ES8602798A1 - Un procedimiento para la preparacion de nuevos analogos de la mitomicina. - Google Patents

Un procedimiento para la preparacion de nuevos analogos de la mitomicina.

Info

Publication number
ES8602798A1
ES8602798A1 ES531338A ES531338A ES8602798A1 ES 8602798 A1 ES8602798 A1 ES 8602798A1 ES 531338 A ES531338 A ES 531338A ES 531338 A ES531338 A ES 531338A ES 8602798 A1 ES8602798 A1 ES 8602798A1
Authority
ES
Spain
Prior art keywords
compounds
amino
disulfide group
amino disulfides
disulfides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531338A
Other languages
English (en)
Other versions
ES531338A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES531338A0 publication Critical patent/ES531338A0/es
Publication of ES8602798A1 publication Critical patent/ES8602798A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS ANALOGOS DE LA MITOMICINA.CONSISTE EN HACER REACCIONAR DE 1 A 4 MOLES DE UNA AMINA DE FORMULAS R7-ALQ1-SS-ALQ2NH2 O R8-SS-ALQ2NH2 CON 1 MOL DE UN MITOSANO DE FORMULA (III) EN UN LIQUIDO ORGANICO INERTE A LA REACCION, A TEMPERATURA DE -15 A 50 C, DURANTE SUFICIENTE TIEMPO PARA DAR LUGAR A LA FORMACION DE UNA CANTIDAD APRECIABLE DE ANALOGOS DE LA MITOMICINA DE FORMULAS (I) O (II) DONDE ALQ1 ES UN GRUPO ALQUILENO DE CABEZA LINEAL O RAMIFICADA DE C 1 A 6; ALQ2 ES UN GRUPO ALQUILENO DE CADENA LINEAL O RAMIFICADA DE C 2 A 6; R ES H, ALQUILO INFERIOR Y OTROS; R7 ES HIDROXI, HALOGENO, AMINO Y OTROS; Y R8 ES ALQUILO DE C 1 A 12, ALIQUENILO O ALQUINILO DE C 3 A 12 Y OTROS. SE UTILIZAN COMO INHIBIDORES DE LOS TUMORES ANIMALES EXPERIMENTALES.
ES531338A 1983-04-11 1984-04-06 Un procedimiento para la preparacion de nuevos analogos de la mitomicina. Expired ES8602798A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48401683A 1983-04-11 1983-04-11
US06/581,291 US4803212A (en) 1983-04-11 1984-02-24 Amino disulfides

Publications (2)

Publication Number Publication Date
ES531338A0 ES531338A0 (es) 1985-12-01
ES8602798A1 true ES8602798A1 (es) 1985-12-01

Family

ID=27047825

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531338A Expired ES8602798A1 (es) 1983-04-11 1984-04-06 Un procedimiento para la preparacion de nuevos analogos de la mitomicina.

Country Status (23)

Country Link
US (1) US4803212A (es)
KR (1) KR890001488B1 (es)
AT (1) AT387019B (es)
AU (1) AU577523B2 (es)
CA (1) CA1285567C (es)
CH (1) CH661273A5 (es)
CY (1) CY1533A (es)
DE (1) DE3413489A1 (es)
DK (1) DK170071B1 (es)
ES (1) ES8602798A1 (es)
FI (1) FI78701C (es)
FR (1) FR2543953B1 (es)
GB (1) GB2140799B (es)
GR (1) GR79579B (es)
HK (1) HK82690A (es)
IE (1) IE57348B1 (es)
IT (1) IT1176003B (es)
LU (1) LU85295A1 (es)
MX (1) MX9202850A (es)
MY (1) MY102071A (es)
NL (1) NL8401104A (es)
PT (1) PT78399B (es)
SE (1) SE461735B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
US4866180A (en) * 1984-02-24 1989-09-12 Bristol-Myers Company Amino disulfide thiol exchange products
JPS60255789A (ja) * 1984-06-01 1985-12-17 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体，その製造法および抗腫瘍剤
AU581673B2 (en) * 1984-09-04 1989-03-02 Bristol-Myers Company Substituted 7-oxomitosanes
US4888341A (en) * 1984-09-04 1989-12-19 University Patents, Inc. 6-substituted mitomycin analogs
US4927943A (en) * 1984-09-04 1990-05-22 Bristol-Myers Company Substituted 7-oxomitosanes
EP0197799B1 (en) * 1985-04-10 1990-09-12 Kyowa Hakko Kogyo Kabushiki Kaisha Pharmacologically active mitomycin derivatives
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPS63150282A (ja) * 1986-12-13 1988-06-22 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
ZA886812B (en) * 1987-11-23 1989-07-26 Bristol Myers Co Anti-tumor prodrugs
US5075454A (en) * 1990-03-08 1991-12-24 Bristol-Myers Squibb Company 7-(diphenylmethyl)oxy-9a-methoxymitosane
US5175303A (en) * 1990-03-08 1992-12-29 Bristol-Myers Squibb Company Preparation of 7-(diphenylmethyl)oxy-9A-methoxymitosane

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3660578A (en) * 1957-04-06 1972-05-02 Kyowa Hakko Kogyo Kk Mitomycin c
NL129868C (es) * 1963-06-07
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
NL130086C (es) * 1964-07-14 1970-06-15
US3332944A (en) * 1964-11-02 1967-07-25 American Cyanamid Co Antibiotic derivatives of mitomycins a, b, c and porfiromycin
JPS5439098A (en) * 1977-08-31 1979-03-24 Kyowa Hakko Kogyo Co Ltd Mitomycin c derivatives
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
GB2093643A (en) * 1981-02-17 1982-09-02 Standard Telephones Cables Ltd DC-to-DC converter
NZ199617A (en) * 1981-05-15 1985-08-30 University Patents Inc Azirino(2',3',:3,4)pyrrolo(1,2-a)indole-4,7-dione derivatives and pharmaceutical compositions
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
EP0116208B1 (en) * 1982-12-07 1988-03-30 Kyowa Hakko Kogyo Co., Ltd. Mitomycin analogues
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes
AU581673B2 (en) * 1984-09-04 1989-03-02 Bristol-Myers Company Substituted 7-oxomitosanes

Also Published As

Publication number Publication date
DK170071B1 (da) 1995-05-15
FI78701C (fi) 1989-09-11
MY102071A (en) 1992-03-31
PT78399A (en) 1984-05-01
AU2595184A (en) 1984-10-18
CA1285567C (en) 1991-07-02
IE57348B1 (en) 1992-08-12
ES531338A0 (es) 1985-12-01
GR79579B (es) 1984-10-30
ATA122384A (de) 1988-04-15
DE3413489A1 (de) 1984-10-11
KR890001488B1 (ko) 1989-05-04
CY1533A (en) 1990-11-16
IE840878L (en) 1984-10-11
IT8420478A0 (it) 1984-04-10
IT1176003B (it) 1987-08-12
SE8401999L (sv) 1984-10-12
GB2140799A (en) 1984-12-05
SE8401999D0 (sv) 1984-04-10
US4803212A (en) 1989-02-07
GB8409242D0 (en) 1984-05-23
HK82690A (en) 1990-10-19
AU577523B2 (en) 1988-09-29
NL8401104A (nl) 1984-11-01
LU85295A1 (fr) 1984-11-28
MX9202850A (es) 1992-06-30
FI841380A (fi) 1984-10-12
FR2543953A1 (fr) 1984-10-12
DK183984A (da) 1984-10-12
DK183984D0 (da) 1984-04-09
FI78701B (fi) 1989-05-31
AT387019B (de) 1988-11-25
PT78399B (en) 1986-07-17
FI841380A0 (fi) 1984-04-06
GB2140799B (en) 1987-04-08
CH661273A5 (de) 1987-07-15
SE461735B (sv) 1990-03-19
FR2543953B1 (fr) 1988-08-26
DE3413489C2 (es) 1991-07-25

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