FR2365586A1 - Derives de la 4-n-acylfortimicine b et procede de transformation chimique de la fortimicine b en fortimicine a - Google Patents
Derives de la 4-n-acylfortimicine b et procede de transformation chimique de la fortimicine b en fortimicine aInfo
- Publication number
- FR2365586A1 FR2365586A1 FR7728633A FR7728633A FR2365586A1 FR 2365586 A1 FR2365586 A1 FR 2365586A1 FR 7728633 A FR7728633 A FR 7728633A FR 7728633 A FR7728633 A FR 7728633A FR 2365586 A1 FR2365586 A1 FR 2365586A1
- Authority
- FR
- France
- Prior art keywords
- fortimicin
- derivatives
- acylfortimicin
- chemical transformation
- transformation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Dérivés de la 4-N-acylfortimicine B et procédé de transfor mation chimique de la fortimicine B en fortimicine A. Ces dérivés ont comme formule :
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/725,829 US4091032A (en) | 1976-09-23 | 1976-09-23 | 4-N-acylfortimicin B derivatives and the chemical conversion of fortimicin B to fortimicin A |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2365586A1 true FR2365586A1 (fr) | 1978-04-21 |
FR2365586B1 FR2365586B1 (fr) | 1982-12-17 |
Family
ID=24916124
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7728633A Granted FR2365586A1 (fr) | 1976-09-23 | 1977-09-22 | Derives de la 4-n-acylfortimicine b et procede de transformation chimique de la fortimicine b en fortimicine a |
Country Status (17)
Country | Link |
---|---|
US (2) | US4091032A (fr) |
JP (1) | JPS5368752A (fr) |
AR (1) | AR224722A1 (fr) |
AU (1) | AU519064B2 (fr) |
BE (1) | BE859012A (fr) |
CA (1) | CA1114809A (fr) |
DE (1) | DE2742949C2 (fr) |
DK (1) | DK419877A (fr) |
ES (2) | ES462566A1 (fr) |
FR (1) | FR2365586A1 (fr) |
GB (2) | GB1591606A (fr) |
GR (1) | GR63596B (fr) |
NO (1) | NO773256L (fr) |
NZ (1) | NZ185239A (fr) |
PH (1) | PH16052A (fr) |
SE (1) | SE7710683L (fr) |
ZA (2) | ZA775652B (fr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ185515A (en) * | 1976-10-28 | 1980-08-26 | Abbott Lab | Fortimicin d and ke from culturing micromonospora olivoasterospora |
JPS5466679A (en) * | 1977-11-07 | 1979-05-29 | Kyowa Hakko Kogyo Co Ltd | Novel antibiotic substance fortimicin kf and fortimicin kg, and their preparation |
US4214075A (en) * | 1977-12-21 | 1980-07-22 | Abbott Laboratories | 6'-Epi-fortimicin A and B derivatives |
JPS6041679B2 (ja) * | 1978-03-03 | 1985-09-18 | 協和醗酵工業株式会社 | 新抗生物質ホ−テイマイシンkg↓1,kg↓2およびkg↓3ならびにそれらの製造法 |
US4234717A (en) * | 1978-03-30 | 1980-11-18 | American Cyanamid Company | Antibacterial antibiotic BM782 |
US4208407A (en) * | 1979-02-05 | 1980-06-17 | Abbott Laboratories | 5-Deoxyfortimicin A, 2,5-dideoxyfortimicin A and the corresponding 4-N-acyl and alkyl fortimicin B derivatives thereof and intermediates therefor |
US4207415A (en) * | 1979-02-05 | 1980-06-10 | Abbott Laboratories | Method of producing 2-deoxyfortimicin A |
US4214078A (en) * | 1979-03-29 | 1980-07-22 | Abbott Laboratories | Fortimicin AL |
US4213972A (en) * | 1979-03-29 | 1980-07-22 | Abbott Laboratories | 4-N, 2'-N and 4,2'Di-N-fortimicins AH and AI |
BE882501A (fr) * | 1979-03-29 | 1980-09-29 | Abbott Lab | 2-epifortimicine a et derives, et leurs applications therapeutiques |
US4213974A (en) * | 1979-03-29 | 1980-07-22 | Abbott Laboratories | 4-N,2'-N and 4,2'-Di-N-fortimicin AO derivatives |
US4216210A (en) * | 1979-03-29 | 1980-08-05 | Abbott Laboratories | Fortimicins AM and AP derivatives |
US4293689A (en) * | 1979-03-29 | 1981-10-06 | Abbott Laboratories | Method of producing 3-O-demethylfortimicin B from fortimicin AN |
US4331804A (en) * | 1979-03-29 | 1982-05-25 | Abbott Laboratories | 2-Epi-fortimicin A and derivatives |
US4213971A (en) * | 1979-03-29 | 1980-07-22 | Abbott Laboratories | 4-N, 2'-N and 4,2'-Di-N-fortimicin AD derivatives |
US4214079A (en) * | 1979-03-29 | 1980-07-22 | Abbott Laboratories | 4-N, 2'-N and 4,2'-Di-N-fortimicin AL derivatives |
US4218442A (en) * | 1979-03-29 | 1980-08-19 | Abbott Laboratories | 1-Epi-fortimicin A and derivatives |
US4219643A (en) * | 1979-03-29 | 1980-08-26 | Abbott Laboratories | Fortimicin AN |
US4226979A (en) * | 1979-03-29 | 1980-10-07 | Abbott Laboratories | Fortimicin AK |
US4219644A (en) * | 1979-03-29 | 1980-08-26 | Abbott Laboratories | Fortimicins AH and AI |
US4219642A (en) * | 1979-03-29 | 1980-08-26 | Abbott Laboratories | Fortimicin AO |
US4214080A (en) * | 1979-03-29 | 1980-07-22 | Abbott Laboratories | Fortimicins AM and AP |
US4275193A (en) * | 1979-09-26 | 1981-06-23 | Abbott Laboratories | 4,5-Carbamates of fortimicin B |
US4263429A (en) * | 1979-09-26 | 1981-04-21 | Abbott Laboratories | 1,2,6-Tri-N-benzyloxycarbonylfortimicin B-4,5-carbamate and 1,2,6-tri-N-acetylfortimicin B-4,5-carbamate |
US4431799A (en) * | 1979-09-26 | 1984-02-14 | Abbott Laboratories | 6'-Modified fortimicin compounds |
US4230846A (en) * | 1979-09-26 | 1980-10-28 | Abbott Laboratories | 1,5-Carbamates of fortimicin B and derivatives |
US4273925A (en) * | 1979-09-26 | 1981-06-16 | Abbott Laboratories | 1,2-Modified fortimicins A and B, intermediates therefor and method for their manufacture |
US4269970A (en) * | 1979-09-26 | 1981-05-26 | Abbott Laboratories | 1,2-Carbamates of fortimicin B and derivatives |
US4232147A (en) * | 1979-09-26 | 1980-11-04 | Abbott Laboratories | 4-N-Acylfortimicin B-1,5-carbamates |
US4252972A (en) * | 1979-09-26 | 1981-02-24 | Abbott Laboratories | Fortimicin B-1,2:4,5-bis-carbamates |
US4340727A (en) * | 1979-09-26 | 1982-07-20 | Abbott Laboratories | 1,2-Modified fortimicins A and B, intermediates therefor and method for their manufacture |
US4382926A (en) * | 1980-04-01 | 1983-05-10 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Formimidoyl A and B useful as semi-synthetic aminoglycosidic antibiotics |
US4338308A (en) * | 1980-11-10 | 1982-07-06 | Abbott Laboratories | 4-N-β-Lysyl-2'-N-des-β-lysyl antibiotic AX-127B-1 and the pharmaceutically acceptable salts thereof |
US4338309A (en) * | 1980-11-10 | 1982-07-06 | Abbott Laboratories | 4',5'-Dihydro-antibiotic AX-127B-1; 2'-N-des-β-lysyl-4',5'-dihydro-antibiotic AX-127B-1; and 4-N-derivatives thereof |
US4338307A (en) * | 1980-11-10 | 1982-07-06 | Abbott Laboratories | 2'-N-Des-β-lysyl antibiotic AX-127B-1 and 4-N-acyl and alkyl derivatives thereof |
IE54288B1 (en) * | 1982-03-05 | 1989-08-16 | Fujisawa Pharmaceutical Co | New 1,4-diaminocyclitol derivatives, processes for their preparation and pharmaceutical compositions containing them |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2226159A1 (fr) * | 1973-04-17 | 1974-11-15 | Kyowa Hakko Kogyo Kk |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3931400A (en) * | 1973-04-17 | 1976-01-06 | Abbott Laboratories | Fortimicin B and process for production thereof |
JPS5145675B2 (fr) * | 1973-07-23 | 1976-12-04 | ||
JPS50145588A (fr) * | 1974-05-16 | 1975-11-21 |
-
1976
- 1976-09-23 US US05/725,829 patent/US4091032A/en not_active Expired - Lifetime
-
1977
- 1977-09-20 GR GR54390A patent/GR63596B/el unknown
- 1977-09-20 CA CA287,098A patent/CA1114809A/fr not_active Expired
- 1977-09-21 ZA ZA00775652A patent/ZA775652B/xx unknown
- 1977-09-21 ZA ZA00775651A patent/ZA775651B/xx unknown
- 1977-09-22 FR FR7728633A patent/FR2365586A1/fr active Granted
- 1977-09-22 NO NO773256A patent/NO773256L/no unknown
- 1977-09-22 DK DK419877A patent/DK419877A/da not_active Application Discontinuation
- 1977-09-22 GB GB4211/79A patent/GB1591606A/en not_active Expired
- 1977-09-22 ES ES462566A patent/ES462566A1/es not_active Expired
- 1977-09-22 JP JP11453277A patent/JPS5368752A/ja active Pending
- 1977-09-22 AU AU29025/77A patent/AU519064B2/en not_active Expired
- 1977-09-22 GB GB39568/77A patent/GB1591320A/en not_active Expired
- 1977-09-22 NZ NZ185239A patent/NZ185239A/xx unknown
- 1977-09-23 DE DE2742949A patent/DE2742949C2/de not_active Expired
- 1977-09-23 AR AR269316A patent/AR224722A1/es active
- 1977-09-23 SE SE7710683A patent/SE7710683L/xx not_active Application Discontinuation
- 1977-09-23 BE BE181169A patent/BE859012A/fr unknown
-
1978
- 1978-03-20 US US05/888,085 patent/US4155902A/en not_active Expired - Lifetime
- 1978-08-16 ES ES472608A patent/ES472608A1/es not_active Expired
-
1980
- 1980-09-25 PH PH24630A patent/PH16052A/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2226159A1 (fr) * | 1973-04-17 | 1974-11-15 | Kyowa Hakko Kogyo Kk |
Non-Patent Citations (1)
Title |
---|
EXBK/77 * |
Also Published As
Publication number | Publication date |
---|---|
ES472608A1 (es) | 1979-02-16 |
NZ185239A (en) | 1980-08-26 |
ES462566A1 (es) | 1978-11-16 |
AU2902577A (en) | 1979-03-29 |
ZA775652B (en) | 1979-04-25 |
SE7710683L (sv) | 1978-03-24 |
BE859012A (fr) | 1978-03-23 |
AR224722A1 (es) | 1982-01-15 |
GB1591320A (en) | 1981-06-17 |
JPS5368752A (en) | 1978-06-19 |
US4155902A (en) | 1979-05-22 |
DE2742949C2 (de) | 1983-08-04 |
AU519064B2 (en) | 1981-11-05 |
ZA775651B (en) | 1979-07-25 |
US4091032A (en) | 1978-05-23 |
FR2365586B1 (fr) | 1982-12-17 |
GB1591606A (en) | 1981-06-24 |
DE2742949A1 (de) | 1978-03-30 |
CA1114809A (fr) | 1981-12-22 |
PH16052A (en) | 1983-06-02 |
GR63596B (en) | 1979-11-26 |
NO773256L (no) | 1978-03-29 |
DK419877A (da) | 1978-03-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |