-order fibre channel packet delivery
US20100204178A1 (en) 2006-10-02 2010-08-12 James Cloyd Novel parenteral carbamazepine formulation
DE102005056194A1 (de) * 2005-11-21 2007-07-12 Combinature Biopharm Ag Neue Lipopeptid Zusammensetzungen
US7795207B2 (en) 2005-11-21 2010-09-14 Harald Labischinski Lipopeptide compositions
EP1954292B1 (en) * 2005-11-28 2014-05-07 Verrow Pharmaceuticals, Inc. Compositions useful for reducing nephrotoxicity and methods of use thereof
US7658913B2 (en) * 2005-11-28 2010-02-09 Verrow Pharmaceuticals, Inc. Compositions useful for reducing nephrotoxicity and methods of use thereof
MX2010010998A (es) * 2008-04-07 2011-01-25 Chelsea Therapeutics Inc Composiciones de antifolato.
EP2324041A4 (en) 2008-08-13 2012-06-13 Targanta Therapeutics Corp PHOSPHONIZED RIFAMYCINS AND ITS APPLICATION FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS
EP3006038B1 (en) 2008-08-30 2024-07-03 The Medicines Company Single doses of oritavancin for treating or preventing a bacterial infection
CA2760159C (en) 2009-04-28 2021-01-12 Thomas Parr, Jr. Methods of treating bacterial infections using oritavancin
WO2011005832A1 (en) * 2009-07-08 2011-01-13 Chelsea Therapeutics, Inc. Stable crystalline polymorphs of the dipotassium salt of (s) -2- {4- [2- (2, 4-diamin0-quinaz0lin-6-yl) -ethyl] -benzoylamino} -4-methylenξ-penta nedioic acid
EP2496237A2 (en) * 2009-11-06 2012-09-12 Chelsea Therapeutics, Inc. Enzyme inhibiting compounds
US20110237609A1 (en) * 2010-03-29 2011-09-29 Chelsea Therapeutics, Inc. Antifolate compositions
US8658652B2 (en) 2010-12-07 2014-02-25 Chelsea Therapeutics, Inc. Antifolate combinations
CA2904387C (en) 2013-03-15 2021-12-07 Melinta Therapeutics, Inc. Methods of treating infections in overweight and obese patients using antibiotics
PL3038616T3 (pl) 2013-08-26 2023-08-07 Melinta Therapeutics, Inc. Metody leczenia bakteriemii i zapalenia kości i szpiku z zastosowaniem orytawancyny
US9697843B2 (en) * 2014-04-30 2017-07-04 Qualcomm Incorporated High band excitation signal generation
AU2017221435A1 (en) * 2016-02-18 2018-09-06 Melinta Therapeutics, Inc. Oritavancin formulations
US20200171124A1 (en) 2016-04-15 2020-06-04 Lupin Limited Topical compositions for ophthalmic and otic use
CN107325159A (zh) * 2016-04-29 2017-11-07 中国科学院上海药物研究所 一类万古霉素衍生物、其制备方法、药物组合物和用途
BR112018072948A2 (pt) 2016-05-09 2019-02-19 Xellia Pharmaceuticals Aps composição farmacêutica líquida, e, método para a estabilização de um antibiótico glicopeptídeo em uma solução farmacêutica líquida.
US11072668B2 (en) 2017-01-03 2021-07-27 The University Of North Carolina At Chapel Hill Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto
AU2018247167B2 (en) 2017-03-28 2024-05-16 The University Of North Carolina At Chapel Hill Nitric oxide-releasing polyaminoglycosides as biodegradable antibacterial scaffolds and methods pertaining thereto
IL271777B2 (en) 2017-07-07 2024-09-01 Epicentrx Inc Preparations for intravenous administration of medical substances
CN107987131B (zh) * 2017-11-16 2021-03-09 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的化合物、其制备方法和应用
CN111836648A (zh) 2018-03-06 2020-10-27 北卡罗来纳大学查佩尔希尔分校 作为可生物降解抗菌支架的一氧化氮释放型环糊精以及其相关方法
WO2019238557A1 (en) 2018-06-13 2019-12-19 Dybly Ag Preparation of condensed triazepine derivatives and their use as bet inhibitors
US11421044B2 (en) 2018-12-28 2022-08-23 The University Of North Carolina At Chapel Hill Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto
US11433115B2 (en) 2020-10-30 2022-09-06 Somerset Therapeutics, Llc Glycopeptide antibiotics liquid formulations and methods and uses thereof
EP4014965A1 (en) 2020-12-16 2022-06-22 EVER Valinject GmbH Aqueous solution
EP4014969A1 (en) 2020-12-16 2022-06-22 EVER Valinject GmbH Aqueous solution
WO2024079223A1 (en) 2022-10-12 2024-04-18 Xellia Pharmaceuticals Aps Liquid dalbavancin composition

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US87494A (en) * 1869-03-02 William h
US63916A (en) * 1867-04-16 Improvement in cotton peess
US229775A (en) * 1880-07-06 Eobeet h
US77280A (en) * 1868-04-28 John l
US207797A (en) * 1878-09-10 Improvement in check-rein hooks
US73371A (en) * 1868-01-14 Robert moxley
US4371673A (en) 1980-07-21 1983-02-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble forms of retinoids
DE3372705D1 (en) 1982-04-30 1987-09-03 Takeda Chemical Industries Ltd Pharmaceutical composition and its use
DE3346123A1 (de) 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4698327A (en) 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4639433A (en) * 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
US4643987A (en) 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
EP0335545B2 (en) 1988-03-29 1998-09-23 University Of Florida Pharmaceutical formulations for parenteral use
US5411947A (en) 1989-06-28 1995-05-02 Vestar, Inc. Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
US5196404B1 (en) 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
CA2031803C (en) 1989-12-13 2001-05-29 Ramakrishnan Nagarajan Improvements in or relating to glycopeptide deriveratives
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9012663D0 (en) * 1990-06-07 1990-08-01 Erba Carlo Spa Galenic formulations containing cyclodextrins
KR100212162B1 (ko) 1990-06-15 1999-08-02 루시에 라포인테-쇼우, 카르타 커티 케이 히루딘의 아미노산 시퀸스를 기재로 한 트롬빈 억제제
US5750509A (en) 1991-07-29 1998-05-12 Gruppo Lepetit S.P.A. Amide derivatives of antibiotic A 40926
EP0610295A1 (en) * 1991-10-16 1994-08-17 Schering Corporation Lipophilic oligosaccharide antibiotic salt compositions
IT1251751B (it) * 1991-10-31 1995-05-23 Sclavo Ricerca S R L Metodo per la coltura di microrganismi dei generi helicobacter, campylobacter e arcobacter, utilizzando terreni di coltura contenenti ciclodestrine o metil-cellulosa o loro miscele
US5602112A (en) 1992-06-19 1997-02-11 Supergen, Inc. Pharmaceutical formulation
US5472954A (en) 1992-07-14 1995-12-05 Cyclops H.F. Cyclodextrin complexation
US5324718A (en) 1992-07-14 1994-06-28 Thorsteinn Loftsson Cyclodextrin/drug complexation
AU672862B2 (en) * 1992-12-02 1996-10-17 Insite Vision Incorporated Cyclodextrin and polymer based drug delivery system
CA2134753A1 (en) 1993-03-08 1994-09-15 Peter K. Chiang Cyclodextrin-peptide compositions
CA2156719A1 (en) 1993-03-12 1994-09-15 Ramesh Prakash Recombinant epstein-barr virus protein and its use in vaccine
AU7935494A (en) 1993-10-25 1995-05-22 National Research Council Of Canada Bivalent thrombin inhibitors
US5840684A (en) 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
TW457248B (en) 1994-01-28 2001-10-01 Lilly Co Eli Glycopeptide antibiotic derivatives
SE510830C2 (sv) * 1995-02-16 1999-06-28 Pure Pulse Technologies Inc Sätt att med god hållbarhet förpacka färskt kött i en förpackning av plast
US5919756A (en) 1996-06-28 1999-07-06 Eli Lilly And Company Amides
ATE252369T1 (de) 1996-08-09 2003-11-15 Alcon Mfg Ltd Konservierungssysteme fur cyclodextrine enthaltende arzneimittel
US5776912A (en) * 1996-12-20 1998-07-07 Schering Corporation Lipophilic oligosaccharide antibiotic compositions
US5916873A (en) 1997-04-17 1999-06-29 Eli Lilly And Company Teicoplanin derivatives
US5874418A (en) 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
US6046177A (en) 1997-05-05 2000-04-04 Cydex, Inc. Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
DK0889056T3 (da) * 1997-07-01 2006-07-17 Pfizer Prod Inc Process for making a cyclodextrin
GB2344713B (en) * 1998-02-10 2003-05-07 Furuno Electric Co Display system
SI1140993T1 (en) * 1998-12-23 2003-12-31 Theravance, Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
JP2003512017A (ja) 1998-12-23 2003-04-02 アベンティス、パストゥール、リミテッド クラミジア抗原および対応するｄｎａ断片ならびにその使用
DE19911097A1 (de) 1999-03-12 2000-09-14 Basf Ag Verfahren zur Herstellung von festen cyclodextrinhaltigen Dosierungsformen
US6518243B1 (en) 1999-04-02 2003-02-11 Trustees Of Princeton University Desleucyl glycopeptide antibiotics and methods of making same
WO2001083520A2 (en) * 2000-05-02 2001-11-08 Theravance,Inc Polyacid glycopeptide derivatives
SI1278549T1 (sl) 2000-05-02 2009-04-30 Theravance Inc Sestavek, ki vsebuje ciklodekstrin in glikopeptidni antibiotik
PL218223B1 (pl) * 2000-06-21 2014-10-31 Cubist Pharmaceuticals Kompozycja farmaceutyczna do doustnego dostarczania cefalosporyny
US6872804B2 (en) * 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
AU2001259302A1 (en) 2000-06-22 2002-01-02 Yongqi Mu Glycopeptide disulfide and thioester derivatives
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
WO2001098329A1 (en) * 2000-06-22 2001-12-27 Theravance, Inc. Polyhydroxy glycopeptide derivatives
AU2001259303A1 (en) * 2000-06-22 2002-01-02 Advanced Medicine, Inc. Glycopeptide carboxy-saccharide derivatives
US6969706B1 (en) * 2004-05-12 2005-11-29 Allergan, Inc. Preserved pharmaceutical compositions comprising cyclodextrins
US9216185B2 (en) * 2008-07-11 2015-12-22 Fundacion Para La Investigacion Biomedica Del Hospital Gregorio Maranon Use of cilastatin to reduce nephrotatoxicity of various compounds

Also Published As

Publication number Publication date
ATE416791T1 (de) 2008-12-15
US6858584B2 (en) 2005-02-22
EP1278549A2 (en) 2003-01-29
CA2726789A1 (en) 2001-11-08
AU2001259306A1 (en) 2001-11-12
CN1223378C (zh) 2005-10-19
US7067483B2 (en) 2006-06-27
US20020077280A1 (en) 2002-06-20
SI1278549T1 (sl) 2009-04-30
JP2008231109A (ja) 2008-10-02
EP1278549B1 (en) 2008-12-10
DE60136926D1 (de) 2009-01-22
CA2408008A1 (en) 2001-11-08
WO2001082971A3 (en) 2002-05-23
WO2001082971A2 (en) 2001-11-08
US8158580B2 (en) 2012-04-17
CA2408008C (en) 2011-01-18
JP4870314B2 (ja) 2012-02-08
US20050032676A1 (en) 2005-02-10
US7026288B2 (en) 2006-04-11
US20050026820A1 (en) 2005-02-03
JP2003531869A (ja) 2003-10-28
CN1441680A (zh) 2003-09-10
US20100081609A1 (en) 2010-04-01
US20060194717A1 (en) 2006-08-31
US7544364B2 (en) 2009-06-09
ES2316445T3 (es) 2009-04-16

Similar Documents

Publication Publication Date Title
BR0110530A (pt) Composições farmacêuticas contendo um antibiótico glicopeptìdico e uma ciclodextrina
DK1169060T3 (da) Natriumkanalblokkerpræparater og anvendelse deraf
SG153833A1 (en) Methods of treatment of endobronchial infections
CY1107467T1 (el) Χρηση οξεογονων υδρογονοτροφων στελεχων για την προληψη ή την αγωγη πεπτικων διαταραχων
PT1311285E (pt) Composicao farmaceutica liquida contendo um derivado de eritropoietina
DE60030741D1 (de) Chinazoline verbindungen als heilmittel
BR0000003A (pt) Azalidas e métodos de preparação das mesmas
BR0210122A (pt) Composto ou um sal farmaceuticamente aceitável do mesmo, método para o tratamento ou prevenção de uma doença, uso do composto ou de seu sal, e, método para preparar o mesmo
AR034343A1 (es) Combinaciones farmaceuticas
ATE388153T1 (de) Quervernetzte glycopeptid-cephalosporin- antibiotika
AP2001002142A0 (en) 13-membered azalides and their use as antibiotic agents.
SV2002000235A (es) Composiciones farmaceuticas que comprenden valdecoxib
ATE450540T1 (de) Quervernetzte glycopeptid-cephalosporin- antibiotika
ATE314376T1 (de) Kreuzverquerte glycopeptid-cephalosporin- antibiotika
HUP0004282A2 (hu) 2-Halogén-6-0-szubsztituált ketolidszármazékok
ATE556088T1 (de) Konjugat beinhaltend cephalosporin und glykopeptidantibiotikum
BR0002577A (pt) Suspensões orais de trovafloxacina
BRPI0411176A (pt) combinação farmacêutica consistindo de modafinil e outra droga
ATE376557T1 (de) Antimikrobielle sulfonamide-derivate von lipopeptidantibiotika
ATE350064T1 (de) Pharmazeutische zusammensetzungen von rapamycines
DK1181300T3 (da) 6-O-carbamatketolidderivater
SE0004827D0 (sv) Therapeutic compounds
AR030660A1 (es) Composicion farmaceutica para la prevencion o el tratamiento de una enfermedad asociada con un exceso de la produccion de il-12
WO2002057281A3 (en) Aminoglycosides as antibiotics
ATE320820T1 (de) Pharmazeutische zusammensetzungen von antibiotika und fruktan-gemische

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]

Free format text: DE ACORDO COM O ART.34 "II" DA LPI (LEI 9279, DE 14/05/96), O EXAME FICA SUSPENSO PARA QUE O REQUERENTE APRESENTE DOCUMENTOS NECESSARIOS A REGULARIZACAO DO PROCESSO E EXAME DO PEDIDO.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.

B15K Others concerning applications: alteration of classification

Ipc: B82Y 5/00 (2011.01), A61K 9/00 (2006.01), A61K 9/0