GR3026150T3 - Thrombin inhibitors based on the amino acid sequence of hirudin - Google Patents
Thrombin inhibitors based on the amino acid sequence of hirudinInfo
- Publication number
- GR3026150T3 GR3026150T3 GR980400324T GR980400324T GR3026150T3 GR 3026150 T3 GR3026150 T3 GR 3026150T3 GR 980400324 T GR980400324 T GR 980400324T GR 980400324 T GR980400324 T GR 980400324T GR 3026150 T3 GR3026150 T3 GR 3026150T3
- Authority
- GR
- Greece
- Prior art keywords
- amino acid
- hirudin
- acid sequence
- thrombin inhibitors
- inhibitors based
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53832290A | 1990-06-15 | 1990-06-15 | |
PCT/CA1991/000213 WO1991019734A2 (en) | 1990-06-15 | 1991-06-14 | Thrombin inhibitors based on the amino acid sequence of hirudin |
Publications (1)
Publication Number | Publication Date |
---|---|
GR3026150T3 true GR3026150T3 (en) | 1998-05-29 |
Family
ID=24146434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR980400324T GR3026150T3 (en) | 1990-06-15 | 1998-02-16 | Thrombin inhibitors based on the amino acid sequence of hirudin |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0536177B1 (el) |
JP (1) | JP2669510B2 (el) |
KR (1) | KR100212162B1 (el) |
AT (1) | ATE160356T1 (el) |
AU (1) | AU654820B2 (el) |
CA (1) | CA2085465C (el) |
DE (1) | DE69128247T2 (el) |
DK (1) | DK0536177T3 (el) |
ES (1) | ES2111567T3 (el) |
FI (1) | FI925696A0 (el) |
GR (1) | GR3026150T3 (el) |
HU (1) | HUT63440A (el) |
NO (1) | NO309040B1 (el) |
WO (1) | WO1991019734A2 (el) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
US5240913A (en) * | 1989-08-18 | 1993-08-31 | Biogen, Inc. | Inhibitors of thrombin |
US6060451A (en) * | 1990-06-15 | 2000-05-09 | The National Research Council Of Canada | Thrombin inhibitors based on the amino acid sequence of hirudin |
EP0540574B1 (en) * | 1990-07-24 | 1996-09-11 | Merrell Pharmaceuticals Inc. | Anticoagulant peptides |
US5242810A (en) * | 1990-12-07 | 1993-09-07 | Biogen, Inc. | Bifunctional inhibitors of thrombin and platelet activation |
US5656600A (en) * | 1993-03-25 | 1997-08-12 | Corvas International, Inc. | α-ketoamide derivatives as inhibitors of thrombosis |
IT1265023B1 (it) * | 1993-04-16 | 1996-10-28 | Dev Biotechnological Processes | Inibitori della trombina, loro preparazione ed uso per applicazioni terapeutiche, profilattiche e diagnostiche |
JP3532920B2 (ja) * | 1993-06-11 | 2004-05-31 | メレル ファーマスーティカルズ インコーポレイテッド | 三機能性の抗血栓及び抗血小板ペプチド類 |
EP0725797B1 (en) * | 1993-10-25 | 2001-01-10 | National Research Council Of Canada | Bivalent thrombin inhibitors |
GB9506212D0 (en) * | 1995-03-27 | 1995-05-17 | Iaf Biochem Int | Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component |
AU2001259306A1 (en) | 2000-05-02 | 2001-11-12 | Advanced Medicine, Inc. | Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8305985D0 (en) * | 1983-03-04 | 1983-04-07 | Szelke M | Enzyme inhibition |
JPS606647A (ja) * | 1983-06-17 | 1985-01-14 | Microbial Chem Res Found | アルフアメニン及びその関連化合物と合成法 |
US5196404B1 (en) | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
-
1991
- 1991-06-14 AT AT91910717T patent/ATE160356T1/de not_active IP Right Cessation
- 1991-06-14 AU AU80855/91A patent/AU654820B2/en not_active Ceased
- 1991-06-14 HU HU923968A patent/HUT63440A/hu unknown
- 1991-06-14 ES ES91910717T patent/ES2111567T3/es not_active Expired - Lifetime
- 1991-06-14 DE DE69128247T patent/DE69128247T2/de not_active Expired - Fee Related
- 1991-06-14 KR KR1019920703243A patent/KR100212162B1/ko not_active IP Right Cessation
- 1991-06-14 EP EP91910717A patent/EP0536177B1/en not_active Expired - Lifetime
- 1991-06-14 JP JP3510319A patent/JP2669510B2/ja not_active Expired - Fee Related
- 1991-06-14 CA CA002085465A patent/CA2085465C/en not_active Expired - Fee Related
- 1991-06-14 DK DK91910717T patent/DK0536177T3/da active
- 1991-06-14 WO PCT/CA1991/000213 patent/WO1991019734A2/en active IP Right Grant
-
1992
- 1992-12-14 NO NO924834A patent/NO309040B1/no unknown
- 1992-12-15 FI FI925696A patent/FI925696A0/fi unknown
-
1998
- 1998-02-16 GR GR980400324T patent/GR3026150T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0536177B1 (en) | 1997-11-19 |
NO309040B1 (no) | 2000-12-04 |
NO924834D0 (no) | 1992-12-14 |
AU654820B2 (en) | 1994-11-24 |
HUT63440A (en) | 1993-08-30 |
DK0536177T3 (da) | 1998-07-27 |
ATE160356T1 (de) | 1997-12-15 |
DE69128247D1 (de) | 1998-01-02 |
JPH06500073A (ja) | 1994-01-06 |
FI925696A (fi) | 1992-12-15 |
JP2669510B2 (ja) | 1997-10-29 |
CA2085465C (en) | 2001-07-24 |
ES2111567T3 (es) | 1998-03-16 |
EP0536177A1 (en) | 1993-04-14 |
DE69128247T2 (de) | 1998-03-19 |
FI925696A0 (fi) | 1992-12-15 |
HU9203968D0 (en) | 1993-03-29 |
WO1991019734A3 (en) | 1992-02-20 |
CA2085465A1 (en) | 1991-12-16 |
KR100212162B1 (ko) | 1999-08-02 |
NO924834L (no) | 1992-12-15 |
AU8085591A (en) | 1992-01-07 |
WO1991019734A2 (en) | 1991-12-26 |
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