NO924834D0 - Trombin-inhibitorer basert paa aminosyresekvensen til hirudin - Google Patents

Trombin-inhibitorer basert paa aminosyresekvensen til hirudin

Info

Publication number
NO924834D0
NO924834D0 NO924834A NO924834A NO924834D0 NO 924834 D0 NO924834 D0 NO 924834D0 NO 924834 A NO924834 A NO 924834A NO 924834 A NO924834 A NO 924834A NO 924834 D0 NO924834 D0 NO 924834D0
Authority
NO
Norway
Prior art keywords
amino acid
hirudin
acid sequence
thrombin inhibitors
inhibitors based
Prior art date
Application number
NO924834A
Other languages
English (en)
Other versions
NO309040B1 (no
NO924834L (no
Inventor
John Dimaio
Feng Ni
Yasuo Konishi
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Publication of NO924834D0 publication Critical patent/NO924834D0/no
Publication of NO924834L publication Critical patent/NO924834L/no
Publication of NO309040B1 publication Critical patent/NO309040B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
NO924834A 1990-06-15 1992-12-14 AnalogifremgangsmÕte for fremstilling av terapeutisk aktive peptid-derivater NO309040B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53832290A 1990-06-15 1990-06-15
PCT/CA1991/000213 WO1991019734A2 (en) 1990-06-15 1991-06-14 Thrombin inhibitors based on the amino acid sequence of hirudin

Publications (3)

Publication Number Publication Date
NO924834D0 true NO924834D0 (no) 1992-12-14
NO924834L NO924834L (no) 1992-12-15
NO309040B1 NO309040B1 (no) 2000-12-04

Family

ID=24146434

Family Applications (1)

Application Number Title Priority Date Filing Date
NO924834A NO309040B1 (no) 1990-06-15 1992-12-14 AnalogifremgangsmÕte for fremstilling av terapeutisk aktive peptid-derivater

Country Status (14)

Country Link
EP (1) EP0536177B1 (no)
JP (1) JP2669510B2 (no)
KR (1) KR100212162B1 (no)
AT (1) ATE160356T1 (no)
AU (1) AU654820B2 (no)
CA (1) CA2085465C (no)
DE (1) DE69128247T2 (no)
DK (1) DK0536177T3 (no)
ES (1) ES2111567T3 (no)
FI (1) FI925696A (no)
GR (1) GR3026150T3 (no)
HU (1) HUT63440A (no)
NO (1) NO309040B1 (no)
WO (1) WO1991019734A2 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
CA2086243C (en) * 1990-07-24 2001-10-02 John L. Krstenansky Anticoagulant peptides
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
IT1265023B1 (it) * 1993-04-16 1996-10-28 Dev Biotechnological Processes Inibitori della trombina, loro preparazione ed uso per applicazioni terapeutiche, profilattiche e diagnostiche
DE69432983T2 (de) * 1993-06-11 2004-04-29 Merrell Pharmaceuticals Inc., Cincinnati Trifunktionelle antithrombin-und antiplättchenpeptide
ATE198603T1 (de) * 1993-10-25 2001-01-15 Ca Nat Research Council Bivalente thrombininhibitore
GB9506212D0 (en) * 1995-03-27 1995-05-17 Iaf Biochem Int Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component
SI1278549T1 (sl) 2000-05-02 2009-04-30 Theravance Inc Sestavek, ki vsebuje ciklodekstrin in glikopeptidni antibiotik

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
JPS606647A (ja) * 1983-06-17 1985-01-14 Microbial Chem Res Found アルフアメニン及びその関連化合物と合成法
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin

Also Published As

Publication number Publication date
DE69128247T2 (de) 1998-03-19
EP0536177B1 (en) 1997-11-19
FI925696A0 (fi) 1992-12-15
JPH06500073A (ja) 1994-01-06
ATE160356T1 (de) 1997-12-15
NO309040B1 (no) 2000-12-04
AU654820B2 (en) 1994-11-24
DK0536177T3 (da) 1998-07-27
CA2085465C (en) 2001-07-24
WO1991019734A2 (en) 1991-12-26
WO1991019734A3 (en) 1992-02-20
DE69128247D1 (de) 1998-01-02
FI925696A (fi) 1992-12-15
NO924834L (no) 1992-12-15
EP0536177A1 (en) 1993-04-14
KR100212162B1 (ko) 1999-08-02
JP2669510B2 (ja) 1997-10-29
AU8085591A (en) 1992-01-07
HUT63440A (en) 1993-08-30
ES2111567T3 (es) 1998-03-16
GR3026150T3 (en) 1998-05-29
HU9203968D0 (en) 1993-03-29
CA2085465A1 (en) 1991-12-16

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