FI925696A - Pao hirudinets aminosyrasekvens baserade trombininhibitorer - Google Patents

Pao hirudinets aminosyrasekvens baserade trombininhibitorer Download PDF

Info

Publication number
FI925696A
FI925696A FI925696A FI925696A FI925696A FI 925696 A FI925696 A FI 925696A FI 925696 A FI925696 A FI 925696A FI 925696 A FI925696 A FI 925696A FI 925696 A FI925696 A FI 925696A
Authority
FI
Finland
Prior art keywords
thrombin inhibitor
hirudinets
aminosyrase
baserade
pao
Prior art date
Application number
FI925696A
Other languages
English (en)
Other versions
FI925696A0 (fi
Inventor
John Dimaio
Feng Ni
Yasuo Konishi
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Publication of FI925696A publication Critical patent/FI925696A/fi
Publication of FI925696A0 publication Critical patent/FI925696A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI925696A 1990-06-15 1992-12-15 Pao hirudinets aminosyrasekvens baserade trombininhibitorer FI925696A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53832290A 1990-06-15 1990-06-15
PCT/CA1991/000213 WO1991019734A2 (en) 1990-06-15 1991-06-14 Thrombin inhibitors based on the amino acid sequence of hirudin

Publications (2)

Publication Number Publication Date
FI925696A true FI925696A (fi) 1992-12-15
FI925696A0 FI925696A0 (fi) 1992-12-15

Family

ID=24146434

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925696A FI925696A0 (fi) 1990-06-15 1992-12-15 Pao hirudinets aminosyrasekvens baserade trombininhibitorer

Country Status (14)

Country Link
EP (1) EP0536177B1 (fi)
JP (1) JP2669510B2 (fi)
KR (1) KR100212162B1 (fi)
AT (1) ATE160356T1 (fi)
AU (1) AU654820B2 (fi)
CA (1) CA2085465C (fi)
DE (1) DE69128247T2 (fi)
DK (1) DK0536177T3 (fi)
ES (1) ES2111567T3 (fi)
FI (1) FI925696A0 (fi)
GR (1) GR3026150T3 (fi)
HU (1) HUT63440A (fi)
NO (1) NO309040B1 (fi)
WO (1) WO1991019734A2 (fi)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
KR100195424B1 (ko) * 1990-07-24 1999-06-15 슈테펜엘.네스비트 항응고성 펩티드
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
IT1265023B1 (it) * 1993-04-16 1996-10-28 Dev Biotechnological Processes Inibitori della trombina, loro preparazione ed uso per applicazioni terapeutiche, profilattiche e diagnostiche
DK0702696T3 (da) * 1993-06-11 2003-11-17 Merrell Pharma Inc Trifunktionelle antithrombin- og antiblodpladepeptider
US6127337A (en) * 1993-10-25 2000-10-03 National Research Council Of Canada Bivalent thrombin inhibitors
GB9506212D0 (en) * 1995-03-27 1995-05-17 Iaf Biochem Int Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component
ATE416791T1 (de) 2000-05-02 2008-12-15 Theravance Inc Zusammensetzung die eine zyklodextrin und ein glykopeptid-antibiotikum enthält

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
JPS606647A (ja) * 1983-06-17 1985-01-14 Microbial Chem Res Found アルフアメニン及びその関連化合物と合成法
US5196404B1 (en) 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin

Also Published As

Publication number Publication date
GR3026150T3 (en) 1998-05-29
NO309040B1 (no) 2000-12-04
AU8085591A (en) 1992-01-07
ES2111567T3 (es) 1998-03-16
JP2669510B2 (ja) 1997-10-29
CA2085465C (en) 2001-07-24
KR100212162B1 (ko) 1999-08-02
CA2085465A1 (en) 1991-12-16
NO924834L (no) 1992-12-15
WO1991019734A3 (en) 1992-02-20
DE69128247D1 (de) 1998-01-02
FI925696A0 (fi) 1992-12-15
ATE160356T1 (de) 1997-12-15
JPH06500073A (ja) 1994-01-06
NO924834D0 (no) 1992-12-14
EP0536177B1 (en) 1997-11-19
HUT63440A (en) 1993-08-30
AU654820B2 (en) 1994-11-24
WO1991019734A2 (en) 1991-12-26
DK0536177T3 (da) 1998-07-27
EP0536177A1 (en) 1993-04-14
DE69128247T2 (de) 1998-03-19
HU9203968D0 (en) 1993-03-29

Similar Documents

Publication Publication Date Title
ATE208401T1 (de) Thrombin inhibitore mit einer hirudin-ähnlichen sequenz
IS1805B (is) Aðferð til að framleiða nýjar peptíðafleiður sem eru þrombíntálmar
DE3864020D1 (de) Anordnung zur beseitigung von aktiven mitteln, oertlich verwendet gegen feste tumoren.
FI925696A0 (fi) Pao hirudinets aminosyrasekvens baserade trombininhibitorer
PT81990B (pt) Processo para a preparacao de derivados peptidicos inibidores da renina e das proteases acidas
ES2080549T3 (es) Medicamentos a base de derivados de polihidroximetileno, procedimiento para su preparacion y empleo.
DK0439442T3 (da) Faktor X-LACI-hybridprotein
SE8901552D0 (sv) Acid addition salts of amidated or glycine, their preparation and use
ES2057572T3 (es) Agentes de reconocimiento.
ES2058771T3 (es) Preparado combinado con efecto antitrombotico.
DE3467340D1 (en) Process for purification of 1,2-unsaturated carboxylic acids and/or esters thereof
PT878195E (pt) Utilizacao de um composto 2-aroil-3-arilbenzo(b)tiofeno para a reducao de fibrinogenio
SE9101586D0 (sv) Modified thioredoxin and its use
IT1261959B (it) Composizione farmaceutica atta a migliorare la biodisponibilita' dell'acido eicosapentaenoico e decosaesaenoico
LV12370A (lv) Lidzeklis reimatoida artrita un radniecigo artritu arstesanai