ES2081742B1 - Procedimiento para preparar inmunoglobulina purificada. - Google Patents
Procedimiento para preparar inmunoglobulina purificada.Info
- Publication number
- ES2081742B1 ES2081742B1 ES09250029A ES9250029A ES2081742B1 ES 2081742 B1 ES2081742 B1 ES 2081742B1 ES 09250029 A ES09250029 A ES 09250029A ES 9250029 A ES9250029 A ES 9250029A ES 2081742 B1 ES2081742 B1 ES 2081742B1
- Authority
- ES
- Spain
- Prior art keywords
- antibody
- column
- applying
- absorb
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 3
- 239000003929 acidic solution Substances 0.000 abstract 2
- 101710120037 Toxin CcdB Proteins 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000007717 exclusion Effects 0.000 abstract 1
- 238000005342 ion exchange Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 238000001542 size-exclusion chromatography Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909022547A GB9022547D0 (en) | 1990-10-17 | 1990-10-17 | Purified immunoglobulin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2081742A1 ES2081742A1 (es) | 1996-03-01 |
| ES2081742B1 true ES2081742B1 (es) | 1996-10-01 |
Family
ID=10683866
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09250029A Expired - Lifetime ES2081742B1 (es) | 1990-10-17 | 1991-10-17 | Procedimiento para preparar inmunoglobulina purificada. |
| ES91917891T Expired - Lifetime ES2112865T5 (es) | 1990-10-17 | 1991-10-17 | Anticuerpos igg purificados. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91917891T Expired - Lifetime ES2112865T5 (es) | 1990-10-17 | 1991-10-17 | Anticuerpos igg purificados. |
Country Status (29)
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| DK0610447T3 (da) * | 1991-10-15 | 1999-08-23 | Btg Int Ltd | CDw52-specifikt antistof til behandling af T-cellemedieret inflammation af leddene |
| GB9125768D0 (en) * | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
| GB9300501D0 (en) * | 1993-01-09 | 1993-03-03 | Wellcome Found | Purification of immunoglobulin |
| EP0841942B2 (fr) † | 1995-08-01 | 2007-12-12 | Sanofi Pasteur | Procede de production industrielle d'un vaccin contre l'encephalite japonaise et vaccin obtenu |
| US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| CZ292465B6 (cs) * | 1996-02-09 | 2003-09-17 | Abbott Laboratories (Bermuda) Ltd. | Lidské protilátky k lidskému TNFalfa |
| GB9603256D0 (en) * | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| US20030023043A1 (en) * | 2000-03-02 | 2003-01-30 | Kazuhisa Uchida | Method of separating and purifying protein |
| EP2336149A1 (en) | 2001-03-09 | 2011-06-22 | Chugai Seiyaku Kabushiki Kaisha | Protein purification method |
| ATE421536T1 (de) * | 2001-06-05 | 2009-02-15 | Genetics Inst Llc | Verfahren zur reinigung stark anionischer proteine |
| GB0220894D0 (en) * | 2002-09-09 | 2002-10-16 | Millipore Uk Ltd | Method of separation |
| DK2261230T3 (en) | 2002-09-11 | 2017-06-12 | Chugai Pharmaceutical Co Ltd | Method of Protein Purification. |
| JP5116971B2 (ja) | 2002-10-15 | 2013-01-09 | インターセル アーゲー | Ｂ群連鎖球菌の接着因子をコードする核酸、ｂ群連鎖球菌の接着因子、およびその使用 |
| GB0304576D0 (en) * | 2003-02-28 | 2003-04-02 | Lonza Biologics Plc | Protein a chromatography |
| BRPI0417993A (pt) * | 2003-12-22 | 2007-04-27 | Genzyme Corp | anticorpo anti-cd52 para tratamento da diabetes |
| SI1869065T1 (sl) * | 2005-03-11 | 2020-08-31 | Wyeth Llc | Postopek kromatografije z nizko porazdelitvijo |
| EP4368721A3 (en) | 2007-09-26 | 2024-12-18 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
| SI2708559T1 (en) | 2008-04-11 | 2018-07-31 | Chugai Seiyaku Kabushiki Kaisha | An antigen-binding molecule capable of repeatably binding to two or more antigenic molecules |
| SG10201608169QA (en) | 2009-05-13 | 2016-11-29 | Genzyme Corp | Anti-human cd52 immunoglobulins |
| CA2761885A1 (en) | 2009-05-13 | 2010-11-18 | Genzyme Corporation | Methods and compositions for treating lupus |
| EP2519536A4 (en) * | 2009-12-29 | 2013-06-05 | Reddys Lab Ltd Dr | PROTEIN PURIFICATION BY ION EXCHANGE |
| JP5873016B2 (ja) | 2010-06-21 | 2016-03-01 | 協和発酵キリン株式会社 | アミノ酸を利用したタンパク質の精製方法 |
| RU2467783C2 (ru) * | 2010-07-30 | 2012-11-27 | Закрытое акционерное общество "БиоХимМак СТ" | Способ хроматографического выделения иммуноглобулина |
| TWI761912B (zh) | 2010-11-30 | 2022-04-21 | 日商中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| GB201109238D0 (en) * | 2011-06-01 | 2011-07-13 | Antitope Ltd | Antibodies |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| US9650411B2 (en) | 2012-08-07 | 2017-05-16 | Kyowa Hakko Kirin Co., Ltd. | Method of purifying protein |
| US9206390B2 (en) | 2012-09-02 | 2015-12-08 | Abbvie, Inc. | Methods to control protein heterogeneity |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| AU2013381687A1 (en) | 2013-03-12 | 2015-09-24 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
| US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| AU2013203043B2 (en) | 2013-03-15 | 2016-10-06 | Takeda Pharmaceutical Company Limited | Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs |
| AR095199A1 (es) | 2013-03-15 | 2015-09-30 | Genzyme Corp | Anticuerpos anti-cd52 |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| MY181081A (en) | 2013-12-27 | 2020-12-17 | Chugai Pharmaceutical Co Ltd | Method for purifying antibody having low isoelectric point |
| AR103161A1 (es) | 2014-12-19 | 2017-04-19 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina y regiones fc variantes así como métodos de uso |
| JP6823596B2 (ja) | 2015-07-31 | 2021-02-03 | 中外製薬株式会社 | アニオン性ポリマーによる抗体を含有する組成物の精製方法 |
| JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | 抗ミオスタチン抗体および使用方法 |
| KR102359192B1 (ko) | 2016-07-25 | 2022-02-04 | 세파론, 인코포레이티드 | 친화성 크로마토그래피 세정 완충액 |
| WO2018025982A1 (ja) | 2016-08-05 | 2018-02-08 | 中外製薬株式会社 | Ｉｌ－８関連疾患の治療用又は予防用組成物 |
| EP3950099A4 (en) | 2019-03-29 | 2022-05-18 | Asahi Kasei Medical Co., Ltd. | Method for purifying protein |
| US12383884B2 (en) | 2019-04-08 | 2025-08-12 | Asahi Kasei Medical Co., Ltd. | Polyamide medium for purifying protein-containing solution and method for producing polyamide medium |
| JP7583411B2 (ja) | 2019-04-10 | 2024-11-14 | 中外製薬株式会社 | Ｆｃ領域改変抗体の精製方法 |
| WO2022260091A1 (ja) | 2021-06-10 | 2022-12-15 | 三菱ケミカル株式会社 | 合成吸着剤、抗体の精製方法及び抗体の製造方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5118796A (en) * | 1987-12-09 | 1992-06-02 | Centocor, Incorporated | Efficient large-scale purification of immunoglobulins and derivatives |
| CA1339198C (en) * | 1988-02-12 | 1997-08-05 | Gregory Paul Winter | Antibodies to the antigen campath-1 |
-
1990
- 1990-10-17 GB GB909022547A patent/GB9022547D0/en active Pending
-
1991
- 1991-10-16 ZA ZA926191A patent/ZA926191B/xx unknown
- 1991-10-16 NZ NZ240247A patent/NZ240247A/en not_active IP Right Cessation
- 1991-10-16 MY MYPI92001385A patent/MY136210A/en unknown
- 1991-10-16 IE IE356091A patent/IE913560A1/en not_active IP Right Cessation
- 1991-10-16 ZA ZA918259A patent/ZA918259B/xx unknown
- 1991-10-16 GR GR910100425A patent/GR910100425A/el unknown
- 1991-10-16 IL IL10272691A patent/IL102726A/en not_active IP Right Cessation
- 1991-10-16 PT PT99248A patent/PT99248B/pt not_active IP Right Cessation
- 1991-10-16 NZ NZ244114A patent/NZ244114A/en not_active IP Right Cessation
- 1991-10-16 TW TW080108178A patent/TW283710B/zh not_active IP Right Cessation
- 1991-10-16 IT ITRM910788A patent/IT1250064B/it active IP Right Grant
- 1991-10-16 IL IL99761A patent/IL99761A0/xx unknown
- 1991-10-16 FR FR9112738A patent/FR2668164A1/fr active Granted
- 1991-10-16 BE BE9100946A patent/BE1004226A5/fr not_active IP Right Cessation
- 1991-10-16 MY MYPI91001909A patent/MY119030A/en unknown
- 1991-10-17 AT AT0900791A patent/ATA900791A/de not_active Application Discontinuation
- 1991-10-17 DE DE69128774T patent/DE69128774T3/de not_active Expired - Lifetime
- 1991-10-17 ES ES09250029A patent/ES2081742B1/es not_active Expired - Lifetime
- 1991-10-17 CA CA002069481A patent/CA2069481C/en not_active Expired - Lifetime
- 1991-10-17 EP EP91917891A patent/EP0504363B2/en not_active Expired - Lifetime
- 1991-10-17 DK DK91917891T patent/DK0504363T4/da active
- 1991-10-17 ES ES91917891T patent/ES2112865T5/es not_active Expired - Lifetime
- 1991-10-17 JP JP3516509A patent/JP2638680B2/ja not_active Expired - Lifetime
- 1991-10-17 HU HU9202000A patent/HUT64601A/hu unknown
- 1991-10-17 CH CH2655/92A patent/CH681455A5/fr not_active IP Right Cessation
- 1991-10-17 KR KR1019920701427A patent/KR960015399B1/ko not_active Expired - Lifetime
- 1991-10-17 WO PCT/GB1991/001816 patent/WO1992007084A1/en active IP Right Grant
- 1991-10-17 CH CH1901/92A patent/CH681305A5/fr not_active IP Right Cessation
- 1991-10-17 AT AT91917891T patent/ATE162552T1/de not_active IP Right Cessation
-
1992
- 1992-02-28 GB GB9209529A patent/GB2253397A/en not_active Withdrawn
- 1992-05-25 FI FI922380A patent/FI110003B/fi not_active IP Right Cessation
- 1992-05-27 LU LU88122A patent/LU88122A1/xx unknown
- 1992-06-17 FI FI922824A patent/FI110002B/fi not_active IP Right Cessation
- 1992-06-29 MX MX9203794A patent/MX9203794A/es unknown
- 1992-08-04 IL IL102726A patent/IL102726A0/xx unknown
- 1992-08-13 FR FR9209998A patent/FR2677997A1/fr not_active Withdrawn
- 1992-09-23 AU AU25321/92A patent/AU658926B2/en not_active Expired
- 1992-10-20 GR GR920100471A patent/GR920100471A/el unknown
- 1992-10-20 PT PT100988A patent/PT100988B/pt not_active IP Right Cessation
- 1992-10-30 KR KR1019920702699A patent/KR100193314B1/ko not_active Expired - Lifetime
-
1994
- 1994-08-11 AU AU70242/94A patent/AU7024294A/en not_active Abandoned
- 1994-10-07 US US08/319,598 patent/US5644036A/en not_active Expired - Lifetime
-
1997
- 1997-04-28 BR BR1100358-8A patent/BR1100358A/pt active IP Right Grant
- 1997-11-13 AU AU45218/97A patent/AU716402B2/en not_active Expired
-
1998
- 1998-04-10 GR GR980400777T patent/GR3026588T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19911017 Kind code of ref document: B1 Effective date: 19911017 |
|
| FA2A | Application withdrawn |
Effective date: 19970314 |