MX22095A - Proceso mejorado para compuestos anticonvulsivos de amino acidos ciclicos y productos resultantes. - Google Patents
Proceso mejorado para compuestos anticonvulsivos de amino acidos ciclicos y productos resultantes.Info
- Publication number
- MX22095A MX22095A MX22095A MX2209590A MX22095A MX 22095 A MX22095 A MX 22095A MX 22095 A MX22095 A MX 22095A MX 2209590 A MX2209590 A MX 2209590A MX 22095 A MX22095 A MX 22095A
- Authority
- MX
- Mexico
- Prior art keywords
- improved process
- amino acid
- resulting products
- acid cyclic
- cyclic acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/10—Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/12—Formation of amino and carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/04—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers
- C07C257/06—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers having carbon atoms of imino-carboxyl groups bound to hydrogen atoms, to acyclic carbon atoms, or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se describe un proceso mejorado para la preparación de aminóacidos cíclicos mediante una sintesis novedosa, en donde un derivado de dinitrilo se convierte en dos pasos en los productos deseados, así como los intermedios valiosos usados en el proceso.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39905689A | 1989-08-25 | 1989-08-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX22095A true MX22095A (es) | 1994-03-31 |
Family
ID=23577949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX22095A MX22095A (es) | 1989-08-25 | 1990-08-24 | Proceso mejorado para compuestos anticonvulsivos de amino acidos ciclicos y productos resultantes. |
Country Status (4)
Country | Link |
---|---|
US (1) | US5132451A (es) |
KR (1) | KR0169475B1 (es) |
MX (1) | MX22095A (es) |
ZA (1) | ZA906766B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5319135A (en) * | 1989-08-25 | 1994-06-07 | Warner-Lambert Company | Process for cyclic amino acid anticonvulsant compounds |
US5637767A (en) * | 1995-06-07 | 1997-06-10 | Warner-Lambert Company | Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
NZ331143A (en) * | 1996-03-14 | 2001-06-29 | Warner Lambert Co | Substituted cyclic amino acids as pharmaceutical agents |
US6372792B1 (en) | 1996-04-26 | 2002-04-16 | Guy Chouinard | Method for treating anxiety, anxiety disorders and insomnia |
US6255526B1 (en) | 1996-12-24 | 2001-07-03 | Teva Pharmaceutical Industries Ltd. | Preparation of gabapentin |
AU9318398A (en) | 1997-10-07 | 1999-04-27 | Warner-Lambert Company | Process for preparing a cyclic amino acid anticonvulsant compound |
PL199500B1 (pl) * | 1997-10-27 | 2008-09-30 | Warner Lambert Co | Cykliczne aminokwasy, kompozycja farmaceutyczna i zastosowanie cyklicznych aminokwasów |
IL153441A0 (en) * | 2000-06-16 | 2003-07-06 | Teva Pharma | Stable gabapentin having ph within a controlled range |
AU2001268426A1 (en) | 2000-06-16 | 2002-01-02 | Teva Pharmaceutical Industries Ltd. | Stable gabapentin containing more than 2o ppm of chlorine ion |
ITMI20012750A1 (it) | 2001-12-21 | 2003-06-21 | Procos Spa | Processo per la produzione dell'acido 1-(amminometil)-cicloesil-acetico in forma pura |
US20030119908A1 (en) * | 2001-12-21 | 2003-06-26 | Zambon Group S.P.A. | Stable gabapentin compositions |
DE10210195B4 (de) * | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
DE10210190A1 (de) * | 2002-03-07 | 2003-09-25 | Sanol Arznei Schwarz Gmbh | Aza-Spiroverbindungen |
US20040034248A1 (en) * | 2002-04-16 | 2004-02-19 | Taro Pharmaceutical Industries, Ltd. | Process for preparing gabapentin |
US7196216B2 (en) * | 2002-11-18 | 2007-03-27 | Nicholas Piramal India Limited | Process for preparation of Gabapentin |
WO2004093866A1 (en) * | 2003-03-25 | 2004-11-04 | Kiel Laboratories, Inc. | Process for preparing phenolic acid salts of gabapentin |
WO2004093867A2 (en) * | 2003-03-25 | 2004-11-04 | Kiel Laboratories, Inc. | Phenolic acid salts of gabapentin in liquid and/or semi-solid dosage forms and methods of use |
WO2004093827A2 (en) * | 2003-03-25 | 2004-11-04 | Kiel Laboratories, Inc. | Phenolic acid salts of gabapentin in solid dosage forms and methods of use |
US7439387B2 (en) * | 2003-04-21 | 2008-10-21 | Matrix Laboratories Ltd. | Process for the preparation of Gabapentin form-II |
US20050148792A1 (en) * | 2004-01-02 | 2005-07-07 | Damodaragounder Gopal | Process for the preparation of gabapentin |
CN101437787A (zh) * | 2006-05-05 | 2009-05-20 | 辉瑞科学技术爱尔兰有限公司 | 用于制备加巴喷丁的方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3354203A (en) * | 1963-11-04 | 1967-11-21 | Dow Chemical Co | Preparation of omega-amino acids |
JPS4822692B1 (es) * | 1963-12-24 | 1973-07-07 | ||
DE1543677A1 (de) * | 1966-12-07 | 1969-10-09 | Henkel & Cie Gmbh | Verfahren zur Herstellung von primaeren Aminen |
US3558709A (en) * | 1968-04-19 | 1971-01-26 | Huels Chemische Werke Ag | Process for the preparation of amines or diamines by the catalytic hydrogenation of nitriles and dinitriles |
US4007226A (en) * | 1970-07-29 | 1977-02-08 | Eastman Kodak Company | Nitrile hydrogenation process |
DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
DE2557220A1 (de) * | 1975-12-19 | 1977-06-23 | Goedecke Ag | N-substituierte spirolactame |
DE2611690A1 (de) * | 1976-03-19 | 1977-09-22 | Goedecke Ag | Cyclische sulfonyloxyimide |
JPS54100316A (en) * | 1978-01-25 | 1979-08-08 | Meiji Seika Kaisha Ltd | Preparation of derivative of aminobutyric acid |
US4250093A (en) * | 1979-06-29 | 1981-02-10 | The Standard Oil Company (Ohio) | Process for the preparation of laotams |
US4226802A (en) * | 1979-10-29 | 1980-10-07 | Zoecon Corporation | 2-(4-Trifluoromethylphenylamino)-3-methylbutanoic acid esters and intermediates therefor |
US4665225A (en) * | 1985-09-12 | 1987-05-12 | Union Camp Corporation | Cycloaliphatic amino carboxylic acid |
US4739120A (en) * | 1986-08-21 | 1988-04-19 | The Dow Chemical Company | Process for the hydrogenation of nitriles to primary amines |
-
1990
- 1990-08-10 US US07/564,623 patent/US5132451A/en not_active Expired - Lifetime
- 1990-08-24 KR KR1019900013103A patent/KR0169475B1/ko not_active IP Right Cessation
- 1990-08-24 ZA ZA906766A patent/ZA906766B/xx unknown
- 1990-08-24 MX MX22095A patent/MX22095A/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR910004548A (ko) | 1991-03-28 |
ZA906766B (en) | 1992-04-29 |
US5132451A (en) | 1992-07-21 |
KR0169475B1 (ko) | 1999-03-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX22095A (es) | Proceso mejorado para compuestos anticonvulsivos de amino acidos ciclicos y productos resultantes. | |
ES2070519T3 (es) | Proceso para la sintesis de (4r-cis)-1,1-dimetiletil-6-cianometil-2,2-dimetil-1,3-dioxano-4-acetato. | |
GEP20012580B (en) | Substituted 4-Hydroxy-Phenylalcanoic Acid Derivatives With Agonist Activity to PPAR-Gamma, Methods for Their Production, Pharmaceutical Conposition and Methods for Treatment | |
BG60538B1 (bg) | Нови //бис(арил)метилен/-1-пиперидинил/-алкил-пиримидинони | |
BG60431B1 (bg) | Производни на бензоксазол- и бензотиазоламини | |
AR015886A1 (es) | Sintesis de intermediarios utiles en la preparacion de compuestos triciclicos bromo-sustituidos | |
EA199900580A1 (ru) | Фармацевтические производные аминофосфоновой кислоты | |
EA200200096A1 (ru) | Новые производные витамина d с циклическими субструктурами в боковых цепях, способ и промежуточные продукты для их получения и их применение для получения лекарственных средств | |
ES2065446T3 (es) | Proceso para la preparacion de amino-compuestos ciclicos con actividad anticonvulsiva. | |
ES2066931T3 (es) | Procedimiento para la inversion estereoquimica de los (2s,3s)-2-amino-3-fenil-1,3-propanodioles en sus (2r,3r)-enantiomeros. | |
ES2039196T3 (es) | Procedimiento para preparar 4-(1,2,5,6-tetrahidro-1-alquil-3-piridinil)-2-tiazolaminas y 4-(hexahidro-1-alquil-3-piridinil)-2-tiazolaminas. | |
EA199800354A1 (ru) | Способ получения производных камптотецина | |
FI925497A (fi) | Menetelmä synteettisten isohirudiinien valmistamiseksi, joilla on parantunut stabiilisuus | |
ES2151743T3 (es) | Procedimiento para la preparacion de n-((1-n-butil-4-piperidinil)metil)-3,4-dihidro-2h-(1,3)-oxazino(3,2-a)indol-10-carboxamida y las sales y productos intermedios en el procedimiento. | |
ES2062205T3 (es) | Metodo para producir 2,2-dimetil-3-hidroxipropil-2,2-dimetil-3-hidroxipropionato. | |
NO994049L (no) | Metode for aa fremstille farmasöytiske forbindelser | |
AR005878A1 (es) | Procedimiento para la elaboracion del ester metilico del acido 2-(2- metilfenil)-3-metoxiacrilico | |
ES2046528T3 (es) | Derivados heterotetraciclicos de lactamas, proceso para su preparacion y composiciones farmaceuticas a base de los mismos. | |
ES2090156T3 (es) | Procedimiento para la preparacion de castanoespermina. | |
MX9203061A (es) | Preparacion de alcanosulfonamidas | |
FI956247A0 (fi) | Uusia menetelmiä (S)-4-amino-hepta-5,6-dieenihappo ja sen välituotteiden valmistamiseksi | |
ES2117406T3 (es) | Recuperacion de reactivos y productos en la produccion de compuestos anulares con puentes alquenilo. | |
MX9303902A (es) | Polimeros de sacaridos lewis x y procedimiento para su preparacion. | |
ES2042571T3 (es) | N-(s-3-metilftanoil)-d-gamma-glutamil-glicil-d-alanina cristalina, y procedimientos y productos intermedios de la misma. | |
ES2052812T3 (es) | Un procedimiento para la preparacion de derivados de pirrolizina. |