ATE162552T1 - Gereinigte igg antikörper - Google Patents

Gereinigte igg antikörper

Info

Publication number
ATE162552T1
ATE162552T1 AT91917891T AT91917891T ATE162552T1 AT E162552 T1 ATE162552 T1 AT E162552T1 AT 91917891 T AT91917891 T AT 91917891T AT 91917891 T AT91917891 T AT 91917891T AT E162552 T1 ATE162552 T1 AT E162552T1
Authority
AT
Austria
Prior art keywords
antibody
column
prepn
cdw52
purified
Prior art date
Application number
AT91917891T
Other languages
English (en)
Inventor
Paul Ian Nicholas Ramage
Geoffrey Langley Court Allen
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10683866&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE162552(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of ATE162552T1 publication Critical patent/ATE162552T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT91917891T 1990-10-17 1991-10-17 Gereinigte igg antikörper ATE162552T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909022547A GB9022547D0 (en) 1990-10-17 1990-10-17 Purified immunoglobulin

Publications (1)

Publication Number Publication Date
ATE162552T1 true ATE162552T1 (de) 1998-02-15

Family

ID=10683866

Family Applications (2)

Application Number Title Priority Date Filing Date
AT91917891T ATE162552T1 (de) 1990-10-17 1991-10-17 Gereinigte igg antikörper
AT0900791A ATA900791A (de) 1990-10-17 1991-10-17 Gereinigtes immunoglobulin

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT0900791A ATA900791A (de) 1990-10-17 1991-10-17 Gereinigtes immunoglobulin

Country Status (29)

Country Link
US (1) US5644036A (de)
EP (1) EP0504363B2 (de)
JP (1) JP2638680B2 (de)
KR (2) KR960015399B1 (de)
AT (2) ATE162552T1 (de)
AU (3) AU658926B2 (de)
BE (1) BE1004226A5 (de)
BR (1) BR1100358A (de)
CA (1) CA2069481C (de)
CH (2) CH681305A5 (de)
DE (1) DE69128774T3 (de)
DK (1) DK0504363T4 (de)
ES (2) ES2112865T5 (de)
FI (2) FI110003B (de)
FR (2) FR2668164A1 (de)
GB (2) GB9022547D0 (de)
GR (3) GR910100425A (de)
HU (1) HUT64601A (de)
IE (1) IE913560A1 (de)
IL (3) IL99761A0 (de)
IT (1) IT1250064B (de)
LU (1) LU88122A1 (de)
MX (1) MX9203794A (de)
MY (2) MY136210A (de)
NZ (2) NZ244114A (de)
PT (2) PT99248B (de)
TW (1) TW283710B (de)
WO (1) WO1992007084A1 (de)
ZA (2) ZA926191B (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
EP0610447B1 (de) * 1991-10-15 1998-12-16 Btg International Limited VERWENDUNG EINES CDw52-SPEZIFISCHEN ANTIKÖRPERS ZUR BEHANDLUNG VON DURCH T-ZELLEN VERMITTELTEN GELENKENTZÜNDUNGEN
GB9125768D0 (en) * 1991-12-04 1992-02-05 Hale Geoffrey Therapeutic method
GB9300501D0 (en) * 1993-01-09 1993-03-03 Wellcome Found Purification of immunoglobulin
KR19990036028A (ko) † 1995-08-01 1999-05-25 다니엘 케르니 일본뇌염 백신의 공업적인 생산방법 및 이에 의한 백신
US6090382A (en) * 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
DE122004000004I1 (de) * 1996-02-09 2004-08-12 Abott Biotechnology Ltd Humane Antikörper welche an Humanen TNFalpha binden.
GB9603256D0 (en) * 1996-02-16 1996-04-17 Wellcome Found Antibodies
US20030023043A1 (en) * 2000-03-02 2003-01-30 Kazuhisa Uchida Method of separating and purifying protein
ES2869895T3 (es) 2001-03-09 2021-10-26 Chugai Pharmaceutical Co Ltd Método de purificación de proteínas
EP1404428B1 (de) * 2001-06-05 2006-07-19 Genetics Institute, LLC Verfahren zur reinigung hochanionischer proteine
GB0220894D0 (en) * 2002-09-09 2002-10-16 Millipore Uk Ltd Method of separation
CA2497364C (en) 2002-09-11 2013-03-19 Chugai Seiyaku Kabushiki Kaisha Protein purification method
CN102174533A (zh) 2002-10-15 2011-09-07 英特塞尔股份公司 编码b族链球菌粘着因子的核酸、b族链球菌的粘着因子和它们的用途
GB0304576D0 (en) * 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
JP2007515492A (ja) * 2003-12-22 2007-06-14 ジェンザイム コーポレイション 糖尿病の抗ｃｄ５２抗体治療法
SI1869065T1 (sl) * 2005-03-11 2020-08-31 Wyeth Llc Postopek kromatografije z nizko porazdelitvijo
CN107551270A (zh) 2008-04-11 2018-01-09 中外制药株式会社 与多个分子的抗原反复结合的抗原结合分子
TWI614267B (zh) 2009-05-13 2018-02-11 建新公司 抗人類ｃｄ５２免疫球蛋白
RU2607022C2 (ru) 2009-05-13 2017-01-10 Джензим Корпорейшн Способы и композиции для лечения волчанки
WO2011090719A2 (en) * 2009-12-29 2011-07-28 Dr. Reddy's Laboratories Ltd. Protein purification by ion exchange
JP5873016B2 (ja) 2010-06-21 2016-03-01 協和発酵キリン株式会社 アミノ酸を利用したタンパク質の精製方法
RU2467783C2 (ru) * 2010-07-30 2012-11-27 Закрытое акционерное общество "БиоХимМак СТ" Способ хроматографического выделения иммуноглобулина
RU2658504C9 (ru) 2010-11-30 2018-08-21 Чугаи Сейяку Кабусики Кайся Антигенсвязывающая молекула, способная многократно связываться с множеством антигенных молекул
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
GB201109238D0 (en) * 2011-06-01 2011-07-13 Antitope Ltd Antibodies
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
US9650411B2 (en) 2012-08-07 2017-05-16 Kyowa Hakko Kirin Co., Ltd. Method of purifying protein
CA2883272A1 (en) 2012-09-02 2014-03-06 Abbvie Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
EP2830651A4 (de) 2013-03-12 2015-09-02 Abbvie Inc An humanes tnf-alpha bindende humane antikörper und verfahren zur herstellung davon
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
AR095199A1 (es) 2013-03-15 2015-09-30 Genzyme Corp Anticuerpos anti-cd52
AU2013203043B2 (en) * 2013-03-15 2016-10-06 Takeda Pharmaceutical Company Limited Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
RU2714967C2 (ru) 2013-12-27 2020-02-21 Чугаи Сейяку Кабусики Кайся Способ очистки антител с низкой изоэлектрической точкой
TWI808330B (zh) 2014-12-19 2023-07-11 日商中外製藥股份有限公司 抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法
WO2017022651A1 (ja) 2015-07-31 2017-02-09 中外製薬株式会社 アニオン性ポリマーによる抗体を含有する組成物の精製方法
KR102359192B1 (ko) 2016-07-25 2022-02-04 세파론, 인코포레이티드 친화성 크로마토그래피 세정 완충액
SG11201801024XA (en) 2016-08-05 2018-05-30 Chugai Pharmaceutical Co Ltd Therapeutic or preventive compositions for il-8-related diseases
CN113646066B (zh) 2019-03-29 2024-05-31 旭化成医疗株式会社 蛋白质的纯化方法
CN113692420B (zh) 2019-04-08 2023-09-12 旭化成医疗株式会社 用于纯化含蛋白质的溶液的聚酰胺介质及其制造方法
WO2020209318A1 (ja) 2019-04-10 2020-10-15 中外製薬株式会社 Ｆｃ領域改変抗体の精製方法
WO2022260091A1 (ja) 2021-06-10 2022-12-15 三菱ケミカル株式会社 合成吸着剤、抗体の精製方法及び抗体の製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118796A (en) * 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
JP3121823B2 (ja) * 1988-02-12 2001-01-09 ビーティージー・インターナショナル・リミテッド 抗体におけるまたは抗体に関する改良

Also Published As

Publication number Publication date
ES2112865T3 (es) 1998-04-16
AU4521897A (en) 1998-02-12
FR2668164B1 (de) 1995-04-14
US5644036A (en) 1997-07-01
GB9022547D0 (en) 1990-11-28
JP2638680B2 (ja) 1997-08-06
EP0504363B1 (de) 1998-01-21
FI922380A (fi) 1992-05-25
KR920703108A (ko) 1992-12-17
MY119030A (en) 2005-03-31
AU716402B2 (en) 2000-02-24
GR910100425A (el) 1992-09-25
ZA926191B (en) 1993-04-16
FI922824A (fi) 1992-06-17
PT99248B (pt) 1999-04-30
JPH05504579A (ja) 1993-07-15
DE69128774T2 (de) 1998-06-04
IL102726A (en) 2002-08-14
KR100193314B1 (ko) 1999-06-15
KR960015399B1 (ko) 1996-11-13
CA2069481C (en) 2003-07-29
ES2081742B1 (es) 1996-10-01
ES2081742A1 (es) 1996-03-01
BR1100358A (pt) 2000-03-28
EP0504363A1 (de) 1992-09-23
PT99248A (pt) 1993-06-30
GB9209529D0 (en) 1992-07-01
AU658926B2 (en) 1995-05-04
TW283710B (de) 1996-08-21
FI110003B (fi) 2002-11-15
MY136210A (en) 2008-08-29
WO1992007084A1 (en) 1992-04-30
HU9202000D0 (en) 1992-10-28
ZA918259B (en) 1993-04-16
AU649078B2 (en) 1994-05-12
PT100988A (pt) 1994-02-28
GR920100471A (el) 1994-06-30
LU88122A1 (fr) 1993-03-15
AU8729491A (en) 1992-05-20
DE69128774T3 (de) 2007-08-16
NZ240247A (en) 1994-03-25
IL102726A0 (en) 1993-01-31
IE913560A1 (en) 1992-04-22
FI922824A0 (fi) 1992-06-17
ATA900791A (de) 1996-06-15
ES2112865T5 (es) 2007-09-16
ITRM910788A0 (it) 1991-10-16
BE1004226A5 (fr) 1992-10-13
ITRM910788A1 (it) 1993-04-16
FR2677997A1 (fr) 1992-12-24
IT1250064B (it) 1995-03-30
CH681455A5 (de) 1993-03-31
AU2532192A (en) 1993-02-11
CH681305A5 (de) 1993-02-26
FI110002B (fi) 2002-11-15
MX9203794A (es) 1992-07-01
CA2069481A1 (en) 1992-04-18
DK0504363T4 (da) 2007-05-29
FI922380A0 (fi) 1992-05-25
GB2253397A (en) 1992-09-09
HUT64601A (en) 1994-01-28
NZ244114A (en) 1995-06-27
PT100988B (pt) 1999-08-31
AU7024294A (en) 1995-01-05
DK0504363T3 (da) 1998-09-21
FR2668164A1 (fr) 1992-04-24
IL99761A0 (en) 1992-08-18
DE69128774D1 (de) 1998-02-26
GR3026588T3 (en) 1998-07-31
EP0504363B2 (de) 2007-02-07

Similar Documents

Publication Publication Date Title
DE69128774T2 (de) GEREINIGTE IgG ANTIKÖRPER
MX9603637A (es) Purificacion de anticuerpo.
EP0185034A4 (de)
ES8100502A1 (es) Un procedimiento para purificar proteinas con pesos moleculares superiores a 12.000,en particular interferon
AU7067287A (en) Method and apparatus for separating proteins
Dimitrijevic et al. Purification and characterization of an estrogen-binding peroxidase from human fetuses
ES2068392T3 (es) Procedimiento de purificacion de interferon.
GB9001593D0 (en) Thiophilic absorbents
FR2411202A1 (fr) Procede d'extraction et de purification de la globuline transporteur d'hormones thyroidiennes tbg

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
UEP Publication of translation of european patent specification

Ref document number: 0504363

Country of ref document: EP

EELA Cancelled due to lapse of time