ES2111019T3 - Derivados de espicamicina y utilizacion de los mismos. - Google Patents
Derivados de espicamicina y utilizacion de los mismos.Info
- Publication number
- ES2111019T3 ES2111019T3 ES92111782T ES92111782T ES2111019T3 ES 2111019 T3 ES2111019 T3 ES 2111019T3 ES 92111782 T ES92111782 T ES 92111782T ES 92111782 T ES92111782 T ES 92111782T ES 2111019 T3 ES2111019 T3 ES 2111019T3
- Authority
- ES
- Spain
- Prior art keywords
- chem
- denotes
- integer
- carbon atoms
- given number
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE DESCRIBE UN DERIVADO DE LA ESPICAMICINA NUEVO REPRESENTADO POR LA FORMULA (I) O UNA SAL SUYA: DONDE R REPRESENTA UN ALQUENIL CON UN NUMERO DADO DE ATOMOS DE CARBONO, UN HALOALQUIL CON UN NUMERO DADO DE ATOMOS DE CARBONO, CH3(CH2)NCH(OH)H3(CH2)N-1CH(OH)-CH2 UILCON CIERTO GRUPO Y UN NUMERO DADO DE ATOMOS DE CARBONO, (DONDE A ES 2 Y B ES UN ENTERO DE 10 A 15), CH3(CH2)CSO2O(CH2)D-, (DONDE C ES UN ENTERO DE 0 A 3 Y D ES UN ENTERO DE 10 A 15), (CH3)3SI(CH2)10-, (CH3)3SI-C TRIPLE ENLACE C-(CH2)8-, O (DONDE X REPRESENTA O O S), Y R1 Y R2 SON DIFERENTES ENTRE SI Y REPRESENTA H U OH, QUE EXHIBE UN EFECTO ANTI TUMOR EXCELENTE Y TIENE UN ELEVADO INDICE TERAPEUTICO. TAMBIEN SE DESCRIBE UN AGENTE ANTITUMOR QUE CONTIENE AL MENOS UNO DE LOS COMPUESTOS DESCRITOS ARRIBA EN UNA CANTIDAD EFECTIVA.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19890391 | 1991-07-12 | ||
JP32684591 | 1991-11-15 | ||
JP4110665A JP2783722B2 (ja) | 1991-07-12 | 1992-04-03 | スピカマイシン誘導体およびそれを含む抗腫瘍剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2111019T3 true ES2111019T3 (es) | 1998-03-01 |
Family
ID=27311786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92111782T Expired - Lifetime ES2111019T3 (es) | 1991-07-12 | 1992-07-10 | Derivados de espicamicina y utilizacion de los mismos. |
Country Status (16)
Country | Link |
---|---|
US (2) | US5461036A (es) |
EP (1) | EP0525479B1 (es) |
JP (1) | JP2783722B2 (es) |
KR (1) | KR100253050B1 (es) |
AT (1) | ATE159948T1 (es) |
AU (1) | AU657551B2 (es) |
CA (1) | CA2073567C (es) |
DE (1) | DE69222992T2 (es) |
DK (1) | DK0525479T3 (es) |
ES (1) | ES2111019T3 (es) |
FI (1) | FI105815B (es) |
GR (1) | GR3025293T3 (es) |
HK (1) | HK1001729A1 (es) |
HU (1) | HU221808B1 (es) |
NO (1) | NO178500C (es) |
SG (1) | SG52704A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7017208B2 (en) * | 1995-08-04 | 2006-03-28 | Hill-Rom Services, Inc. | Hospital bed |
US5905069A (en) * | 1998-01-26 | 1999-05-18 | The General Hospital Corporation | Methods of decreasing or preventing pain using spicamycin or derivatives thereof |
ATE253051T1 (de) * | 1999-01-22 | 2003-11-15 | Kirin Brewery | Chinolinderivate und chinazolinderivate |
ATE504302T1 (de) | 2000-09-20 | 2011-04-15 | Gen Hospital Corp | Methoden zur verminderung oder verhinderung von schmerzen mit spicamycin-derivaten |
US20060074014A1 (en) * | 2002-11-18 | 2006-04-06 | Vicuron Pharmaceuticals Inc. | Dalbavancin compositions for treatment of bacterial infections |
US20050004011A1 (en) * | 2002-11-18 | 2005-01-06 | Marco Cavaleri | Compositions and methods for treating bacterial infections with protein-dalbavancin complexes |
DE602004022429D1 (de) * | 2003-09-11 | 2009-09-17 | Invista Tech Sarl | Verfahren zur hydrocyanierung von ungesättigten carbonsäure-derivaten |
JP4608651B2 (ja) * | 2004-06-24 | 2011-01-12 | 財団法人ヒューマンサイエンス振興財団 | 抗ガン作用を有する化合物、その製造方法及び抗ガン剤 |
US8119829B2 (en) * | 2004-09-08 | 2012-02-21 | Invista North America S.A.R.L. | Process of hydrocyanation of unsaturated carboxylic acid derivatives |
JP5753784B2 (ja) * | 2008-10-10 | 2015-07-22 | ダラ・バイオサイエンシズ,インコーポレイテッド | スピカマイシン誘導体を用いて疼痛を治療又は予防する方法 |
EP2597082A1 (de) | 2011-11-24 | 2013-05-29 | Symrise AG | Verbindungen zur Maskierung eines unangenehmen Geschmacks |
JP2015524482A (ja) * | 2012-08-09 | 2015-08-24 | ダラ・バイオサイエンシズ,インコーポレイテッド | スピカマイシン誘導体を含む組成物およびその使用方法 |
WO2015061481A1 (en) | 2013-10-23 | 2015-04-30 | Dara Biosciences, Inc. | Methods of treating liquid tumors using compositions comprising spicamycin derivatives |
CN110386874B (zh) * | 2018-04-16 | 2022-10-04 | 湖北金鹤化工有限公司 | 一种12-酮基硬脂酸酯及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3155647A (en) | 1963-07-24 | 1964-11-03 | Olin Mathieson | Septaciding and derivatives thereof |
US3264195A (en) * | 1963-07-24 | 1966-08-02 | Squibb & Sons Inc | Process for the preparation of septacidin and derivatives |
US4086416A (en) * | 1977-05-17 | 1978-04-25 | Stanford Research Institute | Septacidin analogs |
JPS59161389A (ja) * | 1983-03-07 | 1984-09-12 | Eisai Co Ltd | 7−カルボキシメトキシフエニルアセトアミドセフエム誘導体,その製造法およびそれからなる抗菌剤 |
JPS59161396A (ja) | 1983-03-04 | 1984-09-12 | Kirin Brewery Co Ltd | 新規抗生物質スピカマイシン |
US4975434A (en) * | 1986-05-27 | 1990-12-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antiviral and anticancer cyclopentenyl cytosine |
WO1990015811A1 (en) | 1989-06-16 | 1990-12-27 | Kirin Beer Kabushiki Kaisha | Spicamycin x and its use |
-
1992
- 1992-04-03 JP JP4110665A patent/JP2783722B2/ja not_active Expired - Lifetime
- 1992-07-08 NO NO922674A patent/NO178500C/no not_active IP Right Cessation
- 1992-07-08 US US07/910,640 patent/US5461036A/en not_active Expired - Lifetime
- 1992-07-09 FI FI923170A patent/FI105815B/fi active
- 1992-07-10 AT AT92111782T patent/ATE159948T1/de active
- 1992-07-10 HU HU9202285A patent/HU221808B1/hu not_active IP Right Cessation
- 1992-07-10 EP EP92111782A patent/EP0525479B1/en not_active Expired - Lifetime
- 1992-07-10 ES ES92111782T patent/ES2111019T3/es not_active Expired - Lifetime
- 1992-07-10 DE DE69222992T patent/DE69222992T2/de not_active Expired - Lifetime
- 1992-07-10 DK DK92111782.6T patent/DK0525479T3/da active
- 1992-07-10 CA CA002073567A patent/CA2073567C/en not_active Expired - Lifetime
- 1992-07-10 SG SG1996008096A patent/SG52704A1/en unknown
- 1992-07-10 AU AU19600/92A patent/AU657551B2/en not_active Ceased
- 1992-07-11 KR KR1019920012373A patent/KR100253050B1/ko not_active IP Right Cessation
-
1995
- 1995-04-26 US US08/429,303 patent/US5631238A/en not_active Expired - Lifetime
-
1997
- 1997-11-06 GR GR970401503T patent/GR3025293T3/el unknown
-
1998
- 1998-01-21 HK HK98100557A patent/HK1001729A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO922674D0 (no) | 1992-07-08 |
DK0525479T3 (da) | 1998-04-20 |
FI923170A (fi) | 1993-01-13 |
HUT61773A (en) | 1993-03-01 |
US5631238A (en) | 1997-05-20 |
GR3025293T3 (en) | 1998-02-27 |
HK1001729A1 (en) | 1998-07-03 |
AU657551B2 (en) | 1995-03-16 |
EP0525479A1 (en) | 1993-02-03 |
HU9202285D0 (en) | 1992-10-28 |
JPH05186494A (ja) | 1993-07-27 |
HU221808B1 (hu) | 2003-01-28 |
NO178500B (no) | 1996-01-02 |
EP0525479B1 (en) | 1997-11-05 |
SG52704A1 (en) | 1998-09-28 |
NO922674L (no) | 1993-01-13 |
DE69222992D1 (de) | 1997-12-11 |
FI105815B (fi) | 2000-10-13 |
JP2783722B2 (ja) | 1998-08-06 |
DE69222992T2 (de) | 1998-03-05 |
FI923170A0 (fi) | 1992-07-09 |
AU1960092A (en) | 1993-01-14 |
CA2073567A1 (en) | 1993-01-13 |
ATE159948T1 (de) | 1997-11-15 |
KR930002370A (ko) | 1993-02-23 |
US5461036A (en) | 1995-10-24 |
KR100253050B1 (ko) | 2000-04-15 |
NO178500C (no) | 1996-04-10 |
CA2073567C (en) | 1998-05-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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