GR3026150T3 - Thrombin inhibitors based on the amino acid sequence of hirudin - Google Patents

Thrombin inhibitors based on the amino acid sequence of hirudin

Info

Publication number
GR3026150T3
GR3026150T3 GR980400324T GR980400324T GR3026150T3 GR 3026150 T3 GR3026150 T3 GR 3026150T3 GR 980400324 T GR980400324 T GR 980400324T GR 980400324 T GR980400324 T GR 980400324T GR 3026150 T3 GR3026150 T3 GR 3026150T3
Authority
GR
Greece
Prior art keywords
amino acid
hirudin
acid sequence
thrombin inhibitors
inhibitors based
Prior art date
Application number
GR980400324T
Other languages
English (en)
Inventor
John Dimaio
Feng Ni
Yasuo Konishi
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Publication of GR3026150T3 publication Critical patent/GR3026150T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
GR980400324T 1990-06-15 1998-02-16 Thrombin inhibitors based on the amino acid sequence of hirudin GR3026150T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53832290A 1990-06-15 1990-06-15
PCT/CA1991/000213 WO1991019734A2 (en) 1990-06-15 1991-06-14 Thrombin inhibitors based on the amino acid sequence of hirudin

Publications (1)

Publication Number Publication Date
GR3026150T3 true GR3026150T3 (en) 1998-05-29

Family

ID=24146434

Family Applications (1)

Application Number Title Priority Date Filing Date
GR980400324T GR3026150T3 (en) 1990-06-15 1998-02-16 Thrombin inhibitors based on the amino acid sequence of hirudin

Country Status (14)

Country Link
EP (1) EP0536177B1 (el)
JP (1) JP2669510B2 (el)
KR (1) KR100212162B1 (el)
AT (1) ATE160356T1 (el)
AU (1) AU654820B2 (el)
CA (1) CA2085465C (el)
DE (1) DE69128247T2 (el)
DK (1) DK0536177T3 (el)
ES (1) ES2111567T3 (el)
FI (1) FI925696A0 (el)
GR (1) GR3026150T3 (el)
HU (1) HUT63440A (el)
NO (1) NO309040B1 (el)
WO (1) WO1991019734A2 (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
EP0540574B1 (en) * 1990-07-24 1996-09-11 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
IT1265023B1 (it) * 1993-04-16 1996-10-28 Dev Biotechnological Processes Inibitori della trombina, loro preparazione ed uso per applicazioni terapeutiche, profilattiche e diagnostiche
JP3532920B2 (ja) * 1993-06-11 2004-05-31 メレル ファーマスーティカルズ インコーポレイテッド 三機能性の抗血栓及び抗血小板ペプチド類
EP0725797B1 (en) * 1993-10-25 2001-01-10 National Research Council Of Canada Bivalent thrombin inhibitors
GB9506212D0 (en) * 1995-03-27 1995-05-17 Iaf Biochem Int Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component
AU2001259306A1 (en) 2000-05-02 2001-11-12 Advanced Medicine, Inc. Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
JPS606647A (ja) * 1983-06-17 1985-01-14 Microbial Chem Res Found アルフアメニン及びその関連化合物と合成法
US5196404B1 (en) 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin

Also Published As

Publication number Publication date
EP0536177B1 (en) 1997-11-19
NO309040B1 (no) 2000-12-04
NO924834D0 (no) 1992-12-14
AU654820B2 (en) 1994-11-24
HUT63440A (en) 1993-08-30
DK0536177T3 (da) 1998-07-27
ATE160356T1 (de) 1997-12-15
DE69128247D1 (de) 1998-01-02
JPH06500073A (ja) 1994-01-06
FI925696A (fi) 1992-12-15
JP2669510B2 (ja) 1997-10-29
CA2085465C (en) 2001-07-24
ES2111567T3 (es) 1998-03-16
EP0536177A1 (en) 1993-04-14
DE69128247T2 (de) 1998-03-19
FI925696A0 (fi) 1992-12-15
HU9203968D0 (en) 1993-03-29
WO1991019734A3 (en) 1992-02-20
CA2085465A1 (en) 1991-12-16
KR100212162B1 (ko) 1999-08-02
NO924834L (no) 1992-12-15
AU8085591A (en) 1992-01-07
WO1991019734A2 (en) 1991-12-26

Similar Documents

Publication Publication Date Title
HK1005511A1 (en) Thrombin inhibitors based on the amino acid sequence of hirudin
IS1805B (is) Aðferð til að framleiða nýjar peptíðafleiður sem eru þrombíntálmar
GR3026150T3 (en) Thrombin inhibitors based on the amino acid sequence of hirudin
JPS562962A (en) Glycolic acid oxidase inhibitor 44substitutedd33hydroxyy33pyrolinee2*55done
ATE124997T1 (de) Enzymatische entfernung einer aminoterminalen proteinsequenz.
JPS5646809A (en) Glycolic acid oxidase inhibitor of 44*substituted thiazolyl**33hydroxyy33 pyrrolinee2*55dione
GR860399B (en) Process for obtaining peptidic derivatives pepstatine analogs renines inhibitors and proteases acids
ES2080549T3 (es) Medicamentos a base de derivados de polihidroximetileno, procedimiento para su preparacion y empleo.
EP0439442A3 (en) Factor x-laci hybrid protein
SE8901552D0 (sv) Acid addition salts of amidated or glycine, their preparation and use
GR3032779T3 (en) A method for using lipoprotein associated coagulation inhibitor to treat sepsis.
ES2057572T3 (es) Agentes de reconocimiento.
ATE228847T1 (de) Inhibitoren von katalytischen antikörpern
NO900920D0 (no) Aprotinin-homologer og fremgangsmaate ved fremstilling av aprotinin og aprotininhomologer i gjaer.
NO921223D0 (no) Kombinasjonspreparat med antitrombotisk virkning
ATE150018T1 (de) Imidazolyl-substituierte phenylessigsäureprolinamide
AU7470681A (en) Glicentin related purified peptide having 30 amino acids
IT1261959B (it) Composizione farmaceutica atta a migliorare la biodisponibilita' dell'acido eicosapentaenoico e decosaesaenoico
LV12370A (lv) Lidzeklis reimatoida artrita un radniecigo artritu arstesanai