ATE115946T1 - Neuer prozess zur herstellung eines benzoesäurederivates. - Google Patents
Neuer prozess zur herstellung eines benzoesäurederivates.Info
- Publication number
- ATE115946T1 ATE115946T1 AT91906248T AT91906248T ATE115946T1 AT E115946 T1 ATE115946 T1 AT E115946T1 AT 91906248 T AT91906248 T AT 91906248T AT 91906248 T AT91906248 T AT 91906248T AT E115946 T1 ATE115946 T1 AT E115946T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- benzoic acid
- formula
- producing
- acid derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7143390 | 1990-03-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE115946T1 true ATE115946T1 (de) | 1995-01-15 |
Family
ID=13460393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91906248T ATE115946T1 (de) | 1990-03-20 | 1991-03-15 | Neuer prozess zur herstellung eines benzoesäurederivates. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5214202A (de) |
EP (1) | EP0478787B1 (de) |
JP (2) | JP3001632B2 (de) |
KR (1) | KR960014911B1 (de) |
AT (1) | ATE115946T1 (de) |
AU (1) | AU628732B2 (de) |
DE (1) | DE69106098T2 (de) |
DK (1) | DK0478787T3 (de) |
ES (1) | ES2069285T3 (de) |
FI (1) | FI915445A0 (de) |
GR (1) | GR3015138T3 (de) |
HU (2) | HU210300B (de) |
NO (1) | NO300206B1 (de) |
WO (1) | WO1991014673A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5264578A (en) | 1987-03-20 | 1993-11-23 | Allergan, Inc. | Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity |
US5534641A (en) | 1994-12-29 | 1996-07-09 | Allergan | Acetylenes disubstituted with 2-tetrahydropyranoxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
US5648514A (en) | 1994-12-29 | 1997-07-15 | Allergan | Substituted acetylenes having retinoid-like biological activity |
US5675033A (en) | 1995-06-06 | 1997-10-07 | Allergan | 2,4-pentadienoic acid derivatives having retinoid-like biological activity |
US5917082A (en) | 1995-06-06 | 1999-06-29 | Allergan Sales, Inc. | 2,4-pentadienoic acid derivatives having retinoid-like biological activity |
US5776699A (en) * | 1995-09-01 | 1998-07-07 | Allergan, Inc. | Method of identifying negative hormone and/or antagonist activities |
US6218128B1 (en) | 1997-09-12 | 2001-04-17 | Allergan Sales, Inc. | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities |
US5958954A (en) | 1995-09-01 | 1999-09-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US6008204A (en) | 1995-09-01 | 1999-12-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US5952345A (en) | 1995-09-01 | 1999-09-14 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US5675024A (en) | 1995-11-22 | 1997-10-07 | Allergan | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity |
US5741896A (en) | 1996-06-21 | 1998-04-21 | Allergan | O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5773594A (en) | 1996-06-21 | 1998-06-30 | Allergan | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5763635A (en) | 1996-06-21 | 1998-06-09 | Allergan | Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity |
US6555690B2 (en) | 1996-06-21 | 2003-04-29 | Allergan, Inc. | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5728846A (en) | 1996-12-12 | 1998-03-17 | Allergan | Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives |
US6037488A (en) | 1997-04-19 | 2000-03-14 | Allergan Sales, Inc. | Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity |
US5919970A (en) | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
DE60143166D1 (de) * | 2000-09-01 | 2010-11-11 | Toko Pharmaceutical Ind Co Ltd | Verfahren zur herstellung von kristallen von benzoesäure-derivaten |
US6620963B1 (en) | 2002-09-19 | 2003-09-16 | Allergan, Inc. | TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-PHENYL AND TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-HETEROARYL AND RELATED COMPOUNDS HAVING RARα RECEPTOR SELECTIVE BIOLOGICAL ACTIVITY |
US6727277B1 (en) | 2002-11-12 | 2004-04-27 | Kansas State University Research Foundation | Compounds affecting cholesterol absorption |
CN101200435B (zh) * | 2006-12-12 | 2011-12-07 | 江苏恒瑞医药股份有限公司 | 他米巴罗汀ⅱ型结晶的制备方法 |
WO2008120711A1 (ja) | 2007-03-30 | 2008-10-09 | Tmrc Co., Ltd. | タミバロテンカプセル剤 |
WO2009114966A1 (zh) * | 2008-03-19 | 2009-09-24 | 江苏恒瑞医药股份有限公司 | 他米巴罗汀ii型结晶的制备方法 |
CN101665449B (zh) * | 2009-09-24 | 2012-12-12 | 山东大学 | 他米巴罗汀的水溶性前药及其制备方法与应用 |
CN102633673A (zh) * | 2012-03-30 | 2012-08-15 | 上海共价化学科技有限公司 | 他米巴罗汀的合成方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2500157C2 (de) * | 1975-01-03 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung |
US4227014A (en) * | 1978-02-27 | 1980-10-07 | American Cyanamid Company | 4-[(Cycloalkyl or cycloalkenyl substituted)amino, alkylamino or alkenylamino]benzoic acids and salts thereof |
DK214679A (da) * | 1978-06-09 | 1979-12-10 | Chugai Pharmaceutical Co Ltd | Terephthalsyremonoamid derivater fremgangsmaade til deres fremstilling samt antiallergiske midler indeholdende disse |
JPS6176440A (ja) * | 1984-09-19 | 1986-04-18 | Koichi Shiyudo | 安息香酸誘導体 |
US4808631A (en) * | 1986-11-07 | 1989-02-28 | Hoffmann-La Roche Inc. | Aromatic acid derivatives |
US4989090A (en) * | 1989-04-05 | 1991-01-29 | Yves C. Faroudja | Television scan line doubler including temporal median filter |
-
1991
- 1991-03-15 JP JP3505852A patent/JP3001632B2/ja not_active Expired - Lifetime
- 1991-03-15 US US07/778,985 patent/US5214202A/en not_active Expired - Lifetime
- 1991-03-15 EP EP91906248A patent/EP0478787B1/de not_active Expired - Lifetime
- 1991-03-15 DE DE69106098T patent/DE69106098T2/de not_active Expired - Lifetime
- 1991-03-15 KR KR1019910701646A patent/KR960014911B1/ko not_active IP Right Cessation
- 1991-03-15 HU HU9202856A patent/HU210300B/hu not_active IP Right Cessation
- 1991-03-15 DK DK91906248.9T patent/DK0478787T3/da active
- 1991-03-15 AU AU74826/91A patent/AU628732B2/en not_active Ceased
- 1991-03-15 HU HU913801A patent/HU208417B/hu not_active IP Right Cessation
- 1991-03-15 AT AT91906248T patent/ATE115946T1/de not_active IP Right Cessation
- 1991-03-15 ES ES91906248T patent/ES2069285T3/es not_active Expired - Lifetime
- 1991-03-15 WO PCT/JP1991/000350 patent/WO1991014673A1/ja active IP Right Grant
- 1991-11-18 FI FI915445A patent/FI915445A0/fi unknown
- 1991-11-19 NO NO914519A patent/NO300206B1/no not_active IP Right Cessation
-
1995
- 1995-02-22 GR GR950400358T patent/GR3015138T3/el unknown
-
1999
- 1999-07-16 JP JP11203717A patent/JP3076569B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
HU208417B (en) | 1993-10-28 |
JP3076569B2 (ja) | 2000-08-14 |
US5214202A (en) | 1993-05-25 |
NO300206B1 (no) | 1997-04-28 |
NO914519L (no) | 1992-01-07 |
AU628732B2 (en) | 1992-09-17 |
FI915445A0 (fi) | 1991-11-18 |
GR3015138T3 (en) | 1995-05-31 |
HUT61270A (en) | 1992-12-28 |
KR960014911B1 (ko) | 1996-10-21 |
HU210300B (en) | 1995-03-28 |
NO914519D0 (no) | 1991-11-19 |
EP0478787B1 (de) | 1994-12-21 |
AU7482691A (en) | 1991-10-21 |
WO1991014673A1 (en) | 1991-10-03 |
DK0478787T3 (da) | 1995-02-20 |
DE69106098D1 (de) | 1995-02-02 |
EP0478787A1 (de) | 1992-04-08 |
DE69106098T2 (de) | 1995-05-24 |
JP2000034262A (ja) | 2000-02-02 |
JP3001632B2 (ja) | 2000-01-24 |
EP0478787A4 (en) | 1992-07-01 |
HU9202856D0 (en) | 1992-11-30 |
HU913801D0 (en) | 1992-07-28 |
HUT61272A (en) | 1992-12-28 |
KR920702342A (ko) | 1992-09-03 |
ES2069285T3 (es) | 1995-05-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |