DK0536177T3 - Thrombininhibitorer baseret på aminosyresekvensenaf hirudin - Google Patents

Thrombininhibitorer baseret på aminosyresekvensenaf hirudin

Info

Publication number
DK0536177T3
DK0536177T3 DK91910717T DK91910717T DK0536177T3 DK 0536177 T3 DK0536177 T3 DK 0536177T3 DK 91910717 T DK91910717 T DK 91910717T DK 91910717 T DK91910717 T DK 91910717T DK 0536177 T3 DK0536177 T3 DK 0536177T3
Authority
DK
Denmark
Prior art keywords
amino acid
hirudin
acid sequence
thrombin inhibitors
inhibitors based
Prior art date
Application number
DK91910717T
Other languages
English (en)
Inventor
John Dimaio
Feng Ni
Yasuo Konishi
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Application granted granted Critical
Publication of DK0536177T3 publication Critical patent/DK0536177T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK91910717T 1990-06-15 1991-06-14 Thrombininhibitorer baseret på aminosyresekvensenaf hirudin DK0536177T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53832290A 1990-06-15 1990-06-15
PCT/CA1991/000213 WO1991019734A2 (en) 1990-06-15 1991-06-14 Thrombin inhibitors based on the amino acid sequence of hirudin

Publications (1)

Publication Number Publication Date
DK0536177T3 true DK0536177T3 (da) 1998-07-27

Family

ID=24146434

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91910717T DK0536177T3 (da) 1990-06-15 1991-06-14 Thrombininhibitorer baseret på aminosyresekvensenaf hirudin

Country Status (14)

Country Link
EP (1) EP0536177B1 (da)
JP (1) JP2669510B2 (da)
KR (1) KR100212162B1 (da)
AT (1) ATE160356T1 (da)
AU (1) AU654820B2 (da)
CA (1) CA2085465C (da)
DE (1) DE69128247T2 (da)
DK (1) DK0536177T3 (da)
ES (1) ES2111567T3 (da)
FI (1) FI925696A (da)
GR (1) GR3026150T3 (da)
HU (1) HUT63440A (da)
NO (1) NO309040B1 (da)
WO (1) WO1991019734A2 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
EP0540574B1 (en) * 1990-07-24 1996-09-11 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
IT1265023B1 (it) * 1993-04-16 1996-10-28 Dev Biotechnological Processes Inibitori della trombina, loro preparazione ed uso per applicazioni terapeutiche, profilattiche e diagnostiche
EP0702696B1 (en) * 1993-06-11 2003-07-30 Merrell Pharmaceuticals Inc. Trifunctional antithrombin and antiplatelet peptides
ES2153433T3 (es) * 1993-10-25 2001-03-01 Ca Nat Research Council Inhibidores de trombina bivalentes.
GB9506212D0 (en) * 1995-03-27 1995-05-17 Iaf Biochem Int Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component
BR0110530A (pt) 2000-05-02 2003-04-08 Theravance Inc Composições farmacêuticas contendo um antibiótico glicopeptìdico e uma ciclodextrina

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
JPS606647A (ja) * 1983-06-17 1985-01-14 Microbial Chem Res Found アルフアメニン及びその関連化合物と合成法
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin

Also Published As

Publication number Publication date
JP2669510B2 (ja) 1997-10-29
WO1991019734A2 (en) 1991-12-26
FI925696A0 (fi) 1992-12-15
FI925696A (fi) 1992-12-15
DE69128247D1 (de) 1998-01-02
NO924834D0 (no) 1992-12-14
WO1991019734A3 (en) 1992-02-20
KR100212162B1 (ko) 1999-08-02
NO924834L (no) 1992-12-15
EP0536177B1 (en) 1997-11-19
ATE160356T1 (de) 1997-12-15
AU654820B2 (en) 1994-11-24
HUT63440A (en) 1993-08-30
EP0536177A1 (en) 1993-04-14
CA2085465A1 (en) 1991-12-16
NO309040B1 (no) 2000-12-04
GR3026150T3 (en) 1998-05-29
AU8085591A (en) 1992-01-07
JPH06500073A (ja) 1994-01-06
CA2085465C (en) 2001-07-24
ES2111567T3 (es) 1998-03-16
HU9203968D0 (en) 1993-03-29
DE69128247T2 (de) 1998-03-19

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