ES2109239T3 - 5-(1-aminociclohexil)-2(1h)-piridinona y compuestos relacionados. - Google Patents

5-(1-aminociclohexil)-2(1h)-piridinona y compuestos relacionados.

Info

Publication number
ES2109239T3
ES2109239T3 ES90912876T ES90912876T ES2109239T3 ES 2109239 T3 ES2109239 T3 ES 2109239T3 ES 90912876 T ES90912876 T ES 90912876T ES 90912876 T ES90912876 T ES 90912876T ES 2109239 T3 ES2109239 T3 ES 2109239T3
Authority
ES
Spain
Prior art keywords
image
loweralkyl
hydrogen
piridinone
aminociclohexil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90912876T
Other languages
English (en)
Inventor
Richard Charles Effland
David Marc Fink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ES2109239T3 publication Critical patent/ES2109239T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN LOS COMPUESTOS QUE TIENEN LA FORMULA (I), DONDE N ES 1, 2 O 3; R SUB 1 ES HIDROGENO, FORMILO, ALQUILCARBONILO INFERIOR, ALQUILCARBONILO INFERIOR DE ARILO, ALQUILO INFERIOR, ALQUILO INFERIOR DE ARILO, (A) O (B), R SUB 5 Y R SUB 6 SON INDEPENDIENTEMENTE ALQUILO INFERIOR O ALTERNATIVAMENTE EL GRUPO (C) QUE TOMADO COMO UN TODO ES (D), (E), (F) O (G); R SUB 2 ES HIDROGENO, ALQUILO INFERIOR, ALQUENILO INFERIOR, ALQUILO INFERIOR DE ARILO, -CH SUB 2C (EQUIVALE) CH, (H), (I), (J), R SUB 7 Y R SUB 8 SON INDEPENDIENTEMENTE ALQUILO INFERIOR O ALTERNATIVAMENTE EL GRUPO (K) QUE TOMANDO COMO UN TODO ES (L), (M) O (N); R SUB 3 ES HIDROGENO O ALQUILO INFERIOR; Y R SUB 4 ES HIDROGENO O ALQUILO INFERIOR; CUYOS COMPUESTOS SON UTILES COMO AGENTES ANALGESICOS Y TAMBIEN PARA EL TRATAMIENTO DE VARIAS DISFUNCIONES DE LA MEMORIA.
ES90912876T 1989-08-16 1990-08-16 5-(1-aminociclohexil)-2(1h)-piridinona y compuestos relacionados. Expired - Lifetime ES2109239T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/394,448 US4978663A (en) 1989-08-16 1989-08-16 5-(1-aminocyclohexyl)-2(1H)-pyridinone compounds which have pharmaceutical utility

Publications (1)

Publication Number Publication Date
ES2109239T3 true ES2109239T3 (es) 1998-01-16

Family

ID=23558997

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90912876T Expired - Lifetime ES2109239T3 (es) 1989-08-16 1990-08-16 5-(1-aminociclohexil)-2(1h)-piridinona y compuestos relacionados.

Country Status (14)

Country Link
US (1) US4978663A (es)
EP (1) EP0487602B1 (es)
JP (3) JP2557568B2 (es)
KR (1) KR927003532A (es)
AT (1) ATE155458T1 (es)
AU (1) AU652126B2 (es)
CA (2) CA2063594C (es)
DE (1) DE69031075T2 (es)
DK (1) DK0487602T3 (es)
ES (1) ES2109239T3 (es)
FI (1) FI920637A0 (es)
HU (2) HUT67589A (es)
NO (1) NO920600L (es)
WO (1) WO1991002721A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW473479B (en) 1997-12-19 2002-01-21 Takeda Chemical Industries Ltd Phosphonocephem derivatives, their production and use
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
ATE496906T1 (de) 2007-09-14 2011-02-15 Ortho Mcneil Janssen Pharm 1',3'-disubstituierte 4-phenyl-3,4,5,6-tetrahydro-2h,1'h-ä1,4'übipyri inyl-2'-one
CA2698929C (en) * 2007-09-14 2016-01-19 Addex Pharma S.A. 1,3-disubstituted-4-phenyl-1h-pyridin-2-ones
AU2008297876B2 (en) 2007-09-14 2011-07-07 Addex Pharma S.A. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
CN101861316B (zh) * 2007-11-14 2013-08-21 奥梅-杨森制药有限公司 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
CA2735764C (en) 2008-09-02 2016-06-14 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
AU2009304293B2 (en) 2008-10-16 2012-04-26 Addex Pharma S.A. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
US8691813B2 (en) 2008-11-28 2014-04-08 Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
CA2760259C (en) 2009-05-12 2018-05-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
RS53075B (en) 2009-05-12 2014-04-30 Janssen Pharmaceuticals Inc. 1,2,4-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
PL2649069T3 (pl) 2010-11-08 2016-01-29 Janssen Pharmaceuticals Inc Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
EP2661435B1 (en) 2010-11-08 2015-08-19 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
EP2643320B1 (en) 2010-11-08 2015-03-04 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
KR20200126026A (ko) 2014-01-21 2020-11-05 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
CN109999033B (zh) 2014-01-21 2022-12-23 詹森药业有限公司 包括代谢型谷氨酸能受体亚型2的正别构调节物或正位激动剂的组合及其用途
CN112409266A (zh) * 2019-08-22 2021-02-26 江苏阿尔法药业有限公司 一种索菲布韦中间体及其制备方法
CN112409267A (zh) * 2019-08-22 2021-02-26 江苏阿尔法药业有限公司 一种索菲布韦中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA903224A (en) * 1972-06-20 F. Czaja Robert Process for the production of pyridones
GB851577A (en) * 1958-03-06 1960-10-19 Parke Davis & Co Pyridine compounds and methods for producing the same
US3655897A (en) * 1971-01-25 1972-04-11 Merck & Co Inc Anti-inflammatory agents
JPS61165372A (ja) * 1985-01-17 1986-07-26 Daicel Chem Ind Ltd ５−ハロピリジン−３−カルボキサミド化合物
DE3823991A1 (de) * 1988-07-15 1990-02-15 Basf Ag Heterocyclisch substituierte (alpha)-aryl-acrylsaeureester und fungizide, die diese verbindungen enthalten

Also Published As

Publication number Publication date
CA2063594C (en) 2002-07-16
KR927003532A (ko) 1992-12-18
CA2063594A1 (en) 1991-02-17
EP0487602A1 (en) 1992-06-03
WO1991002721A1 (en) 1991-03-07
JP2557568B2 (ja) 1996-11-27
DK0487602T3 (da) 1998-02-09
NO920600L (no) 1992-04-14
HU9200461D0 (en) 1992-05-28
JPH09100287A (ja) 1997-04-15
AU652126B2 (en) 1994-08-18
NO920600D0 (no) 1992-02-14
CA2332188C (en) 2007-01-23
EP0487602A4 (en) 1993-03-17
CA2332188A1 (en) 1991-02-17
JP2708736B2 (ja) 1998-02-04
JPH04507421A (ja) 1992-12-24
US4978663A (en) 1990-12-18
AU6284290A (en) 1991-04-03
JP2708737B2 (ja) 1998-02-04
DE69031075D1 (de) 1997-08-21
ATE155458T1 (de) 1997-08-15
FI920637A0 (fi) 1992-02-14
JPH09100288A (ja) 1997-04-15
EP0487602B1 (en) 1997-07-16
HUT67589A (en) 1995-04-28
DE69031075T2 (de) 1998-02-26

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