ES2065446T3 - Proceso para la preparacion de amino-compuestos ciclicos con actividad anticonvulsiva. - Google Patents

Proceso para la preparacion de amino-compuestos ciclicos con actividad anticonvulsiva.

Info

Publication number
ES2065446T3
ES2065446T3 ES90116264T ES90116264T ES2065446T3 ES 2065446 T3 ES2065446 T3 ES 2065446T3 ES 90116264 T ES90116264 T ES 90116264T ES 90116264 T ES90116264 T ES 90116264T ES 2065446 T3 ES2065446 T3 ES 2065446T3
Authority
ES
Spain
Prior art keywords
preparation
amino
cyclic compounds
seizure activity
converted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90116264T
Other languages
English (en)
Inventor
Rex Allen Jennings
Ronald Everett Seamans
James Robert Zeller
Don Richard Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/564,623 external-priority patent/US5132451A/en
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2065446T3 publication Critical patent/ES2065446T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/10—Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/12—Formation of amino and carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)

Abstract

UN PROCESO PARA PREPARAR ACIDOS AMINO CICLICOS POR UNA NUEVA SINTESIS DONDE UN DERIVADO DE DINITRILO SE CONVIERTE EN DESFASES EN EL PRODUCTO DESEADO.
ES90116264T 1989-08-25 1990-08-24 Proceso para la preparacion de amino-compuestos ciclicos con actividad anticonvulsiva. Expired - Lifetime ES2065446T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39905689A 1989-08-25 1989-08-25
US07/564,623 US5132451A (en) 1989-08-25 1990-08-10 Process for cyclic amino acid anticonvulsant compounds

Publications (1)

Publication Number Publication Date
ES2065446T3 true ES2065446T3 (es) 1995-02-16

Family

ID=27016485

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90116264T Expired - Lifetime ES2065446T3 (es) 1989-08-25 1990-08-24 Proceso para la preparacion de amino-compuestos ciclicos con actividad anticonvulsiva.

Country Status (17)

Country Link
US (1) US5693845A (es)
EP (1) EP0414262B1 (es)
JP (1) JP2945728B2 (es)
AT (1) ATE114637T1 (es)
AU (2) AU633612B2 (es)
CA (1) CA2023874A1 (es)
DE (1) DE69014480T2 (es)
DK (1) DK0414262T3 (es)
ES (1) ES2065446T3 (es)
FI (1) FI107914B (es)
HK (1) HK1000799A1 (es)
IE (1) IE66824B1 (es)
MY (1) MY106864A (es)
NO (1) NO179407C (es)
NZ (1) NZ235044A (es)
PH (2) PH27359A (es)
PT (1) PT95097B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894476A (en) * 1988-05-02 1990-01-16 Warner-Lambert Company Gabapentin monohydrate and a process for producing the same
FI905584A (fi) * 1989-11-16 1991-05-17 Lonza Ag Foerfarande foer framstaellning av 1-(aminometyl)cyklohexanaettikssyra.
IL153441A0 (en) * 2000-06-16 2003-07-06 Teva Pharma Stable gabapentin having ph within a controlled range
AU2001268426A1 (en) 2000-06-16 2002-01-02 Teva Pharmaceutical Industries Ltd. Stable gabapentin containing more than 2o ppm of chlorine ion
US20030119908A1 (en) * 2001-12-21 2003-06-26 Zambon Group S.P.A. Stable gabapentin compositions
BRPI0411654A (pt) * 2003-06-19 2006-08-08 Pfizer Prod Inc preparação biocatalìtica de ácido 1-cianocicloexanoacético
GB0416228D0 (en) 2004-07-20 2004-08-25 Sandoz Ind Products S A Process for the preparation of gabapentin
CN101484413B (zh) 2006-06-30 2014-05-14 Zach系统股份公司 制备加巴喷丁的方法
JP4872950B2 (ja) 2008-03-05 2012-02-08 ソニー株式会社 非水電解質二次電池
EP2923694B1 (en) 2014-03-27 2018-11-14 Sanovel Ilac Sanayi ve Ticaret A.S. Oral liquid pharmaceutical solution of gabapentin
CN107235850B (zh) * 2017-05-31 2019-07-26 浙江工业大学 利用1-氰基环己基乙酸直接合成加巴喷丁的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2264354A (en) * 1937-12-22 1941-12-02 Ig Farbenindustrie Ag Addition products of dienes and unsaturated esters, ketones, or nitriles
US2467927A (en) * 1947-05-29 1949-04-19 Goodrich Co B F Preparation of monomeric alkyl alpha-cyano-acrylates
US2502412A (en) * 1948-02-07 1950-04-04 Goodrich Co B F Preparation of vinylidene cyanide by pyrolysis of novel 4, 4-disubstituted cyclohexenes
US2575376A (en) * 1949-10-21 1951-11-20 Gen Mills Inc Formyl cyclohexene nitriles and esters
DE1445664A1 (de) * 1963-07-04 1969-11-27 Klinke Desitin Werk Verfahren zur Herstellung von alpha,alpha-disubstituierten Succinimiden
JPS4822692B1 (es) * 1963-12-24 1973-07-07
US3515740A (en) * 1967-02-20 1970-06-02 Orville D Frampton Cyano cyclohexenyl compounds
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
GB1478224A (en) * 1975-01-24 1977-06-29 Science Union & Cie Dispiroalkanes processes for their preparation and pharma ceutical compositions containing them
DE2557220A1 (de) * 1975-12-19 1977-06-23 Goedecke Ag N-substituierte spirolactame
DE2611690A1 (de) * 1976-03-19 1977-09-22 Goedecke Ag Cyclische sulfonyloxyimide
DE2626467C2 (de) * 1976-06-12 1984-11-22 Gödecke AG, 1000 Berlin 1-(N-Isopropylaminomethyl)-cyclohexanessigsäure, Verfahren zu deren Herstellung und diese Verbindung enthaltende Arzneimittel
US4226802A (en) * 1979-10-29 1980-10-07 Zoecon Corporation 2-(4-Trifluoromethylphenylamino)-3-methylbutanoic acid esters and intermediates therefor
GB8606255D0 (en) * 1986-03-13 1986-04-16 Wyeth John & Brother Ltd Nitriles
US4894476A (en) * 1988-05-02 1990-01-16 Warner-Lambert Company Gabapentin monohydrate and a process for producing the same
YU162789A (en) * 1988-09-01 1990-12-31 Lonza Ag 2-aza-4-(alcoxycarbonyl) spiro/4,5/decan-3-ones
DE3928184A1 (de) * 1989-08-25 1991-02-28 Goedecke Ag Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte

Also Published As

Publication number Publication date
FI107914B (fi) 2001-10-31
HK1000799A1 (en) 1998-05-01
NO903732D0 (no) 1990-08-24
DE69014480T2 (de) 1995-04-20
PH27359A (en) 1993-06-21
AU6124790A (en) 1991-02-28
MY106864A (en) 1995-08-30
EP0414262A2 (en) 1991-02-27
PT95097A (pt) 1991-04-18
ATE114637T1 (de) 1994-12-15
AU633612B2 (en) 1993-02-04
DK0414262T3 (da) 1995-05-15
JP2945728B2 (ja) 1999-09-06
JPH03236359A (ja) 1991-10-22
NO179407B (no) 1996-06-24
PH30922A (en) 1997-12-23
NO179407C (no) 1996-10-02
AU640582B2 (en) 1993-08-26
PT95097B (pt) 1997-04-30
AU3214593A (en) 1993-03-25
CA2023874A1 (en) 1991-02-26
NZ235044A (en) 1994-05-26
EP0414262B1 (en) 1994-11-30
US5693845A (en) 1997-12-02
IE66824B1 (en) 1996-02-07
DE69014480D1 (de) 1995-01-12
EP0414262A3 (en) 1991-06-05
IE903094A1 (en) 1991-02-27
FI904164A0 (fi) 1990-08-22
NO903732L (no) 1991-02-26

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