CN1441680A - 含有糖肽抗生素和环糊精的药物组合物 - Google Patents
含有糖肽抗生素和环糊精的药物组合物 Download PDFInfo
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- CN1441680A CN1441680A CN01810474A CN01810474A CN1441680A CN 1441680 A CN1441680 A CN 1441680A CN 01810474 A CN01810474 A CN 01810474A CN 01810474 A CN01810474 A CN 01810474A CN 1441680 A CN1441680 A CN 1441680A
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- replacement
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- alkyl
- alkynyl
- alkenyl
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- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- UORVGPXVDQYIDP-UHFFFAOYSA-N trihydridoboron Substances B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- JHIKFOISFAQTJQ-YZANBJIASA-N vancomycin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O1)C(=O)[C@@H]2NC(=O)[C@@H]2NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC)[C@H](O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3O JHIKFOISFAQTJQ-YZANBJIASA-N 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
化合物A | 羟丙基-β-环糊精 | 5%葡萄糖水溶液(无菌) | |
2A | 200mg | 1g | 适量至100mL |
2B | 200mg | 5g | 适量至100mL |
2C | 200mg | 25g | 适量至100mL |
2D | 200mg | 30g | 适量至100mL |
化合物(制剂) | 血清浓度(μl/ml) | 回收的%(为未改变的母体) | ||
尿 | 肝脏 | 肾脏 | ||
化合物A(25%CD) | 0.86(0.19) | 90.91(8.39) | 1.90(0.32) | 0.62(0.12) |
化合物A(5%CD) | 1.66(0.33) | 40.51(18.57) | 4.89(0.81) | 2.08(0.43) |
化合物A(1%CD) | 17.1(12.1) | 17.45(6.92) | 8.47(0.46) | 5.68(2.49) |
化合物A(D5W) | 59.8(27.1) | 12.61(4.60) | 14.19(3.41) | 17.82(4.94) |
化合物 | 制剂 | BUN(mg/dL) | 肌酐(mg/bL) |
载体 | 25%(w/v)CD | 14±1 | 0.26±0.06 |
化合物A | 25%(w/v)CD | 13±2 | 0.26±0.02 |
载体 | 5%(w/v)CD | 10±1 | 0.21±0.01 |
化合物A | 5%(w/v)CD | 18±5 | 0.31±0.07 |
载体 | 1%(w/v)CD | 13±2 | 0.24±0.01 |
化合物A | 1%(w/v)CD | 26±5 | 0.34±0.08 |
载体 | D5W | 12±2 | 0.28±0.02 |
化合物A | D5W | 67±2 | 0.72±0.08 |
Claims (19)
Applications Claiming Priority (14)
Application Number | Priority Date | Filing Date | Title |
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US20117800P | 2000-05-02 | 2000-05-02 | |
US60/201,178 | 2000-05-02 | ||
US21341700P | 2000-06-22 | 2000-06-22 | |
US21341000P | 2000-06-22 | 2000-06-22 | |
US21314600P | 2000-06-22 | 2000-06-22 | |
US21341500P | 2000-06-22 | 2000-06-22 | |
US21342800P | 2000-06-22 | 2000-06-22 | |
US60/213,415 | 2000-06-22 | ||
US60/213,146 | 2000-06-22 | ||
US60/213,410 | 2000-06-22 | ||
US60/213,428 | 2000-06-22 | ||
US60/213,417 | 2000-06-22 | ||
US22672700P | 2000-08-18 | 2000-08-18 | |
US60/226,727 | 2000-08-18 |
Publications (2)
Publication Number | Publication Date |
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CN1441680A true CN1441680A (zh) | 2003-09-10 |
CN1223378C CN1223378C (zh) | 2005-10-19 |
Family
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CNB018104746A Expired - Lifetime CN1223378C (zh) | 2000-05-02 | 2001-05-01 | 含有糖肽抗生素和环糊精的药物组合物 |
Country Status (12)
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US (5) | US6858584B2 (zh) |
EP (1) | EP1278549B1 (zh) |
JP (2) | JP4870314B2 (zh) |
CN (1) | CN1223378C (zh) |
AT (1) | ATE416791T1 (zh) |
AU (1) | AU2001259306A1 (zh) |
BR (1) | BR0110530A (zh) |
CA (2) | CA2408008C (zh) |
DE (1) | DE60136926D1 (zh) |
ES (1) | ES2316445T3 (zh) |
SI (1) | SI1278549T1 (zh) |
WO (1) | WO2001082971A2 (zh) |
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-
2001
- 2001-05-01 SI SI200130903T patent/SI1278549T1/sl unknown
- 2001-05-01 AU AU2001259306A patent/AU2001259306A1/en not_active Abandoned
- 2001-05-01 JP JP2001579844A patent/JP4870314B2/ja not_active Expired - Lifetime
- 2001-05-01 BR BR0110530-2A patent/BR0110530A/pt not_active Application Discontinuation
- 2001-05-01 AT AT01932810T patent/ATE416791T1/de not_active IP Right Cessation
- 2001-05-01 US US09/846,893 patent/US6858584B2/en not_active Expired - Lifetime
- 2001-05-01 WO PCT/US2001/014000 patent/WO2001082971A2/en active Application Filing
- 2001-05-01 CA CA2408008A patent/CA2408008C/en not_active Expired - Lifetime
- 2001-05-01 CA CA2726789A patent/CA2726789A1/en not_active Abandoned
- 2001-05-01 EP EP01932810A patent/EP1278549B1/en not_active Expired - Lifetime
- 2001-05-01 CN CNB018104746A patent/CN1223378C/zh not_active Expired - Lifetime
- 2001-05-01 ES ES01932810T patent/ES2316445T3/es not_active Expired - Lifetime
- 2001-05-01 DE DE60136926T patent/DE60136926D1/de not_active Expired - Lifetime
-
2004
- 2004-08-31 US US10/930,585 patent/US7026288B2/en not_active Expired - Lifetime
- 2004-08-31 US US10/931,122 patent/US7067483B2/en not_active Expired - Lifetime
-
2006
- 2006-04-25 US US11/410,597 patent/US7544364B2/en not_active Expired - Lifetime
-
2008
- 2008-04-03 JP JP2008097622A patent/JP2008231109A/ja active Pending
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2009
- 2009-04-29 US US12/431,940 patent/US8158580B2/en not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8277779B2 (en) | 2005-11-28 | 2012-10-02 | Rowe Vernon D | Compositions useful for reducing nephrotoxicity and methods of use thereof |
CN109069580A (zh) * | 2016-05-09 | 2018-12-21 | 埃克斯利亚制药有限公司 | 稳定化的糖肽抗生素配制品 |
CN107987131A (zh) * | 2017-11-16 | 2018-05-04 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的化合物、其制备方法和应用 |
CN107987131B (zh) * | 2017-11-16 | 2021-03-09 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的化合物、其制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
ATE416791T1 (de) | 2008-12-15 |
US6858584B2 (en) | 2005-02-22 |
EP1278549A2 (en) | 2003-01-29 |
CA2726789A1 (en) | 2001-11-08 |
AU2001259306A1 (en) | 2001-11-12 |
CN1223378C (zh) | 2005-10-19 |
US7067483B2 (en) | 2006-06-27 |
BR0110530A (pt) | 2003-04-08 |
US20020077280A1 (en) | 2002-06-20 |
SI1278549T1 (sl) | 2009-04-30 |
JP2008231109A (ja) | 2008-10-02 |
EP1278549B1 (en) | 2008-12-10 |
DE60136926D1 (de) | 2009-01-22 |
CA2408008A1 (en) | 2001-11-08 |
WO2001082971A3 (en) | 2002-05-23 |
WO2001082971A2 (en) | 2001-11-08 |
US8158580B2 (en) | 2012-04-17 |
CA2408008C (en) | 2011-01-18 |
JP4870314B2 (ja) | 2012-02-08 |
US20050032676A1 (en) | 2005-02-10 |
US7026288B2 (en) | 2006-04-11 |
US20050026820A1 (en) | 2005-02-03 |
JP2003531869A (ja) | 2003-10-28 |
US20100081609A1 (en) | 2010-04-01 |
US20060194717A1 (en) | 2006-08-31 |
US7544364B2 (en) | 2009-06-09 |
ES2316445T3 (es) | 2009-04-16 |
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