ATE160356T1 - Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz - Google Patents

Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz

Info

Publication number
ATE160356T1
ATE160356T1 AT91910717T AT91910717T ATE160356T1 AT E160356 T1 ATE160356 T1 AT E160356T1 AT 91910717 T AT91910717 T AT 91910717T AT 91910717 T AT91910717 T AT 91910717T AT E160356 T1 ATE160356 T1 AT E160356T1
Authority
AT
Austria
Prior art keywords
hirudin
sequence
thrombin
thrombin inhibitors
bulky hydrophobic
Prior art date
Application number
AT91910717T
Other languages
English (en)
Inventor
John Dimaio
Feng Ni
Yasuo Konishi
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Application granted granted Critical
Publication of ATE160356T1 publication Critical patent/ATE160356T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT91910717T 1990-06-15 1991-06-14 Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz ATE160356T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53832290A 1990-06-15 1990-06-15

Publications (1)

Publication Number Publication Date
ATE160356T1 true ATE160356T1 (de) 1997-12-15

Family

ID=24146434

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91910717T ATE160356T1 (de) 1990-06-15 1991-06-14 Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz

Country Status (14)

Country Link
EP (1) EP0536177B1 (de)
JP (1) JP2669510B2 (de)
KR (1) KR100212162B1 (de)
AT (1) ATE160356T1 (de)
AU (1) AU654820B2 (de)
CA (1) CA2085465C (de)
DE (1) DE69128247T2 (de)
DK (1) DK0536177T3 (de)
ES (1) ES2111567T3 (de)
FI (1) FI925696A (de)
GR (1) GR3026150T3 (de)
HU (1) HUT63440A (de)
NO (1) NO309040B1 (de)
WO (1) WO1991019734A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
AU648096B2 (en) * 1990-07-24 1994-04-14 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
IT1265023B1 (it) * 1993-04-16 1996-10-28 Dev Biotechnological Processes Inibitori della trombina, loro preparazione ed uso per applicazioni terapeutiche, profilattiche e diagnostiche
KR100330465B1 (ko) * 1993-06-11 2002-11-23 메렐 파마슈티칼스 인크. 삼관능성항트롬빈및항혈소판펩티드
ATE198603T1 (de) * 1993-10-25 2001-01-15 Ca Nat Research Council Bivalente thrombininhibitore
GB9506212D0 (en) * 1995-03-27 1995-05-17 Iaf Biochem Int Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component
SI1278549T1 (sl) 2000-05-02 2009-04-30 Theravance Inc Sestavek, ki vsebuje ciklodekstrin in glikopeptidni antibiotik

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
JPS606647A (ja) * 1983-06-17 1985-01-14 Microbial Chem Res Found アルフアメニン及びその関連化合物と合成法
US5196404B1 (en) 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin

Also Published As

Publication number Publication date
GR3026150T3 (en) 1998-05-29
HU9203968D0 (en) 1993-03-29
EP0536177B1 (de) 1997-11-19
CA2085465C (en) 2001-07-24
FI925696A0 (fi) 1992-12-15
EP0536177A1 (de) 1993-04-14
AU654820B2 (en) 1994-11-24
DE69128247D1 (de) 1998-01-02
JPH06500073A (ja) 1994-01-06
AU8085591A (en) 1992-01-07
JP2669510B2 (ja) 1997-10-29
WO1991019734A3 (en) 1992-02-20
KR100212162B1 (ko) 1999-08-02
NO924834L (no) 1992-12-15
NO309040B1 (no) 2000-12-04
WO1991019734A2 (en) 1991-12-26
DK0536177T3 (da) 1998-07-27
CA2085465A1 (en) 1991-12-16
NO924834D0 (no) 1992-12-14
DE69128247T2 (de) 1998-03-19
HUT63440A (en) 1993-08-30
FI925696A (fi) 1992-12-15
ES2111567T3 (es) 1998-03-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee