ES472608A1 - Un procedimiento de preparacion de derivados de 4-n-acilo- fortimicina b - Google Patents
Un procedimiento de preparacion de derivados de 4-n-acilo- fortimicina bInfo
- Publication number
- ES472608A1 ES472608A1 ES472608A ES472608A ES472608A1 ES 472608 A1 ES472608 A1 ES 472608A1 ES 472608 A ES472608 A ES 472608A ES 472608 A ES472608 A ES 472608A ES 472608 A1 ES472608 A1 ES 472608A1
- Authority
- ES
- Spain
- Prior art keywords
- fortimicin
- acylfortimicin
- derivatives
- chemical conversion
- aminoacyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de 4-N-acilfortimicina B de estructura **(Fórmula)** donde R es acilo, aminoacilo, N-monoalquil(inferior)aminoacilo, N,N-dialquil(inferior)aminoacilo, hidroxi-aminoacilo sustituido o aminoacilo sustituido de fórmula O=C-CH2NHR1 donde R1 es un radical acilo derivado de un aminoácido o de un péptido corto, y sus sales farmacéuticamente aceptables. Los compuestos son útiles como intermediarios en la preparación de derivados de 4-N-alquil (o alquil sustituido) fortimicina B. Además de su utilidad como intermediarios, algunos de los compuestos de esta invención también son útiles como agentes antimicrobianos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/725,829 US4091032A (en) | 1976-09-23 | 1976-09-23 | 4-N-acylfortimicin B derivatives and the chemical conversion of fortimicin B to fortimicin A |
Publications (1)
Publication Number | Publication Date |
---|---|
ES472608A1 true ES472608A1 (es) | 1979-02-16 |
Family
ID=24916124
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES462566A Expired ES462566A1 (es) | 1976-09-23 | 1977-09-22 | Un procedimiento de preparacion de derivados de 4-n-acilfor-timicina b. |
ES472608A Expired ES472608A1 (es) | 1976-09-23 | 1978-08-16 | Un procedimiento de preparacion de derivados de 4-n-acilo- fortimicina b |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES462566A Expired ES462566A1 (es) | 1976-09-23 | 1977-09-22 | Un procedimiento de preparacion de derivados de 4-n-acilfor-timicina b. |
Country Status (17)
Country | Link |
---|---|
US (2) | US4091032A (es) |
JP (1) | JPS5368752A (es) |
AR (1) | AR224722A1 (es) |
AU (1) | AU519064B2 (es) |
BE (1) | BE859012A (es) |
CA (1) | CA1114809A (es) |
DE (1) | DE2742949C2 (es) |
DK (1) | DK419877A (es) |
ES (2) | ES462566A1 (es) |
FR (1) | FR2365586A1 (es) |
GB (2) | GB1591606A (es) |
GR (1) | GR63596B (es) |
NO (1) | NO773256L (es) |
NZ (1) | NZ185239A (es) |
PH (1) | PH16052A (es) |
SE (1) | SE7710683L (es) |
ZA (2) | ZA775652B (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ185515A (en) * | 1976-10-28 | 1980-08-26 | Abbott Lab | Fortimicin d and ke from culturing micromonospora olivoasterospora |
JPS5466679A (en) * | 1977-11-07 | 1979-05-29 | Kyowa Hakko Kogyo Co Ltd | Novel antibiotic substance fortimicin kf and fortimicin kg, and their preparation |
US4214075A (en) * | 1977-12-21 | 1980-07-22 | Abbott Laboratories | 6'-Epi-fortimicin A and B derivatives |
JPS6041679B2 (ja) * | 1978-03-03 | 1985-09-18 | 協和醗酵工業株式会社 | 新抗生物質ホ−テイマイシンkg↓1,kg↓2およびkg↓3ならびにそれらの製造法 |
US4234717A (en) * | 1978-03-30 | 1980-11-18 | American Cyanamid Company | Antibacterial antibiotic BM782 |
US4208407A (en) * | 1979-02-05 | 1980-06-17 | Abbott Laboratories | 5-Deoxyfortimicin A, 2,5-dideoxyfortimicin A and the corresponding 4-N-acyl and alkyl fortimicin B derivatives thereof and intermediates therefor |
US4207415A (en) * | 1979-02-05 | 1980-06-10 | Abbott Laboratories | Method of producing 2-deoxyfortimicin A |
US4214078A (en) * | 1979-03-29 | 1980-07-22 | Abbott Laboratories | Fortimicin AL |
US4213972A (en) * | 1979-03-29 | 1980-07-22 | Abbott Laboratories | 4-N, 2'-N and 4,2'Di-N-fortimicins AH and AI |
BE882501A (fr) * | 1979-03-29 | 1980-09-29 | Abbott Lab | 2-epifortimicine a et derives, et leurs applications therapeutiques |
US4213974A (en) * | 1979-03-29 | 1980-07-22 | Abbott Laboratories | 4-N,2'-N and 4,2'-Di-N-fortimicin AO derivatives |
US4216210A (en) * | 1979-03-29 | 1980-08-05 | Abbott Laboratories | Fortimicins AM and AP derivatives |
US4293689A (en) * | 1979-03-29 | 1981-10-06 | Abbott Laboratories | Method of producing 3-O-demethylfortimicin B from fortimicin AN |
US4331804A (en) * | 1979-03-29 | 1982-05-25 | Abbott Laboratories | 2-Epi-fortimicin A and derivatives |
US4213971A (en) * | 1979-03-29 | 1980-07-22 | Abbott Laboratories | 4-N, 2'-N and 4,2'-Di-N-fortimicin AD derivatives |
US4214079A (en) * | 1979-03-29 | 1980-07-22 | Abbott Laboratories | 4-N, 2'-N and 4,2'-Di-N-fortimicin AL derivatives |
US4218442A (en) * | 1979-03-29 | 1980-08-19 | Abbott Laboratories | 1-Epi-fortimicin A and derivatives |
US4219643A (en) * | 1979-03-29 | 1980-08-26 | Abbott Laboratories | Fortimicin AN |
US4226979A (en) * | 1979-03-29 | 1980-10-07 | Abbott Laboratories | Fortimicin AK |
US4219644A (en) * | 1979-03-29 | 1980-08-26 | Abbott Laboratories | Fortimicins AH and AI |
US4219642A (en) * | 1979-03-29 | 1980-08-26 | Abbott Laboratories | Fortimicin AO |
US4214080A (en) * | 1979-03-29 | 1980-07-22 | Abbott Laboratories | Fortimicins AM and AP |
US4275193A (en) * | 1979-09-26 | 1981-06-23 | Abbott Laboratories | 4,5-Carbamates of fortimicin B |
US4263429A (en) * | 1979-09-26 | 1981-04-21 | Abbott Laboratories | 1,2,6-Tri-N-benzyloxycarbonylfortimicin B-4,5-carbamate and 1,2,6-tri-N-acetylfortimicin B-4,5-carbamate |
US4431799A (en) * | 1979-09-26 | 1984-02-14 | Abbott Laboratories | 6'-Modified fortimicin compounds |
US4230846A (en) * | 1979-09-26 | 1980-10-28 | Abbott Laboratories | 1,5-Carbamates of fortimicin B and derivatives |
US4273925A (en) * | 1979-09-26 | 1981-06-16 | Abbott Laboratories | 1,2-Modified fortimicins A and B, intermediates therefor and method for their manufacture |
US4269970A (en) * | 1979-09-26 | 1981-05-26 | Abbott Laboratories | 1,2-Carbamates of fortimicin B and derivatives |
US4232147A (en) * | 1979-09-26 | 1980-11-04 | Abbott Laboratories | 4-N-Acylfortimicin B-1,5-carbamates |
US4252972A (en) * | 1979-09-26 | 1981-02-24 | Abbott Laboratories | Fortimicin B-1,2:4,5-bis-carbamates |
US4340727A (en) * | 1979-09-26 | 1982-07-20 | Abbott Laboratories | 1,2-Modified fortimicins A and B, intermediates therefor and method for their manufacture |
US4382926A (en) * | 1980-04-01 | 1983-05-10 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Formimidoyl A and B useful as semi-synthetic aminoglycosidic antibiotics |
US4338308A (en) * | 1980-11-10 | 1982-07-06 | Abbott Laboratories | 4-N-β-Lysyl-2'-N-des-β-lysyl antibiotic AX-127B-1 and the pharmaceutically acceptable salts thereof |
US4338309A (en) * | 1980-11-10 | 1982-07-06 | Abbott Laboratories | 4',5'-Dihydro-antibiotic AX-127B-1; 2'-N-des-β-lysyl-4',5'-dihydro-antibiotic AX-127B-1; and 4-N-derivatives thereof |
US4338307A (en) * | 1980-11-10 | 1982-07-06 | Abbott Laboratories | 2'-N-Des-β-lysyl antibiotic AX-127B-1 and 4-N-acyl and alkyl derivatives thereof |
IE54288B1 (en) * | 1982-03-05 | 1989-08-16 | Fujisawa Pharmaceutical Co | New 1,4-diaminocyclitol derivatives, processes for their preparation and pharmaceutical compositions containing them |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3931400A (en) * | 1973-04-17 | 1976-01-06 | Abbott Laboratories | Fortimicin B and process for production thereof |
JPS5246311B2 (es) * | 1973-04-17 | 1977-11-24 | ||
JPS5145675B2 (es) * | 1973-07-23 | 1976-12-04 | ||
JPS50145588A (es) * | 1974-05-16 | 1975-11-21 |
-
1976
- 1976-09-23 US US05/725,829 patent/US4091032A/en not_active Expired - Lifetime
-
1977
- 1977-09-20 GR GR54390A patent/GR63596B/el unknown
- 1977-09-20 CA CA287,098A patent/CA1114809A/en not_active Expired
- 1977-09-21 ZA ZA00775652A patent/ZA775652B/xx unknown
- 1977-09-21 ZA ZA00775651A patent/ZA775651B/xx unknown
- 1977-09-22 FR FR7728633A patent/FR2365586A1/fr active Granted
- 1977-09-22 NO NO773256A patent/NO773256L/no unknown
- 1977-09-22 DK DK419877A patent/DK419877A/da not_active Application Discontinuation
- 1977-09-22 GB GB4211/79A patent/GB1591606A/en not_active Expired
- 1977-09-22 ES ES462566A patent/ES462566A1/es not_active Expired
- 1977-09-22 JP JP11453277A patent/JPS5368752A/ja active Pending
- 1977-09-22 AU AU29025/77A patent/AU519064B2/en not_active Expired
- 1977-09-22 GB GB39568/77A patent/GB1591320A/en not_active Expired
- 1977-09-22 NZ NZ185239A patent/NZ185239A/xx unknown
- 1977-09-23 DE DE2742949A patent/DE2742949C2/de not_active Expired
- 1977-09-23 AR AR269316A patent/AR224722A1/es active
- 1977-09-23 SE SE7710683A patent/SE7710683L/xx not_active Application Discontinuation
- 1977-09-23 BE BE181169A patent/BE859012A/xx unknown
-
1978
- 1978-03-20 US US05/888,085 patent/US4155902A/en not_active Expired - Lifetime
- 1978-08-16 ES ES472608A patent/ES472608A1/es not_active Expired
-
1980
- 1980-09-25 PH PH24630A patent/PH16052A/en unknown
Also Published As
Publication number | Publication date |
---|---|
NZ185239A (en) | 1980-08-26 |
ES462566A1 (es) | 1978-11-16 |
AU2902577A (en) | 1979-03-29 |
ZA775652B (en) | 1979-04-25 |
SE7710683L (sv) | 1978-03-24 |
BE859012A (fr) | 1978-03-23 |
AR224722A1 (es) | 1982-01-15 |
GB1591320A (en) | 1981-06-17 |
FR2365586A1 (fr) | 1978-04-21 |
JPS5368752A (en) | 1978-06-19 |
US4155902A (en) | 1979-05-22 |
DE2742949C2 (de) | 1983-08-04 |
AU519064B2 (en) | 1981-11-05 |
ZA775651B (en) | 1979-07-25 |
US4091032A (en) | 1978-05-23 |
FR2365586B1 (es) | 1982-12-17 |
GB1591606A (en) | 1981-06-24 |
DE2742949A1 (de) | 1978-03-30 |
CA1114809A (en) | 1981-12-22 |
PH16052A (en) | 1983-06-02 |
GR63596B (en) | 1979-11-26 |
NO773256L (no) | 1978-03-29 |
DK419877A (da) | 1978-03-24 |
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