ATE155458T1 - 5-(1-aminocyclohexyl)-2(1h)-pyridinon und verwandte verbindungen - Google Patents
5-(1-aminocyclohexyl)-2(1h)-pyridinon und verwandte verbindungenInfo
- Publication number
- ATE155458T1 ATE155458T1 AT90912876T AT90912876T ATE155458T1 AT E155458 T1 ATE155458 T1 AT E155458T1 AT 90912876 T AT90912876 T AT 90912876T AT 90912876 T AT90912876 T AT 90912876T AT E155458 T1 ATE155458 T1 AT E155458T1
- Authority
- AT
- Austria
- Prior art keywords
- image
- loweralkyl
- hydrogen
- pyridinone
- aminocyclohexyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/394,448 US4978663A (en) | 1989-08-16 | 1989-08-16 | 5-(1-aminocyclohexyl)-2(1H)-pyridinone compounds which have pharmaceutical utility |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE155458T1 true ATE155458T1 (de) | 1997-08-15 |
Family
ID=23558997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90912876T ATE155458T1 (de) | 1989-08-16 | 1990-08-16 | 5-(1-aminocyclohexyl)-2(1h)-pyridinon und verwandte verbindungen |
Country Status (14)
Country | Link |
---|---|
US (1) | US4978663A (de) |
EP (1) | EP0487602B1 (de) |
JP (3) | JP2557568B2 (de) |
KR (1) | KR927003532A (de) |
AT (1) | ATE155458T1 (de) |
AU (1) | AU652126B2 (de) |
CA (2) | CA2332188C (de) |
DE (1) | DE69031075T2 (de) |
DK (1) | DK0487602T3 (de) |
ES (1) | ES2109239T3 (de) |
FI (1) | FI920637A0 (de) |
HU (2) | HUT67589A (de) |
NO (1) | NO920600L (de) |
WO (1) | WO1991002721A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW473479B (en) | 1997-12-19 | 2002-01-21 | Takeda Chemical Industries Ltd | Phosphonocephem derivatives, their production and use |
TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
EP2200985B1 (de) | 2007-09-14 | 2011-07-13 | Ortho-McNeil-Janssen Pharmaceuticals, Inc. | 1,3-disubstituierte 4-(aryl-x-phenyl)-1h-pyridin-2-one |
CN101801951B (zh) | 2007-09-14 | 2013-11-13 | 杨森制药有限公司 | 1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮 |
AU2008297877C1 (en) * | 2007-09-14 | 2013-11-07 | Addex Pharma S.A. | 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones |
CN101861316B (zh) * | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
ES2439291T3 (es) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos |
JP5656848B2 (ja) | 2008-10-16 | 2015-01-21 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体 |
US8691813B2 (en) | 2008-11-28 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
MX2011011962A (es) | 2009-05-12 | 2012-02-28 | Janssen Pharmaceuticals Inc | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostericos positivos de receptores de glutamato metabotropico (mglur2). |
ME01573B (me) | 2009-05-12 | 2014-09-20 | Addex Pharma Sa | DERIVATI 1,2,4-TRIAZOLO[4,3-a]PIRIDINA I NJIHOVA UPOTREBA U TRETMANU ILI PREVENCIJI NEUROLOŠKIH I PSIHIJATRIJSKIH POREMEĆAJA |
US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
AU2011328195B2 (en) | 2010-11-08 | 2015-04-02 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
JP5852666B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
PL3096790T3 (pl) | 2014-01-21 | 2020-01-31 | Janssen Pharmaceutica, N.V. | Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie |
KR20200036063A (ko) | 2014-01-21 | 2020-04-06 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
CN112409266A (zh) * | 2019-08-22 | 2021-02-26 | 江苏阿尔法药业有限公司 | 一种索菲布韦中间体及其制备方法 |
CN112409267A (zh) * | 2019-08-22 | 2021-02-26 | 江苏阿尔法药业有限公司 | 一种索菲布韦中间体的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA903224A (en) * | 1972-06-20 | F. Czaja Robert | Process for the production of pyridones | |
GB851577A (en) * | 1958-03-06 | 1960-10-19 | Parke Davis & Co | Pyridine compounds and methods for producing the same |
US3655897A (en) * | 1971-01-25 | 1972-04-11 | Merck & Co Inc | Anti-inflammatory agents |
JPS61165372A (ja) * | 1985-01-17 | 1986-07-26 | Daicel Chem Ind Ltd | 5−ハロピリジン−3−カルボキサミド化合物 |
DE3823991A1 (de) * | 1988-07-15 | 1990-02-15 | Basf Ag | Heterocyclisch substituierte (alpha)-aryl-acrylsaeureester und fungizide, die diese verbindungen enthalten |
-
1989
- 1989-08-16 US US07/394,448 patent/US4978663A/en not_active Expired - Lifetime
-
1990
- 1990-08-16 EP EP90912876A patent/EP0487602B1/de not_active Expired - Lifetime
- 1990-08-16 KR KR1019920700362A patent/KR927003532A/ko not_active Application Discontinuation
- 1990-08-16 ES ES90912876T patent/ES2109239T3/es not_active Expired - Lifetime
- 1990-08-16 WO PCT/US1990/004522 patent/WO1991002721A1/en active IP Right Grant
- 1990-08-16 CA CA002332188A patent/CA2332188C/en not_active Expired - Lifetime
- 1990-08-16 CA CA002063594A patent/CA2063594C/en not_active Expired - Lifetime
- 1990-08-16 AT AT90912876T patent/ATE155458T1/de not_active IP Right Cessation
- 1990-08-16 JP JP2512071A patent/JP2557568B2/ja not_active Expired - Lifetime
- 1990-08-16 HU HU9200461A patent/HUT67589A/hu unknown
- 1990-08-16 DE DE69031075T patent/DE69031075T2/de not_active Expired - Lifetime
- 1990-08-16 DK DK90912876.1T patent/DK0487602T3/da active
- 1990-08-16 AU AU62842/90A patent/AU652126B2/en not_active Ceased
- 1990-08-16 HU HU9200461A patent/HU9200461D0/hu unknown
-
1992
- 1992-02-14 NO NO92920600A patent/NO920600L/no unknown
- 1992-02-14 FI FI920637A patent/FI920637A0/fi unknown
-
1996
- 1996-05-14 JP JP8118930A patent/JP2708737B2/ja not_active Expired - Lifetime
- 1996-05-14 JP JP8118929A patent/JP2708736B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2708736B2 (ja) | 1998-02-04 |
CA2332188C (en) | 2007-01-23 |
HUT67589A (en) | 1995-04-28 |
JP2708737B2 (ja) | 1998-02-04 |
DK0487602T3 (da) | 1998-02-09 |
EP0487602B1 (de) | 1997-07-16 |
US4978663A (en) | 1990-12-18 |
CA2063594C (en) | 2002-07-16 |
JPH09100287A (ja) | 1997-04-15 |
FI920637A0 (fi) | 1992-02-14 |
HU9200461D0 (en) | 1992-05-28 |
DE69031075T2 (de) | 1998-02-26 |
CA2063594A1 (en) | 1991-02-17 |
AU652126B2 (en) | 1994-08-18 |
CA2332188A1 (en) | 1991-02-17 |
JP2557568B2 (ja) | 1996-11-27 |
KR927003532A (ko) | 1992-12-18 |
JPH04507421A (ja) | 1992-12-24 |
NO920600L (no) | 1992-04-14 |
EP0487602A4 (en) | 1993-03-17 |
EP0487602A1 (de) | 1992-06-03 |
JPH09100288A (ja) | 1997-04-15 |
ES2109239T3 (es) | 1998-01-16 |
DE69031075D1 (de) | 1997-08-21 |
AU6284290A (en) | 1991-04-03 |
WO1991002721A1 (en) | 1991-03-07 |
NO920600D0 (no) | 1992-02-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEIH | Change in the person of patent owner | ||
UEP | Publication of translation of european patent specification | ||
EEFA | Change of the company name | ||
EELA | Cancelled due to lapse of time |