ES2064435T3 - Aceleracion de la lisis de los coagulos. - Google Patents
Aceleracion de la lisis de los coagulos.Info
- Publication number
- ES2064435T3 ES2064435T3 ES89303293T ES89303293T ES2064435T3 ES 2064435 T3 ES2064435 T3 ES 2064435T3 ES 89303293 T ES89303293 T ES 89303293T ES 89303293 T ES89303293 T ES 89303293T ES 2064435 T3 ES2064435 T3 ES 2064435T3
- Authority
- ES
- Spain
- Prior art keywords
- clots
- hapten
- binding molecule
- thrombolytic agent
- preventing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Abstract
LOS COAGULOS DE SANGRE Y EL INFARTO DE MIOCARDIO PUEDEN SER TRATADOS POR ADMINISTRACION DE UNA MOLECULA QUE SE UNE A HAPTENO, CAPAZ DE PREVENIR LA INHIBICION DE PLASMINA POR LA ALFA - 2 ANTIPLASMINA ENDOGENA. LA MOLECULA QUE SE UNE A HAPTENO PUEDE SER COADMINISTRADA CON UN AGENTE TROMBOLITICO CAPAZ DE DISOLVER LOS COAGULOS DE PLAQUETAS DE FIBRINA O DE INHIBIR SU FORMACION. ESTO CONDUCE A UNA DESTRUCCION AUMENTADA DE LOS COAGULOS A LA VEZ QUE SE DISMINUYE LA DEGRADACION DEL FIBRINOGENO Y SE PREVIENE LA REOCLUSION DE LA ARTERIA CORONARIA AFECTADA, INCLUSO EN AUSENCIA DE HEPARINA Y CUANDO LA CONCENTRACION DE AGENTE TROMBOLITICO ES MENOR QUE LA REQUERIDA POR OTRAS TERAPIAS POTENCIALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17722288A | 1988-04-04 | 1988-04-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2064435T3 true ES2064435T3 (es) | 1995-02-01 |
Family
ID=22647707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89303293T Expired - Lifetime ES2064435T3 (es) | 1988-04-04 | 1989-04-04 | Aceleracion de la lisis de los coagulos. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0336693B1 (es) |
JP (1) | JP2871775B2 (es) |
KR (1) | KR100194113B1 (es) |
AT (1) | ATE114480T1 (es) |
AU (1) | AU628041B2 (es) |
CA (1) | CA1341377C (es) |
DE (1) | DE68919504T2 (es) |
DK (1) | DK174062B1 (es) |
ES (1) | ES2064435T3 (es) |
FI (1) | FI102812B (es) |
GR (1) | GR3015182T3 (es) |
HU (1) | HU207349B (es) |
NO (1) | NO301374B1 (es) |
WO (1) | WO1989009817A1 (es) |
ZA (1) | ZA892464B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5357042A (en) * | 1984-04-23 | 1994-10-18 | The General Hospital Corporation | Synthetic peptides capable of eliciting fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity |
US5453269A (en) * | 1986-04-14 | 1995-09-26 | The General Hospital Corporation | Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use |
US5582862A (en) | 1988-04-04 | 1996-12-10 | General Hospital Corporation | Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin |
US5372812A (en) * | 1988-04-04 | 1994-12-13 | The General Hospital Corporation | Composition and method for acceleration of clot lysis |
US5811265A (en) * | 1988-08-19 | 1998-09-22 | The General Hospital Corporation | Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use |
US5609869A (en) * | 1988-08-19 | 1997-03-11 | The General Hospital Corporation | Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use |
JPH02268694A (ja) * | 1989-04-07 | 1990-11-02 | Teijin Ltd | 血栓溶解剤 |
EP0941345A2 (en) * | 1996-09-20 | 1999-09-15 | The General Hospital Corporation | Chimeric, humanized and single chain antibodies to alpha-2-antiplasmin |
US6524675B1 (en) | 1999-05-13 | 2003-02-25 | 3M Innovative Properties Company | Adhesive-back articles |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0735340B2 (ja) * | 1985-05-23 | 1995-04-19 | 帝人株式会社 | 血栓溶解促進剤 |
ATE142502T1 (de) * | 1986-05-15 | 1996-09-15 | Univ Emory | Injizierbares arzneimittel zum schutz vor gewebebeschädigung durch ischemie |
-
1989
- 1989-03-15 AU AU32845/89A patent/AU628041B2/en not_active Ceased
- 1989-03-15 KR KR1019890702259A patent/KR100194113B1/ko not_active IP Right Cessation
- 1989-03-15 HU HU892304A patent/HU207349B/hu not_active IP Right Cessation
- 1989-03-15 WO PCT/US1989/001065 patent/WO1989009817A1/en active IP Right Grant
- 1989-03-15 JP JP1503381A patent/JP2871775B2/ja not_active Expired - Fee Related
- 1989-03-29 CA CA000594988A patent/CA1341377C/en not_active Expired - Fee Related
- 1989-04-04 ES ES89303293T patent/ES2064435T3/es not_active Expired - Lifetime
- 1989-04-04 DE DE68919504T patent/DE68919504T2/de not_active Expired - Fee Related
- 1989-04-04 AT AT89303293T patent/ATE114480T1/de not_active IP Right Cessation
- 1989-04-04 EP EP89303293A patent/EP0336693B1/en not_active Expired - Lifetime
- 1989-04-04 ZA ZA892464A patent/ZA892464B/xx unknown
-
1990
- 1990-10-03 NO NO904294A patent/NO301374B1/no not_active IP Right Cessation
- 1990-10-03 FI FI904867A patent/FI102812B/fi not_active IP Right Cessation
- 1990-10-04 DK DK199002401A patent/DK174062B1/da not_active IP Right Cessation
-
1995
- 1995-02-27 GR GR940403885T patent/GR3015182T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3015182T3 (en) | 1995-05-31 |
ATE114480T1 (de) | 1994-12-15 |
CA1341377C (en) | 2002-07-16 |
AU628041B2 (en) | 1992-09-10 |
EP0336693B1 (en) | 1994-11-30 |
NO904294L (no) | 1990-12-04 |
FI904867A0 (fi) | 1990-10-03 |
JPH03504717A (ja) | 1991-10-17 |
AU3284589A (en) | 1989-11-03 |
HUT56394A (en) | 1991-08-28 |
ZA892464B (en) | 1989-12-27 |
HU207349B (en) | 1993-03-29 |
HU892304D0 (en) | 1991-07-29 |
EP0336693A3 (en) | 1990-03-21 |
NO301374B1 (no) | 1997-10-20 |
FI102812B1 (fi) | 1999-02-26 |
DK174062B1 (da) | 2002-05-13 |
DE68919504D1 (de) | 1995-01-12 |
KR900700129A (ko) | 1990-08-11 |
DE68919504T2 (de) | 1995-06-29 |
FI102812B (fi) | 1999-02-26 |
DK240190A (da) | 1990-10-04 |
KR100194113B1 (ko) | 1999-06-15 |
JP2871775B2 (ja) | 1999-03-17 |
EP0336693A2 (en) | 1989-10-11 |
NO904294D0 (no) | 1990-10-03 |
DK240190D0 (da) | 1990-10-04 |
WO1989009817A1 (en) | 1989-10-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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