ES2069285T3 - Nuevo metodo para la preparacion de derivados del acido benzoico. - Google Patents
Nuevo metodo para la preparacion de derivados del acido benzoico.Info
- Publication number
- ES2069285T3 ES2069285T3 ES91906248T ES91906248T ES2069285T3 ES 2069285 T3 ES2069285 T3 ES 2069285T3 ES 91906248 T ES91906248 T ES 91906248T ES 91906248 T ES91906248 T ES 91906248T ES 2069285 T3 ES2069285 T3 ES 2069285T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- benzoic acid
- formula
- preparation
- acid derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Developing Agents For Electrophotography (AREA)
- Paper (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7143390 | 1990-03-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2069285T3 true ES2069285T3 (es) | 1995-05-01 |
Family
ID=13460393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91906248T Expired - Lifetime ES2069285T3 (es) | 1990-03-20 | 1991-03-15 | Nuevo metodo para la preparacion de derivados del acido benzoico. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5214202A (de) |
EP (1) | EP0478787B1 (de) |
JP (2) | JP3001632B2 (de) |
KR (1) | KR960014911B1 (de) |
AT (1) | ATE115946T1 (de) |
AU (1) | AU628732B2 (de) |
DE (1) | DE69106098T2 (de) |
DK (1) | DK0478787T3 (de) |
ES (1) | ES2069285T3 (de) |
FI (1) | FI915445A0 (de) |
GR (1) | GR3015138T3 (de) |
HU (2) | HU210300B (de) |
NO (1) | NO300206B1 (de) |
WO (1) | WO1991014673A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5264578A (en) | 1987-03-20 | 1993-11-23 | Allergan, Inc. | Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity |
US5648514A (en) | 1994-12-29 | 1997-07-15 | Allergan | Substituted acetylenes having retinoid-like biological activity |
US5534641A (en) | 1994-12-29 | 1996-07-09 | Allergan | Acetylenes disubstituted with 2-tetrahydropyranoxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
US5675033A (en) | 1995-06-06 | 1997-10-07 | Allergan | 2,4-pentadienoic acid derivatives having retinoid-like biological activity |
US5917082A (en) | 1995-06-06 | 1999-06-29 | Allergan Sales, Inc. | 2,4-pentadienoic acid derivatives having retinoid-like biological activity |
US6218128B1 (en) | 1997-09-12 | 2001-04-17 | Allergan Sales, Inc. | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities |
US5776699A (en) * | 1995-09-01 | 1998-07-07 | Allergan, Inc. | Method of identifying negative hormone and/or antagonist activities |
US5958954A (en) | 1995-09-01 | 1999-09-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US6008204A (en) | 1995-09-01 | 1999-12-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US5952345A (en) | 1995-09-01 | 1999-09-14 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US5675024A (en) | 1995-11-22 | 1997-10-07 | Allergan | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity |
US5763635A (en) | 1996-06-21 | 1998-06-09 | Allergan | Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity |
US5741896A (en) | 1996-06-21 | 1998-04-21 | Allergan | O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5773594A (en) | 1996-06-21 | 1998-06-30 | Allergan | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US6555690B2 (en) | 1996-06-21 | 2003-04-29 | Allergan, Inc. | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5728846A (en) | 1996-12-12 | 1998-03-17 | Allergan | Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives |
US6037488A (en) | 1997-04-19 | 2000-03-14 | Allergan Sales, Inc. | Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity |
US5919970A (en) | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
DE60143166D1 (de) | 2000-09-01 | 2010-11-11 | Toko Pharmaceutical Ind Co Ltd | Verfahren zur herstellung von kristallen von benzoesäure-derivaten |
US6620963B1 (en) | 2002-09-19 | 2003-09-16 | Allergan, Inc. | TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-PHENYL AND TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-HETEROARYL AND RELATED COMPOUNDS HAVING RARα RECEPTOR SELECTIVE BIOLOGICAL ACTIVITY |
US6727277B1 (en) | 2002-11-12 | 2004-04-27 | Kansas State University Research Foundation | Compounds affecting cholesterol absorption |
CN101200435B (zh) * | 2006-12-12 | 2011-12-07 | 江苏恒瑞医药股份有限公司 | 他米巴罗汀ⅱ型结晶的制备方法 |
WO2008120711A1 (ja) | 2007-03-30 | 2008-10-09 | Tmrc Co., Ltd. | タミバロテンカプセル剤 |
WO2009114966A1 (zh) * | 2008-03-19 | 2009-09-24 | 江苏恒瑞医药股份有限公司 | 他米巴罗汀ii型结晶的制备方法 |
CN101665449B (zh) * | 2009-09-24 | 2012-12-12 | 山东大学 | 他米巴罗汀的水溶性前药及其制备方法与应用 |
CN102633673A (zh) * | 2012-03-30 | 2012-08-15 | 上海共价化学科技有限公司 | 他米巴罗汀的合成方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2500157C2 (de) * | 1975-01-03 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung |
US4227014A (en) * | 1978-02-27 | 1980-10-07 | American Cyanamid Company | 4-[(Cycloalkyl or cycloalkenyl substituted)amino, alkylamino or alkenylamino]benzoic acids and salts thereof |
DK214679A (da) * | 1978-06-09 | 1979-12-10 | Chugai Pharmaceutical Co Ltd | Terephthalsyremonoamid derivater fremgangsmaade til deres fremstilling samt antiallergiske midler indeholdende disse |
JPS6176440A (ja) * | 1984-09-19 | 1986-04-18 | Koichi Shiyudo | 安息香酸誘導体 |
US4808631A (en) * | 1986-11-07 | 1989-02-28 | Hoffmann-La Roche Inc. | Aromatic acid derivatives |
US4989090A (en) * | 1989-04-05 | 1991-01-29 | Yves C. Faroudja | Television scan line doubler including temporal median filter |
-
1991
- 1991-03-15 DK DK91906248.9T patent/DK0478787T3/da active
- 1991-03-15 ES ES91906248T patent/ES2069285T3/es not_active Expired - Lifetime
- 1991-03-15 DE DE69106098T patent/DE69106098T2/de not_active Expired - Lifetime
- 1991-03-15 WO PCT/JP1991/000350 patent/WO1991014673A1/ja active IP Right Grant
- 1991-03-15 JP JP3505852A patent/JP3001632B2/ja not_active Expired - Lifetime
- 1991-03-15 AU AU74826/91A patent/AU628732B2/en not_active Ceased
- 1991-03-15 EP EP91906248A patent/EP0478787B1/de not_active Expired - Lifetime
- 1991-03-15 HU HU9202856A patent/HU210300B/hu not_active IP Right Cessation
- 1991-03-15 AT AT91906248T patent/ATE115946T1/de not_active IP Right Cessation
- 1991-03-15 KR KR1019910701646A patent/KR960014911B1/ko not_active IP Right Cessation
- 1991-03-15 US US07/778,985 patent/US5214202A/en not_active Expired - Lifetime
- 1991-03-15 HU HU913801A patent/HU208417B/hu not_active IP Right Cessation
- 1991-11-18 FI FI915445A patent/FI915445A0/fi unknown
- 1991-11-19 NO NO914519A patent/NO300206B1/no not_active IP Right Cessation
-
1995
- 1995-02-22 GR GR950400358T patent/GR3015138T3/el unknown
-
1999
- 1999-07-16 JP JP11203717A patent/JP3076569B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
NO914519L (no) | 1992-01-07 |
HU208417B (en) | 1993-10-28 |
KR960014911B1 (ko) | 1996-10-21 |
HUT61272A (en) | 1992-12-28 |
EP0478787A1 (de) | 1992-04-08 |
HU913801D0 (en) | 1992-07-28 |
NO300206B1 (no) | 1997-04-28 |
HUT61270A (en) | 1992-12-28 |
DE69106098D1 (de) | 1995-02-02 |
US5214202A (en) | 1993-05-25 |
GR3015138T3 (en) | 1995-05-31 |
KR920702342A (ko) | 1992-09-03 |
HU9202856D0 (en) | 1992-11-30 |
EP0478787B1 (de) | 1994-12-21 |
JP2000034262A (ja) | 2000-02-02 |
FI915445A0 (fi) | 1991-11-18 |
JP3076569B2 (ja) | 2000-08-14 |
ATE115946T1 (de) | 1995-01-15 |
NO914519D0 (no) | 1991-11-19 |
EP0478787A4 (en) | 1992-07-01 |
DK0478787T3 (da) | 1995-02-20 |
HU210300B (en) | 1995-03-28 |
DE69106098T2 (de) | 1995-05-24 |
WO1991014673A1 (en) | 1991-10-03 |
JP3001632B2 (ja) | 2000-01-24 |
AU628732B2 (en) | 1992-09-17 |
AU7482691A (en) | 1991-10-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2069285T3 (es) | Nuevo metodo para la preparacion de derivados del acido benzoico. | |
US5387594A (en) | Di(aromatic) compounds and their use in human and veterinary medicine and in cosmetics | |
FR2365586A1 (fr) | Derives de la 4-n-acylfortimicine b et procede de transformation chimique de la fortimicine b en fortimicine a | |
ES2148184T3 (es) | Utilizacion del acido 9-cis retinoico, sus sales y esteres, para el tratamiento de tumores epiteliales. | |
US5798354A (en) | Use of adamantyl-substituted polycyclic acetylene compounds in skin and hair treatment | |
Field | Grignard Reagents of Sulfones. I. Preparation and Reactions of β-Phenyl-β-hydroxyethyl Phenyl Sulfone1 | |
EA001060B1 (ru) | Диароматические соединения пропинила или диенила, промежуточные соединения, фармацевтические и косметические композиции на основе указанных соединений и применение косметических композиций | |
US5332856A (en) | Bi-aromatic esters, a process for their preparation and their use in human or veterinary medicine and in cosmetic compositions | |
ES2089733T3 (es) | Proceso para preparar esteres y amidas de acidos grasos de sales de acido sulfonico. | |
ES2172549T3 (es) | Nuevas sales por adicion de acidos de cefem, cristalinas, y procedimiento para su preparacion. | |
NO882614D0 (no) | Anvendelse av jordalkalisater av eterkarboksylsyrer som katalysatorer for alkoksylering. | |
PT666252E (pt) | Guanidinas de acidos alquilcarboxilicos substituidas com grupos fenilo possuindo grupos perfluoroalquilo processo para a sua preparacao sua utilizacao como medicamento ou meio de diagnostico bem como medicamento que as contem | |
US4421927A (en) | New cinnamoyl-cinnamic acid derivative, and its use as pharmaceutical | |
BRPI0620667A2 (pt) | composto bifenìlico, composição farmaceutica, composição cosmética, uso de um composto e processo de preparação de um composto | |
US2383074A (en) | Alkamine derivatives of o-alkoxymethyl benzoic acid | |
MX9401260A (es) | COMPUESTO DE BIBENZOATO DE BIS-ß-HIDROXIETILO. | |
US3042709A (en) | Esterification of naphthalene dicarboxylic acids | |
JPH061752A (ja) | アリールアクリル酸類及びそれらのエステル類の製造方法 | |
US4845270A (en) | Propanone 1,3-disulfonic acid as an esterification catalyst | |
ES545080A0 (es) | Procedimiento para la obtencion de arilacetatos halogenados | |
ES445148A1 (es) | Procedimiento de preparacion de nuevos dervados tiazolicos. | |
JPS5535056A (en) | 3-substituted acetophenone and its preparation | |
MX168945B (es) | Proceso novedoso para la preparacion de carbamatos o diuretanos alifaticos | |
DE2126785A1 (de) | ||
GB779322A (en) | 2-benzenesulphonamido pyrimidines and their production |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 478787 Country of ref document: ES |