ES2076139T3 - Derivados de purina antivirales y procedimiento para su preparacion. - Google Patents

Derivados de purina antivirales y procedimiento para su preparacion.

Info

Publication number
ES2076139T3
ES2076139T3 ES86309667T ES86309667T ES2076139T3 ES 2076139 T3 ES2076139 T3 ES 2076139T3 ES 86309667 T ES86309667 T ES 86309667T ES 86309667 T ES86309667 T ES 86309667T ES 2076139 T3 ES2076139 T3 ES 2076139T3
Authority
ES
Spain
Prior art keywords
hydrogen
ch2oh
preparation
procedure
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES86309667T
Other languages
English (en)
Inventor
Michael Raymond Beecha Harnden
Paul Graham Wyatt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858530813A external-priority patent/GB8530813D0/en
Priority claimed from GB868603228A external-priority patent/GB8603228D0/en
Priority claimed from GB868620849A external-priority patent/GB8620849D0/en
Priority claimed from GB868626041A external-priority patent/GB8626041D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of ES2076139T3 publication Critical patent/ES2076139T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Jib Cranes (AREA)
  • Sub-Exchange Stations And Push- Button Telephones (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • General Factory Administration (AREA)
  • Nonmetallic Welding Materials (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

COMPUESTOS DE FORMULA (I), Y SALES FARMACOLOGICAMENTE ACEPTABLES DEL MISMO, DONDE R1 ES HIDROGENO O CH2OH; R2 ES HIDROGENO O (DONDE R1 ES HIDROGENO), HIDROXI O CH2OH; R3 ES CH2OH O (DONDE R1 Y R2 SON AMBOS HIDROGENO), CH(OH) CH2OH; R4 ES HIDROGENO, HIDROXI, AMINO O OR5 DONDE R5 ES C1-6 ALQUILO, FENILO O FENIL C1-2 ALQUILO, CUALQUIERA DE LAS MITADES FENILO PUEDEN SER SUSTITUIDAS POR UNO O DOS GRUPOS HALO, C1-4 ALQUILO O C1-4 ALCOXI Y EN EL CUAL CUALQUIER GRUPO OH EN R1, R2 Y/O R3 PUEDE ESTAR EN LA FORMA DE O-ACIL, FOSFATO, ACETAL CICLICO O CARBONATO CICLICO DERIVADOS DEL MISMO, QUE TENGAN ACTIVIDAD ANTIVIRICA, PROCESOS E INTERMEDIARIOS PARA SU PREPARACION Y USO COMO FARMACOS.
ES86309667T 1985-12-13 1986-12-11 Derivados de purina antivirales y procedimiento para su preparacion. Expired - Lifetime ES2076139T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB858530813A GB8530813D0 (en) 1985-12-13 1985-12-13 Compounds
GB868603228A GB8603228D0 (en) 1986-02-10 1986-02-10 Compounds
GB868620849A GB8620849D0 (en) 1986-08-28 1986-08-28 Compounds
GB868626041A GB8626041D0 (en) 1986-10-31 1986-10-31 Compounds

Publications (1)

Publication Number Publication Date
ES2076139T3 true ES2076139T3 (es) 1995-11-01

Family

ID=27449713

Family Applications (1)

Application Number Title Priority Date Filing Date
ES86309667T Expired - Lifetime ES2076139T3 (es) 1985-12-13 1986-12-11 Derivados de purina antivirales y procedimiento para su preparacion.

Country Status (19)

Country Link
EP (1) EP0242482B1 (es)
JP (1) JPH085886B2 (es)
KR (1) KR940010033B1 (es)
AT (1) ATE127466T1 (es)
AU (1) AU599066B2 (es)
CA (1) CA1296726C (es)
DE (1) DE3650384T2 (es)
DK (1) DK166823B1 (es)
ES (1) ES2076139T3 (es)
FI (1) FI85143C (es)
GR (1) GR3018105T3 (es)
HU (1) HU200461B (es)
IL (1) IL80947A (es)
MA (1) MA20828A1 (es)
MY (1) MY101126A (es)
NO (1) NO166226C (es)
NZ (1) NZ218598A (es)
PL (3) PL150926B1 (es)
PT (1) PT83911B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8602346D0 (en) * 1986-01-30 1986-03-05 Wellcome Found Antiviral combinations
GB8713695D0 (en) * 1987-06-11 1987-07-15 Beecham Group Plc Process
US4965270A (en) * 1987-05-30 1990-10-23 Beecham Group P.L.C. Purine derivatives
GB8712744D0 (en) * 1987-05-30 1987-07-01 Beecham Group Plc Active compounds
GB8724765D0 (en) * 1987-10-22 1987-11-25 Beecham Group Plc Process
SE8801729D0 (sv) * 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
EP0353955A3 (en) * 1988-08-02 1991-08-14 Beecham Group Plc Novel compounds
DK135489D0 (da) * 1989-03-20 1989-03-20 Gea Farmaceutisk Fabrik As Fremgangsmaade til fremstilling af 9-substituerede guaninderivater og mellemprodukter til brug ved fremgangsmaaden
GB8907173D0 (en) * 1989-03-30 1989-05-10 Beecham Group Plc Novel compounds
GB8912043D0 (en) * 1989-05-25 1989-07-12 Beecham Group Plc Novel compounds
GB8918827D0 (en) * 1989-08-17 1989-09-27 Beecham Group Plc Novel compounds
US5252575A (en) * 1989-08-17 1993-10-12 Beecham Group P.L.C. Antiviral purine derivatives with improved gastrointestinal absorption
GB9107896D0 (en) * 1991-04-13 1991-05-29 Smithkline Beecham Plc Pharmaceuticals
JP2720681B2 (ja) * 1992-01-06 1998-03-04 株式会社村田製作所 移動体の移動検出装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU573540B2 (en) * 1982-10-14 1988-06-16 Wellcome Foundation Limited, The 6-hydrogen purine derivatives
IL72173A0 (en) * 1983-06-24 1984-10-31 Merck & Co Inc Guanine derivatives,their preparation and pharmaceutical compositions containing them
HUT39145A (en) * 1984-12-12 1986-08-28 Syntex Inc Process for preparing alkoxy-methyl-ether and alkoxy-methyl ester derivatives

Also Published As

Publication number Publication date
DK595886D0 (da) 1986-12-11
DK595886A (da) 1987-06-14
ATE127466T1 (de) 1995-09-15
FI85143C (fi) 1992-03-10
FI865075A (fi) 1987-06-14
MY101126A (en) 1991-07-31
NO865014D0 (no) 1986-12-11
DE3650384T2 (de) 1996-06-13
EP0242482A3 (en) 1989-02-08
FI85143B (fi) 1991-11-29
IL80947A (en) 1990-01-18
AU6644386A (en) 1987-06-18
AU599066B2 (en) 1990-07-12
EP0242482A2 (en) 1987-10-28
PL272031A1 (en) 1989-01-05
HUT43069A (en) 1987-09-28
HU200461B (en) 1990-06-28
PL150926B1 (en) 1990-07-31
KR880005129A (ko) 1988-06-28
CA1296726C (en) 1992-03-03
NO166226B (no) 1991-03-11
NZ218598A (en) 1990-10-26
PT83911B (pt) 1989-05-12
NO865014L (no) 1987-06-15
EP0242482B1 (en) 1995-09-06
PL150925B1 (en) 1990-07-31
KR940010033B1 (ko) 1994-10-21
GR3018105T3 (en) 1996-02-29
JPS62181279A (ja) 1987-08-08
DK166823B1 (da) 1993-07-19
NO166226C (no) 1991-06-19
PL272032A1 (en) 1989-01-05
PL150841B1 (en) 1990-07-31
FI865075A0 (fi) 1986-12-12
MA20828A1 (fr) 1987-07-01
PT83911A (en) 1987-01-01
PL262930A1 (en) 1988-09-01
JPH085886B2 (ja) 1996-01-24
DE3650384D1 (de) 1995-10-12

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