DE69128774D1 - GEREINIGTE IgG ANTIKÖRPER - Google Patents

GEREINIGTE IgG ANTIKÖRPER

Info

Publication number
DE69128774D1
DE69128774D1 DE69128774T DE69128774T DE69128774D1 DE 69128774 D1 DE69128774 D1 DE 69128774D1 DE 69128774 T DE69128774 T DE 69128774T DE 69128774 T DE69128774 T DE 69128774T DE 69128774 D1 DE69128774 D1 DE 69128774D1
Authority
DE
Germany
Prior art keywords
antibody
column
prepn
cdw52
purified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69128774T
Other languages
English (en)
Other versions
DE69128774T2 (de
DE69128774T3 (de
Inventor
Paul Ramage
Geoffrey Langley Court Allen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10683866&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69128774(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE69128774D1 publication Critical patent/DE69128774D1/de
Publication of DE69128774T2 publication Critical patent/DE69128774T2/de
Application granted granted Critical
Publication of DE69128774T3 publication Critical patent/DE69128774T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69128774T 1990-10-17 1991-10-17 GEREINIGTE IgG ANTIKÖRPER Expired - Lifetime DE69128774T3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909022547A GB9022547D0 (en) 1990-10-17 1990-10-17 Purified immunoglobulin
GB9022547 1990-10-17
PCT/GB1991/001816 WO1992007084A1 (en) 1990-10-17 1991-10-17 Purified cdw52-specific antibodies

Publications (3)

Publication Number Publication Date
DE69128774D1 true DE69128774D1 (de) 1998-02-26
DE69128774T2 DE69128774T2 (de) 1998-06-04
DE69128774T3 DE69128774T3 (de) 2007-08-16

Family

ID=10683866

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69128774T Expired - Lifetime DE69128774T3 (de) 1990-10-17 1991-10-17 GEREINIGTE IgG ANTIKÖRPER

Country Status (29)

Country Link
US (1) US5644036A (de)
EP (1) EP0504363B2 (de)
JP (1) JP2638680B2 (de)
KR (2) KR960015399B1 (de)
AT (2) ATA900791A (de)
AU (3) AU658926B2 (de)
BE (1) BE1004226A5 (de)
BR (1) BR1100358A (de)
CA (1) CA2069481C (de)
CH (2) CH681305A5 (de)
DE (1) DE69128774T3 (de)
DK (1) DK0504363T4 (de)
ES (2) ES2081742B1 (de)
FI (2) FI110003B (de)
FR (2) FR2668164A1 (de)
GB (2) GB9022547D0 (de)
GR (3) GR910100425A (de)
HU (1) HUT64601A (de)
IE (1) IE913560A1 (de)
IL (3) IL102726A (de)
IT (1) IT1250064B (de)
LU (1) LU88122A1 (de)
MX (1) MX9203794A (de)
MY (2) MY136210A (de)
NZ (2) NZ244114A (de)
PT (2) PT99248B (de)
TW (1) TW283710B (de)
WO (1) WO1992007084A1 (de)
ZA (2) ZA918259B (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
CA2120911A1 (en) * 1991-10-15 1993-04-29 Geoffrey Hale Medicaments
GB9125768D0 (en) * 1991-12-04 1992-02-05 Hale Geoffrey Therapeutic method
GB9300501D0 (en) * 1993-01-09 1993-03-03 Wellcome Found Purification of immunoglobulin
KR19990036028A (ko) † 1995-08-01 1999-05-25 다니엘 케르니 일본뇌염 백신의 공업적인 생산방법 및 이에 의한 백신
US6090382A (en) * 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
BRPI9715219B8 (pt) * 1996-02-09 2015-07-07 Abbvie Biotechnology Ltd Vetor recombinante de expressão, e célula hospedeira procariótica.
GB9603256D0 (en) * 1996-02-16 1996-04-17 Wellcome Found Antibodies
US20030023043A1 (en) * 2000-03-02 2003-01-30 Kazuhisa Uchida Method of separating and purifying protein
WO2002072615A1 (fr) * 2001-03-09 2002-09-19 Chugai Seiyaku Kabushiki Kaisha Methode de purification de proteines
NZ530025A (en) * 2001-06-05 2005-06-24 Inst Genetics Llc Methods for purifying highly anionic proteins
GB0220894D0 (en) * 2002-09-09 2002-10-16 Millipore Uk Ltd Method of separation
SI2261230T1 (sl) 2002-09-11 2017-08-31 Chugai Seiyaku Kabushiki Kaisha Postopek čiščenja proteinov
WO2004035618A2 (en) 2002-10-15 2004-04-29 Intercell Ag Nucleic acids coding for adhesion factor of group b streptococcus, adhesion factors of group b streptococcus and further uses thereof
GB0304576D0 (en) * 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
JP2007515492A (ja) * 2003-12-22 2007-06-14 ジェンザイム コーポレイション 糖尿病の抗ｃｄ５２抗体治療法
CN104610422A (zh) * 2005-03-11 2015-05-13 惠氏公司 弱分配层析的方法
EP3521311A1 (de) 2008-04-11 2019-08-07 Chugai Seiyaku Kabushiki Kaisha Zur wiederholten bindung an zwei oder mehr antigenmoleküle fähiges, antigenbindendes molekül
MY160126A (en) 2009-05-13 2017-02-28 Genzyme Corp Anti-human cd52 immunoglobulins
CA2761885A1 (en) 2009-05-13 2010-11-18 Genzyme Corporation Methods and compositions for treating lupus
EP2695889A1 (de) * 2009-12-29 2014-02-12 Dr. Reddy's Laboratories Limited Proteinreinigung durch Ionenaustausch
EP2583973B1 (de) 2010-06-21 2018-03-21 Kyowa Hakko Kirin Co., Ltd. Verfahren zur reinigung von proteinen mit aminosäuren
RU2467783C2 (ru) * 2010-07-30 2012-11-27 Закрытое акционерное общество "БиоХимМак СТ" Способ хроматографического выделения иммуноглобулина
CA2819356C (en) 2010-11-30 2023-01-24 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
EP2702077A2 (de) 2011-04-27 2014-03-05 AbbVie Inc. Verfahren zur steuerung des galactosylierungsprofil von rekombinant exprimierten proteinen
GB201109238D0 (en) * 2011-06-01 2011-07-13 Antitope Ltd Antibodies
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
US9650411B2 (en) 2012-08-07 2017-05-16 Kyowa Hakko Kirin Co., Ltd. Method of purifying protein
WO2014035475A1 (en) 2012-09-02 2014-03-06 Abbvie Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
AU2013381687A1 (en) 2013-03-12 2015-09-24 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
AU2013203043B2 (en) * 2013-03-15 2016-10-06 Takeda Pharmaceutical Company Limited Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs
AR095199A1 (es) 2013-03-15 2015-09-30 Genzyme Corp Anticuerpos anti-cd52
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
RU2714967C2 (ru) 2013-12-27 2020-02-21 Чугаи Сейяку Кабусики Кайся Способ очистки антител с низкой изоэлектрической точкой
NZ730607A (en) 2014-12-19 2022-07-01 Chugai Pharmaceutical Co Ltd Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
JP6823596B2 (ja) 2015-07-31 2021-02-03 中外製薬株式会社 アニオン性ポリマーによる抗体を含有する組成物の精製方法
EP3487868A4 (de) 2016-07-25 2020-07-29 Cephalon, Inc. Waschpuffer für affinitätschromatografie
CN109689099B (zh) 2016-08-05 2023-02-28 中外制药株式会社 用于预防或治疗il-8相关疾病的组合物
EP3950099A4 (de) 2019-03-29 2022-05-18 Asahi Kasei Medical Co., Ltd. Verfahren zur reinigung von proteinen
EP3954725B1 (de) 2019-04-08 2024-03-06 Asahi Kasei Medical Co., Ltd. Polyamidmedium zur reinigung einer protein enthaltenden lösung und verfahren zur herstellung eines polyamidmediums
KR20210149779A (ko) 2019-04-10 2021-12-09 추가이 세이야쿠 가부시키가이샤 Fc 영역 개변 항체의 정제 방법
JPWO2022260091A1 (de) 2021-06-10 2022-12-15

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118796A (en) * 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
JP3121823B2 (ja) * 1988-02-12 2001-01-09 ビーティージー・インターナショナル・リミテッド 抗体におけるまたは抗体に関する改良

Also Published As

Publication number Publication date
FI922380A (fi) 1992-05-25
HUT64601A (en) 1994-01-28
ZA918259B (en) 1993-04-16
KR960015399B1 (ko) 1996-11-13
EP0504363A1 (de) 1992-09-23
GB9022547D0 (en) 1990-11-28
NZ244114A (en) 1995-06-27
FR2677997A1 (fr) 1992-12-24
ES2112865T3 (es) 1998-04-16
DE69128774T2 (de) 1998-06-04
PT100988B (pt) 1999-08-31
LU88122A1 (fr) 1993-03-15
NZ240247A (en) 1994-03-25
MX9203794A (es) 1992-07-01
ATE162552T1 (de) 1998-02-15
JPH05504579A (ja) 1993-07-15
IE913560A1 (en) 1992-04-22
DK0504363T4 (da) 2007-05-29
FI922380A0 (fi) 1992-05-25
FI922824A (fi) 1992-06-17
AU658926B2 (en) 1995-05-04
GR3026588T3 (en) 1998-07-31
CA2069481C (en) 2003-07-29
FI110003B (fi) 2002-11-15
PT99248A (pt) 1993-06-30
IT1250064B (it) 1995-03-30
TW283710B (de) 1996-08-21
GB9209529D0 (en) 1992-07-01
ITRM910788A0 (it) 1991-10-16
FR2668164B1 (de) 1995-04-14
IL99761A0 (en) 1992-08-18
EP0504363B2 (de) 2007-02-07
CA2069481A1 (en) 1992-04-18
ATA900791A (de) 1996-06-15
AU4521897A (en) 1998-02-12
GR910100425A (el) 1992-09-25
KR920703108A (ko) 1992-12-17
GR920100471A (el) 1994-06-30
AU8729491A (en) 1992-05-20
DE69128774T3 (de) 2007-08-16
ES2081742B1 (es) 1996-10-01
MY136210A (en) 2008-08-29
HU9202000D0 (en) 1992-10-28
IL102726A (en) 2002-08-14
ITRM910788A1 (it) 1993-04-16
MY119030A (en) 2005-03-31
CH681455A5 (de) 1993-03-31
AU649078B2 (en) 1994-05-12
JP2638680B2 (ja) 1997-08-06
BE1004226A5 (fr) 1992-10-13
EP0504363B1 (de) 1998-01-21
IL102726A0 (en) 1993-01-31
ES2112865T5 (es) 2007-09-16
AU716402B2 (en) 2000-02-24
AU7024294A (en) 1995-01-05
WO1992007084A1 (en) 1992-04-30
PT99248B (pt) 1999-04-30
CH681305A5 (de) 1993-02-26
AU2532192A (en) 1993-02-11
GB2253397A (en) 1992-09-09
DK0504363T3 (da) 1998-09-21
PT100988A (pt) 1994-02-28
FI110002B (fi) 2002-11-15
ZA926191B (en) 1993-04-16
KR100193314B1 (ko) 1999-06-15
BR1100358A (pt) 2000-03-28
ES2081742A1 (es) 1996-03-01
FR2668164A1 (fr) 1992-04-24
US5644036A (en) 1997-07-01
FI922824A0 (fi) 1992-06-17

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings