GR3018105T3 - Antiviral purine derivatives and process for their preparation. - Google Patents

Antiviral purine derivatives and process for their preparation.

Info

Publication number
GR3018105T3
GR3018105T3 GR950403221T GR950403221T GR3018105T3 GR 3018105 T3 GR3018105 T3 GR 3018105T3 GR 950403221 T GR950403221 T GR 950403221T GR 950403221 T GR950403221 T GR 950403221T GR 3018105 T3 GR3018105 T3 GR 3018105T3
Authority
GR
Greece
Prior art keywords
hydrogen
ch2oh
preparation
alkyl
phenyl
Prior art date
Application number
GR950403221T
Other languages
English (en)
Inventor
Michael Raymond Harnden
Paul Graham Wyatt
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858530813A external-priority patent/GB8530813D0/en
Priority claimed from GB868603228A external-priority patent/GB8603228D0/en
Priority claimed from GB868620849A external-priority patent/GB8620849D0/en
Priority claimed from GB868626041A external-priority patent/GB8626041D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of GR3018105T3 publication Critical patent/GR3018105T3/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50Three nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Sub-Exchange Stations And Push- Button Telephones (AREA)
  • Jib Cranes (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Nonmetallic Welding Materials (AREA)
  • General Factory Administration (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GR950403221T 1985-12-13 1995-11-16 Antiviral purine derivatives and process for their preparation. GR3018105T3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB858530813A GB8530813D0 (en) 1985-12-13 1985-12-13 Compounds
GB868603228A GB8603228D0 (en) 1986-02-10 1986-02-10 Compounds
GB868620849A GB8620849D0 (en) 1986-08-28 1986-08-28 Compounds
GB868626041A GB8626041D0 (en) 1986-10-31 1986-10-31 Compounds

Publications (1)

Publication Number Publication Date
GR3018105T3 true GR3018105T3 (en) 1996-02-29

Family

ID=27449713

Family Applications (1)

Application Number Title Priority Date Filing Date
GR950403221T GR3018105T3 (en) 1985-12-13 1995-11-16 Antiviral purine derivatives and process for their preparation.

Country Status (19)

Country Link
EP (1) EP0242482B1 (el)
JP (1) JPH085886B2 (el)
KR (1) KR940010033B1 (el)
AT (1) ATE127466T1 (el)
AU (1) AU599066B2 (el)
CA (1) CA1296726C (el)
DE (1) DE3650384T2 (el)
DK (1) DK166823B1 (el)
ES (1) ES2076139T3 (el)
FI (1) FI85143C (el)
GR (1) GR3018105T3 (el)
HU (1) HU200461B (el)
IL (1) IL80947A (el)
MA (1) MA20828A1 (el)
MY (1) MY101126A (el)
NO (1) NO166226C (el)
NZ (1) NZ218598A (el)
PL (3) PL150841B1 (el)
PT (1) PT83911B (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8602346D0 (en) * 1986-01-30 1986-03-05 Wellcome Found Antiviral combinations
GB8712744D0 (en) * 1987-05-30 1987-07-01 Beecham Group Plc Active compounds
GB8713695D0 (en) * 1987-06-11 1987-07-15 Beecham Group Plc Process
US4965270A (en) * 1987-05-30 1990-10-23 Beecham Group P.L.C. Purine derivatives
GB8724765D0 (en) * 1987-10-22 1987-11-25 Beecham Group Plc Process
SE8801729D0 (sv) * 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
EP0353955A3 (en) * 1988-08-02 1991-08-14 Beecham Group Plc Novel compounds
DK135489D0 (da) * 1989-03-20 1989-03-20 Gea Farmaceutisk Fabrik As Fremgangsmaade til fremstilling af 9-substituerede guaninderivater og mellemprodukter til brug ved fremgangsmaaden
GB8907173D0 (en) * 1989-03-30 1989-05-10 Beecham Group Plc Novel compounds
GB8912043D0 (en) * 1989-05-25 1989-07-12 Beecham Group Plc Novel compounds
GB8918827D0 (en) * 1989-08-17 1989-09-27 Beecham Group Plc Novel compounds
US5252575A (en) * 1989-08-17 1993-10-12 Beecham Group P.L.C. Antiviral purine derivatives with improved gastrointestinal absorption
GB9107896D0 (en) * 1991-04-13 1991-05-29 Smithkline Beecham Plc Pharmaceuticals
JP2720681B2 (ja) * 1992-01-06 1998-03-04 株式会社村田製作所 移動体の移動検出装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
DE3376326D1 (en) * 1982-10-14 1988-05-26 Wellcome Found Antiviral purine derivatives
PT78769A (en) * 1983-06-24 1984-07-01 Merck & Co Inc Process for preparing (s)-9-(2,3-dihydroxy-1-propoxymethyl)guanine and derivatives thereof useful as antiviral agents
ES8705889A1 (es) * 1984-12-12 1987-06-01 Syntex Inc Un metodo para preparar eteres alcaximetilicos y esteres alcoximetilicos de derivados de guananina.

Also Published As

Publication number Publication date
IL80947A (en) 1990-01-18
HU200461B (en) 1990-06-28
DK595886A (da) 1987-06-14
NZ218598A (en) 1990-10-26
NO166226C (no) 1991-06-19
PL150841B1 (en) 1990-07-31
ES2076139T3 (es) 1995-11-01
PL272032A1 (en) 1989-01-05
PT83911A (en) 1987-01-01
MA20828A1 (fr) 1987-07-01
PL150925B1 (en) 1990-07-31
EP0242482A2 (en) 1987-10-28
JPH085886B2 (ja) 1996-01-24
FI85143C (fi) 1992-03-10
PL272031A1 (en) 1989-01-05
EP0242482A3 (en) 1989-02-08
FI85143B (fi) 1991-11-29
FI865075A0 (fi) 1986-12-12
NO166226B (no) 1991-03-11
FI865075A (fi) 1987-06-14
AU6644386A (en) 1987-06-18
DK595886D0 (da) 1986-12-11
ATE127466T1 (de) 1995-09-15
MY101126A (en) 1991-07-31
JPS62181279A (ja) 1987-08-08
HUT43069A (en) 1987-09-28
DK166823B1 (da) 1993-07-19
EP0242482B1 (en) 1995-09-06
PL262930A1 (en) 1988-09-01
KR880005129A (ko) 1988-06-28
NO865014D0 (no) 1986-12-11
DE3650384D1 (de) 1995-10-12
CA1296726C (en) 1992-03-03
NO865014L (no) 1987-06-15
AU599066B2 (en) 1990-07-12
KR940010033B1 (ko) 1994-10-21
PT83911B (pt) 1989-05-12
DE3650384T2 (de) 1996-06-13
PL150926B1 (en) 1990-07-31

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