ES2102971A1 - Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion. - Google Patents

Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion.

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Publication number
ES2102971A1
ES2102971A1 ES09600168A ES9600168A ES2102971A1 ES 2102971 A1 ES2102971 A1 ES 2102971A1 ES 09600168 A ES09600168 A ES 09600168A ES 9600168 A ES9600168 A ES 9600168A ES 2102971 A1 ES2102971 A1 ES 2102971A1
Authority
ES
Spain
Prior art keywords
strain
prrs
vaccines
respiratory syndrome
porcine reproductive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09600168A
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English (en)
Other versions
ES2102971B1 (es
Inventor
Burch Reina Alemany
Maso Enric Espuna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Hipra SA
Original Assignee
Laboratorios Hipra SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Hipra SA filed Critical Laboratorios Hipra SA
Priority to ES09600168A priority Critical patent/ES2102971B1/es
Priority to UA97105158A priority patent/UA68326C2/uk
Priority to CA002216436A priority patent/CA2216436A1/en
Priority to US08/930,330 priority patent/US6001370A/en
Priority to HU9801124A priority patent/HUP9801124A3/hu
Priority to EP96940665A priority patent/EP0835929A1/en
Priority to CN96194133A priority patent/CN1185806A/zh
Priority to KR1019970706672A priority patent/KR19980703268A/ko
Priority to PCT/ES1996/000234 priority patent/WO1997027288A1/es
Priority to JP9526571A priority patent/JP3068204B2/ja
Priority to PL96322455A priority patent/PL185841B1/pl
Priority to CZ19973377A priority patent/CZ286766B6/cs
Priority to BR9604888A priority patent/BR9604888A/pt
Publication of ES2102971A1 publication Critical patent/ES2102971A1/es
Priority to MXPA/A/1997/007302A priority patent/MXPA97007302A/es
Application granted granted Critical
Publication of ES2102971B1 publication Critical patent/ES2102971B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10061—Methods of inactivation or attenuation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/815—Viral vaccine for porcine species, e.g. swine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE DESCRIBE UNA NUEVA CEPA ATENUADA (CNMC INSTITUT PASTEUR I-1642) DEL VIRUS CAUSANTE DE LA ENFERMEDAD DEL GANADO PORCINO CONOCIDA COMO SINDROME RESPIRATORIO Y REPRODUCTIVO PORCINO (PRRS), ASI COMO UN PROCEDIMIENTO DE ATENUACION Y REPLICACION DE LA MISMA POR MEDIO DEL EMPLEO DE UN NUEVO CLON OBTENIDO A PARTIR DE CEDULAS DE RIÑON DE MONO MA-104 (CNMC INSTITUT PASTEUR I-1643). DEBIDO A SU INOCUIDAD PARA LOS SUIDOS Y A SU ELEVADA ACTIVIDAD INMUNOGENICA, LA MENCIONADA NUEVA CEPA ATENUADA PERMITE OBTENER VACUNAS Y MEDIOS DE DIAGNOSTICO QUE POSIBILITAN UN DIAGNOSTICO PRECOZ DEL PRRS Y UN EFICAZ TRATAMIENTO PREVENTIVO DE DICHA ENFERMEDAD.
ES09600168A 1996-01-25 1996-01-25 Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion. Expired - Fee Related ES2102971B1 (es)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ES09600168A ES2102971B1 (es) 1996-01-25 1996-01-25 Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion.
UA97105158A UA68326C2 (en) 1996-01-25 1996-04-12 An attenuated strain of the virus causing the porcine reproductive and respiratory syndrom (prrs), a vaccine for porcine protection from prrs, a method for preparation of active vaccine against prrs
CZ19973377A CZ286766B6 (en) 1996-01-25 1996-12-04 Attenuated virus strain, process of its preparation, vaccine, process of its preparation, cellular clone and use of the attenuated strain
HU9801124A HUP9801124A3 (en) 1996-01-25 1996-12-04 New attenuated strain of the virus causing the porcine reproductive respiratory syndrome (prrs), vaccines and diagnostic means obtainable with said strain, and production process
EP96940665A EP0835929A1 (en) 1996-01-25 1996-12-04 New attenuated strain of the virus causing the porcine reproductive respiratory syndrome (prrs), vaccines and diagnostic means obtainable with said strain, and production process
CN96194133A CN1185806A (zh) 1996-01-25 1996-12-04 诱发猪生殖和呼吸综合征(prrs)的病毒的新的减毒株,由其产生的疫苗和诊断试剂盒及其制备方法
KR1019970706672A KR19980703268A (ko) 1996-01-25 1996-12-04 돼지의 생식 및 호흡 장애 증후군(prrs)을 유발하는 바이러스의 신종 약독화 균주와, 그 균주로써 얻을 수 있는 백신 및 진단수단과, 제조공정
PCT/ES1996/000234 WO1997027288A1 (es) 1996-01-25 1996-12-04 Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion
CA002216436A CA2216436A1 (en) 1996-01-25 1996-12-04 New attenuated strain of the virus causing the porcine reproductive and respiratory syndrome (prrs), vaccines and diagnostic kits derived from the same, and procedures for the obtaining of the same
PL96322455A PL185841B1 (pl) 1996-01-25 1996-12-04 Nowy atenuowany szczep wirusa powodującego zespółNowy atenuowany szczep wirusa powodującego zespółrozrodczy i oddechowy świń (PRRS), szczepionki i zrozrodczy i oddechowy świń (PRRS), szczepionki i zestawy diagnostyczne otrzymane z tego wirusa orazestawy diagnostyczne otrzymane z tego wirusa orazsposoby ich otrzymywaniasposoby ich otrzymywania
US08/930,330 US6001370A (en) 1996-01-25 1996-12-04 Attenuated strain of the virus causing the porcine reproductive respiratory syndrome (PRRS), and vaccines
BR9604888A BR9604888A (pt) 1996-01-25 1996-12-04 Nova linhagem atenuada do vírus causador da síndrome suína reprodutiva e respiratória (prrs) vacinas clone celularderivado da linha estável de células renais de macaco ma-104 kits de diagnóstico obteníveis com a mesma procedimentos para a sua obtenção e uso da mesma
JP9526571A JP3068204B2 (ja) 1996-01-25 1996-12-04 ブタの生殖・呼吸症候群（ｐｒｒｓ）を惹起するウイルスの新規弱毒化株、それに由来するワクチンおよび診断キットならびにそれらの取得方法。
MXPA/A/1997/007302A MXPA97007302A (es) 1996-01-25 1997-09-24 Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09600168A ES2102971B1 (es) 1996-01-25 1996-01-25 Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion.

Publications (2)

Publication Number Publication Date
ES2102971A1 true ES2102971A1 (es) 1997-08-01
ES2102971B1 ES2102971B1 (es) 1998-03-01

Family

ID=8293550

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09600168A Expired - Fee Related ES2102971B1 (es) 1996-01-25 1996-01-25 Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion.

Country Status (13)

Country Link
US (1) US6001370A (es)
EP (1) EP0835929A1 (es)
JP (1) JP3068204B2 (es)
KR (1) KR19980703268A (es)
CN (1) CN1185806A (es)
BR (1) BR9604888A (es)
CA (1) CA2216436A1 (es)
CZ (1) CZ286766B6 (es)
ES (1) ES2102971B1 (es)
HU (1) HUP9801124A3 (es)
PL (1) PL185841B1 (es)
UA (1) UA68326C2 (es)
WO (1) WO1997027288A1 (es)

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US5695766A (en) * 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
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EP0839912A1 (en) * 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
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EP1156111A1 (en) * 2000-05-19 2001-11-21 Stichting Dienst Landbouwkundig Onderzoek Chimeric arterivirus-like particles
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TWI627281B (zh) 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 降低ｐｃｖ－２組合物殺病毒活性之方法及具有改良免疫原性之ｐｃｖ－２組合物
MX346636B (es) 2011-02-17 2017-03-27 Boehringer Ingelheim Vetmedica Gmbh Procedimiento para la produccion a escala comercial de prrsv.
DK2675475T3 (en) 2011-02-17 2015-09-14 Boehringer Ingelheim Vetmed NEW EUROPEAN PRRSV TRIAL
KR101281361B1 (ko) * 2011-07-18 2013-07-02 서울대학교산학협력단 북미형 돼지 생식기 호흡기 증후군 바이러스 예방 백신 조성물 및 이를 포함하는 혼합백신 조성물
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
WO2013017570A1 (en) 2011-07-29 2013-02-07 Boehringer Ingelheim Vetmedica Gmbh Novel prrs virus inducing type i interferon in susceptible cells
JP6386999B2 (ja) * 2012-05-17 2018-09-05 ゾエティス・エルエルシー ブタ生殖および呼吸症候群（ｐｒｒｓ）ウイルスに対する離乳前の効果的なワクチン接種
CA2892948C (en) 2012-12-07 2022-09-20 The Board Of Trustees Of The University Of Illinois Porcine reproductive and respiratory syndrome virus compositions and uses thereof
CN105073130A (zh) 2013-03-15 2015-11-18 勃林格殷格翰动物保健公司 猪生殖与呼吸综合征病毒、组合物、疫苗及使用方法
MX2020010248A (es) 2013-12-20 2020-10-16 Boehringer Ingelheim Vetmedica Gmbh Variante del virus prrs, clon de adnc del virus europeo y sus usos.
MY191895A (en) 2016-11-03 2022-07-18 Boehringer Ingelheim Vetmedica Gmbh Vaccine against porcine parvovirus and porcine reproductive and respiratory syndrome virus and methods of production thereof

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PL322455A1 (en) 1998-02-02
CN1185806A (zh) 1998-06-24
CA2216436A1 (en) 1997-07-31
ES2102971B1 (es) 1998-03-01
WO1997027288A1 (es) 1997-07-31
EP0835929A1 (en) 1998-04-15
CZ286766B6 (en) 2000-06-14
UA68326C2 (en) 2004-08-16
MX9707302A (es) 1998-06-30
JP3068204B2 (ja) 2000-07-24
KR19980703268A (ko) 1998-10-15
US6001370A (en) 1999-12-14
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