ES2085422T3 - Gen de acetilhidrolasa de cefalosporina y proteina codificada por dicho gen. - Google Patents
Gen de acetilhidrolasa de cefalosporina y proteina codificada por dicho gen.Info
- Publication number
- ES2085422T3 ES2085422T3 ES91303789T ES91303789T ES2085422T3 ES 2085422 T3 ES2085422 T3 ES 2085422T3 ES 91303789 T ES91303789 T ES 91303789T ES 91303789 T ES91303789 T ES 91303789T ES 2085422 T3 ES2085422 T3 ES 2085422T3
- Authority
- ES
- Spain
- Prior art keywords
- gene
- cephalosporin
- protein
- enzyme
- gen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/07—Bacillus
- C12R2001/125—Bacillus subtilis ; Hay bacillus; Grass bacillus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
Abstract
SE PROPORCIONA UN GEN DE CEFALOSPORINA ACETILHIDROLASA, UNA MOLECULA DE ADN RECOMBINADA PREPARADO POR LA INTRODUCCION DE DICHO GEN EN UN VECTOR UTILIZADO EN UN SISTEMA DE VECTOR RECEPTOR E.COLI, CELULAS E.COLI TRANSFORMADAS CON DICHA MOLECULA ADN RECOMBINADA, UNA PROTEINA TENIENDO LA SECUENCIA AMINO ACIDA CODIFICADA POR DICHO GEN, UNA ENZIMA QUE ES UN MULTITEMPORIZADOR DE DICHA PROTEINA, Y UN PROCESO PARA PREPARAR DICHA PROTEINA O ENZIMA, SIENDO DICHA CEFALOSPORINA ACETILNIDROLASA UNA ENZIMA UTIL PARA CONVERTIR CEFALOSPORINAS TALES COMO CEFALOSPORINAS C Y 7-ACA EN UNAS DEACETILADAS TALES COMO DEACETILCEFALOSPORINA C Y DEACETIL 7-ACA QUE SON UTILES COMO INTERMEDIARIAS PARA PREPARAR UNA VARIEDAD DE ANTIBIOTICOS DE CEFALOSPORINA DERIVADOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11348390 | 1990-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2085422T3 true ES2085422T3 (es) | 1996-06-01 |
Family
ID=14613433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91303789T Expired - Lifetime ES2085422T3 (es) | 1990-04-27 | 1991-04-26 | Gen de acetilhidrolasa de cefalosporina y proteina codificada por dicho gen. |
Country Status (15)
Country | Link |
---|---|
US (2) | US5281525A (es) |
EP (1) | EP0454478B1 (es) |
JP (1) | JP2651288B2 (es) |
KR (1) | KR960014703B1 (es) |
CN (2) | CN1047202C (es) |
AT (1) | ATE133450T1 (es) |
AU (1) | AU638124B2 (es) |
CA (1) | CA2040707C (es) |
DE (1) | DE69116593T2 (es) |
DK (1) | DK0454478T3 (es) |
ES (1) | ES2085422T3 (es) |
GR (1) | GR3018790T3 (es) |
IL (1) | IL97915A (es) |
NZ (1) | NZ237878A (es) |
RU (1) | RU2103364C1 (es) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1250698B (it) * | 1991-07-24 | 1995-04-21 | Mini Ricerca Scient Tecnolog | Processo per la preparazione enzimatica di acidi 7-ammino-cefalosporanici. |
EP1142991A3 (en) * | 1993-08-06 | 2003-03-12 | Brigham Young University Technology Transfer Office | Monoclonal antibodies to thymidine kinase isozymes |
AT408660B (de) * | 1998-01-28 | 2002-02-25 | Biochemie Gmbh | Nukleinsäure-molekül, das für cephalosporin-acetylesterase kodiert |
KR100270508B1 (ko) * | 1998-04-24 | 2001-02-01 | 고두모 | 신규세파로스포린디아세틸라아제유전자및이를이용한단백질제조방법 |
US20030215421A1 (en) * | 1999-07-21 | 2003-11-20 | Mcdonald John R. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
US7157418B1 (en) | 1998-07-22 | 2007-01-02 | Osprey Pharmaceuticals, Ltd. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
US6597946B2 (en) * | 1998-11-09 | 2003-07-22 | Transpharma Ltd. | Electronic card for transdermal drug delivery and analyte extraction |
ES2156812B1 (es) * | 1999-04-09 | 2002-02-01 | Antibioticos Sau | Una proteasa extracelular de acremonium chrysogenum con actividad cpc-acetilhidrolasa y su utilizacion para la sintesis de derivados desacetilados de cefalosporina c e inactivacion del gen para aumentar la produccion de cefalosporina. |
RU2209244C2 (ru) * | 2001-04-28 | 2003-07-27 | Закрытое акционерное общество "АСГЛ-Фармацевтические Инновации" | Нуклеиновая кислота, кодирующая лидерную последовательность (варианты), вектор на основе плазмиды р6803-platform (варианты), лидерный пептид (варианты) и способ получения белков |
US6727277B1 (en) | 2002-11-12 | 2004-04-27 | Kansas State University Research Foundation | Compounds affecting cholesterol absorption |
ES2272115B1 (es) * | 2004-02-13 | 2008-03-16 | Universidad De Murcia | Produccion de formas quimericas de cefalosporina c acetilasa. |
US7311906B2 (en) | 2004-04-30 | 2007-12-25 | Brigham Young University | Anti-viral activity of an anti-thymidine kinase monoclonal antibody |
US7837998B2 (en) | 2004-05-21 | 2010-11-23 | Nathaniel Lallatin | Anti-cancer activity of an anti-thymidine kinase monoclonal antibody |
US8551486B2 (en) | 2004-05-21 | 2013-10-08 | Savoy Pharmaceuticals, Inc. | Monoclonal antibodies to human thymidine kinase to treat cancer |
US8288136B2 (en) | 2005-12-13 | 2012-10-16 | E. I. Du Pont De Nemours And Company | Production of peracids using an enzyme having perhydrolysis activity |
US7723083B2 (en) | 2005-12-13 | 2010-05-25 | E.I. Du Pont De Nemours And Company | Production of peracids using an enzyme having perhydrolysis activity |
US7951566B2 (en) * | 2005-12-13 | 2011-05-31 | E.I. Du Pont De Nemours And Company | Production of peracids using an enzyme having perhydrolysis activity |
US7964378B2 (en) | 2005-12-13 | 2011-06-21 | E.I. Du Pont De Nemours And Company | Production of peracids using an enzyme having perhydrolysis activity |
EP1960529B1 (en) * | 2005-12-13 | 2010-02-24 | E.I. Du Pont De Nemours And Company | Production of peracids using an enzyme having perhydrolysis activity |
US8518675B2 (en) | 2005-12-13 | 2013-08-27 | E. I. Du Pont De Nemours And Company | Production of peracids using an enzyme having perhydrolysis activity |
US7473658B2 (en) * | 2006-11-13 | 2009-01-06 | E. I. Du Pont Nemours And Company | Partially fluorinated amino acid derivatives as gelling and surface active agents |
WO2009013611A2 (en) * | 2007-07-26 | 2009-01-29 | Orchid Chemicals & Pharmaceuticals Limited | Modified esterase and its applications |
CN102177234A (zh) * | 2008-08-13 | 2011-09-07 | 纳幕尔杜邦公司 | 酶促过酸制备的控制 |
CN102264894B (zh) * | 2008-10-03 | 2014-08-27 | 纳幕尔杜邦公司 | 酶催化法过酸生成制剂 |
US8277651B2 (en) | 2009-03-13 | 2012-10-02 | Terrasep, Llc | Methods and apparatus for centrifugal liquid chromatography |
CA2763568A1 (en) | 2009-07-27 | 2011-02-10 | E.I. Du Pont De Nemours And Company | Enzymatic in situ preparation of peracid-based removable antimicrobial coating compositions and methods of use |
US20110177148A1 (en) * | 2009-07-27 | 2011-07-21 | E. I. Du Pont De Nemours And Company | Enzymatic in situ preparation of peracid-based removable antimicrobial coating compositions and methods of use |
US8222012B2 (en) | 2009-10-01 | 2012-07-17 | E. I. Du Pont De Nemours And Company | Perhydrolase for enzymatic peracid production |
US7927854B1 (en) | 2009-12-07 | 2011-04-19 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
US7960528B1 (en) * | 2009-12-07 | 2011-06-14 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
US7923233B1 (en) | 2009-12-07 | 2011-04-12 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
US7932072B1 (en) | 2009-12-07 | 2011-04-26 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
US7910347B1 (en) | 2009-12-07 | 2011-03-22 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
WO2011082345A2 (en) | 2009-12-30 | 2011-07-07 | Brigham Young University | Compositions and methods for cancer management using antibodies binding to nucleotide salvage pathway enzymes and complexes thereof |
US8450091B2 (en) * | 2010-03-26 | 2013-05-28 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved specific activity |
WO2011119706A1 (en) | 2010-03-26 | 2011-09-29 | E.I. Dupont De Nemours And Company | Perhydrolase providing improved specific activity |
CN102822281A (zh) | 2010-03-26 | 2012-12-12 | 纳幕尔杜邦公司 | 包含聚芳硫醚的聚合物熔体 |
WO2011119703A1 (en) | 2010-03-26 | 2011-09-29 | E.I. Dupont De Nemours And Company | Process for the purification of proteins |
WO2011119708A1 (en) | 2010-03-26 | 2011-09-29 | E.I. Dupont De Nemours And Company | Perhydrolase providing improved specific activity |
US8389255B2 (en) | 2010-03-26 | 2013-03-05 | E.I. De Pont De Nemours And Company | Perhydrolase providing improved specific activity |
KR20140114269A (ko) * | 2010-12-20 | 2014-09-26 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 표적화된 과가수분해효소 |
WO2012087789A1 (en) | 2010-12-21 | 2012-06-28 | E.I. Dupont De Nemours And Company | Perhydrolase variant providing improved specific activity |
US8389257B2 (en) | 2010-12-21 | 2013-03-05 | E. I. Du Pont De Nemours And Company | Perhydrolase variant providing improved specific activity |
US8389256B2 (en) | 2010-12-21 | 2013-03-05 | E.I. Du Pont De Nemours And Company | Perhydrolase variant providing improved specific activity |
WO2012087790A1 (en) | 2010-12-21 | 2012-06-28 | E.I. Dupont De Nemours And Company | Perhydrolase variant providing improved specific activity |
WO2012087786A1 (en) | 2010-12-21 | 2012-06-28 | E.I. Dupont De Nemours And Company | Perhydrolase variant providing improved specific activity |
WO2012087785A1 (en) | 2010-12-21 | 2012-06-28 | E.I. Dupont De Nemours And Company | Perhydrolase variant providing improved specific activity |
WO2012087788A1 (en) | 2010-12-21 | 2012-06-28 | E.I. Dupont De Nemours And Company | Perhydrolase variant providing improved specific activity |
US8389259B2 (en) | 2010-12-21 | 2013-03-05 | E.I. Du Pont De Nemours And Company | Perhydrolase variant providing improved specific activity |
US8546119B2 (en) | 2011-10-25 | 2013-10-01 | E. I. Du Pont De Nemours And Company | Perhydrolase variant providing improved specific activity |
US8962294B2 (en) | 2011-10-25 | 2015-02-24 | E. I. Du Pont De Nemours And Company | Perhydrolase variant providing improved specific activity |
US8809030B2 (en) | 2011-10-25 | 2014-08-19 | E. I. Du Pont De Nemours And Company | Perhydrolase variant providing improved specific activity |
US8546120B2 (en) | 2011-10-25 | 2013-10-01 | E. I. Du Pont De Nemours And Company | Perhydrolase variant providing improved specific activity |
US8956843B2 (en) | 2011-10-25 | 2015-02-17 | E. I. Du Pont De Nemours And Company | Perhydrolase variant providing improved specific activity |
US8735125B2 (en) | 2011-10-25 | 2014-05-27 | E. I. Du Pont De Nemours And Company | Perhydrolase variant providing improved specific activity |
US8486679B2 (en) | 2011-10-25 | 2013-07-16 | E. I. Du Pont De Nemours And Company | Perhydrolase variant providing improved specific activity |
WO2013062885A1 (en) | 2011-10-25 | 2013-05-02 | E.I. Dupont De Nemours And Company | Perhydrolase variant providing improved specific activity |
US8557556B2 (en) | 2011-10-25 | 2013-10-15 | E. I. Du Pont De Nemours And Company | Perhydrolase variant providing improved specific activity |
WO2013096045A1 (en) | 2011-12-19 | 2013-06-27 | E. I. Du Pont De Nemours And Company | Perhydrolase variants providing improved specific activity in the presence of surfactant |
WO2013148185A1 (en) | 2012-03-30 | 2013-10-03 | E. I. Du Pont De Nemours And Company | Enzymes useful for peracid production |
CN104364384B (zh) | 2012-03-30 | 2018-12-28 | 纳幕尔杜邦公司 | 对于过酸的生产有用的酶 |
WO2013148184A1 (en) | 2012-03-30 | 2013-10-03 | E. I. Du Pont De Nemours And Company | Enzymes useful for peracid production |
US8865437B2 (en) | 2012-03-30 | 2014-10-21 | E. I. Du Pont De Nemours And Company | Enzymes useful for peracid production |
BR112014024424B1 (pt) | 2012-03-30 | 2022-04-05 | E.I. Du Pont De Nemours And Company | Processo para a produção de um ácido peroxicarboxílico, composição, sistema de geração e fornecimento de perácido e polipeptídeo isolado |
CN111517481A (zh) * | 2020-06-18 | 2020-08-11 | 山东海景天环保科技股份公司 | 一种皮革废水深度脱氮用复合碳源及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH475284A (de) * | 1963-11-19 | 1969-07-15 | Ciba Geigy | Verfahren zur Herstellung von Desacetyl-7-amino-cephalosporansäure |
JPS49132294A (es) * | 1973-04-24 | 1974-12-18 | ||
SE8005266L (sv) * | 1979-07-19 | 1981-01-20 | Glaxo Group Ltd | Framstellning av en cefalosporin genom jesning |
US4459405A (en) * | 1982-11-16 | 1984-07-10 | Eli Lilly And Company | Desacetylcephalosporin sulfones |
DE3432060A1 (de) * | 1984-08-31 | 1986-03-06 | Bayer Ag, 5090 Leverkusen | Immobilisierte zellen von bacillus subtilis, immobilisierungsverfahren und verwendung des praeparats zur abspaltung der 3-acetoxygruppe aus 7-ss-acylamido-cephalosporansaeuren |
EP0322032A3 (en) * | 1987-12-21 | 1991-01-30 | Merck & Co. Inc. | One-step enzymatic conversion of cephalosporin c and derivatives to 7-aminocephalosporanic acid and derivatives |
-
1991
- 1991-04-17 CA CA002040707A patent/CA2040707C/en not_active Expired - Lifetime
- 1991-04-18 NZ NZ237878A patent/NZ237878A/xx unknown
- 1991-04-22 US US07/688,299 patent/US5281525A/en not_active Expired - Lifetime
- 1991-04-22 IL IL9791591A patent/IL97915A/xx not_active IP Right Cessation
- 1991-04-23 AU AU75354/91A patent/AU638124B2/en not_active Expired
- 1991-04-25 JP JP3095166A patent/JP2651288B2/ja not_active Expired - Lifetime
- 1991-04-26 EP EP91303789A patent/EP0454478B1/en not_active Expired - Lifetime
- 1991-04-26 DK DK91303789.1T patent/DK0454478T3/da active
- 1991-04-26 DE DE69116593T patent/DE69116593T2/de not_active Expired - Lifetime
- 1991-04-26 RU SU4895364A patent/RU2103364C1/ru active
- 1991-04-26 AT AT91303789T patent/ATE133450T1/de not_active IP Right Cessation
- 1991-04-26 ES ES91303789T patent/ES2085422T3/es not_active Expired - Lifetime
- 1991-04-27 KR KR1019910006792A patent/KR960014703B1/ko not_active IP Right Cessation
- 1991-04-27 CN CN91103234A patent/CN1047202C/zh not_active Expired - Lifetime
-
1992
- 1992-11-25 US US07/980,517 patent/US5338676A/en not_active Expired - Lifetime
-
1996
- 1996-01-25 GR GR960400069T patent/GR3018790T3/el unknown
-
1998
- 1998-01-05 CN CNB981039324A patent/CN1155712C/zh not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR960014703B1 (ko) | 1996-10-19 |
US5338676A (en) | 1994-08-16 |
CN1227872A (zh) | 1999-09-08 |
CN1155712C (zh) | 2004-06-30 |
DK0454478T3 (da) | 1996-02-12 |
IL97915A0 (en) | 1992-06-21 |
AU7535491A (en) | 1991-11-07 |
EP0454478A1 (en) | 1991-10-30 |
DE69116593D1 (de) | 1996-03-07 |
AU638124B2 (en) | 1993-06-17 |
IL97915A (en) | 2000-08-31 |
DE69116593T2 (de) | 1996-07-04 |
US5281525A (en) | 1994-01-25 |
CN1058045A (zh) | 1992-01-22 |
CA2040707C (en) | 2002-07-09 |
JPH04228079A (ja) | 1992-08-18 |
CN1047202C (zh) | 1999-12-08 |
KR910018549A (ko) | 1991-11-30 |
JP2651288B2 (ja) | 1997-09-10 |
RU2103364C1 (ru) | 1998-01-27 |
EP0454478B1 (en) | 1996-01-24 |
NZ237878A (en) | 1993-02-25 |
CA2040707A1 (en) | 1991-10-28 |
ATE133450T1 (de) | 1996-02-15 |
GR3018790T3 (en) | 1996-04-30 |
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